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The Laminin Protein

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Sequence Alignment of the Laminin Protein (Homo sapiens)  (with Clustalw)a

Isoform Sequence Alignment of Laminin

laminin alpha subunit

alpha3-1  MAAAARPRGRALGPVLPPTPLLLLVLRVLPACGATARDPGAAAGLSLHPTYFNLAEAARI 60
alpha3-2  ------------------------------------------------------------
alpha5    --MAKRLCAGSALCVRGPRGPAPLLLVGLALLGAARAREEAGGGFSLHPPYFNLAEGARI 58
alpha2a   --------MPGAAGVLLLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALI 52
alpha2b   --------MPGAAGVLLLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALI 52
alpha1    ----------MRGGVLLVLLLC-----VAAQCRQ----------RGLFPAILNLASNAHI 35
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  WATATCGERGPGEG--RPQPELYCKLVGGPTAPGSGH-TIQGQFCDYCN--SEDPRKAHP 115
alpha3-2  ------------------------------------------------------------
alpha5    AASATCGEEAPARGSPRPTEDLYCKLVGGPVAGGDPNQTIRGQYCDICT--AANSNKAHP 116
alpha2a   TTNATCGEKG---------PEMYCKLVEH-----VPGQPVRNPQCRICNQNSSNPNQRHP 98
alpha2b   TTNATCGEKG---------PEMYCKLVEH-----VPGQPVRNPQCRICNQNSSNPNQRHP 98
alpha1    STNATCGEKG---------PEMFCKLVEH-----VPGRPVRNPQCRICDGNSANPRERHP 81
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  VTNAIDGSERWWQSPPLSSGTQYNRVNLTLDLGQLFHVAYILIKFANSPRPDLWVLERSV 175
alpha3-2  ------------------------------------------------------------
alpha5    ASNAIDGTERWWQSPPLSRGLEYNEVNVTLDLGQVFHVAYVLIKFANSPRPDLWVLERSM 176
alpha2a   ITNAIDGKNTWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSL 158
alpha2b   ITNAIDGKNTWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSL 158
alpha1    ISHAIDGTNNWWQSPSIQNGREYHWVTITLDLRQVFQVAYVIIKAANAPRPGNWILERSL 141
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  DFGSTYSPWQYFAHSKVDCLKEFGREANMA---VTRDDDVLCVTEYSRIVPLENGEVVVS 232
alpha3-2  ------------------------------------------------------------
alpha5    DFGRTYQPWQFFASSKRDCLERFGPQTLER---ITRDDAAICTTEYSRIVPLENGEIVVS 233
alpha2a   DD-VEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHIS 217
alpha2b   DD-VEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHIS 217
alpha1    DG-TTFSPWQYYAVSDSECLSRYNITPRRGPPTYRADDEVICTSYYSRLVPLEHGEIHTS 200
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  LINGRPGAKNFTFSHTLREFTKATNIRLRFLRTNTLLGHLISKAQR-----DPTVTRRYY 287
alpha3-2  ------------------------------------------------------------
alpha5    LVNGRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLLGHLMGKALR-----DPTVTRRYY 288
alpha2a   LINGRPSAD--DPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYY 275
alpha2b   LINGRPSAD--DPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYY 275
alpha1    LINGRPSAD--DLSPKLLEFTSARYIRLRLQRIRTLNADLMTLSHREPKELDPIVTRRYY 258
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  YSIKDISIGGQCVCNGHAEVCNINNPEKLF--RCECQHHTCGETCDRCCTGYNQRRWRPA 345
alpha3-2  ------------------------------------------------------------
alpha5    YSIKDISIGGRCVCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPWKPA 348
alpha2a   YSVKDISVGGMCICYGHARACPLDPATNKS--RCECEHNTCGDSCDQCCPGFHQKPWRAG 333
alpha2b   YSVKDISVGGMCICYGHARACPLDPATNKS--RCECEHNTCGDSCDQCCPGFHQKPWRAG 333
alpha1    YSIKDISVGGMCICYGHASSCPWDETTKKL--QCQCEHNTCGESCNRCCPGYHQQPWRPG 316
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  AWEQSHECEACNCHGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQC 405
alpha3-2  ------------------------------------------------------------
alpha5    TANSANECQSCNCYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERC 408
alpha2a   TFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETC 393
alpha2b   TFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETC 393
alpha1    TVSSGNTCEACNCHNKAKDCYYDESVAKQKKSLNTAGQFRGGGVCINCLQNTMGINCETC 376
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  AKGYYRPYGVPVDAPDGCIPCSCDPEHADG-CEQGSGRCHCKPNFHGDNCEKCAIGYYNF 464
alpha3-2  ------------------------------------------------------------
alpha5    LPGFYRSPNHPLDSPHVCRRCNCESDFTDGTCEDLTGRCYCRPNFSGERCDVCAEGFTGF 468
alpha2a   TDGFFRPKGVSPNYPRPCQPCHCD------------------------------------ 417
alpha2b   TDGFFRPKGVSPNYPRPCQPCHCD------------------------------------ 417
alpha1    IDGYYRPHKVSPYEDEPCRPCNCD------------------------------------ 400
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  PFCLRIP---------IFPVSTPSSEDPVAGDIKG------------------------- 490
alpha3-2  ------------------------------------------------------------
alpha5    PSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPNFQGTHCEL 528
alpha2a   ------------------------------------------------------------
alpha2b   ------------------------------------------------------------
alpha1    ------------------------------------------------------------
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  ----------------------------------------------------------CD 492
alpha3-2  ------------------------------------------------------------
alpha5    CAPGFYGPGCQPCQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPLCQLCG 588
alpha2a   ------------------------------------------------------------
alpha2b   ------------------------------------------------------------
alpha1    ------------------------------------------------------------
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  CNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRS--------------------------- 525
alpha3-2  ------------------------------------------------------------
alpha5    CSPAGTLPEGCDEAGRCLCQPEFAGPHCDRCRPGYHGFPNCQACTCDPRGALDQLCGAGG 648
alpha2a   --PIGSLNEVCVKD---------------------------------------------- 429
alpha2b   --PIGSLNEVCVKD---------------------------------------------- 429
alpha1    --PVGSLSSVCIKD---------------------------------------------- 412
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  ------------------GFYSFPICQACWCSALGSYQMPCSSVTGQCECRPGVTGQRCD 567
alpha3-2  ------------------------------------------------------------
alpha5    LCRCRPGYTGTACQECSPGFHGFPSCVPCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCD 708
alpha2a   ---------------------------------EKH--ARRGLAPGSCHCKTGFGGVSCD 454
alpha2b   ---------------------------------EKH--ARRGLAPGSCHCKTGFGGVSCD 454
alpha1    ---------------------------------DLHSDLHNGKQPGQCPCKEGYTGEKCD 439
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  RCLSGAYDFPHCQGSSSACDPAGTIN----SNLGYCQCKLHVEGPTCSRCKLLYWNLDKE 623
alpha3-2  ------------------------------------------------------------
alpha5    TCVPGAYNFPYCEAGSCHPAGLAPVDPALPEAQVPCMCRAHVEGPSCDRCKPGFWGLSPS 768
alpha2a   RCARGYTGYPDCKACNCSGLGSKNEDP----CFGPCICKENVEGGDCSRCKSGFFNLQED 510
alpha2b   RCARGYTGYPDCKACNCSGLGSKNEDP----CFGPCICKENVEGGDCSRCKSGFFNLQED 510
alpha1    RCQLGYKDYPTCVSCGCNPVGSASDEP----CTGPCVCKENVEGKACDRCKPGFYNLKEK 495
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  NPSGCSECKCHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGYFALEKSNYFGCQG 683
alpha3-2  ------------------------------------------------------------
alpha5    NPEGCTRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQACASCKDGFFGLDQADYFGCRS 828
alpha2a   NWKGCDECFCSGVSNR--------------CQSSYWTYGKIQDMSGWYLTDLPGRIRVAP 556
alpha2b   NWKGCDECFCSGVSNR--------------CQSSYWTYGKIQDMSGWYLTDLPGRIRVAP 556
alpha1    NPRGCSECFCFGVSDV--------------CSSLSWPVGQVNSMSGWLVTDLISPRKIPS 541
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  CQCDIGGALSSMCSGPSGVCQCREHVVGKVCQRPENNYYFPDLHHMKYEIEDGSTPNGRD 743
alpha3-2  ------------------------------------------------------------
alpha5    CRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHYLPDLHHLRLELEEAATPEGHA 888
alpha2a   QQDDLDSPQ-----------QISISNAEARQALPHSYYWSAPAPYLGNKLPAVGGQLTFT 605
alpha2b   QQDDLDSPQ-----------QISISNAEARQALPHSYYWSAPAPYLGNKLPAVGGQLTFT 605
alpha1    QQDALGGRH-----------QVSINNTAVMQRLAPKYYWAAPEAYLGNKLTAFGGFLKYT 590
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  LRFGFDPLAFPEFSWRGYAQMTSVQNDVRITLNVGKSSGSLFRVILRYVNPGTEAVSGHI 803
alpha3-2  ------------------------------------------------------------
alpha5    VRFGFNPLEFENFSWRGYAQMAPVQP--RIVARLNLTSPDLFWLVFRYVNRGAMSVSGRV 946
alpha2a   ISYDLE---------------------------EEEEDTERVLQLMIILEGNDLSIS--- 635
alpha2b   ISYDLE---------------------------EEEEDTERVLQLMIILEGNDLSIS--- 635
alpha1    VSYDIP---------------------------VETVDSNLMSHADVIIKGNGLTLS--- 620
alpha4    ------------------------------------------------------------
                                                                      

