Sequence Alignment of the Sodium Ion Channel (with Clustalw)a
Isoform Sequence Alignment
of the Sodium Ion Channel
alpha subunit
alpha1.1 ---MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPD----KKDDDENGPKPNS 53
alpha1.2 ---MAQSVLVPPGPDSFRFFTRESLAAIEQRIAEEKAKRPKQER---KDEDDENGPKPNS 54
alpha1.3 ---MAQALLVPPGPESFRLFTRESLAAIEKRAAEEKAKKPKKE----QDNDDENKPKPNS 53
alpha1.4 MARPSLCTLVPLGPECLRPFTRESLAAIEQRAVEEEARLQRNK----QMEIEEPERKPRS 56
alpha1.5 ----MANFLLPRGTSSFRRFTRESLAAIEKRMAEKQARGSTTLQESREGLPEEEAPRPQL 56
alphax -------MLASPEPKGLVPFTKESFELIKQHIAKTHN-----------EDHEEEDLKPNP 42
alpha1.6 ---MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNS 57
alpha1.7 -----MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEE----KKDDDEEAPKPSS 51
alpha1.8 ----MEFPIGSLETNNFRRFTPESLVEIEKQIAAKQGT-KKAREKHREQKDQEEKPRPQL 55
alpha1.9 -MDDRCYPVIFPDERNFRPFTSDSLAAIEKRIAIQKEK-KKS----KDQTGEVPQPRPQL 54
: : ** :*: *::: . . : :*
alpha1.1 DLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKK-TFIVLNKGKAIFRFSATSALYILT 112
alpha1.2 DLEAGKSLPFIYGDIPPEMVSVPLEDLDPYYINKK-TFIVLNKGKAISRFSATPALYILT 113
alpha1.3 DLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKK-TFIVMNKGKAIFRFSATSALYILT 112
alpha1.4 DLEAGKNLPMIYGDPPPEVIGIPLEDLDPYYSNKK-TFIVLNKGKAIFRFSATPALYLLS 115
alpha1.5 DLQASKKLPDLYGNPPQELIGEPLEDLDPFYSTQK-TFIVLNKGKTIFRFSATNALYVLS 115
alphax DLEVGKKLPFIYGNLSQGMVSEPLEDVDPYYYKKKNTFIVLNKNRTIFRFNAASILCTLS 102
alpha1.6 DLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQK-TFVVLNRGKTLFRFSATPALYILS 116
alpha1.7 DLEAGKQLPFIYGDIPPGMVSEPLEDLDPYYADKK-TFIVLNKGKTIFRFNATPALYMLS 110
alpha1.8 DLKACNQLPKFYGELPAELIGEPLEDLDPFYSTHR-TFMVLNKGRTISRFSATRALWLFS 114
alpha1.9 DLKASRKLPKLYGDIPRELIGKPLEDLDPFYRNHK-TFMVLNRKRTIYRFSAKHALFIFG 113
**:. ..** :**: . ::. ****.**:* :: **:*:*: ::: **.* * :
alpha1.1 PFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNP----PDWTKNVEYTFTGIYTFE 168
alpha1.2 PFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTMSNP----PDWTKNVEYTFTGIYTFE 169
alpha1.3 PLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNP----PDWTKNVEYTFTGIYTFE 168
alpha1.4 PFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDP----PPWSKNVEYTFTGIYTFE 171
alpha1.5 PFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDP----PPWTKYVEYTFTAIYTFE 171
alphax PFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSLTNL----PKWRPVLENTLLGIYTFE 158
alpha1.6 PFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP----PDWSKNVEYTFTGIYTFE 172
alpha1.7 PFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMNNP----PDWTKNVEYTFTGIYTFE 166
alpha1.8 PFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTR-------TDLPEKIEYVFTVIYTFE 167
alpha1.9 PFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFE 173
*: :* :::: :*. *.::* ::: :*: *: . * .: ** **
alpha1.1 SLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVT--EFVDLGNVSALRTFRVLRALKT 226
alpha1.2 SLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVT--EFVDLGNVSALRTFRVLRALKT 227
alpha1.3 SLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVT--EFVSLGNVSALRTFRVLRALKT 226
alpha1.4 SLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLT--EFVDLGNISALRTFRVLRALKT 229
alpha1.5 SLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYTT--EFVDLGNVSALRTFRVLRALKT 229
alphax ILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVII--RYSPLDFIPTLQTARTLRILKI 216
alpha1.6 SLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYIT--EFVNLGNVSALRTFRVLRALKT 230
alpha1.7 SLVKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLT--EFVNLGNVSALRTFRVLRALKT 224
alpha1.8 ALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVG--TAIDLRGISGLRTFRVLRALKT 225
alpha1.9 ALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIKLLP-LRTFRVFRALKA 232
*:*::***. *::* ******* * : : :. *:* *.:* **
alpha1.1 ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNAS 286
alpha1.2 ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSS 287
alpha1.3 ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSA 286
alpha1.4 ITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFN- 288
alpha1.5 ISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALN- 288
alphax IPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCFRWPQE--- 273
alpha1.6 ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWP----- 285
alpha1.7 ISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLE--- 281
alpha1.8 VSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVN- 284
alpha1.9 ISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNI- 291
:.: ** :**.*::.:*:* .* :**.* **:*:*:* ** *.*. **.
