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Macromolecule Insights - Protein Bioinformatics Analysis

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The Sodium Ion Channel

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Sequence Alignment of the Sodium Ion Channel (with Clustalw)a

Isoform Sequence Alignment of the Sodium Ion Channel

alpha subunit

alpha1.1  ---MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPD----KKDDDENGPKPNS 53
alpha1.2  ---MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQER---KDEDDENGPKPNS 54
alpha1.3  ---MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKE----QDNDDENKPKPNS 53
alpha1.4  MARPSLCTLVPLGPECLRPFTRESLAAIEQRAVEEEARLQRNK----QMEIEEPERKPRS 56
alpha1.5  ----MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQL 56
alphax    -------MLASPEPKGLVPFTKESFELIKQHIAKTHN-----------EDHEEEDLKPNP 42
alpha1.6  ---MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNS 57
alpha1.7  -----MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEE----KKDDDEEAPKPSS 51
alpha1.8  ----MEFPIGSLETNNFRRFTPESLVEIEKQIAAKQGT-KKAREKHREQKDQEEKPRPQL 55
alpha1.9  -MDDRCYPVIFPDERNFRPFTSDSLAAIEKRIAIQKEK-KKS----KDQTGEVPQPRPQL 54
                  :       :  ** :*:  *::: .  .               :    :*  

alpha1.1  DLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKK-TFIVLNKGKAIFRFSATSALYILT 112
alpha1.2  DLEAGKSLPFIYGDIPPEMVSVPLEDLDPYYINKK-TFIVLNKGKAISRFSATPALYILT 113
alpha1.3  DLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKK-TFIVMNKGKAIFRFSATSALYILT 112
alpha1.4  DLEAGKNLPMIYGDPPPEVIGIPLEDLDPYYSNKK-TFIVLNKGKAIFRFSATPALYLLS 115
alpha1.5  DLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQK-TFIVLNKGKTIFRFSATNALYVLS 115
alphax    DLEVGKKLPFIYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLS 102
alpha1.6  DLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQK-TFVVLNRGKTLFRFSATPALYILS 116
alpha1.7  DLEAGKQLPFIYGDIPPGMVSEPLEDLDPYYADKK-TFIVLNKGKTIFRFNATPALYMLS 110
alpha1.8  DLKACNQLPKFYGELPAELIGEPLEDLDPFYSTHR-TFMVLNKGRTISRFSATRALWLFS 114
alpha1.9  DLKASRKLPKLYGDIPRELIGKPLEDLDPFYRNHK-TFMVLNRKRTIYRFSAKHALFIFG 113
          **:. ..** :**: .  ::. ****.**:*  :: **:*:*: ::: **.*   *  : 

alpha1.1  PFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNP----PDWTKNVEYTFTGIYTFE 168
alpha1.2  PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP----PDWTKNVEYTFTGIYTFE 169
alpha1.3  PLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNP----PDWTKNVEYTFTGIYTFE 168
alpha1.4  PFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDP----PPWSKNVEYTFTGIYTFE 171
alpha1.5  PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP----PPWTKYVEYTFTAIYTFE 171
alphax    PFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNL----PKWRPVLENTLLGIYTFE 158
alpha1.6  PFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP----PDWSKNVEYTFTGIYTFE 172
alpha1.7  PFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNP----PDWTKNVEYTFTGIYTFE 166
alpha1.8  PFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTR-------TDLPEKIEYVFTVIYTFE 167
alpha1.9  PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFE 173
          *:  :*  :::: :*. *.::*  ::: :*: *:        .      * .:  ** **

alpha1.1  SLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVT--EFVDLGNVSALRTFRVLRALKT 226
alpha1.2  SLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVT--EFVDLGNVSALRTFRVLRALKT 227
alpha1.3  SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVT--EFVSLGNVSALRTFRVLRALKT 226
alpha1.4  SLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLT--EFVDLGNISALRTFRVLRALKT 229
alpha1.5  SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTT--EFVDLGNVSALRTFRVLRALKT 229
alphax    ILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVII--RYSPLDFIPTLQTARTLRILKI 216
alpha1.6  SLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYIT--EFVNLGNVSALRTFRVLRALKT 230
alpha1.7  SLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLT--EFVNLGNVSALRTFRVLRALKT 224
alpha1.8  ALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVG--TAIDLRGISGLRTFRVLRALKT 225
alpha1.9  ALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLP-LRTFRVFRALKA 232
           *:*::***.    *::* *******  *  :          :  :. *:* *.:* ** 

alpha1.1  ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNAS 286
alpha1.2  ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSS 287
alpha1.3  ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSA 286
alpha1.4  ITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFN- 288
alpha1.5  ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALN- 288
alphax    IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQE--- 273
alpha1.6  ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWP----- 285
alpha1.7  ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLE--- 281
alpha1.8  VSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVN- 284
alpha1.9  ISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNI- 291
          :.:   ** :**.*::.:*:* .* :**.* **:*:*:*  ** *.*. **.        