alpha3-1  TIYPSWG-------AAQSKEIIFLPSKEPAFVTVPGNGFADPFSITPGIWVACIKAEGVL 856
alpha3-2  ------------------------------------------------------------
alpha5    SVREEGRSATCANCTAQSQPVAFPPSTEPAFITVPQRGFGEPFVLNPGTWALRVEAEGVL 1006
alpha2a   --------------TAQDEVYLHPSEEHTNVLLLKEESFTIHGTHFPVRRKEFMTVLANL 681
alpha2b   --------------TAQDEVYLHPSEEHTNVLLLKEESFTIHGTHFPVRRKEFMTVLANL 681
alpha1    --------------TQAEGLSLQPYEEYLNVVRLVPENFQDFHSKRQIDRDQLMTVLANV 666
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  LDYLVLLPRDYYEASVLQLPVTEPCAY---AGPPQENCLLYQHLPVTRFPCTLACEARHF 913
alpha3-2  ------------------------------------------------------------
alpha5    LDYVVLLPSAYYEAALLQLRVTEACTYRPSAQQSGDNCLLYTHLPLDGFPSAAGLEALCR 1066
alpha2a   KRVLLQITYSFGMDAIFRLSS--------------------------------------- 702
alpha2b   KRVLLQITYSFGMDAIFRLSS--------------------------------------- 702
alpha1    THLLIRANYNSAKMALYRLES--------------------------------------- 687
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  LLDGEPRPVAVRQPTPAHPVMVDLSGREVELHLRLRIPQVGHYVVVVEYSTEAAQLFVVD 973
alpha3-2  ------------------------------------------------------------
alpha5    QDNSLPRPCPTEQLSPSHPPLITCTGSDVDVQLQVAVPQPGRYALVVEYANEDARQEVGV 1126
alpha2a   ----------------------------VNLESAVSYPTDGSIAAAVEVCQCPPGYTGSS 734
alpha2b   ----------------------------VNLESAVSYPTDGSIAAAVEVCQCPPGYTGSS 734
alpha1    ----------------------------VSLDIASSNAIDLVVAADVEHCECPQGYTGTS 719
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  VNVKSSGSVLAGQVNIYSCNYSVLCRSAVIDHMSRIAMYELLADADIQLKGHMARFLLHQ 1033
alpha3-2  ------------------------------------------------------------
alpha5    AVHTPQRAPQQGLLSLHPCLYSTLCRGTARDTQDHLAVFHLDSEASVRLTAEQARFFLHG 1186
alpha2a   CESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTG------------- 781
alpha2b   CESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTG------------- 781
alpha1    CESCLSGYYRVDGILFGGICQPCECHGHAAECN-VHGVCIACAHNTT------------- 765
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  VCIIPIEEFSAEYVRPQVHCIASYGRFVNQSATCVSLAHETPPTALILDVLSGRPFPH-- 1091
alpha3-2  ------------------------------------------------------------
alpha5    VTLVPIEEFSPEFVEPRVSCISSHGAFGPNSAACLPSRFPKPPQPIILRDCQVIPLPPGL 1246
alpha2a   ---------------------------GPYCDKCLPGFYGEPTK---------------- 798
alpha2b   ---------------------------GPYCDKCLPGFYGEPTK---------------- 798
alpha1    ---------------------------GVHCEQCLPGFYGEPSR---------------- 782
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  -----------------LPQQSSPSVDVLPGVTLKAPQNQVTLRGRVPHLGRYVFVIHFY 1134
alpha3-2  ------------------------------------------------------------
alpha5    PLTHAQDLTPAMSPAGPRPRPPTAVDPDAEPTLLREPQATVVFTTHVPTLGRYAFLLHGY 1306
alpha2a   -----------------------GTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGC 835
alpha2b   -----------------------GTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGC 835
alpha1    -----------------------GTPGDCQPCACPLTIASNNFSPTCHLNDGDEVVCDWC 819
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  QAAHPTFPAQVSVDGGWPRAGSFHASFCPHVLGCRDQVIAEGQIEFDISEPEVAATVKVP 1194
alpha3-2  ------------------------------------------------------------
alpha5    QPAHPTFPVEVLINAGRVWQGHANASFCPHGYGCRTLVVCEGQALLDVTHSELTVTVRVP 1366
alpha2a   PVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTG 895
alpha2b   PVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTG 895
alpha1    APGYSGAWCERCADGYYGNPTVPGESCVPCDCSGNVDPSEAGHCDSVTGECLKCLGNTDG 879
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  EGKSLVLVRVLVVPAENYDYQILHKKSMDKSLEFITNCGKNSFYLDPQTASRFCKNSARS 1254
alpha3-2  ------------------------------------------------------------
alpha5    KGRWLWLDYVLVVPENVYSFGYLREEPLDKSYDFISHCAAQGYHISPSSSSLFCRNAAAS 1426
alpha2a   RYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGT 955
alpha2b   RYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGT 955
alpha1    AHCERCADGFYGDAVTAKNCRACECHVKGSHSAVCHLETGLCDCKPNVTGQQCDQCLHGY 939
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  LVAFYHKGALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFPR--CKPC 1312
alpha3-2  ------------------------------------------------------------
alpha5    LSLFYNNGARPCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFPN--CRPC 1484
alpha2a   FGLQSARGCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTAC 1014
alpha2b   FGLQSARGCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTAC 1014
alpha1    YGLDSGHGCRPCNCSVAGSVSDGCTD-EGQCHCVPGVAGKRCDRCAHGFYAYQDGSCTPC 998
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  SCGRR--LCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMAGCEGCNCSRRGTIEAAMPE 1370
alpha3-2  ---------------------------------------------------------MPP 3
alpha5    DCGAR--LCDELTGQCICPPRTIPPDCLLCQPQTFGCHPLVGCEECNCSGPGIQELTDPT 1542
alpha2a   ECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVG---SLDFQ 1071
alpha2b   ECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVG---SLDFQ 1071
alpha1    DCPHTQNTCDPETGECVCPPHTQGVKCEECEDGHWGYDAEVGCQACNCSLVG---STHHR 1055
alpha4    ----------------------------------------------------------MA 2
                                                                            

