The Lysozyme Protein

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Sequence Alignment of the Lyoszyme Protein (with Clustalw) a

Species Sequence Alignment 

Human           --------MKALIVLGLVLLSVTVQG---------KVFERCELARTLKRLGMDGYRGISL 43
Chimpanzee      --------MKALIVLGLVLLSVTVQG---------KVFERCELARTLKRLGMDGYRGISL 43
Mouse           --------MKALLTLGLLLLSVTAQA---------KVYNRCELARILKRNGMDGYRGVKL 43
Rat             --------MKALLVLGFLLLSASVQA---------KIYERCEFARTLKRNGMSGYYGVSL 43
Pig             --------MKTLLVLALLLLSVSVQA---------KVYDRCEFARILKKSGMDGYRGVSL 43
Zebrafish       --------MRLAVVFLCLAWMSSCES---------KTLGRCDVYKIFKNEGLDGFEGFSI 43
Chicken         MLGKNDPMCLVLVLLGLTALLGICQGGTGCYGSVSRIDTTGASCRTAKPEGLS-YCGVRA 59
                            : :         :.         :        :  *  *:. : *.  

Human           ANWMCLAKWESG-----------------------------YNTRATNYNAGDRSTDYGI 74
Chimpanzee      ANWMCLAKWESG-----------------------------YNTRATNYNAGDRSTDYGI 74
Mouse           ADWVCLAQHESN-----------------------------YNTRATNYNRGDRSTDYGI 74
Rat             ADWVCLAQHESN-----------------------------YNTQARNYNPGDQSTDYGI 74
Pig             ANWVCLAKWESN-----------------------------FNTKATNYNPGSQSTDYGI 74
Zebrafish       GNYVCTAYWESR-----------------------------FKTHRVR--SADTGKDYGI 72
Chicken         SRTIAERDLGSMNKYKVLIKRVGEALCIEPAVIAGIISRESHAGKILKNGWGDRGNGFGL 119
                .  :.     *                              .  :  .   .. ...:*:

Human           FQINSRYWCNDGKTPGAVNACH-LSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNR 133
Chimpanzee      FQINSRYWCNDGKTPGAVNACH-LSCSALLQDNIADAVACAKRVVRDPQGIRAWVAWRNR 133
Mouse           FQINSRYWCNDGKTPRSKNACG-INCSALLQDDITAAIQCAKRVVRDPQGIRAWVAWRTQ 133
Rat             FQINSRYWCNDGKTPRAKNACG-IPCSALLQDDITQAIQCAKRVVRDPQGIRAWVAWQRH 133
Pig             FQINSRYWCNDGKTPKAVNACH-ISCKVLLDDDLSQDIECAKRVVRDPQGIKAWVAWKAH 133
Zebrafish       FQINSFKWCDDG-TPGGKNLCK-VACSDLLNDDLKASVGCAKLIVK-MDGLKSWETWDSY 129
Chicken         MQVDKRYHKIEGTWNGEAHIRQGTRILIDMVKKIQRKFPRWTRDQQLKGGISAYNAGVGN 179
                :*::.     :*      :          : ..:   .   .   :   *: :: :    

Human           CQNRD-------VRQYVQGCGV---------- 148
Chimpanzee      CQNRD-------VRQYVQGCGV---------- 148
Mouse           CQNRD-------LSQYIRNCGV---------- 148
Rat             CKNRD-------LSGYIRNCGV---------- 148
Pig             CQNKD-------VSQYIRGCKL---------- 148
Zebrafish       CNGRK-------MSRWVKGCEQRKQSLRA--- 151
Chicken         VRSYERMDIGTLHDDYSNDVVARAQYFKQHGY 211
                 .. .          : ..            

Accession Numbers:  Human - NP_000230; Chimpanzee - NP_001009073; Mouse - NP_038618; Rat - NP_036903; Pig - NP_999557; Chicken - NP_001001470; Zebrafish - NP_631919

Predicted General Properties of the Lyoszyme Protein  (Homo sapiens) - Primary Sequence Analysis (with ProtParam) b

Number of amino acids: 148 Molecular weight: 16537.0 Theoretical pI: 9.38
Amino acid composition:
Ala (A) 15 10.1% Arg (R) 14 9.5% Asn (N) 10 6.8% Asp (D) 8 5.4% Cys (C) 8 5.4% Gln (Q) 7 4.7% Glu (E) 3 2.0% Gly (G) 13 8.8% His (H) 1 0.7% Ile (I) 6 4.1% Leu (L) 13 8.8% Lys (K) 6 4.1% Met (M) 3 2.0% Phe (F) 2 1.4% Pro (P) 2 1.4% Ser (S) 7 4.7% Thr (T) 6 4.1% Trp (W) 5 3.4% Tyr (Y) 6 4.1% Val (V) 13 8.8% Asx (B) 0 0.0% Glx (Z) 0 0.0% Xaa (X) 0 0.0%
Total number of negatively charged residues (Asp + Glu): 11 Total number of positively charged residues (Arg + Lys): 20 Atomic composition: Carbon C 719 Hydrogen H 1146 Nitrogen N 220 Oxygen O 207 Sulfur S 11 Formula: C719H1146N220O207S11 Total number of atoms: 2303 Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 36940 Abs 0.1% (=1 g/l) 2.234, assuming ALL Cys residues appear as half cystines Ext. coefficient 36440 Abs 0.1% (=1 g/l) 2.204, assuming NO Cys residues appear as half cystines Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo). Instability index: The instability index (II) is computed to be 27.71 This classifies the protein as stable. Aliphatic index: 85.68 Grand average of hydropathicity (GRAVY): -0.195

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Recent Articles on the Lysozyme Protein

pubmed: lysozyme
Combining structure and dynamics: non-denaturing high-pressure effect on lysozyme in solution.
Ortore MG, Spinozzi F, Mariani P, Paciaroni A, Barbosa LR, Amenitsch H, Steinhart M, Ollivier J, Russo D
J R Soc Interface 


 

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