alpha1.1  LEEHSIEKN-ITVNYNGTLIN----------------------ETVFEFDWKSYIQDSRY 323
alpha1.2  FEINITSFFNNSLDGNGTTFN----------------------RTVSIFNWDEYIEDKSH 325
alpha1.3  FETNTTSYFNGTMDSNGTFVN----------------------VTMSTFNWKDYIGDDSH 324
alpha1.4  -DTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGN 347
alpha1.5  -------------GTNGSVEADG----------------------LVWESLDLYLSDPEN 313
alphax    -------------NENETLHN----------------------RTGNPY----YIRETEN 294
alpha1.6  ------------INFNESYLE----------------------NGTKGFDWEEYINNKTN 311
alpha1.7  ---------------NNETLE----------------------SIMNTLESEEDFR--KY 302
alpha1.8  -------------ETTNYSSHR----------------------------------KPDI 297
alpha1.9  -------------SNPEAYDH--------------------------------------C 300
                                                                      

alpha1.1  HYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDF 383
alpha1.2  FYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDF 385
alpha1.3  FYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDY 384
alpha1.4  FYFLEGSNDALLCGNSSDAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDY 407
alpha1.5  YLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDC 373
alphax    FYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDY 354
alpha1.6  FYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDY 371
alpha1.7  FYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDY 362
alpha1.8  YINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDS 357
alpha1.9  FEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDS 360
          .    .     :**   . . *.  * * :   **: .:*.:*.*.*:::::****:** 

alpha1.1  WENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAE 443
alpha1.2  WENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAE 445
alpha1.3  WENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAE 444
alpha1.4  WENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEE 467
alpha1.5  WERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKR 433
alphax    PEVLYHLILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPK 414
alpha1.6  WENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAE 431
alpha1.7  WENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELE 422
alpha1.8  WERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKK 417
alpha1.9  WEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKM 420
           * *::  * ::*   ::**::: *: ***: .* *.:::*** *:::      :  *  

alpha1.1  FQQMIEQLKKQQEAAQQAATAT--ASEHSREPSAAGRLS----DSSSEASKLSSKSAKER 497
alpha1.2  FQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFS----ESSSVASKLSSKSEKEL 501
alpha1.3  FQQMLEQLKKQQEEAQAVAAAS-AASRDFSGIGGLGELL----ESSSEASKLSSKSAKEW 499
alpha1.4  FQQMLEKFKKHQEELEKAKAAQ---------ALEGGEAD--------------------- 497
alpha1.5  FQEAMEMLKKEHEALTIRGVDT---------VSRSSLEM----------SPLAPVNSHER 474
alphax    FQQTGKELQEGNE------------------TDEAK------------------------ 432
alpha1.6  FKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKER 491
alpha1.7  FQQMLDRLKKEQEEAEAIAAAA-AEYTSIRRSRIMGLSE-----SSSETSKLSSKSAKER 476
alpha1.8  FQEALEMLRKEQEVLAALGIDT---------TSLHSHNG----------SPLTSKNASER 458
alpha1.9  FQEAQQLLKEEKEALVAMGIDR---------SSLTSLET----------SYFTPK----K 457
          *:   . ::: :*                                               

alpha1.1  RNRRKKRKQKEQSGGEEKDEDE-FQKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSL 556
alpha1.2  KNRRKKKKQKEQSGEEEKNDR--VRKSESEDSIRRKGFRFSLEGSRLTYEKRFSSPHQSL 559
alpha1.3  RNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDGNRLTSDKKFCSPHQSL 559
alpha1.4  ------------------------------------------------------------
alpha1.5  RSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRR 534
alphax    ------------------------------------------------------------
alpha1.6  RNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPD--NRIG--RKFSIMNQSL 547
alpha1.7  RNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSP 536
alpha1.8  RHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPE 518
alpha1.9  RKLFG-------------------NKKRKSFFLRESGKD----------QPPGSDS---- 484
                                                                      

alpha1.1  LSIRGSLFSPRRNSRTSLFSFRG--RAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRH 614
alpha1.2  LSIRGSLFSPRRNSRASLFSFRG--RAKDIGSENDFADDEHSTFEDNDSRRDSLFVPHRH 617
alpha1.3  LSIRGSLFSPRRNSKTSIFSFRG--RAKDVGSENDFADDEHSTFEDSESRRDSLFVPHRH 617
alpha1.4  ------------------------------------------------------------
alpha1.5  RDLGSEADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNST 594
alphax    ------------------------------------------------------------
alpha1.6  LSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRA 607
alpha1.7  LSIRGSLFSARRSSRTSLFSFKG--RGRDIGSETEFADDEHSIFGDNESRRGSLFVPHRP 594
alpha1.8  GVTDDGVFPGDHESHRGSLLLGGGAGQQGPLPR---SPLPQPSNPDSRHGEDEHQPPPTS 575
alpha1.9  ----------DEDCQK----------------------KPQLLEQTKRLSQN-------- 504
                                                                      