alpha3-1  CDRDSGQCRCKPRITGRQCDRCASGFYRFPECVPCNCNRDGTEPGVCD---------PGT 1421
alpha3-2  AVRRSACSMGWLWIFGAALGQCLG------------------------------------ 27
alpha5    CDTDSGQCKCRPNVTGRRCDTCSPGFHGYPRCRPCDCHEAGTAPGVCD---------PLT 1593
alpha2a   CNVNTGQCNCHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQT 1131
alpha2b   CNVNTGQCNCHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQT 1131
alpha1    CDVVTGHCQCKSKFGGRACDQCSLGYRDFPDCVPCDCDLRGTSGDACNLEQGLCGCVEET 1115

alpha4    LSSAWRSVLPLWLLWSAACSRAASG----------------------------------- 27
                             . .     .                                      

alpha3-1  GACLCKENVEGTECNVCREGSFHLDPANLKGCTSCFCFGVNNQC-HSSHKRRTKFVDMLG 1480
alpha3-2  ---------------------------------------------YSSQQQR-------- 34
alpha5    GQCYCKENVQGPKCDQCSLGTFSLDAANPKGCTRCFCFGATERC-RSSSYTRQEFVDMEG 1652
alpha2a   GQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAE 1191
alpha2b   GQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAE 1191
alpha1    GACPCKENVFGPQCNECREGTFALRADNPLGCSPCFCSGLSHLCSELEDYVRTPVTLGSD 1175
alpha4    --------------------------------------------------------DDNA 31
                                                                            

alpha3-1  WHLETADRVDIPVSFNPGSNSMVADLQELPATIHSAS------WVAPTSYLGDKVSSYGG 1534
alpha3-2  ----------VPFLQPPGQSQLQASYVEFRP----------------------------- 55
alpha5    WVLLSTDRQVVPHERQPGTEMLRADLRHVPEAVPEAFPEL--YWQAPPSYLGDRVSSYGG 1710
alpha2a   QTILPLVDEALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGG 1251
alpha2b   QTILPLVDEALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGG 1251
alpha1    QPLLRVVSQSNLRGTTEGVYYQAPDFLLDAATVRQHIRAEPFYWRLPQQFQGDQLMAYGG 1235
alpha4    FPFDIEGSSAVGRQDPPETSEPRVALGRLPP----------------------------- 62
                                                                            

alpha3-1  YLTYQAKSFGLPGDMVL-LEKKPDV-QLTGQHMSIIYEETNTPRPDRLHHGRVHVVEGNF 1592
alpha3-2  ------------------------------------------------------------
alpha5    TLRYELHSETQRGDVFVPMESRPDV-VLQGNQMSITFLEPAYPTPGHVHRGQLQLVEGNF 1769
alpha2a   KLKYAIYFEAREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEW 1311
alpha2b   KLKYAIYFEAREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEW 1311
alpha1    KLKYSVAFYSLDGVGTSNFEPQVLIKGGR-IRKQVIYMDAPAPENGVRQEQEVAMRENFW 1294
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  RHAS----SRAPVSREELMTVLSRLADVRIQGLYFTETQRLTLSEVGLEEASDTGSGRIA 1648
alpha3-2  ------------------------------------------------------------
alpha5    RHTE----TRNTVSREELMMVLASLEQLQIRALFSQISSAVFLRRVALEVASPAGQGALA 1825
alpha2a   KYYGDDPRVHRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMT 1371
alpha2b   KYYGDDPRVHRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMT 1371
alpha1    KYFN--SVSEKPVTREDFMSVLSDIEYILIKASYGQGLQQSRISDISMEVGRKAEKLHPE 1352
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  L----AVEICACPPAYAGDSCQGCSPGYYR--------DHKGLYTGRCVPCNCNGHSNQC 1696
alpha3-2  --------------------SQGCSPGYYR--------DHKGLYTGRCVPCNCNGHSNQC 87
alpha5    S----NVELCLCPASYRGDSCQECAPGFYR--------DVKGLFLGRCVPCQCHGHSDRC 1873
alpha2a   P-PADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGG-RTPGPTLGTCVPCQCNGHSSLC 1429
alpha2b   P-PADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGG-RTPGPTLGTCVPCQCNGHSSLC 1429
alpha1    EEVASLLENCVCPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSDTC 1412
alpha4    -------------------AAEKCNAGFFH------------TLSGECVPCDCNGNSNEC 91
                              .: * .*:.:               . ****.*:.:*. *

alpha3-1  QDGSGICVNCQHNTAGEHCERCQEGYYG---NAVHGSCRACPCPH---TNSFATGCVVNG 1750
alpha3-2  QDGSGICVNCQHNTAGEHCERCQEGYYG---NAVHGSCRACPCPH---TNSFATGCVVNG 141
alpha5    LPGSGVCVDCQHNTEGAHCERCQAGFVSS-RDDPSAPCVSCPCPLSVPSNNFAEGCVLRG 1932
alpha2a   DPETSICQNCQHHTAGDFCERCALGYYGI-VKGLPNDCQQCACPLISSSNNFSPSCVAEG 1488
alpha2b   DPETSICQNCQHHTAGDFCERCALGYYGI-VKGLPNDCQQCACPLISSSNNFSPSCVAEG 1488
alpha1    DPNTGKCLNCGDNTAGDHCDVCTSGYYGK-VTGSASDCALCACPHSPPAS-FSPTCVLEG 1470
alpha4    LDGSGYCVHCQRNTTGEHCEKCLDGYIGDSIRGAPQFCQPCPCPLPHLAN-FAESCYRKN 150
             :. * .*  :* * .*: *  *: .         *  *.**    :. *:  *  ..

alpha3-1  GDVR--CSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQ----LGSCHPLTGD 1804
alpha3-2  GDVR--CSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQ----LGSCHPLTGD 195
alpha5    GRTQ--CLCKPGYAGASCERCAPGFFGNPLVLGSSCQPCDCSGNGDPNLLFSDCDPLTGA 1990
alpha2a   LDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGS---LPVPCDPVTGF 1545
alpha2b   LDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGS---LPVPCDPVTGF 1545
alpha1    DHDFRCDACLLGYEGKHCERCSSSYYGNPQTPGGSCQKCDCNPHGS---VHGDCDRTSGQ 1527
alpha4    GAVR--CICNENYAGPNCERCAPGYYGNPLLIGSTCKKCDCSGNSDPNLIFEDCDEVTGQ 208
                  *  .* *  ****:..: *.*   *.:*: *.*.  ..       *.  :* 

alpha3-1  CINQEPKDSSP------------------------------------------------- 1815
alpha3-2  CINQEPKDSSP------------------------------------------------- 206
alpha5    CRGCLRHTTGPRCEICAPGFYGNALLPGNCTRCDCTPCGTEACDPHSGHCLCKAGVTGRR 2050
alpha2a   CTCRPGATGRKCDG---------------------------------------------- 1559
alpha2b   CTCRPGATGRKCDG---------------------------------------------- 1559
alpha1    CVCRLGASGLRCDE---------------------------------------------- 1541
alpha4    CRNCLRNTTGFKCERCAPGYYGDARIAKNCAVCN-------------------------- 242
          *                                                           