alpha1.1 LEEHSIEKN-ITVNYNGTLIN----------------------ETVFEFDWKSYIQDSRY 323
alpha1.2 FEINITSFFNNSLDGNGTTFN----------------------RTVSIFNWDEYIEDKSH 325
alpha1.3 FETNTTSYFNGTMDSNGTFVN----------------------VTMSTFNWKDYIGDDSH 324
alpha1.4 -DTNTTWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGN 347
alpha1.5 -------------GTNGSVEADG----------------------LVWESLDLYLSDPEN 313
alphax -------------NENETLHN----------------------RTGNPY----YIRETEN 294
alpha1.6 ------------INFNESYLE----------------------NGTKGFDWEEYINNKTN 311
alpha1.7 ---------------NNETLE----------------------SIMNTLESEEDFR--KY 302
alpha1.8 -------------ETTNYSSHR----------------------------------KPDI 297
alpha1.9 -------------SNPEAYDH--------------------------------------C 300
alpha1.1 HYFLEGFLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDF 383
alpha1.2 FYFLEGQNDALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDF 385
alpha1.3 FYVLDGQKDPLLCGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDY 384
alpha1.4 FYFLEGSNDALLCGNSSDAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDY 407
alpha1.5 YLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDC 373
alphax FYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSFGWALFALFRLMAQDY 354
alpha1.6 FYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDY 371
alpha1.7 FYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQDY 362
alpha1.8 YINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDS 357
alpha1.9 FEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDS 360
. . :** . . *. * * : **: .:*.:*.*.*:::::****:**
alpha1.1 WENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAE 443
alpha1.2 WENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAE 445
alpha1.3 WENLYQLTLRAAGKTYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAE 444
alpha1.4 WENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAEDKEKEEE 467
alpha1.5 WERLYQQTLRSAGKIYMIFFMLVIFLGSFYLVNLILAVVAMAYEEQNQATIAETEEKEKR 433
alphax PEVLYHLILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQRVGEISKKIEPK 414
alpha1.6 WENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAE 431
alpha1.7 WENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKELE 422
alpha1.8 WERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKK 417
alpha1.9 WEKLYQQTLRTTGLYSVFFFIVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKM 420
* *:: * ::* ::**::: *: ***: .* *.:::*** *::: : *
alpha1.1 FQQMIEQLKKQQEAAQQAATAT--ASEHSREPSAAGRLS----DSSSEASKLSSKSAKER 497
alpha1.2 FQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFS----ESSSVASKLSSKSEKEL 501
alpha1.3 FQQMLEQLKKQQEEAQAVAAAS-AASRDFSGIGGLGELL----ESSSEASKLSSKSAKEW 499
alpha1.4 FQQMLEKFKKHQEELEKAKAAQ---------ALEGGEAD--------------------- 497
alpha1.5 FQEAMEMLKKEHEALTIRGVDT---------VSRSSLEM----------SPLAPVNSHER 474
alphax FQQTGKELQEGNE------------------TDEAK------------------------ 432
alpha1.6 FKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRSSSEISKLSSKSAKER 491
alpha1.7 FQQMLDRLKKEQEEAEAIAAAA-AEYTSIRRSRIMGLSE-----SSSETSKLSSKSAKER 476
alpha1.8 FQEALEMLRKEQEVLAALGIDT---------TSLHSHNG----------SPLTSKNASER 458
alpha1.9 FQEAQQLLKEEKEALVAMGIDR---------SSLTSLET----------SYFTPK----K 457
*: . ::: :*
alpha1.1 RNRRKKRKQKEQSGGEEKDEDE-FQKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSL 556
alpha1.2 KNRRKKKKQKEQSGEEEKNDR--VRKSESEDSIRRKGFRFSLEGSRLTYEKRFSSPHQSL 559
alpha1.3 RNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDGNRLTSDKKFCSPHQSL 559
alpha1.4 ------------------------------------------------------------
alpha1.5 RSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRR 534
alphax ------------------------------------------------------------
alpha1.6 RNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPD--NRIG--RKFSIMNQSL 547
alpha1.7 RNRRKKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSP 536
alpha1.8 RHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPE 518
alpha1.9 RKLFG-------------------NKKRKSFFLRESGKD----------QPPGSDS---- 484
alpha1.1 LSIRGSLFSPRRNSRTSLFSFRG--RAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRH 614
alpha1.2 LSIRGSLFSPRRNSRASLFSFRG--RAKDIGSENDFADDEHSTFEDNDSRRDSLFVPHRH 617
alpha1.3 LSIRGSLFSPRRNSKTSIFSFRG--RAKDVGSENDFADDEHSTFEDSESRRDSLFVPHRH 617
alpha1.4 ------------------------------------------------------------
alpha1.5 RDLGSEADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNST 594
alphax ------------------------------------------------------------
alpha1.6 LSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRA 607
alpha1.7 LSIRGSLFSARRSSRTSLFSFKG--RGRDIGSETEFADDEHSIFGDNESRRGSLFVPHRP 594
alpha1.8 GVTDDGVFPGDHESHRGSLLLGGGAGQQGPLPR---SPLPQPSNPDSRHGEDEHQPPPTS 575
alpha1.9 ----------DEDCQK----------------------KPQLLEQTKRLSQN-------- 504
alpha1.1 GERRN-----SNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLP 669