alpha1.1  GERRN-----SNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLP 669
alpha1.2  GERRH-----SNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGPSTLTS-AGQLLP 671
alpha1.3  GERRN-----SNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGPSALTSPTGQLPP 672
alpha1.4  ------------------------------------------------------------
alpha1.5  VDCNG------------------------------------------------------- 599
alphax    ------------------------------------------------------------
alpha1.6  RERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIG--GRLLP 665
alpha1.7  QERRS-----SNISQASRSP---PMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNGQLLP 646
alpha1.8  ELAPG------------------------------------------------------- 580
alpha1.9  ------------------------------------------------------------
                                                                      

alpha1.1  EVIIDKPATDDNGTTTETEMRKRRSSS--------------------------------F 697
alpha1.2  E-----------GTTTETEIRKRRSSS--------------------------------Y 688
alpha1.3  E-----------GTTTETEVRKRRLSS--------------------------------Y 689
alpha1.4  ---------------GDPAHGKDCNGS--------------------------------L 510
alpha1.5  -------------VVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQ 646
alphax    --------------TIQIEMKKRSPIS--------------------------------T 446
alpha1.6  E------------ATTEVEIKKKGPGS--------------------------------L 681
alpha1.7  EVIIDKATSDD-SGTTNQIHKKRRCSS--------------------------------Y 673
alpha1.8  -------------AVDVSAFDAGQKKT--------------------------------- 594
alpha1.9  --------------LSLDHFDEHG------------------------------------ 514
                                                                      

alpha1.1  HVSMDFLEDPSQRQRAMSIASILTNT-VEELEESRQKCPPCWYKFSNIFLIWDCSPYWLK 756
alpha1.2  HVSMDLLEDPTSRQRAMSIASILTNT-MEELEESRQKCPPCWYKFANMCLIWDCCKPWLK 747
alpha1.3  QISMEMLEDSSGRQRAVSIASILTNT-MEELEESRQKCPPCWYRFANVFLIWDCCDAWLK 748
alpha1.4  DTSQGEKGAPRQSGSGDSGIS----DAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLK 566
alpha1.5  APCVDGFEEPGARQRALSAVSVLTSA-LEELEESRHKCPPCWNRLAQRYLIWECCPLWMS 705
alphax    DTSLDVLEDATLRH-------------KEELEKSKKICPLYWYKFAKTFLIWNCSPCWLK 493
alpha1.6  LVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIK 741
alpha1.7  LLSEDMLNDPNLRQRAMSRASILTNT-VEELEESRQKCPPWWYRFAHKFLIWNCSPYWIK 732
alpha1.8  FLSAEYLDEPFRAQRAMSVVSIITSV-LEELEESEQKCPPCLTSLSQKYLIWDCCPMWVK 653
alpha1.9  --------DPLQRQRALSAVSILTIT-MKEQEKSQEPCLPCGENLASKYLVWNCCPQWLC 565
                                      :* *::.. *       :   *:*:*   *: 

alpha1.1  VKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMF 816
alpha1.2  VKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMF 807
alpha1.3  VKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMV 808
alpha1.4  FKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMV 626
alpha1.5  IKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMT 765
alphax    LKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMI 553
alpha1.6  LKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMF 801
alpha1.7  FKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMV 792
alpha1.8  LKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMV 713
alpha1.9  VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
          .*  :  ::  **.:* : :**::*. *:::**: *    . :* :**:**  :* *** 

alpha1.1  LKIIAMDPYYYFQEGWNIFDGFIVTLSLVELG--LANVEGLSVLRSFRLLRVFKLAKSWP 874
alpha1.2  LKIIAMDPYYYFQEGWNIFDGFIVSLSLMELG--LANVEGLSVLRSFRLLRVFKLAKSWP 865
alpha1.3  LKIIAMDPYYYFQEGWNIFDGIIVSLSLMELG--LSNVEGLSVLRSFRLLRVFKLAKSWP 866
alpha1.4  LKLIAMDPYEYFQQGWNIFDSIIVTLSLVELG--LANVQGLSVLRSFRLLRVFKLAKSWP 684
alpha1.5  FKIIALDPYYYFQQGWNIFDSIIVILSLMELG--LSRMSNLSVLRSFRLLRVFKLAKSWP 823
alphax    FKIIAMHPYGYFQVGWNIFDSMIVFHGLIELC--LANVAGMALLRLFRMLRIFKLGKYWP 611
alpha1.6  LKLIAMDPYYYFQEGWNIFDGFIVSLSLMELS--LADVEGLSVLRSFRLLRVFKLAKSWP 859
alpha1.7  LKLIAMDPYEYFQVGWNIFDSLIVTLSLVELF--LADVEGLSVLRSFRLLRVFKLAKSWP 850
alpha1.8  FKIIAFDPYYYFQKKWNIFDCIIVTVSLLELG--VAKKGSLSVLRSFRLLRVFKLAKSWP 771
alpha1.9  LKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWP 685
          :*:**:.** **:  ***** ::.  .: ::   :    . ..** **:**:***.* **

alpha1.1  TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVC------KIASDCQ 928
alpha1.2  TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVC------KISNDCE 919
alpha1.3  TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVC------KINDDCT 920
alpha1.4  TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVC------KIALDCN 738
alpha1.5  TLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRD--------SDSGL 875
alphax    TFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVC------HIDKDCQ 665
alpha1.6  TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVC------KINQDCE 913
alpha1.7  TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVC------KINDDCT 904
alpha1.8  TLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRK----NISAPHEDW 827
alpha1.9  TLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSC 745
          *:: *:  :.**  ** .*.::*  .:*. : .* :*:*..: .                