alpha3-1  ------------------------------------------------------------
alpha3-2  ------------------------------------------------------------
alpha5    CDRCQEGHFGFDGCGGCRPCACGPAAEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLP 2110
alpha2a   ------------------------------------------------------------
alpha2b   ------------------------------------------------------------
alpha1    ------------------------------------------------------------
alpha4    ------------------------------------------------------------
                                                                            

alpha3-1  --------------------------------------------------AEECDDC-DS 1824
alpha3-2  --------------------------------------------------AEECDDC-DS 215
alpha5    EQGCRRCQCPGGRCDPHTGRCNCPPGLSGERCDTCSQQHQVPVPGGPVGHSIHCEVC-DH 2169
alpha2a   ------------------------------------------CKHWHAREGWECVFCGDE 1577
alpha2b   ------------------------------------------CKHWHAREGWECVFCGDE 1577
alpha1    ------------------------------------------CEPRHILMETDCVSCDDE 1559
alpha4    ----------------------------------CGGGPCDSVTGECLEEGFEPPTGCDK 268
                                                              .     * 

alpha3-1  CVMTLLNDLATMGEQLRLVKSQLQGLSASAGLLEQMRHMETQAKDLRNQLLNYRSAISNH 1884
alpha3-2  CVMTLLNDLATMGEQLRLVKSQLQGLSASAGLLEQMRHMETQAKDLRNQLLNYRSAISNH 275
alpha5    CVVLLLDDLERAGALLPAIHEQLRGINASSMAWARLHRLNASIADLQSQLRSPLGPRHET 2229
alpha2a   CTGLLLGDLARLEQMVMSIN-LTGPLPAPYKMLYGLENMTQELKHLLSPQRAPERLIQLA 1636
alpha2b   CTGLLLGDLARLEQMVMSIN-LTGPLPAPYKMLYGLENMTQELKHLLSPQRAPERLIQLA 1636
alpha1    CVGVLLNDLDEIGDAVLSLN-LTGIIPVPYGILSNLENTTKYLQESLLKENMQK---DLG 1615
alpha4    CVWDLTDDLRLAALSIEEGKSGVLSVSSGAAAHRHVNEINATIYLLKTKLSERENQYALR 328
          *.  * .**      :   :     :         :..                      

alpha3-1  GSKIEGLERELTDLNQEFETLQEKAQVNSRKAQTLNNNVNRATQSAKELDVKIKNVIRNV 1944
alpha3-2  GSKIEGLERELTDLNQEFETLQEKAQVNSRKAQTLNNNVNRATQSAKELDVKIKNVIRNV 335
alpha5    AQQLEVLEQQSTSLGQDARRLGGQAVGTRDQASQLLAGTEATLGHAKTLLAAIRAVDRTL 2289
alpha2a   EGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVNEKA 1696
alpha2b   EGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVNEKA 1696
alpha1    KIKLEGVAEETDNLQKKLTRMLASTQKVNRATERIFKESQDLAIAIERLQMSITEIMEKT 1675
alpha4    KIQINNAENTMKSLLSDVEELVEKENQASRKGQLVQKESMDTINHASQLVEQAHDMRDKI 388
            :::       .*      :  .        .             . *      :  . 

alpha3-1  HILLKQISGTDGEGNNVPSGD-FSREWAEAQRMMRELRNRNFGKHLREAEADKRESQLLL 2003
alpha3-2  HILLKQISGTDGEGNNVPSGD-FSREWAEAQRMMRELRNRNFGKHLREAEADKRESQLLL 394
alpha5    SELMSQTGHLGLANASAPSGEQLLRTLAEVERLLWEMRARDLGAPQAAAEAELAAAQRLL 2349
alpha2a   IKLNETLGTRDEAFERN-----LEGLQKEIDQMIKELRRKNLETQKEIAEDELVAAEALL 1751
alpha2b   IKLNETLGTRDEAFERN-----LEGLQKEIDQMIKELRRKNLETQKEIAEDELVAAEALL 1751
alpha1    T-LNQTLDEDFLLPNST-----LQNMQQNGTSLLEIMQIRDFTQLHQNATLELKAAEDLL 1729
alpha4    QEINNKMLYYGEEHELSPKE--ISEKLVLAQKMLEEIRSRQPFFTQRELVDEEADEAYEL 446
            : .                 :         ::  :: ::          :       *

alpha3-1  NRIRTWQKTHQGENNGLANSIRDSLNEYEAKLSDLRARLQEAAAQAKQANGLNQENERAL 2063
alpha3-2  NRIRTWQKTHQGENNGLANSIRDSLNEYEAKLSDLRARLQEAAAQAKQANGLNQENERAL 454
alpha5    ARVQEQLSSLWEENQALATQTRDRLAQHEAGLMDLREALNRAVDATREAQELNSRNQERL 2409
alpha2a   KKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREANRLFAVNQKNM 1811
alpha2b   KKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREANRLFAVNQKNM 1811
alpha1    SQIQENYQKPLEELEVLKEAASHVLSKHNNELKAAEALVREAEAKMQESNHLLLMVNANL 1789
alpha4    LSQAESWQRLHNETRTLFPVVLEQLDDYNAKLSDLQEALDQALNHVRDAEDMNRATAARQ 506
                      * . :     . * .::  :      : .*    :::: :        

alpha3-1  GAIQRQVKEINSLQSDFTKYLTTADSSLLQTNIALQLMEKSQKEYEKLAASLNEARQELS 2123
alpha3-2  GAIQRQVKEINSLQSDFTKYLTTADSSLLQTNIALQLMEKSQKEYEKLAASLNEARQELS 514
alpha5    EEALQRKQELSRDNATLQATLHAARDTLASVFRLLHSLDQAKEELERLAASLDGARTPLL 2469
alpha2a   TALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPMSEELN 1871
alpha2b   TALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPMSEELN 1871
alpha1    REFSDKKLHVQEEQNLTSELIVQGRGLIDAAAAQTDAVQDALEHLEDHQDKLLLWSAKIR 1849
alpha4    RDHEKQQERVREQMEVVNMSLSTSADSLTTPRLTLSELDDIIKNASGIYAEIDGAKSELQ 566
               :   :          :  . . :         ::.  .  .    .:      : 

alpha3-1  DKVRELSRSAG---KTSLVEEAEKHARSLQELAKQLEEIKRNASGDELVRCAVDAATAYE 2180
alpha3-2  DKVRELSRSAG---KTSLVEEAEKHARSLQELAKQLEEIKRNASGDELVRCAVDAATAYE 571
alpha5    QRMQTFSPAGS---KLRLVEAAEAHAQQLGQLALNLSSIILDVNQDRLTQRAIEASNAYS 2526
alpha2a   DKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKN--ISFNATAAFKAYS 1929
alpha2b   DKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKN--ISFNATAAFKAYS 1929
alpha1    HHIDDLVMHMSQRNAVDLVYRAEDHAAEFQRLADVLYSGLENIRN--VSLNATSAAYVHY 1907
alpha4    VKLSNLSNLSH-----DLVQEAIDHAQDLQQEANELSRKLHSSDMNGLVQKALDASNVYE 621
           ::  :            *  *  ** .:   :  *     .     :   *  *  .: 

alpha3-1  NILNAIKAAEDAANRAASASESA--LQTVIKEDLPRKAKTLSSNSDKLLNEAKMTQKKLK 2238
alpha3-2  NILNAIKAAEDAANRAASASESA--LQTVIKEDLPRKAKTLSSNSDKLLNEAKMTQKKLK 629
alpha5    RILQAVQAAEDAAGQALQQADHT--WATVVRQGLVDRAQQLLANS-TALEEAMLQEQQRL 2583
alpha2a   NIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVK 1989
alpha2b   NIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVK 1989
alpha1    NIQSLIEESEELARDAHRTVTETSLLSES----LVSNGKAAVQRSSRFLKEGNNLSRKLP 1963
alpha4    NIVNYVSEANETAEFALNTTDRIYDAVSGIDTQIIYHK----DESENLLNQARELQAKAE 677
          .* . :. ::. *  *                 :         .*   *::.     .  