alpha1.2 GERRH-----SNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGPSTLTS-AGQLLP 671
alpha1.3 GERRN-----SNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGPSALTSPTGQLPP 672
alpha1.4 ------------------------------------------------------------
alpha1.5 VDCNG------------------------------------------------------- 599
alphax ------------------------------------------------------------
alpha1.6 RERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIG--GRLLP 665
alpha1.7 QERRS-----SNISQASRSP---PMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNGQLLP 646
alpha1.8 ELAPG------------------------------------------------------- 580
alpha1.9 ------------------------------------------------------------
alpha1.1 EVIIDKPATDDNGTTTETEMRKRRSSS--------------------------------F 697
alpha1.2 E-----------GTTTETEIRKRRSSS--------------------------------Y 688
alpha1.3 E-----------GTTTETEVRKRRLSS--------------------------------Y 689
alpha1.4 ---------------GDPAHGKDCNGS--------------------------------L 510
alpha1.5 -------------VVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQ 646
alphax --------------TIQIEMKKRSPIS--------------------------------T 446
alpha1.6 E------------ATTEVEIKKKGPGS--------------------------------L 681
alpha1.7 EVIIDKATSDD-SGTTNQIHKKRRCSS--------------------------------Y 673
alpha1.8 -------------AVDVSAFDAGQKKT--------------------------------- 594
alpha1.9 --------------LSLDHFDEHG------------------------------------ 514
alpha1.1 HVSMDFLEDPSQRQRAMSIASILTNT-VEELEESRQKCPPCWYKFSNIFLIWDCSPYWLK 756
alpha1.2 HVSMDLLEDPTSRQRAMSIASILTNT-MEELEESRQKCPPCWYKFANMCLIWDCCKPWLK 747
alpha1.3 QISMEMLEDSSGRQRAVSIASILTNT-MEELEESRQKCPPCWYRFANVFLIWDCCDAWLK 748
alpha1.4 DTSQGEKGAPRQSGSGDSGIS----DAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLK 566
alpha1.5 APCVDGFEEPGARQRALSAVSVLTSA-LEELEESRHKCPPCWNRLAQRYLIWECCPLWMS 705
alphax DTSLDVLEDATLRH-------------KEELEKSKKICPLYWYKFAKTFLIWNCSPCWLK 493
alpha1.6 LVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIK 741
alpha1.7 LLSEDMLNDPNLRQRAMSRASILTNT-VEELEESRQKCPPWWYRFAHKFLIWNCSPYWIK 732
alpha1.8 FLSAEYLDEPFRAQRAMSVVSIITSV-LEELEESEQKCPPCLTSLSQKYLIWDCCPMWVK 653
alpha1.9 --------DPLQRQRALSAVSILTIT-MKEQEKSQEPCLPCGENLASKYLVWNCCPQWLC 565
:* *::.. * : *:*:* *:
alpha1.1 VKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFNNVLTVGNLVFTGIFTAEMF 816
alpha1.2 VKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTAEMF 807
alpha1.3 VKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLVFTGIFTAEMV 808
alpha1.4 FKNIIHLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMV 626
alpha1.5 IKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMT 765
alphax LKEFVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMI 553
alpha1.6 LKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMF 801
alpha1.7 FKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGNLVFTGIFAAEMV 792
alpha1.8 LKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMV 713
alpha1.9 VKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMC 625
.* : :: **.:* : :**::*. *:::**: * . :* :**:** :* ***
alpha1.1 LKIIAMDPYYYFQEGWNIFDGFIVTLSLVELG--LANVEGLSVLRSFRLLRVFKLAKSWP 874
alpha1.2 LKIIAMDPYYYFQEGWNIFDGFIVSLSLMELG--LANVEGLSVLRSFRLLRVFKLAKSWP 865
alpha1.3 LKIIAMDPYYYFQEGWNIFDGIIVSLSLMELG--LSNVEGLSVLRSFRLLRVFKLAKSWP 866
alpha1.4 LKLIAMDPYEYFQQGWNIFDSIIVTLSLVELG--LANVQGLSVLRSFRLLRVFKLAKSWP 684
alpha1.5 FKIIALDPYYYFQQGWNIFDSIIVILSLMELG--LSRMSNLSVLRSFRLLRVFKLAKSWP 823
alphax FKIIAMHPYGYFQVGWNIFDSMIVFHGLIELC--LANVAGMALLRLFRMLRIFKLGKYWP 611
alpha1.6 LKLIAMDPYYYFQEGWNIFDGFIVSLSLMELS--LADVEGLSVLRSFRLLRVFKLAKSWP 859
alpha1.7 LKLIAMDPYEYFQVGWNIFDSLIVTLSLVELF--LADVEGLSVLRSFRLLRVFKLAKSWP 850
alpha1.8 FKIIAFDPYYYFQKKWNIFDCIIVTVSLLELG--VAKKGSLSVLRSFRLLRVFKLAKSWP 771
alpha1.9 LKIIALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWP 685
:*:**:.** **: ***** ::. .: :: : . ..** **:**:***.* **
alpha1.1 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVC------KIASDCQ 928
alpha1.2 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVC------KISNDCE 919
alpha1.3 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVC------KINDDCT 920
alpha1.4 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVC------KIALDCN 738
alpha1.5 TLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRD--------SDSGL 875
alphax TFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVC------HIDKDCQ 665
alpha1.6 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVC------KINQDCE 913
alpha1.7 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVC------KINDDCT 904
alpha1.8 TLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRK----NISAPHEDW 827
alpha1.9 TLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQKSPKLCNPTGPTVSC 745
*:: *: :.** ** .*.::* .:*. : .* :*:*..: .