alpha1.1  LPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAG--QAMCLTVFMMVMVIGNLVVLNL 986
alpha1.2  LPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAG--QTMCLTVFMMVMVIGNLVVLNL 977
alpha1.3  LPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAG--QTMCLIVFMLVMVIGNLVVLNL 978
alpha1.4  LPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVAG--QAMCLTVFLMVMVIGNLVVLNL 796
alpha1.5  LPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVS--GQSLCLLVFLLVMVIGNLVVLNL 933
alphax    LPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAG--QSWCIPFYLMVILIGNLLVLYL 723
alpha1.6  LPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAG--QAMCLIVFMMVMVIGNLVVLNL 971
alpha1.7  LPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAG--QAMCLIVYMMVMVIGNLVVLNL 962
alpha1.8  PR-WHMHDFFHSFLIVFRILCGEWIENMWACMEVG--QKSICLILFLTVMVLGNLVVLNL 884
alpha1.9  LRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNL 805
             *** **:*:** :**:*****:*.:* **: .   .: *: .:: : ::*:*:** *

alpha1.1  FLALLLSSFSADNLA-ATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQKIL 1045
alpha1.2  FLALLLSSFSSDNLA-ATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKAL 1036
alpha1.3  FLALLLSSFSSDNLA-ATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPKVI 1037
alpha1.4  FLALLLSSFSADSLA-ASDEDGEMNNLQIAIGRIKLGIGFAKAFLLGLLHGKILSPKDIM 855
alpha1.5  FLALLLSSFSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKP 992
alphax    FLALVSS-FSSCKDV-TAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNVP------K 775
alpha1.6  FLALLLSSFSADNLA-ATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQRE--A 1028
alpha1.7  FLALLLSSFSSDNLT-AIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKIS 1021
alpha1.8  FIALLLNSFSADNLT-APEDDGEVNNLQVALARIQVFGHRTKQALCSFFSRSCPFP-QPK 942
alpha1.9  FIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRRAFCFVRHTLEHFCHKWCRK--QNL 863
          *:**: . **  .     : :   .::*::: *::     .                   

alpha1.1  DEIKPLDDLNNKKDSCMSNHT-AEIGKDLDYLKDVNGTTSGIGT--------GSSVEKYI 1096
alpha1.2  DEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIG----------SSVEKYV 1086
alpha1.3  EIHE-----GNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGT--------GSSVEKYV 1084
alpha1.4  LSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMG----------LADGPPS 905
alpha1.5  AALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVA 1052
alphax    DTMDHVNEVYVKED--ISDHTLSELSNTQDFLKDKEKSS---------------GTEKNA 818
alpha1.6  DEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIG----------SSVEKYI 1078
alpha1.7  REIRQAEDLNTKKENYISNHTLAEMSKGHNFLKE-KDKISGFG----------SSVDKHL 1070
alpha1.8  AEPELVVKLPLSSSKAENHIAANTARGSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEG 1002
alpha1.9  PQQKEVAGGCAAQSKDIIPLVMEMKRGSETQEELGILTSVPKTLGVRHDWTWL-APLAEE 922
                                          .                           

alpha1.1  IDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKE--KLNE------- 1147
alpha1.2  VDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKE--KLN-------- 1136
alpha1.3  IDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKE--KLN-------- 1134
alpha1.4  SLELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLY------- 958
alpha1.5  ESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQ 1112
alphax    TEN-ESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKE--KIK-------- 867
alpha1.6  IDE-DHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKD--KLD-------- 1127
alpha1.7  MEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKV--RLN-------- 1120
alpha1.8  ESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLG 1062
alpha1.9  E---DDVEFSGEDNAQRITQ---PEPEQ---QAYELHQENKKPTSQRVQSVEIDMFS--- 970
              :  .                : .       :         .               

alpha1.1  --------------------SSSSSEGSTVDIGAPVE--EQPVVEPEETLEPEACFTEGC 1185
alpha1.2  --------------------ATSSSEGSTVDIGAPAEG-EQPEVEPEESLEPEACFTEDC 1175
alpha1.3  --------------------ATSSSEGSTVDVVLPREG-EQAETEPEEDLKPEACFTEGC 1173
alpha1.4  --------------------DGNSSVCSTADYKPPEEDPEEQAEENPEGEQPEECFTEAC 998
alpha1.5  ADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGC 1172
alphax    --------------------QSSSSECSTVDIAISEEE-EMFYGG-----ERSKHLKNGC 901
alpha1.6  --------------------DTSSSEGSTIDIKPEVE--EVPVEQPEEYLDPDACFTEGC 1165
alpha1.7  --------------------RSSSSECSTVDNPLPGEG-EEAEAEPMNSDEPEACFTDGC 1159
alpha1.8  ETWKDESVPQVPAEGV---DDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGC 1119
alpha1.9  ---EDEPHLTIQDPRK---KSDVTSILSECSTIDLQDGFGWLPEMVPKKQ-PERCLPKGF 1023
                                  *  *  .     :               .  : .  