alpha3-1  QEVSPALNNLQQTLNIVTVQKEVIDTNLTTLRDGLHGIQRGDIDAMISSAKSMVRKANDI 2298
alpha3-2  QEVSPALNNLQQTLNIVTVQKEVIDTNLTTLRDGLHGIQRGDIDAMISSAKSMVRKANDI 689
alpha5    GLVWAALQGARTQLRDVRAKKDQLEAHIQAAQA-MLAMDTDETSKKIAHAKAVAAEAQDT 2642
alpha2a   ENE-DHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPN-DTAAKLQAVKDKARQANDT 2047
alpha2b   ENE-DHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPN-DTAAKLQAVKDKARQANDT 2047
alpha1    GIA-LELSELRNKTNRFQENAVEITRQTNESLLILRAIPK-GIRDKGAKTKELATSASQS 2021
alpha4    SSSDEAVADTSRRVGGALARKSALKTRLSDAVKQLQAAERGDAQQRLGQSRLITEEANRT 737
                :            .   :          : .             :  . .*.  

alpha3-1  TDEVLDGLNPIQTDVERIKDTYGRTQNEDFKKALTDADNSVNKLTNKLPDLWRKIESINQ 2358
alpha3-2  TDEVLDGLNPIQTDVERIKDTYGRTQNEDFKKALTDADNSVNKLTNKLPDLWRKIESINQ 749
alpha5    ATRVQSQLQAMQENVERWQGQYEGLRGQDLGQAVLDAGHSVSTLEKTLPQLLAKLSILEN 2702
alpha2a   AKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVKNLEQEAD 2107
alpha2b   AKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVKNLEQEAD 2107
alpha1    AVSTLRDVAGLSQELLNTSASLSRVNTTLRETHQLLQDSTMATLLAGR--KVKDVEIQAN 2079
alpha4    TMEVQQATAPMANNLTNWSQNLQHFDSSAYNTAVNSARDAVRNLTEVVPQLLDQLRTVEQ 797
          :  .      :  ::   .                    :  .:         .:    :

alpha3-1  QLLPLG--------NISDNMDRIRELIQQARDAASKVAVPMRFNGKSGVEVRLPNDLEDL 2410
alpha3-2  QLLPLG--------NISDNMDRIRELIQQARDAASKVAVPMRFNGKSGVEVRLPNDLEDL 801
alpha5    RGVHNAS------LALSASIGRVRELIAQARGAASKVKVPMKFNGRSGVQLRTPRDLADL 2756
alpha2a   RLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGD---CIRTYKPEIKK 2164
alpha2b   RLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGD---CIRTYKPEIKK 2164
alpha1    LLFDRLKPLKMLEENLSRNLSEIKLLISQARKQAASIKVAVSADRD---CIRAYQPQISS 2136
alpha4    KRPASN---------VSASIQRIRELIAQTRSVASKIQVSMMFDGQSAVEVHSRTSMDDL 848
                         :. .: .:: ** *:*  * .: *.:  .      ::      . 

alpha3-1  KGYTSLSLFLQRPNSRE-NGGTENMFVMYLGNKDASRDYIGMAVVDGQLTCVYNLGDREA 2469
alpha3-2  KGYTSLSLFLQRPNSRE-NGGTENMFVMYLGNKDASRDYIGMAVVDGQLTCVYNLGDREA 860
alpha5    AAYTALKFYLQGPEPEP-GQGTEDRFVMYMGSRQATGDYMGVSLRDKKVHWVYQLGEAG- 2814
alpha2a   GSYNNIVVNVKTAVA--------DNLLFYLGS-AKFIDFLAIEMRKGKVSFLWDVGSGVG 2215
alpha2b   GSYNNIVVNVKTAVA--------DNLLFYLGS-AKFIDFLAIEMRKGKVSFLWDVGSGVG 2215
alpha1    TNYNTLTLNVKTQEP--------DNLLFYLGS-STASDFLAVEMRRGRVAFLWDLGSGST 2187
alpha4    KAFTSLSLYMKPPVKRPELTETADQFILYLGSKNAKKEYMGLAIKNDNLVYVYNLGTKDV 908
            :. : . ::            : :::*:*.     :::.: :   .:  ::::*    

alpha3-1  ELQVDQILTKSETKEAVMDRVKFQRIYQFARLNYTKGATSSKPETPGVYDMDGRNSNTLL 2529
alpha3-2  ELQVDQILTKSETKEAVMDRVKFQRIYQFARLNYTKGATSSKPETPGVYDMDGRNSNTLL 920
alpha5    ----PAVLSIDEDIGEQFAAVSLDRTLQFGHMSVTVERQMIQETKG---DTVAPGAEGLL 2867
alpha2a   RVEYPDLTID----DSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTIL 2271
alpha2b   RVEYPDLTID----DSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTIL 2271
alpha1    RLEFPDFPID----DNRWHSIHVARFGNIGSLSVKEMSSNQK---SPTKTSKSPGTANVL 2240
alpha4    EIPLDSKPVSS--WPAYFSIVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLL 966
                              :   *  . . :                          :*

alpha3-1  NLDPENVVFYVGGYPPDFKLPSRLSFPPYKGCIELDDLNENVLSLYNFKKTFNLNTTEVE 2589
alpha3-2  NLDPENVVFYVGGYPPDFKLPSRLSFPPYKGCIELDDLNENVLSLYNFKKTFNLNTTEVE 980
alpha5    NLRPDDFVFYVGGYPSTFTPPPLLRFPGYRGCIEMDTLNEEVVSLYNFERTFQLDTAVDR 2927
alpha2a   DVDAN-AMLFVGGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTV 2330
alpha2b   DVDAN-AMLFVGGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTV 2330
alpha1    DVNNS-TLMFVGGLGGQIKKSPAVKVTHFKGCLGEAFLNGKSIGLWNYIEREGKCRGCFG 2299
alpha4    DLDPEDTVFYVGGVPSNFKLPTSLNLPGFVGCLELATLNNDVISLYNFKHIYNMDPSTSV 1026
          ::  .  :::***    :. .  : .  : **:    :: . :.*:*: .          

alpha3-1  PCRRRKEE-----SDKNYFEGTGYARVP-TQPHAPIPT-FGQTIQTTVDRGLLFFAENGD 2642
alpha3-2  PCRRRKEE-----SDKNYFEGTGYARVP-TQPHAPIPT-FGQTIQTTVDRGLLFFAENGD 1033
alpha5    PCARSKSTGDPWLTDGSYLDGTGFARIS-FDSQISTTKRFEQELRLVSYSGVLFFLKQQS 2986
alpha2a   SPQVEDSE------GTIQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRD 2384
alpha2b   SPQVEDSE------GTIQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRD 2384
alpha1    SSQNEDP--------SFHFDGSGYSVVEKSLP--ATVTQIIMLFNTFSPNGLLLYLGSYG 2349
alpha4    PCARDKLAFTQSRAASYFFDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVN 1086
          .    .            ::* *:: :                :.        :     .