alpha1.1 LPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAG--QAMCLTVFMMVMVIGNLVVLNL 986
alpha1.2 LPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAG--QTMCLTVFMMVMVIGNLVVLNL 977
alpha1.3 LPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAG--QTMCLIVFMLVMVIGNLVVLNL 978
alpha1.4 LPRWHMHDFFHSFLIVFRILCGEWIETMWDCMEVAG--QAMCLTVFLMVMVIGNLVVLNL 796
alpha1.5 LPRWHMMDFFHAFLIIFRILCGEWIETMWDCMEVS--GQSLCLLVFLLVMVIGNLVVLNL 933
alphax LPRWHMHDFFHSFLNVFRILCGEWVETLWDCMEVAG--QSWCIPFYLMVILIGNLLVLYL 723
alpha1.6 LPRWHMHDFFHSFLIVFRVLCGEWIETMWDCMEVAG--QAMCLIVFMMVMVIGNLVVLNL 971
alpha1.7 LPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAG--QAMCLIVYMMVMVIGNLVVLNL 962
alpha1.8 PR-WHMHDFFHSFLIVFRILCGEWIENMWACMEVG--QKSICLILFLTVMVLGNLVVLNL 884
alpha1.9 LRHWHMGDFWHSFLVVFRILCGEWIENMWECMQEANASSSLCVIVFILITVIGKLVVLNL 805
*** **:*:** :**:*****:*.:* **: . .: *: .:: : ::*:*:** *
alpha1.1 FLALLLSSFSADNLA-ATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQKIL 1045
alpha1.2 FLALLLSSFSSDNLA-ATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKAL 1036
alpha1.3 FLALLLSSFSSDNLA-ATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPKVI 1037
alpha1.4 FLALLLSSFSADSLA-ASDEDGEMNNLQIAIGRIKLGIGFAKAFLLGLLHGKILSPKDIM 855
alpha1.5 FLALLLSSFSADNLT-APDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQRPQKP 992
alphax FLALVSS-FSSCKDV-TAEENNEAKNLQLAVARIKKGINYVLLKILCKTQNVP------K 775
alpha1.6 FLALLLSSFSADNLA-ATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQRE--A 1028
alpha1.7 FLALLLSSFSSDNLT-AIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKIS 1021
alpha1.8 FIALLLNSFSADNLT-APEDDGEVNNLQVALARIQVFGHRTKQALCSFFSRSCPFP-QPK 942
alpha1.9 FIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRRAFCFVRHTLEHFCHKWCRK--QNL 863
*:**: . ** . : : .::*::: *:: .
alpha1.1 DEIKPLDDLNNKKDSCMSNHT-AEIGKDLDYLKDVNGTTSGIGT--------GSSVEKYI 1096
alpha1.2 DEIKPLEDLNNKKDSCISNHTTIEIGKDLNYLKDGNGTTSGIG----------SSVEKYV 1086
alpha1.3 EIHE-----GNKIDSCMSNNTGIEISKELNYLRDGNGTTSGVGT--------GSSVEKYV 1084
alpha1.4 LSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHILNHMG----------LADGPPS 905
alpha1.5 AALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVA 1052
alphax DTMDHVNEVYVKED--ISDHTLSELSNTQDFLKDKEKSS---------------GTEKNA 818
alpha1.6 DEVKPLDELYEKKANCIANHTGADIHRNGDFQKNGNGTTSGIG----------SSVEKYI 1078
alpha1.7 REIRQAEDLNTKKENYISNHTLAEMSKGHNFLKE-KDKISGFG----------SSVDKHL 1070
alpha1.8 AEPELVVKLPLSSSKAENHIAANTARGSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEG 1002
alpha1.9 PQQKEVAGGCAAQSKDIIPLVMEMKRGSETQEELGILTSVPKTLGVRHDWTWL-APLAEE 922
.
alpha1.1 IDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKE--KLNE------- 1147
alpha1.2 VDESDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESDMEESKE--KLN-------- 1136
alpha1.3 IDENDYMSFINNPSLTVTVPIAVGESDFENLNTEEFSSESELEESKE--KLN-------- 1134
alpha1.4 SLELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLY------- 958
alpha1.5 ESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQ 1112
alphax TEN-ESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGGSKE--KIK-------- 867
alpha1.6 IDE-DHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKD--KLD-------- 1127
alpha1.7 MEDSDGQSFIHNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKV--RLN-------- 1120
alpha1.8 ESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLG 1062
alpha1.9 E---DDVEFSGEDNAQRITQ---PEPEQ---QAYELHQENKKPTSQRVQSVEIDMFS--- 970
: . : . : .
alpha1.1 --------------------SSSSSEGSTVDIGAPVE--EQPVVEPEETLEPEACFTEGC 1185
alpha1.2 --------------------ATSSSEGSTVDIGAPAEG-EQPEVEPEESLEPEACFTEDC 1175
alpha1.3 --------------------ATSSSEGSTVDVVLPREG-EQAETEPEEDLKPEACFTEGC 1173
alpha1.4 --------------------DGNSSVCSTADYKPPEEDPEEQAEENPEGEQPEECFTEAC 998
alpha1.5 ADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGC 1172
alphax --------------------QSSSSECSTVDIAISEEE-EMFYGG-----ERSKHLKNGC 901
alpha1.6 --------------------DTSSSEGSTIDIKPEVE--EVPVEQPEEYLDPDACFTEGC 1165
alpha1.7 --------------------RSSSSECSTVDNPLPGEG-EEAEAEPMNSDEPEACFTDGC 1159
alpha1.8 ETWKDESVPQVPAEGV---DDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGC 1119
alpha1.9 ---EDEPHLTIQDPRK---KSDVTSILSECSTIDLQDGFGWLPEMVPKKQ-PERCLPKGF 1023
* * . : . : .