alpha1.1  VQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQR 1245
alpha1.2  VRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQR 1235
alpha1.3  IKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQR 1233
alpha1.4  VQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQR 1058
alpha1.5  VRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEER 1232
alphax    RRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYIDQR 961
alpha1.6  VQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQR 1225
alpha1.7  VRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERK 1219
alpha1.8  IRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQK 1179
alpha1.9  GCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQ 1083
                  :.  .        :*::*  **::.**: ** :: ***:*:* *** :::.:

alpha1.1  KTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALG 1305
alpha1.2  KTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALG 1295
alpha1.3  KTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALG 1293
alpha1.4  RVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLG 1118
alpha1.5  KTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLG 1292
alphax    KTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTR- 1020
alpha1.6  KTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALG 1285
alpha1.7  KTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLG 1279
alpha1.8  PTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILE 1239
alpha1.9  PKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLIN---- 1139
            :: :*: :* :**.:*::**:*** *:*:  :*:..*  ***::* :   :*      

alpha1.1  YSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMG 1365
alpha1.2  YSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMG 1355
alpha1.3  YSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMG 1353
alpha1.4  YSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMG 1178
alpha1.5  FAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMG 1352
alphax    ----EELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMG 1076
alpha1.6  YSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMG 1345
alpha1.7  YSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMG 1339
alpha1.8  YSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMG 1299
alpha1.9  ---LMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILG 1196
                :*.: ::: *****.**:** *:*** **: :  . :**:****::**:*.*:*

alpha1.1  VNLFAGKFYHCINTTTG--DRFDIEDVNNHTDCLKLIE-RNETARWKNVKVNFDNVGFGY 1422
alpha1.2  VNLFAGKFYHCINYTTG--EMFDVSVVNNYSECKALIE-SNQTARWKNVKVNFDNVGLGY 1412
alpha1.3  VNLFAGKFYHCVNMTTG--NMFDISDVNNLSDCQALG----KQARWKNVKVNFDNVGAGY 1407
alpha1.4  VNLFAGKFYYCINTTTS--ERFDISEVNNKSECESLMH--TGQVRWLNVKVNYDNVGLGY 1234
alpha1.5  VNLFAGKFGRCINQTEG-DLPLNYTIVNNKSQCESLNL--TGELYWTKVKVNFDNVGAGY 1409
alphax    VDLFAGRFYECIDPTSG--ERFPSSEVMNKSRCESLLF--NESMLWENAKMNFDNVGNGF 1132
alpha1.6  VNLFAGKYHYCFNETSE--IRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGY 1403
alpha1.7  VNLFAGKFYECINTTDG--SRFPASQVPNRSECFALMN-VSQNVRWKNLKVNFDNVGLGY 1396
alpha1.8  VNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNS--TGSFFWVNVKVNFDNVAMGY 1357
alpha1.9  VYFFSGKFGKCINGTD---SVINYTIITNKS----QCE--SGNFSWINQKVNFDNVGNAY 1247
          * :*:*::  *.: *      .    : * :              * : *:*:***. .:

alpha1.1  LSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVI 1482
alpha1.2  LSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVI 1472
alpha1.3  LALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVI 1467
alpha1.4  LSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVI 1294
alpha1.5  LALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1469
alphax    LSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVI 1192
alpha1.6  LALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVI 1463
alpha1.7  LSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVI 1456
alpha1.8  LALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVI 1417
alpha1.9  LALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVI 1307
          *:*******:**  *: :*:**   . ** :* .   * **: ***** *:.*.::: **

alpha1.1  IDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQV 1542
alpha1.2  IDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQV 1532
alpha1.3  IDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQV 1527
alpha1.4  IDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQA 1354
alpha1.5  IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1529
alphax    IDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQA 1252
alpha1.6  IDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQA 1523
alpha1.7  IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQA 1516
alpha1.8  IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQA 1477
alpha1.9  IDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQI 1367
          *****::: *:**.:**:* :*:* *. :***  :..*:*:*** ** ** ::*.** * 

alpha1.1  FDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTI 1602
alpha1.2  FDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTI 1592
alpha1.3  FDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTI 1587
alpha1.4  FDITIMILICLNMVTMMVETDDQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTV 1414
alpha1.5  FDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTN 1589
alphax    FNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTI 1312
alpha1.6  FDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTI 1583
alpha1.7  FDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRHYYFTV 1576
alpha1.8  FDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTN 1537
alpha1.9  FDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTN 1427
          *:: :: ** :: ::** :.  *       *  :* .*: .:* * ::*: ::* :*** 