alpha3-1  R--FISLNIEDGKLMVRYKLNSELPKERGVG--DAINNGRDHSIQIKIGKLQKRMWINVD 2698
alpha3-2  R--FISLNIEDGKLMVRYKLNSELPKERGVG--DAINNGRDHSIQIKIGKLQKRMWINVD 1089
alpha5    Q--FLCLAVQEGSLVLLYDFGAGLKKAVPLQPPPPLTSASKAIQVFLLGGSRKRVLVRVE 3044
alpha2a   LRDFMSVELTDGHIKVSYDLGSGMASVVSNQ-----NHNDGKWKSFTLSRIQKQANISIV 2439
alpha2b   LRDFMSVELTDGHIKVSYDLGSGMASVVSNQ-----NHNDGKWKSFTLSRIQKQANISIV 2439
alpha1    TKDFLSIELFRGRVKVMTDLGSGPITLLTDR-----RYNNGTWYKIAFQRNRKQGVLAVI 2404
alpha4    GSMFFRLEMRNGYLHVFYDFGFSSGRVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVV 1146
             *: : :  * : :  .:.                        : :   ..:  : : 

alpha3-1  --------------VQNTIIDGEVFDFSTYYLGGIP----IAIRERFNISTPA-FRGCMK 2739
alpha3-2  --------------VQNTIIDGEVFDFSTYYLGGIP----IAIRERFNISTPA-FRGCMK 1130
alpha5    RAT-----------VYSVEQDNDLELADAYYLGGVPPDQLPPSLRRLFPTGGS-VRGCVK 3092
alpha2a   DID-TNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKARPEVNLKK-YSGCLK 2497
alpha2b   DID-TNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNL----RPEVNLKK-YSGCLK 2493
alpha1    DAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGLPRSRVV----RRGVTTKS-FVGCIK 2459
alpha4    DRR----------HVKSMDNEKMKIPFTDIYIGGAPPEILQSRALRAHLPLDINFRGCMK 1196
                          .             *.** *         *          **:*

alpha3-1  NLKKTSG-VVRLN--DTVGVTKKCSEDWKLVRSASFSRGGQLSFTDLGLPP-TDHLQASF 2795
alpha3-2  NLKKTSG-VVRLN--DTVGVTKKCSEDWKLVRSASFSRGGQLSFTDLGLPP-TDHLQASF 1186
alpha5    GIKALGK-YVDLKRLNTTGVSAGCTADLLVGRAMTFHGHGFLRLALSNVAPLTGNVYSGF 3151
alpha2a   DIEISRTPYNILSSPDYVGVTKGCSLEN--VYTVSFPKPGFVELSPVPIDV---GTEINL 2552
alpha2b   DIEISRTPYNILSSPDYVGVTKGCSLEN--VYTVSFPKPGFVELSPVPIDV---GTEINL 2548
alpha1    NLEISRSTFDLLRNS--YGVRKGCLLEP--IRSVSFLKGGYIELPPKSLSP---ESEWLV 2512
alpha4    GFQFQKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIAS--IQKISFFDGFEGGF 1254
          .::        *      **   *  :        *   . :                 .

alpha3-1  GFQTFQPSGILLD-------------HQTWTRNLQVTLEDGYIELSTSDSGSP------I 2836
alpha3-2  GFQTFQPSGILLD-------------HQTWTRNLQVTLEDGYIELSTSDSGSP------I 1227
alpha5    GFHSAQDSALLYY-------------RASPDGLCQVSLQQGRVSLQLLRT---------E 3189
alpha2a   SFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLEVHLSTGART-MRKIVI 2611
alpha2b   SFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLEVHLSTGART-MRKIVI 2607
alpha1    TFATTNSSGIILAALGGDVEK-RGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALL 2571
alpha4    NFRTLQPNGLLFY-------------YASGSDVFSISLDNGTVIMDVKGIKVQ------- 1294
           * : : ..::                 :      : *  * : :               

alpha3-1  FKSPQTYMDGLLHYVSVISDNSGLRLLIDDQLLRNSKR------LKHISSSRQSLRLGGS 2890
alpha3-2  FKSPQTYMDGLLHYVSVISDNSGLRLLIDDQLLRNSKR------LKHISSSRQSLRLGGS 1281
alpha5    VKTQAGFADGAPHYVAFYSNATGVWLYVDDQLQQMKPHRGPPPELQPQPEGPPRLLLGGL 3249
alpha2a   RPEPNLFHDGREHSVHVERTRGIFTVQVDENR---RYMQN---LTVEQPIEVKKLFVGGA 2665
alpha2b   RPEPNLFHDGREHSVHVERTRGIFTVQVDENR---RYMQN---LTVEQPIEVKKLFVGGA 2661
alpha1    HAPTGTCSDGQAHSISLVRNRRIITVQLDENNPVEMKLGT---LVESRTINVSNLYVGGI 2628
alpha4    -SVDKQYNDGLSHFVISSVSPTRYELIVDKSRVGSKNPTKG--KIEQTQASEKKFYFGGS 1351
                  **  * :          : :*..                       : .** 

alpha3-1  -------------NFEGCISNVFVQRLSLSPEVLDLTSNSLKRDVSLGGCSLNKPPFLML 2937
alpha3-2  -------------NFEGCISNVFVQRLSLSPEVLDLTSNSLKRDVSLGGCSLNKPPFLML 1328
alpha5    PES------GTIYNFSGCISNVFVQRLLGPQRVFDLQQNLGSVNVSTG----CAPALQAQ 3299
alpha2a   PPEFQPSPLRNIPPFEGCIWNLVIN-----SVPMDFARPVSFKNADIG------RCAHQK 2714
alpha2b   PPEFQPSPLRNIPPFEGCIWNLVIN-----SVPMDFARPVSFKNADIG------RCAHQK 2710
alpha1    PEGEGTSLLTMRRSFHGCIKNLIFN-----LELLDFNSAVGHEQVDLD------TCWLSE 2677
alpha4    PIS------AQYANFTGCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLL 1405
                        * *** *  .          *:       ...              

alpha3-1  L--------KGSTRFNKTKTFRINQLLQDTPVASPRSVKVWQDACSPLPKTQANHGALQF 2989
alpha3-2  L--------KGSTRFNKTKTFRINQLLQDTPVASPRSVKVWQDACSPLPKTQANHGALQF 1380
alpha5    T--------PGLGPRGLQATARKASRRSRQPARHP--------ACMLPPHLRTTRDSYQF 3343
alpha2a   L--------REDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQF 2766
alpha2b   L--------REDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQF 2762
alpha1    R--------PKLAPDAEDSKLLPEPR-----AFP--------EQCVVDAALEYVPGAHQF 2716
alpha4    HKKGKNLSKPKASQNKKGGKSKDAPSWDPVALKLPERNTPRNSHCHLSNSPRAIEHAYQY 1465
                                                      *           : *:

alpha3-1  GDIPTSHLLFKLPQELLKPRSQFAVDMQTTSSRGLVFHTG---TKNSFMALYLSKGRLVF 3046
alpha3-2  GDIPTSHLLFKLPQELLKPRSQFAVDMQTTSSRGLVFHTG---TKNSFMALYLSKGRLVF 1437
alpha5    GGSLSSHLEFVGILARHRNWPSLSMHVLPRSSRGLLLFTARLRPGSPSLALFLSNGHFVA 3403
alpha2a   GLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMAR-INHADFATVQLRNGLPYF 2825
alpha2b   GLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMAR-INHADFATVQLRNGLPYF 2821
alpha1    GLTQNSHFILPFNQSAVRKKLSVELSIRTFASSGLIYYMAH-QNQADYAVLQLHGGRLHF 2775
alpha4    GGTANSRQEFEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSD-QEENDFMTLFLAHGRLVY 1524
          *   .*:  :            . : : . :. *:: . .         .: *  *    

