Sequence Alignment of the PTEN (Phosphatase and Tensin Homolog) Protein (with Clustalw)a
Species Sequence Alignment
of PTEN
Human MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK 60
Dog MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK 60
Mouse MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK 60
Rat MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK 60
Zebrafish MTAKLKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSK 60
*** :*******************************************************
Human HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA 120
Dog HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA 120
Mouse HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA 120
Rat HKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVA 120
Zebrafish HKNHYKIYNLCAERHYDASKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDENHVA 120
*****************::************************************:****
Human AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY 180
Dog AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY 180
Mouse AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY 180
Rat AIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY 180
Zebrafish AIHCKAGKGRTGVMICAYLLHRKKFAEAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSY 180
********************** ** :*********************************
Human LLKNHLDYRPVALLFHKMMFETIPMFSGGTCN-----------------------PQFVV 217
Dog LLKNHLDYRPVALLFHKMMFETIPMFSGGTCN-----------------------PQFVV 217
Mouse LLKNHLDYRPVALLFHKMMFETIPMFSGGTCN-----------------------PQFVV 217
Rat LLKNHLDYRPVALLFHKMMFETIPMFSGGTCN-----------------------PQFVV 217
Zebrafish LLKNKLDYKPVALLFHKMVFQTLPMFSGGTCRDSTVKNRSEVNPQGFKKGSWHWDPQFVV 240
****:***:*********:*:*:********. *****
Human CQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNT 277
Dog CQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNT 277
Mouse CQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNT 277
Rat CQLKVKIYSSNSGPTRREDKLMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNT 277
Zebrafish YQLKVKIHTSNPAHTRREEKHMIFEFPQPLPVCGDIKVEFFHKQSKMMKKDKMFHFWINT 300
******::**.. ****:* * *********************.**:*********:**
Human FFIPGPEETSEKVENGSLCDQEIDSICS---------------------------IERAD 310
Dog FFIPGPEETSEKVENGSLCDQEIDSICS---------------------------IERAD 310
Mouse FFIPGPEETSEKVENGSLCDQEIDSICS---------------------------IERAD 310
Rat FFIPGPEETSEKVENGSLCDQEIDSICS---------------------------IERAD 310
Zebrafish FFIPGPEEAGDKVENGSVVN-DVDSLSCQSQSSPAERDREKERAVAAAALDRERGGERAD 359
********:.:******: : ::**:.. ****
Human NDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVS 370
Dog NDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVS 370
Mouse NDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVS 370
Rat NDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVS 370
Zebrafish GEKDYLILTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNSEASTSTSVTPDVS 419
.:*:**:***************************************.***:*********
Human DNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV 403
Dog DNEPDHYRYSDTTDSDPENEPFDEDQHTQITKV 403
Mouse DNEPDHYRYSDTTDSDPENEPFDEDQHSQITKV 403
Rat DNEPDHYRYSDTTDSDPENEPFDEDQHSQITKV 403
Zebrafish DNEPDHYRYSDTTDSDPENEPFDEEQHAQITKV 452
************************:**:*****
Accession numbers of the PTEN protein sequences used in the protein sequence alignment: human - NP_000305; mouse - NP_032986; rat - NP_113794;
dog - NP_00100319; zebrafish - NP_957002
Predicted General Properties of the PTEN (Phosphatase and Tensin Homolog) Protein (Homo sapiens) - Primary Sequence Analysis (with ProtParam)b
Number of amino acids: 403
Molecular weight: 47166.2
Theoretical pI: 5.94
Total number of negatively charged residues (Asp + Glu): 62
Total number of positively charged residues (Arg + Lys): 54
Atomic composition: Carbon C 2113 Hydrogen H 3215 Nitrogen N 561 Oxygen O 630 Sulfur S 19
Formula: C2113H3215N561O630S19
Total number of atoms: 6538
Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 45895 Abs 0.1% (=1 g/l) 0.973, assuming ALL Cys residues appear as half cystines Ext. coefficient 45270 Abs 0.1% (=1 g/l) 0.960, assuming NO Cys residues appear as half cystines
Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).
Instability index: The instability index (II) is computed to be 44.21 This classifies the protein as unstable.
Aliphatic index: 66.97
Grand average of hydropathicity (GRAVY): -0.690
Bioinformatics References
a Higgins D., Thompson J., Gibson T. Thompson J. D., Higgins D. G., Gibson T. J.(1994). CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting,position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673-4680.
b Gasteiger E., Hoogland C., Gattiker A., Duvaud S., Wilkins M.R., Appel R.D., Bairoch A.; Protein Identification and Analysis Tools on the ExPASy Server;
(In) John M. Walker (ed): The Proteomics Protocols Handbook, Humana Press (2005). pp. 571-607 Full text - Copyright Humana Press.