alpha1.1 VQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQR 1245
alpha1.2 VRKFKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQR 1235
alpha1.3 IKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQR 1233
alpha1.4 VQRWPCLYVDISQGRGKKWWTLRRACFKIVEHNWFETFIVFMILLSSGALAFEDIYIEQR 1058
alpha1.5 VRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEER 1232
alphax RRGSSLGQISGASKKGKIWQNIRKTCCKIVENNWFKCFIGLVTLLSTGTLAFEDIYIDQR 961
alpha1.6 VQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQR 1225
alpha1.7 VRRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVLMILLSSGALAFEDIYIERK 1219
alpha1.8 IRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQK 1179
alpha1.9 GCCFPCCSVDKRKPPWVIWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQ 1083
:. . :*::* **::.**: ** :: ***:*:* *** :::.:
alpha1.1 KTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALG 1305
alpha1.2 KTIKTMLEYADKVFTYIFILEMLLKWVAYGFQVYFTNAWCWLDFLIVDVSLVSLTANALG 1295
alpha1.3 KTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSLVSLVANALG 1293
alpha1.4 RVIRTILEYADKVFTYIFIMEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVANWLG 1118
alpha1.5 KTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLG 1292
alphax KTIKILLEYADMIFTYIFILEMLLKWMAYGFKAYFSNGWYRLDFVVVIVFCLSLIGKTR- 1020
alpha1.6 KTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALG 1285
alpha1.7 KTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLG 1279
alpha1.8 PTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILE 1239
alpha1.9 PKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTTLIN---- 1139
:: :*: :* :**.:*::**:*** *:*: :*:..* ***::* : :*
alpha1.1 YSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMG 1365
alpha1.2 YSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMG 1355
alpha1.3 YSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMG 1353
alpha1.4 YSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMG 1178
alpha1.5 FAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMG 1352
alphax ----EELKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMG 1076
alpha1.6 YSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMG 1345
alpha1.7 YSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMG 1339
alpha1.8 YSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMG 1299
alpha1.9 ---LMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILG 1196
:*.: ::: *****.**:** *:*** **: : . :**:****::**:*.*:*
alpha1.1 VNLFAGKFYHCINTTTG--DRFDIEDVNNHTDCLKLIE-RNETARWKNVKVNFDNVGFGY 1422
alpha1.2 VNLFAGKFYHCINYTTG--EMFDVSVVNNYSECKALIE-SNQTARWKNVKVNFDNVGLGY 1412
alpha1.3 VNLFAGKFYHCVNMTTG--NMFDISDVNNLSDCQALG----KQARWKNVKVNFDNVGAGY 1407
alpha1.4 VNLFAGKFYYCINTTTS--ERFDISEVNNKSECESLMH--TGQVRWLNVKVNYDNVGLGY 1234
alpha1.5 VNLFAGKFGRCINQTEG-DLPLNYTIVNNKSQCESLNL--TGELYWTKVKVNFDNVGAGY 1409
alphax VDLFAGRFYECIDPTSG--ERFPSSEVMNKSRCESLLF--NESMLWENAKMNFDNVGNGF 1132
alpha1.6 VNLFAGKYHYCFNETSE--IRFEIEDVNNKTECEKLMEGNNTEIRWKNVKINFDNVGAGY 1403
alpha1.7 VNLFAGKFYECINTTDG--SRFPASQVPNRSECFALMN-VSQNVRWKNLKVNFDNVGLGY 1396
alpha1.8 VNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNS--TGSFFWVNVKVNFDNVAMGY 1357
alpha1.9 VYFFSGKFGKCINGTD---SVINYTIITNKS----QCE--SGNFSWINQKVNFDNVGNAY 1247
* :*:*:: *.: * . : * : * : *:*:***. .:
alpha1.1 LSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVI 1482
alpha1.2 LSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVI 1472
alpha1.3 LALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVI 1467
alpha1.4 LSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFVIFIIFGSFFTLNLFIGVI 1294
alpha1.5 LALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVI 1469
alphax LSLLQVATFNGWITIMNSAIDSVAVNIQPHFEVNIYMYCYFINFIIFGVFLPLSMLITVI 1192
alpha1.6 LALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVI 1463
alpha1.7 LSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVFIIFGSFFTLNLFIGVI 1456
alpha1.8 LALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVI 1417
alpha1.9 LALLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVI 1307
*:*******:** *: :*:** . ** :* . * **: ***** *:.*.::: **
alpha1.1 IDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQV 1542
alpha1.2 IDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQV 1532
alpha1.3 IDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQV 1527
alpha1.4 IDNFNQQKKKLGGKDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDLVTKQA 1354
alpha1.5 IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQA 1529
alphax IDNFNKHKIKLGGSNIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFDVVTSQA 1252
alpha1.6 IDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQA 1523
