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The Myc Protein

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Sequence Alignment of the Myc Protein (with Clustalw)a

Species Sequence Alignment of Myc

Pig             ---------------MPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAP 45
Cow             ---------------MPLNVSFANKNYDLDYDSVQPYFYCDEEENFYHQQQQSELQPPAP 45
Dog             ---------------MPLNVSFANRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAP 45
Human           MDFFRVVENQQPPATMPLNVSFTNRNYDLDYDSVQPYFYCDEEENFYQQQQQSELQPPAP 60
Mouse           ---------------MPLNVNFTNRNYDLDYDSVQPYFICDEEENFYHQQQQSELQPPAP 45
Rat             MNFLWEVENPTVT-TMPLNVSFANRNYDLDYDSVQPYFICDEEENFYHQQQQSELQPPAP 59
                               *****.*:*:************* ********:************

Pig             SEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVAS-FSPRGDDDGGGGSFSTADQLEMVTE 104
Cow             SEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVAS-FSPRGDDDGGGGSFSSADQLEMVTE 104
Dog             SEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVAS-FSPRGDDDGGGGSFSTADQLEMVTE 104
Human           SEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVTP-FSLRGDNDGGGGSFSTADQLEMVTE 119
Mouse           SEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVATSFSPREDDDGGGGNFSTADQLEMMTE 105
Rat             SEDIWKKFELLPTPPLSPSRRSGLCSPSYVAVATSFSPREDDDGGGGNFSTADQLEMMTE 119
                ********************************:. ** * *:*****.**:******:**

Pig             LLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPIP 164
Cow             LLGGDMVNQSFICDPDDETLIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDGGSPSP 164
Dog             LLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPSP 164
Human           LLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSGSPNP 179
Mouse           LLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSTSLSP 165
Rat             LLGGDMVNQSFICDPDDETFIKNIIIQDCMWSGFSAAAKLVSEKLASYQAARKDSTSLSP 179
                *******************:**********************************. *  *

Pig             ARGHGGYSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKPCASPDSTAFSPSSDSLL 224
Cow             ARGHGGCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKPCASPDSTAFSPSSDSLL 224
Dog             ARGPGGCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKPCASPDSAAFSPSSDSLL 224
Human           ARGHSVCSTSSLYLQDLSAAASECIDPSVVFPYPLNDSSSPKSCASQDSSAFSPSSDSLL 239
Mouse           ARGHSVCSTSSLYLQDLTAAASECIDPSVVFPYPLNDSSSPKSCTSSDSTAFSPSSDSLL 225
Rat             ARGHSVCSTSSLYLQDLTAAASECIDPSVVFPYPLNDSSSPKSCTSSDSTAFSSSSDSLL 239
                *** .  **********:************************.*:* **:***.******

Pig             SSAESSPRGSPEPLALHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQPPAKRSESGSPSA 284
Cow             SSAESSPRASPEPLALHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQPPAKRSESGSPSA 284
Dog             SSAESSPRASPEPLALHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPAKRSESGSPSA 284
Human           SSTESSPQGSPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQAPGKRSESGSPSA 299
Mouse           SS-ESSPRASPEPLVLHEETPPTTSSDSEEEQEDEEEIDVVSVEKRQTPAKRSESGSSPS 284
Rat             SS-ESSPRATPEPLVLHEETPPTTSSDSEEEQDDEEEIDVVSVEKRQPPAKRSESGSSPS 298
                ** ****:.:****.*****************:**************.*.*******..:

Pig             GGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPSAKRAKLDSGRVLKQISNNRKCAS 344
Cow             GSHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRAKLDSGRVLKQISNNRKCAS 344
Dog             GGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRARLDSGRVLKQISNNRKCAS 344
Human           GGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRVKLDSVRVLRQISNNRKCTS 359
Mouse           RGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRAKLDSGRVLKQISNNRKCSS 344
Rat             RGHSKPPHSPLVLKRCHVSTHQHNYAAPPSTRKDYPAAKRAKLDSGRVLKQISNNRKCSS 358
                 .**********************************:***.:*** ***:********:*

Pig             PRSSDTEENDKRRTHNVLERQRRNELKRSFFARRDQIPELENNEKAPKVVILKKATAYIL 404
Cow             PRSSDTEENDKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYIL 404
Dog             PRSSDTEENDKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYIL 404
Human           PRSSDTEENVKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYIL 419
Mouse           PRSSDTEENDKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYIL 404
Rat             PRSSDTEENDKRRTHNVLERQRRNELKRSFFALRDQIPELENNEKAPKVVILKKATAYIL 418
                ********* ********************** ***************************

Pig             SVQAEEQKLVSEKDVLRKRREQLKLKLEQLRNSCP 439
Cow             SVQAEQQKLKSEIDVLQKRREQLKLKLEQIRNSCA 439
Dog             SVQAEEQKLLSEKDLLRKRREQLKHKLEQLRNSGA 439
Human           SVQAEEQKLISEEDLLRKRREQLKHKLEQLRNSCA 454
Mouse           SIQADEHKLTSEKDLLRKRREQLKHKLEQLRNSGA 439
Rat             SVQADEHKLISEKDLLRKRREQLKHKLEQLRNSGA 453
                *:**:::** ** *:*:******* ****:*** .

Accession numbers of the myc protein sequences used in the protein sequence alignment:  Human - NP_002458 ; Mouse - NP_034979; Rat - NP_036735 ; Dog -
NP_001003246 ; Pig - NP_001005154 ; Cow - NP_001039539

Predicted General Properties of the Myc Protein  (Homo sapiens) - Primary Sequence Analysis (with ProtParam)b

Number of amino acids: 454

Molecular weight: 50565.0

Theoretical pI: 5.28 Total number of negatively charged residues (Asp + Glu): 66

Total number of positively charged residues (Arg + Lys): 52

Atomic composition: Carbon C 2186 Hydrogen H 3447 Nitrogen N 625 Oxygen O 725 Sulfur S 15

Formula: C2186H3447N625O725S15

Total number of atoms: 6998

Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 29505 Abs 0.1% (=1 g/l) 0.584, assuming ALL Cys residues appear as half cystines Ext. coefficient 28880 Abs 0.1% (=1 g/l) 0.571, assuming NO Cys residues appear as half cystines

Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).

Instability index: The instability index (II) is computed to be 90.88 This classifies the protein as unstable.

Aliphatic index: 65.73

Grand average of hydropathicity (GRAVY): -0.765

Bioinformatics References

a Higgins D., Thompson J., Gibson T. Thompson J. D., Higgins D. G., Gibson T. J.(1994). CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting,position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673-4680.

b Gasteiger E., Hoogland C., Gattiker A., Duvaud S., Wilkins M.R., Appel R.D., Bairoch A.; Protein Identification and Analysis Tools on the ExPASy Server;
(In) John M. Walker (ed): The Proteomics Protocols Handbook, Humana Press (2005). pp. 571-607  Full text - Copyright Humana Press.

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