alpha1.1  GWNIFDFVVVILSIVGMFLAELIEK--YFVSPTLFRVIRLARIGRILRLIKGAKGIRTLL 1660
alpha1.2  GWNIFDFVVVILSIVGMFLAELIEK--YFVSPTLFRVIRLARIGRILRLIKGAKGIRTLL 1650
alpha1.3  GWNIFDFVVVILSIVGMFLAEMIEK--YFVSPTLFRVIRLARIGRILRLIKGAKGIRTLL 1645
alpha1.4  GWNIFDFVVVILSIVGLALSDLIQK--YFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLL 1472
alpha1.5  SWNIFDFVVVILSIVGTVLSDIIQK--YFFSPTLFRVIRLARIGRILRLIRGAKGIRTLL 1647
alphax    AWNIFDFMVVIFSITGLCLPMTVGS--YLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLM 1370
alpha1.6  GWNIFDFVVVILSIVGMFLADIIEK--YFVSPTLFRVIRLARIGRILRLIKGAKGIRTLL 1641
alpha1.7  GWNIFDFVVVIISIVGMFLADLIET--YFVSPTLFRVIRLARIGRILRLVKGAKGIRTLL 1634
alpha1.8  GWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLL 1597
alpha1.9  GWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLL 1487
          .**:** :**::**..  :.         ..*:*.::: *:** ::*** :..: ::.*:

alpha1.1  FALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQI 1720
alpha1.2  FALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQI 1710
alpha1.3  FALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQI 1705
alpha1.4  FALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEI 1532
alpha1.5  FALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQI 1707
alphax    LPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQV 1430
alpha1.6  FALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQI 1701
alpha1.7  FALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICLFQI 1694
alpha1.8  FALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQI 1657
alpha1.9  FALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQI 1547
          :.**:***:*:** **:**:***::::**  *. *. * **:*: **:**..*::***::

alpha1.1  TTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNM 1780
alpha1.2  TTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNM 1770
alpha1.3  TTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNM 1765
alpha1.4  TTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNM 1592
alpha1.5  TTSAGWDGLLSPILNTGPPYCDPTLPNSN-GSRGDCGSPAVGILFFTTYIIISFLIVVNM 1766
alphax    AIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNM 1490
alpha1.6  TTSAGWDGLLLPILN-RPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNM 1760
alpha1.7  TTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNM 1754
alpha1.8  TTSAGWDGLLSPILNTGPPYCDPNLPNSN-GTRGDCGSPAVGIIFFTTYIIISFLIMVNM 1716
alpha1.9  STSAGWDSLLSPMLRS--------KESCN-SSSENCHLPGIATSYFVSYIIISFLIVVNM 1598
          :  ****.:* .::.             .     :*  *.:.  :* :**:**:*::***

alpha1.1  YIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLN 1840
alpha1.2  YIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLL 1830
alpha1.3  YIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLL 1825
alpha1.4  YIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLR 1652
alpha1.5  YIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLR 1826
alphax    YIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLF 1550
alpha1.6  YIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLR 1820
alpha1.7  YIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLL 1814
alpha1.8  YIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLR 1776
alpha1.9  YIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLR 1658
          **.:::* :. *:::. ..*.****  *:: *::***: **::    *::*. :*  ** 

alpha1.1  LPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSK 1900
alpha1.2  IAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSK 1890
alpha1.3  IAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSK 1885
alpha1.4  IAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSK 1712
alpha1.5  IAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSK 1886
alphax    MAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFK 1610
alpha1.6  VPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSK 1880
alpha1.7  IAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSANPSK 1874
alpha1.8  IPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSK 1836
alpha1.9  VAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLK 1718
          :.:**   :: :***:.  *::**:***:*:* .*:* .  :: :   :*. *: :*  *

alpha1.1  VSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMI 1960
alpha1.2  VSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTL 1950
alpha1.3  VSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMI 1945
alpha1.4  VSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSGDDAPEKEGLL 1772
alpha1.5  ISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREG 1946
alphax    ITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDG-------------- 1656
alpha1.6  VSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLE-------------- 1926
alpha1.7  VSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDGDRD-DDLLNKKDMA 1933
alpha1.8  SSYEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSNTPCVPRA---EEEAASLPDEG 1893
alpha1.9  KLYEPIVTTTKRKEEERGAAIIQKAFRKYMMKVTKGDQGD---------QNDLENGPHSP 1769
             :**.** : *.*   *  :*: :: :  :                            