alpha1.7 IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKIQGCIFDLVTNQA 1516
alpha1.8 IDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQA 1477
alpha1.9 IDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQI 1367
*****::: *:**.:**:* :*:* *. :*** :..*:*:*** ** ** ::*.** *
alpha1.1 FDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLRHYYFTI 1602
alpha1.2 FDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRYYYFTI 1592
alpha1.3 FDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLRHYYFTI 1587
alpha1.4 FDITIMILICLNMVTMMVETDDQSQLKVDILYNINMIFIIIFTGECVLKMLALRQYYFTV 1414
alpha1.5 FDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALRHYYFTN 1589
alphax FNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSIFVMLYTMECILKLIAFRCFYFTI 1312
alpha1.6 FDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTI 1583
alpha1.7 FDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTGECVLKLISLRHYYFTV 1576
alpha1.8 FDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTN 1537
alpha1.9 FDIIIISLIILNMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTN 1427
*:: :: ** :: ::** :. * * :* .*: .:* * ::*: ::* :***
alpha1.1 GWNIFDFVVVILSIVGMFLAELIEK--YFVSPTLFRVIRLARIGRILRLIKGAKGIRTLL 1660
alpha1.2 GWNIFDFVVVILSIVGMFLAELIEK--YFVSPTLFRVIRLARIGRILRLIKGAKGIRTLL 1650
alpha1.3 GWNIFDFVVVILSIVGMFLAEMIEK--YFVSPTLFRVIRLARIGRILRLIKGAKGIRTLL 1645
alpha1.4 GWNIFDFVVVILSIVGLALSDLIQK--YFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLL 1472
alpha1.5 SWNIFDFVVVILSIVGTVLSDIIQK--YFFSPTLFRVIRLARIGRILRLIRGAKGIRTLL 1647
alphax AWNIFDFMVVIFSITGLCLPMTVGS--YLVPPSLVQLILLSRIIHMLRLGKGPKVFHNLM 1370
alpha1.6 GWNIFDFVVVILSIVGMFLADIIEK--YFVSPTLFRVIRLARIGRILRLIKGAKGIRTLL 1641
alpha1.7 GWNIFDFVVVIISIVGMFLADLIET--YFVSPTLFRVIRLARIGRILRLVKGAKGIRTLL 1634
alpha1.8 GWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLL 1597
alpha1.9 GWNLFDCVVVLLSIVSTMISTLENQEHIPFPPTLFRIVRLARIGRILRLVRAARGIRTLL 1487
.**:** :**::**.. :. ..*:*.::: *:** ::*** :..: ::.*:
alpha1.1 FALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQI 1720
alpha1.2 FALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQI 1710
alpha1.3 FALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQI 1705
alpha1.4 FALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVKKESGIDDMFNFETFGNSIICLFEI 1532
alpha1.5 FALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQI 1707
alphax LPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVKKEAGINDVSNFETFGNSMLCLFQV 1430
alpha1.6 FALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQI 1701
alpha1.7 FALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFNFETFGNSMICLFQI 1694
alpha1.8 FALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQI 1657
alpha1.9 FALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESGIDDIFNFKTFASSMLCLFQI 1547
:.**:***:*:** **:**:***::::** *. *. * **:*: **:**..*::***::
alpha1.1 TTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNM 1780
alpha1.2 TTSAGWDGLLAPILNSGPPDCDPDKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNM 1770
alpha1.3 TTSAGWDGLLAPILNSAPPDCDPDTIHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNM 1765
alpha1.4 TTSAGWDGLLNPILNSGPPDCDPNLENPGTSVKGDCGNPSIGICFFCSYIIISFLIVVNM 1592
alpha1.5 TTSAGWDGLLSPILNTGPPYCDPTLPNSN-GSRGDCGSPAVGILFFTTYIIISFLIVVNM 1766
alphax AIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYILISWLIIVNM 1490
alpha1.6 TTSAGWDGLLLPILN-RPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNM 1760
alpha1.7 TTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNM 1754
alpha1.8 TTSAGWDGLLSPILNTGPPYCDPNLPNSN-GTRGDCGSPAVGIIFFTTYIIISFLIMVNM 1716
alpha1.9 STSAGWDSLLSPMLRS--------KESCN-SSSENCHLPGIATSYFVSYIIISFLIVVNM 1598
: ****.:* .::. . :* *.:. :* :**:**:*::***
alpha1.1 YIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLN 1840
alpha1.2 YIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFAKLSDFADALDPPLL 1830
alpha1.3 YIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLL 1825
alpha1.4 YIAIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLR 1652
alpha1.5 YIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLR 1826
alphax YIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAALDPPLF 1550
alpha1.6 YIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLR 1820
alpha1.7 YIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFSKLSDFAAALDPPLL 1814
alpha1.8 YIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLR 1776
alpha1.9 YIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLR 1658
**.:::* :. *:::. ..*.**** *:: *::***: **:: *::*. :* **
alpha1.1 LPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSK 1900