alpha3-1  ALGTDGKKLRIKSKEKCNDGKWHTVVFGHDGEKGRLVVDGLRAREGSLPGNSTISIRAP- 3105
alpha3-2  ALGTDGKKLRIKSKEKCNDGKWHTVVFGHDGEKGRLVVDGLRAREGSLPGNSTISIRAP- 1496
alpha5    QMEGLGTRLRAQSRQRSRPGRWHKVSVRWEKNRILLVTDGARAWSQEGPHRQHQGAEHPQ 3463
alpha2a   SYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPK-KADILDVVG- 2883
alpha2b   SYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPK-KADILDVVG- 2879
alpha1    MFDLGKGRTKVSHPALLSDGKWHTVKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEG- 2834
alpha4    MFNVGHKKLKIRSQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKG- 1583
                   :         * ** :          :  **                    

alpha3-1  ---VYLG-SPPSGKPKSLP--TNS-FVGCLKNFQLDSKPLY--TPSSSFGVSSCLGGPLE 3156
alpha3-2  ---VYLG-SPPSGKPKSLP--TNS-FVGCLKNFQLDSKPLY--TPSSSFGVSSCLGGPLE 1547
alpha5    PHTLFVGGLPASSHSSKLP--VTVGFSGCVKRLRLHGRPLG--APTRMAGVTPCILGPLE 3519
alpha2a   --MLYVGGLPINYTTRRIGP-VTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFAN-AQ 2939
alpha2b   --MLYVGGLPINYTTRRIGP-VTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFAN-AQ 2935
alpha1    --LFYLGGLPSQYQARKIGN-ITHSIPACIGDVTVNSKQLDKDSPVSAFTVNRCYAV-AQ 2890
alpha4    --PIYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASIT--SASQTFSVTPCFEGPME 1639
             .::*  .       :       : .*:  . :         .     *  *     :

alpha3-1  KGIYFSEEGGHVVLAHSVLLGPEFKLVFSIRPRSLTGILIHIGSQ-PGKHLCVYLEAGKV 3215
alpha3-2  KGIYFSEEGGHVVLAHSVLLGPEFKLVFSIRPRSLTGILIHIGSQ-PGKHLCVYLEAGKV 1606
alpha5    AGLFFPGSGGVITLDLPGATLPDVGLELEVRPLAVTGLIFHLGQARTPPYLQLQVTEKQV 3579
alpha2a   RGTYFDGTGFAKAVGG-FKVGLDLLVEFEFRTTTTTGVLLGISSQ-KMDGMGIEMIDEKL 2997
alpha2b   RGTYFDGTGFAKAVGG-FKVGLDLLVEFEFRTTTTTGVLLGISSQ-KMDGMGIEMIDEKL 2993
alpha1    EGTYFDGSGYAALVKEGYKVQSDVNITLEFRTSSQNGVLLGISTA-KVDAIGLELVDGKV 2949
alpha4    TGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSV-NGEYLNVHMKNGQV 1698
           * :*   *    :        .. : :..*. : .* :.          : : :   ::

alpha3-1  TASMDSGAGGTSTSVTP--KQSLCDGQWHSVAVTIKQHILHLELDTDSSYTAG-QIPFPP 3272
alpha3-2  TASMDSGAGGTSTSVTP--KQSLCDGQWHSVAVTIKQHILHLELDTDSSYTAG-QIPFPP 1663
alpha5    LLRADDGAGEFSTSVTR--PSVLCDGQWHRLAVMKSGNVLRLEVDAQSNHTVG-PLLAAA 3636
alpha2a   MFHVDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTS 3057
alpha2b   MFHVDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTS 3053
alpha1    LFHVNNGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRITLIVDGNAVGAESPHTQSTS 3009
alpha4    IVKVNNGIRDFSTSVTP--KQSLCDGRWHRITVIRDSNVVQLDVDSEVNHVVG-PLNPKP 1755
              :.*    ::         ****:** : .    : : * :* :   . .      .

alpha3-1  ASTQEPLHLGGAPANLTTLRIPVWKSFFGCLRNIHVNH-----IPVPVTEALEVQGPVSL 3327
alpha3-2  ASTQEPLHLGGAPANLTTLRIPVWKSFFGCLRNIHVNH-----IPVPVTEALEVQGPVSL 1718
alpha5    AGAPAPLYLGGLPEPMAVQPWP--PAYCGCMRRLAVNR-----SPVAMTRSVEVHGAVGA 3689
alpha2a   ADTNDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNFAKALELRG-VQP 3116
alpha2b   ADTNDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNFAKALELRG-VQP 3112
alpha1    VDTNNPIYVGGYPAGVKQKCLRSQTSFRGCLRKLALIK-SPQVQSFDFSRAFELHG-VFL 3067
alpha4    IDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVIDG-----HPVSFSKAALVSGAVSI 1810
           .   *:.:** *  :         .: **:* : :         . .:.:  : * *  

alpha3-1  NGCPDQ-- 3333
alpha3-2  NGCPDQ-- 1724
alpha5    SGCPAA-- 3695
alpha2a   VSCPAN-- 3122
alpha2b   VSCPAN-- 3118
alpha1    HSCPGTES 3075
alpha4    NSCPAA-- 1816
           .**    

Accession numbers of the laminin alpha subunits used in the protein sequence alignments:  NP_005550 laminin, alpha 1; NP_000417 laminin alpha 2 subunit isoform a;
NP_001073291.1| laminin alpha 2 subunit isoform b; NP_937762 laminin alpha
3 subunit isoform 1; NP_000218 laminin alpha 3 subunit isoform 2;
NP_002281 laminin, alpha 4; NP_005551 laminin alpha 5

laminin beta subunit

beta1     -----------MGLLQLLAFSFLALCRARVRAQEPEFSY-GCAEGSCYPATGDLLIGRAQ 48
beta2     MELTSRERGRGQPLPWELRLGLLLSVLAATLAQAPAPDVPGCSRGSCYPATGDLLVGRAD 60
beta4     -------------MQFQLTLFLHLGWLSYSKAQD------DCNRGACHPTTGDLLVGRNT 41
beta3     ---------------MRPFFLLCFALPGLLHAQQ------ACSRGACYPPVGDLLVGRTR 39
                             : :     .   **        * .*:*:*..****:**  

beta1     KLSVTSTCGLHKPEPYCIVSHLQEDKKCFICNSQDPYHETLNPDSHLIENVVTTFAPNRL 108
beta2     RLTASSTCGLNGPQPYCIVSHLQDEKKCFLCDSRRPFSARDNPHSHRIQNVVTSFAPQRR 120
beta4     QLMASSTCGLSRAQKYCILSYLEGEQKCFICDSRFPYDPYDQPNSHTIENVIVSFEPDRE 101
beta3     FLRASSTCGLTKPETYCTQ-YGEWQMKCCKCDSRQPHNYY----SHRVENVASSSGPMR- 93
           * .:*****  .: **   : : : **  *:*: *.       ** ::**  :  * * 