alpha1.1  IDRINENSITE----KTDLTM-STAACPPSYDRVTKPIVEK---HEQEGKDEKAKGK--- 2009
alpha1.2  IDKLNENSTPE----KTDMTP-STTS-PPSYDSVTKPEKEK---FEKDKSEKEDKGKDIR 2001
alpha1.3  IDKLNGNSTPE----KTDGSS-STTS-PPSYDSVTKPDKEK---FEKDKPEKESKGKEVR 1996
alpha1.4  ANTMSKMYGHE----NGNSSSPSPEEKGEAGDAGPTMGLMPISPSDTAWPPAPPPGQTVR 1828
alpha1.5  LIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSEDLADFPP 2006
alphax    ---------------DRDVHA-TKEG--------AYFDKAK---------EKSPIQSQI- 1682
alpha1.6  ----NGGTHRE----KKESTP-STAS-LPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVR 1976
alpha1.7  FDNVNENSSPE----KTDATS-STTS-PPSYDSVTKPDKEK---YEQDRTEKEDKGKDSK 1984
alpha1.8  FVAFTANENCVL---PDKSETASATSFPPSYESVTRGLSDRVNMRTSSSIQNEDEATSME 1950
alpha1.9  LQTLCN---------------GDLSSFGVAKGKVHCD----------------------- 1791
                                                                      

alpha1.1  ----------
alpha1.2  ESKK------ 2005
alpha1.3  ENQK------ 2000
alpha1.4  PGVKESLV-- 1836
alpha1.5  SPDRDRESIV 2016
alphax    ----------
alpha1.6  ESKC------ 1980
alpha1.7  ESKK------ 1988
alpha1.8  LIAPGP---- 1956
alpha1.9  ----------                    

Accession numbers of the sodium ion channel alpha subunits used in the protein sequence alignment:  alpha1.1 - P35498; alpha1.2 - Q99250; alpha1.3 - Q9NY46; alpha1.4 - P35499; alpha1.5 - Q14524; alphax - Q01118; alpha1.6 - Q9UQD0; alpha1.7 - Q15858; alpha1.8 - Q9Y5Y9; alpha1.9 - Q9UI33

beta subunit

betaIa        --------MGRLLALV--VGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETN 50
betaIb        --------MGRLLALV--VGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETN 50
betaII        MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTVPATLNVLNGSDARLPCTFNSCYTVNH 60
betaIII       -----MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVE 55
betaIIICRA_a  -----MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVE 55
betaIV-1      ----------------------MPGAGDGGKAPARWLGTGLLGLFLLPVTLSLEVSVGKA 38
betaIV-2      ----------------------MPGAGDGGKAPARWLGTGLL------------------ 20
betaIV-3      ----------------------MNNISIVLRD-LEFSDTGKY------------------ 19
betaIVCRA_a   ----------------------MNNISIVLRD-LEFSDTGKY------------------ 19
betaIVCRA_b   ----------------------MPGAGDGGKAPARWLGTGLLGLFLLPVTLSLEVSVGKA 38
                                                                              
betaIa        AETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGT------------ 98
betaIb        AETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGT------------ 98
betaII        KQFSLNWTYQECNNCSEEMFLQFRMKIINLKLER-FQDRVEFSGN--------------- 104
betaIII       ATTVVEWFYRPEGGKDFL-IYEYRNGHQEVESP--FQGRLQWNGS--------------- 97
betaIIICRA_a  ATTVVEWFYRPEGGKDFL-IYEYRNGHQEVESP--FQGRLQWNGS--------------- 97
betaIV-1      TDIYAVNGTEILLPCTFSSCFGFEDLHFRWTYNSSDAFKILIEGTVKNEKSDPKVTLKDD 98
betaIV-2      ------------------------------------------------------------
betaIV-3      ------------------------------------------------------------
betaIVCRA_a   ------------------------------------------------------------
betaIVCRA_b   TDIYAVNGTEILLPCTFSSCFGFEDLHFRWTYNSSDAFKILIEGTVKNEKSDPKVTLKDD 98
                                                                              
betaIa        --------------------KDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSV 138
betaIb        --------------------KDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSV 138
betaII        --------------------PSKYDVSVMLRNVQPEDEGIYNCYIMNPP--DRHRGHGKI 142
betaIII       --------------------KDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKT 137
betaIIICRA_a  --------------------KDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKT 137
betaIV-1      DRITLVGSTKEKMNNISIVLRDLEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRLEEV 158
betaIV-2      --------------------------------------------------------VEEV 24
betaIV-3      -------------------------------TCHVKNPKENNLQHHATIFLQVVDRLEEV 48
betaIVCRA_a   -------------------------------TCHVKNPKENNLQHHATIFLQVVDRLEEV 48
betaIVCRA_b   DRITLVGSTKEKMNNISIVLRDLEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRLEEV 158
                                                                             
