Sequence Alignment of the Myc Protein (with Clustalw)a
Species Sequence Alignment
of Myc
Pig ---------------MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAP 45
Cow ---------------MPLNVSFANKNYDLDYDSVQPYFYCDEEENFYHQQQQSELQPPAP 45
Dog ---------------MPLNVSFANRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAP 45
Human MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAP 60
Mouse ---------------MPLNVNFTNRNYDLDYDSVQPYFICDEEENFYHQQQQSELQPPAP 45
Rat MNFLWEVENPTVT-TMPLNVSFANRNYDLDYDSVQPYFICDEEENFYHQQQQSELQPPAP 59
*****.*:*:************* ********:************
Pig SEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVAS-FSPRGDDDGGGGSFSTADQLEMVTE 104
Cow SEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVAS-FSPRGDDDGGGGSFSSADQLEMVTE 104
Dog SEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVAS-FSPRGDDDGGGGSFSTADQLEMVTE 104
Human SEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTP-FSLRGDNDGGGGSFSTADQLEMVTE 119
Mouse SEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVATSFSPREDDDGGGGNFSTADQLEMMTE 105
Rat SEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVATSFSPREDDDGGGGNFSTADQLEMMTE 119
********************************:. ** * *:*****.**:******:**
Pig LLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPIP 164
Cow LLGGDMVNQSFICDPDDETLIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDGGSPSP 164
Dog LLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPSP 164
Human LLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNP 179
Mouse LLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSTSLSP 165
Rat LLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSTSLSP 179
*******************:**********************************. * *
Pig ARGHGGYSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKPCASPDSTAFSPSSDSLL 224
Cow ARGHGGCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKPCASPDSTAFSPSSDSLL 224
Dog ARGPGGCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKPCASPDSAAFSPSSDSLL 224
Human ARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLL 239
Mouse ARGHSVCSTSSLYLQDLTAAASECIDPSVVFPYPLNDSSSPKSCTSSDSTAFSPSSDSLL 225
Rat ARGHSVCSTSSLYLQDLTAAASECIDPSVVFPYPLNDSSSPKSCTSSDSTAFSSSSDSLL 239
*** . **********:************************.*:* **:***.******
Pig SSAESSPRGSPEPLALHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQPPAKRSESGSPSA 284
Cow SSAESSPRASPEPLALHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQPPAKRSESGSPSA 284
Dog SSAESSPRASPEPLALHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPAKRSESGSPSA 284
Human SSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSA 299
Mouse SS-ESSPRASPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQTPAKRSESGSSPS 284
Rat SS-ESSPRATPEPLVLHEETPPTTSSDSEEEQDDEEEIDVVSVEKRQPPAKRSESGSSPS 298
** ****:.:****.*****************:**************.*.*******..:
Pig GGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPSAKRAKLDSGRVLKQISNNRKCAS 344
Cow GSHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRAKLDSGRVLKQISNNRKCAS 344
Dog GGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRARLDSGRVLKQISNNRKCAS 344
Human GGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTS 359
Mouse RGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRAKLDSGRVLKQISNNRKCSS 344
Rat RGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRAKLDSGRVLKQISNNRKCSS 358
.**********************************:***.:*** ***:********:*
Pig PRSSDTEENDKRRTHNVLERQRRNELKRSFFARRDQIPELENNEKAPKVVILKKATAYIL 404
Cow PRSSDTEENDKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYIL 404
Dog PRSSDTEENDKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYIL 404
Human PRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYIL 419
Mouse PRSSDTEENDKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYIL 404
Rat PRSSDTEENDKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYIL 418
********* ********************** ***************************
Pig SVQAEEQKLVSEKDVLRKRREQLKLKLEQLRNSCP 439
Cow SVQAEQQKLKSEIDVLQKRREQLKLKLEQIRNSCA 439
Dog SVQAEEQKLLSEKDLLRKRREQLKHKLEQLRNSGA 439
Human SVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA 454
Mouse SIQADEHKLTSEKDLLRKRREQLKHKLEQLRNSGA 439
Rat SVQADEHKLISEKDLLRKRREQLKHKLEQLRNSGA 453
*:**:::** ** *:*:******* ****:*** .
Accession numbers of the myc protein sequences used in the protein sequence alignment: Human - NP_002458 ; Mouse - NP_034979; Rat - NP_036735 ; Dog -
NP_001003246 ; Pig - NP_001005154 ; Cow - NP_001039539
Predicted General Properties of the Myc Protein (Homo sapiens) - Primary Sequence Analysis (with ProtParam)b
Number of amino acids: 454
Molecular weight: 50565.0
Theoretical pI: 5.28
Total number of negatively charged residues (Asp + Glu): 66
Total number of positively charged residues (Arg + Lys): 52
Atomic composition: Carbon C 2186 Hydrogen H 3447 Nitrogen N 625 Oxygen O 725 Sulfur S 15
Formula: C2186H3447N625O725S15
Total number of atoms: 6998
Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 29505 Abs 0.1% (=1 g/l) 0.584, assuming ALL Cys residues appear as half cystines Ext. coefficient 28880 Abs 0.1% (=1 g/l) 0.571, assuming NO Cys residues appear as half cystines
Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).
Instability index: The instability index (II) is computed to be 90.88 This classifies the protein as unstable.
Aliphatic index: 65.73
Grand average of hydropathicity (GRAVY): -0.765
Bioinformatics References
a Higgins D., Thompson J., Gibson T. Thompson J. D., Higgins D. G., Gibson T. J.(1994). CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting,position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673-4680.
b Gasteiger E., Hoogland C., Gattiker A., Duvaud S., Wilkins M.R., Appel R.D., Bairoch A.; Protein Identification and Analysis Tools on the ExPASy Server;
(In) John M. Walker (ed): The Proteomics Protocols Handbook, Humana Press (2005). pp. 571-607 Full text - Copyright Humana Press.