alpha1.2 IAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSK 1890
alpha1.3 IAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEDRFMASNPSK 1885
alpha1.4 IAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALKQTMEEKFMAANPSK 1712
alpha1.5 IAKPNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSK 1886
alphax MAKPNKGQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRMEKVVSEIESGFLLANPFK 1610
alpha1.6 VPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSK 1880
alpha1.7 IAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLRSQMEERFMSANPSK 1874
alpha1.8 IPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSK 1836
alpha1.9 VAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEEKFMEANPLK 1718
:.:** :: :***:. *::**:***:*:* .*:* . :: : :*. *: :* *
alpha1.1 VSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKIKGGANLLIKEDMI 1960
alpha1.2 VSYEPITTTLKRKQEEVSAIIIQRAYRRYLLKQKVKKVSSIYKKDKGKECDGTPIKEDTL 1950
alpha1.3 VSYEPITTTLKRKQEEVSAAIIQRNFRCYLLKQRLKNISSNYNKEAIKGRIDLPIKQDMI 1945
alpha1.4 VSYEPITTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQASYMYRHSHDGSGDDAPEKEGLL 1772
alpha1.5 ISYEPITTTLRRKHEEVSAMVIQRAFRRHLLQRSLKHASFLFRQQAGSGLSEEDAPEREG 1946
alphax ITCEPITTTLKRKQEAVSATIIQRAYKNYRLRRNDKNTSDIHMIDG-------------- 1656
alpha1.6 VSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICKKTTSNKLE-------------- 1926
alpha1.7 VSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDGDRD-DDLLNKKDMA 1933
alpha1.8 SSYEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSNTPCVPRA---EEEAASLPDEG 1893
alpha1.9 KLYEPIVTTTKRKEEERGAAIIQKAFRKYMMKVTKGDQGD---------QNDLENGPHSP 1769
:**.** : *.* * :*: :: : :
alpha1.1 IDRINENSITE----KTDLTM-STAACPPSYDRVTKPIVEK---HEQEGKDEKAKGK--- 2009
alpha1.2 IDKLNENSTPE----KTDMTP-STTS-PPSYDSVTKPEKEK---FEKDKSEKEDKGKDIR 2001
alpha1.3 IDKLNGNSTPE----KTDGSS-STTS-PPSYDSVTKPDKEK---FEKDKPEKESKGKEVR 1996
alpha1.4 ANTMSKMYGHE----NGNSSSPSPEEKGEAGDAGPTMGLMPISPSDTAWPPAPPPGQTVR 1828
alpha1.5 LIAYVMSENFSRPLGPPSSSSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSEDLADFPP 2006
alphax ---------------DRDVHA-TKEG--------AYFDKAK---------EKSPIQSQI- 1682
alpha1.6 ----NGGTHRE----KKESTP-STAS-LPSYDSVTKPEKEKQQRAEEGRRERAKRQKEVR 1976
alpha1.7 FDNVNENSSPE----KTDATS-STTS-PPSYDSVTKPDKEK---YEQDRTEKEDKGKDSK 1984
alpha1.8 FVAFTANENCVL---PDKSETASATSFPPSYESVTRGLSDRVNMRTSSSIQNEDEATSME 1950
alpha1.9 LQTLCN---------------GDLSSFGVAKGKVHCD----------------------- 1791
alpha1.1 ----------
alpha1.2 ESKK------ 2005
alpha1.3 ENQK------ 2000
alpha1.4 PGVKESLV-- 1836
alpha1.5 SPDRDRESIV 2016
alphax ----------
alpha1.6 ESKC------ 1980
alpha1.7 ESKK------ 1988
alpha1.8 LIAPGP---- 1956
alpha1.9 ----------
Accession numbers of the sodium ion channel alpha subunits used in the protein sequence alignment: alpha1.1 - P35498; alpha1.2 - Q99250; alpha1.3 - Q9NY46; alpha1.4 - P35499; alpha1.5 - Q14524; alphax - Q01118; alpha1.6 - Q9UQD0; alpha1.7 - Q15858; alpha1.8 - Q9Y5Y9; alpha1.9 - Q9UI33
beta subunit
betaIa --------MGRLLALV--VGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETN 50
betaIb --------MGRLLALV--VGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETN 50
betaII MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTVPATLNVLNGSDARLPCTFNSCYTVNH 60
betaIII -----MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVE 55
betaIIICRA_a -----MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVE 55
betaIV-1 ----------------------MPGAGDGGKAPARWLGTGLLGLFLLPVTLSLEVSVGKA 38
betaIV-2 ----------------------MPGAGDGGKAPARWLGTGLL------------------ 20
betaIV-3 ----------------------MNNISIVLRD-LEFSDTGKY------------------ 19
betaIVCRA_a ----------------------MNNISIVLRD-LEFSDTGKY------------------ 19
betaIVCRA_b ----------------------MPGAGDGGKAPARWLGTGLLGLFLLPVTLSLEVSVGKA 38
betaIa AETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGT------------ 98
betaIb AETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGT------------ 98
betaII KQFSLNWTYQECNNCSEEMFLQFRMKIINLKLER-FQDRVEFSGN--------------- 104
betaIII ATTVVEWFYRPEGGKDFL-IYEYRNGHQEVESP--FQGRLQWNGS--------------- 97
betaIIICRA_a ATTVVEWFYRPEGGKDFL-IYEYRNGHQEVESP--FQGRLQWNGS--------------- 97
betaIV-1 TDIYAVNGTEILLPCTFSSCFGFEDLHFRWTYNSSDAFKILIEGTVKNEKSDPKVTLKDD 98
betaIV-2 ------------------------------------------------------------
betaIV-3 ------------------------------------------------------------
betaIVCRA_a ------------------------------------------------------------
betaIVCRA_b TDIYAVNGTEILLPCTFSSCFGFEDLHFRWTYNSSDAFKILIEGTVKNEKSDPKVTLKDD 98
betaIa --------------------KDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSV 138