betaIa        VKKIHIEVVDKANRDMASIVSEIMMYV------LIVVLTIWLVAEMIYCYKKIAAATETA 192
betaIb        VKKIHIEVVDKGESGAACPFTVTHRRARWRDRWQAVDRTGWLCAWPANRPQQRAEGEGSS 198
betaII        HLQVLMEEPPERDSTVAVIVGASVGGF---------LAVVILVLMVVKCVRRKKEQKLST 193
betaIII       TRLIPLRVTEEAGEDFTSVVSEIMMYI------LLVFLTLWLLIEMIYCYRKVSKAEEAA 191
betaIIICRA_a  TRLIPLRVTEEAGEDFTSVVSEIMMYI------LLVFLTLWLLIEMIYCYRKVSKAEEAA 191
betaIV-1      DNTVTLIILAVVGGVIGLLILILLIKK------------LIIFILKKTREKKKECLVSSS 206
betaIV-2      DNTVTLIILAVVGGVIGLLILILLIKK------------LIIFILKKTREKKKECLVSSS 72
betaIV-3      DNTVTLIILAVVGGVIGLLILILLIKK------------LIIFILKKTREKKKECLVSSS 96
betaIVCRA_a   DNTVTLIILAVVGGVIGLLILILLIKK------------LIIFILKKTREKKKECLVSSS 96
betaIVCRA_b   DNTVTLIILAVVGGVIGLLILILLIKK------------LIIFILKKTREKKKECLVSSS 206
                 : :             .                     :        ::      ::
betaIa        AQENASEY-LAITSESKENCTGVQVAE--------------------------------- 218
betaIb        PSCPLQLWPLFLSSPRRGQSMPVPHRRSGYRTQLCHLCCMTSGRCLLSLSQRVVLGLPGI 258
betaII        DDLKTEEE-----GKTDGEGNPDDGAK--------------------------------- 215
betaIII       -QENASDY-LAIPSENKEN-SAVPVEE--------------------------------- 215
betaIIICRA_a  -QENASDY-LAIPSENKEN-SAVPVEE--------------------------------- 215
betaIV-1      GNDNTENG---LPGSKAEEKPPSKV----------------------------------- 228
betaIV-2      GNDNTENG---LPGSKAEEKPPSKV----------------------------------- 94
betaIV-3      GNDNTENG---LPGSKAEEKPPSKV----------------------------------- 118
betaIVCRA_a   GNDNTENG---LPGSKAEEKPPSKV----------------------------------- 118
betaIVCRA_b   GNDNTENG---LPGSKAEEKPPSKV----------------------------------- 228
               .   .       .    :                                         
betaIa        ----------
betaIb        IIRCVSRGVV 268
betaII        ----------
betaIII       ----------
betaIIICRA_a  ----------
betaIV-1      ----------
betaIV-2      ----------
betaIV-3      ----------
betaIVCRA_a   ----------
betaIVCRA_b   ----------                            

Accession numbers of the sodium ion channel beta subunits used in the protein sequence alignment:  betaIa - NP_001028; betaIb - NP_950238; betaII - NP_004579; betaIII - AAI26266; betaIIICRA_a - EAW67552; betaIV-1 - NP_777594; betaIV-2 - NP_001135820; betaIV-3 - NP_001135821; betaIVCRA_a - EAW67351; betaIVCRA_b - EAW67352

Predicted General Properties of Representative Subunits of the Sodium Ion Channel  - Primary Sequence Analysis (with ProtParam)b

alpha1.1 subunit sodium ion channel

Number of amino acids: 2009

Molecular weight: 228971.6

Theoretical pI: 5.60

Total number of negatively charged residues (Asp + Glu): 239

Total number of positively charged residues (Arg + Lys): 211

Atomic composition: Carbon C 10377 Hydrogen H 16149 Nitrogen N 2647 Oxygen O 2974 Sulfur S 106

Formula: C10377H16149N2647O2974S106

Total number of atoms: 32253

Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 241640 Abs 0.1% (=1 g/l) 1.055, assuming ALL Cys residues appear as half cystines Ext. coefficient 239390 Abs 0.1% (=1 g/l) 1.046, assuming NO Cys residues appear as half cystines

Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).

Instability index: The instability index (II) is computed to be 43.99 This classifies the protein as unstable.

Aliphatic index: 92.66

Grand average of hydropathicity (GRAVY): -0.009

 

betaIa subunit sodium ion channel

Number of amino acids: 218

Molecular weight: 24707.1

Theoretical pI: 4.88

Total number of negatively charged residues (Asp + Glu): 33

Total number of positively charged residues (Arg + Lys): 21

Atomic composition: Carbon C 1093 Hydrogen H 1717 Nitrogen N 285 Oxygen O 340 Sulfur S 13

Formula: C1093H1717N285O340S13

Total number of atoms: 3448

Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 31775 Abs 0.1% (=1 g/l) 1.286, assuming ALL Cys residues appear as half cystines Ext. coefficient 31400 Abs 0.1% (=1 g/l) 1.271, assuming NO Cys residues appear as half cystines

Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).

Instability index: The instability index (II) is computed to be 43.19 This classifies the protein as unstable.

Aliphatic index: 92.06

Grand average of hydropathicity (GRAVY): -0.041

Bioinformatics References

a Higgins D., Thompson J., Gibson T. Thompson J. D., Higgins D. G., Gibson T. J.(1994). CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting,position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673-4680.

b Gasteiger E., Hoogland C., Gattiker A., Duvaud S., Wilkins M.R., Appel R.D., Bairoch A.; Protein Identification and Analysis Tools on the ExPASy Server;
(In) John M. Walker (ed): The Proteomics Protocols Handbook, Humana Press (2005). pp. 571-607  Full text - Copyright Humana Press.

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