betaIb --------------------KDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSV 138
betaII --------------------PSKYDVSVMLRNVQPEDEGIYNCYIMNPP--DRHRGHGKI 142
betaIII --------------------KDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKT 137
betaIIICRA_a --------------------KDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKT 137
betaIV-1 DRITLVGSTKEKMNNISIVLRDLEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRLEEV 158
betaIV-2 --------------------------------------------------------VEEV 24
betaIV-3 -------------------------------TCHVKNPKENNLQHHATIFLQVVDRLEEV 48
betaIVCRA_a -------------------------------TCHVKNPKENNLQHHATIFLQVVDRLEEV 48
betaIVCRA_b DRITLVGSTKEKMNNISIVLRDLEFSDTGKYTCHVKNPKENNLQHHATIFLQVVDRLEEV 158
betaIa VKKIHIEVVDKANRDMASIVSEIMMYV------LIVVLTIWLVAEMIYCYKKIAAATETA 192
betaIb VKKIHIEVVDKGESGAACPFTVTHRRARWRDRWQAVDRTGWLCAWPANRPQQRAEGEGSS 198
betaII HLQVLMEEPPERDSTVAVIVGASVGGF---------LAVVILVLMVVKCVRRKKEQKLST 193
betaIII TRLIPLRVTEEAGEDFTSVVSEIMMYI------LLVFLTLWLLIEMIYCYRKVSKAEEAA 191
betaIIICRA_a TRLIPLRVTEEAGEDFTSVVSEIMMYI------LLVFLTLWLLIEMIYCYRKVSKAEEAA 191
betaIV-1 DNTVTLIILAVVGGVIGLLILILLIKK------------LIIFILKKTREKKKECLVSSS 206
betaIV-2 DNTVTLIILAVVGGVIGLLILILLIKK------------LIIFILKKTREKKKECLVSSS 72
betaIV-3 DNTVTLIILAVVGGVIGLLILILLIKK------------LIIFILKKTREKKKECLVSSS 96
betaIVCRA_a DNTVTLIILAVVGGVIGLLILILLIKK------------LIIFILKKTREKKKECLVSSS 96
betaIVCRA_b DNTVTLIILAVVGGVIGLLILILLIKK------------LIIFILKKTREKKKECLVSSS 206
: : . : :: ::
betaIa AQENASEY-LAITSESKENCTGVQVAE--------------------------------- 218
betaIb PSCPLQLWPLFLSSPRRGQSMPVPHRRSGYRTQLCHLCCMTSGRCLLSLSQRVVLGLPGI 258
betaII DDLKTEEE-----GKTDGEGNPDDGAK--------------------------------- 215
betaIII -QENASDY-LAIPSENKEN-SAVPVEE--------------------------------- 215
betaIIICRA_a -QENASDY-LAIPSENKEN-SAVPVEE--------------------------------- 215
betaIV-1 GNDNTENG---LPGSKAEEKPPSKV----------------------------------- 228
betaIV-2 GNDNTENG---LPGSKAEEKPPSKV----------------------------------- 94
betaIV-3 GNDNTENG---LPGSKAEEKPPSKV----------------------------------- 118
betaIVCRA_a GNDNTENG---LPGSKAEEKPPSKV----------------------------------- 118
betaIVCRA_b GNDNTENG---LPGSKAEEKPPSKV----------------------------------- 228
. . . :
betaIa ----------
betaIb IIRCVSRGVV 268
betaII ----------
betaIII ----------
betaIIICRA_a ----------
betaIV-1 ----------
betaIV-2 ----------
betaIV-3 ----------
betaIVCRA_a ----------
betaIVCRA_b ----------
Accession numbers of the sodium ion channel beta subunits used in the protein sequence alignment: betaIa - NP_001028; betaIb - NP_950238; betaII - NP_004579; betaIII - AAI26266; betaIIICRA_a - EAW67552; betaIV-1 - NP_777594; betaIV-2 - NP_001135820; betaIV-3 - NP_001135821; betaIVCRA_a - EAW67351; betaIVCRA_b - EAW67352
Predicted General Properties of Representative Subunits of the Sodium Ion Channel - Primary Sequence Analysis (with ProtParam)b
alpha1.1
subunit sodium ion channel
Number of amino acids: 2009
Molecular weight: 228971.6
Theoretical pI: 5.60
Total number of negatively charged residues (Asp + Glu): 239
Total number of positively charged residues (Arg + Lys): 211
Atomic composition: Carbon C 10377 Hydrogen H 16149 Nitrogen N 2647 Oxygen O 2974 Sulfur S 106
Formula: C10377H16149N2647O2974S106
Total number of atoms: 32253
Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 241640 Abs 0.1% (=1 g/l) 1.055, assuming ALL Cys residues appear as half cystines Ext. coefficient 239390 Abs 0.1% (=1 g/l) 1.046, assuming NO Cys residues appear as half cystines
Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).
Instability index: The instability index (II) is computed to be 43.99 This classifies the protein as unstable.
Aliphatic index: 92.66
Grand average of hydropathicity (GRAVY): -0.009
betaIa
subunit sodium ion channel
Number of amino acids: 218
Molecular weight: 24707.1
Theoretical pI: 4.88
Total number of negatively charged residues (Asp + Glu): 33
Total number of positively charged residues (Arg + Lys): 21
Atomic composition: Carbon C 1093 Hydrogen H 1717 Nitrogen N 285 Oxygen O 340 Sulfur S 13
Formula: C1093H1717N285O340S13
Total number of atoms: 3448
Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 31775 Abs 0.1% (=1 g/l) 1.286, assuming ALL Cys residues appear as half cystines Ext. coefficient 31400 Abs 0.1% (=1 g/l) 1.271, assuming NO Cys residues appear as half cystines
Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).
Instability index: The instability index (II) is computed to be 43.19 This classifies the protein as unstable.
Aliphatic index: 92.06
Grand average of hydropathicity (GRAVY): -0.041