beta1     KIWWQSENGVENVTIQLDLEAEFHFTHLIMTFKTFRPAAMLIERSSDFGKTWGVYRYFAY 168
beta2     AAWWQSENGIPAVTIQLDLEAEFHFTHLIMTFKTFRPAAMLVERSADFGRTWHVYRYFSY 180
beta4     KKWWQSENGLDHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAK 161
beta3     --WWQSQNDVNPVSLQLDLDRRFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAA 151
            ****:*.:  *:::***:  *:: .::: *:   **.**:***:*:*:.* *::*:: 

beta1     DCEASFPGISTGPMKKVDDIICDSRYSDIEPSTEG-EVIFRALDPAFKIEDPYSPRIQNL 227
beta2     DCGADFPGVPLAPPRHWDDVVCESRYSEIEPSTEG-EVIYRVLDPAIPIPDPYSSRIQNL 239
beta4     DCATSFPNITSGQAQGVGDIVCDSKYSDIEPSTGG-EVVLKVLDPSFEIENPYSPYIQDL 220
beta3     DCTSTFPRVRQGRPQSWQDVRCQSLPQRPNARLNGGKVQLNLMDLVSGIPATQSQKIQEV 211
          ** : ** :  .  :   *: *:*  .  :.   * :*  . :*    *  . *  **::

beta1     LKITNLRIKFVKLHTLGDNLLDSRM-EIREKYYYAVYDMVVRGNCFCYGHASECAPVDGF 286
beta2     LKITNLRVNLTRLHTLGDNLLDPRR-EIREKYYYALYELVVRGNCFCYGHASECAPAPGA 298
beta4     VTLTNLRINFTKLHTLGDALLGRRQNDSLDKYYYALYEMIVRGSCFCNGHASECRPMQKM 280
beta3     GEITNLRVNFTRLAPVPQRGYHPPS------AYYAVSQLRLQGSCFCHGHADRCAPKPGA 265
            :****:::.:* .: :              ***: :: ::*.*** ***..* *    

beta1     N---EEVEGMVHGHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKCNCNEHSIS 343
beta2     P---AHAEGMVHGACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHSHACRKCECHGHTHS 355
beta4     RGDVFSPPGMVHGQCVCQHNTDGPNCERCKDFFQDAPWRPAADLQDNACRSCSCNSHSSR 340
beta3     SAG-PSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSET 324
                    **. *:*:*** * *** *  *:.: ***** . . : *: *.*: *:  

beta1     CHFDMAVYLATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPNFCERCTCDPA 403
beta2     CHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDLRDPAVCRSCDCDPM 415
beta4     CHFDMTTYLASGGLSGGVCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPD 400
beta3     CHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPD 384
          **** :.: *: .  ****:.*:.:* *::*: *:  :::.          *  * *** 

beta1     GSQNEGICDSYTDFSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDPFGCKSCACNPL 463
beta2     GSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRCQQCRDGFFGLSISDRLGCRRCQCNAR 475
beta4     GTISGGICVSHSDPALGSVAGQCLCKENVEGAKCDQCKPNHYGLSATDPLGCQPCDCNPL 460
beta3     GAVPGAPCDP--------VTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNIL 436
          *:   . * .        ::*** ** :* * :*: *: .. .*:  :  **: * **  

beta1     GTIPGGNPCDSETGHCYCKRLVTGQHCDQCLPEHWGLSNDLDGCRPCDCDLGGALNNSCF 523
beta2     GTVPGSTPCDPNSGSCYCKRLVTGRGCDRCLPGHWGLSHDLLGCRPCDCDVGGALDPQCD 535
beta4     GSLP-FLTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHGCSPCDCDIGGAYSNVCS 519
beta3     GSRR-------------------------------------------------------- 440
          *:                                                          

beta1     AESGQCSCRPHMIGRQCNEVEPGYYFATLDHYLYEAEEAN--------------LGPGVS 569
beta2     EGTGQCHCRQHMVGRRCEQVQPGYFRPFLDHLIWEAEDT---------------RGQVLD 580
beta4     PKNGQCECRPHVTGRSCSEPAPGYFFAPLNFYLYEAEEATTLQGLAPLGSETFGQSPAVH 579
beta3     ------------------------------------------------------------
                                                                      

beta1     IVERQYIQDRIPSWTGAGFVRVPEGAYLEFFIDNIPYSMEYDILIRYEPQLPDHWEKAVI 629
beta2     VVERLVTPGETPSWTGSGFVRLQEGQTLEFLVASVPKAMDYDLLLRLEPQVPEQWAELEL 640
beta4     VVLGEPVPGNPVTWTGPGFARVLPGAGLRFAVNNIPFPVDFTIAIHYETQSAADWT-VQI 638
beta3     ------------------------------------------------------------
                                                                      

beta1     TVQRPGRIPTSSRCGNTIPDDDNQVVSLSPGSRYVVLPRPVCFEKGTNYTVRLELPQYTS 689
beta2     IVQRPGPVPAHSLCGHLVPKDDRIQGTLQPHARYLIFPNPVCLEPGISYKLHLKLVR-TG 699
beta4     VVNPPG---GSEHCIPKTLQSKPQSFALPAATRIMLLPTPICLEPDVQYSIDVYFSQPLQ 695
beta3     ------------------------------------------------------------
                                                                            

beta1     SDSDVESPYT----LIDSLVLMPYCKSLDIFTVGGSGDGVVTNSAWETFQRYRCLENSRS 745
beta2     GSAQPETPYSGPGLLIDSLVLLPRVLVLEMFSGGD----AAALERQATFERYQCHEEGLV 755
beta4     GESHAHSHVL-----VDSLGLIPQINSLENF---------CSKQDLDEYQLHNCVEIASA 741
beta3     ------------------------------------------------------------
                                                                            

beta1     VVKTPMTDVCRNIIFSISALLHQTGLACECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNR 805
beta2     PSKTSPSEACAPLLISLSTLIYNGALPCQCNPQGSLSSECNPHGGQCLCKPGVVGRRCDL 815
beta4     MGPQVLPGACERLIISMSAKLHDGAVACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDR 801
beta3     ------------------------------------------------------------
                                                                            

beta1     CAPGTFGFGPSGCKPCECHLQGSVNAFCNPVTGQCHCFQGVYARQCDRCLPGHWGFPSCQ 865
beta2     CAPGYYGFGPTGCQACQCSHEGALSSLCEKTSGQCLCRTGAFGLRCDRCQRGQWGFPSCR 875
beta4     CSTGSYDLGHHGCHPCHCHPQGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPSCH 861
beta3     ------------------------------------------------------------
                                                                            

beta1     PCQCNGHADDCDPVTGECLNCQDYTMGHNCERCLAGYYGDPIIGSGDHCRPCPCPDGPDS 925
beta2     PCVCNGHADECNTHTGACLGCRDHTGGEHCERCIAGFHGDPRLPYGGQCRPCPCPEGPGS 935
beta4     PCPCNRFAELCDPETGSCFNCGGFTTGRNCERCIDGYYGNP--SSGQPCRPCLCPDDPSS 919
beta3     ------------------------------------------------------------
                                                                            

beta1     GRQFARSCYQDPVTLQLACVCDPGYIGSRCDDCASGYFGNPSEVGGSCQPCQCHNNIDTT 985
beta2     QRHFATSCHQDEYSQQIVCHCRAGYTGLRCEACAPGHFGDPSRPGGRCQLCECSGNIDPM 995
beta4     NQYFAHSCYQNLWSSDVICNCLQGYTGTQCGECSTGFYGNPRISGAPCQPCACNNNIDVT 979
beta3     ------------------------------------------------------------
                                                                            

beta1     DPEACDKETGRCLKCLYHTEGEHCQFCRFGYYGDALRQDCRKCVCNYLGTVQEHCN-GSD 1044
beta2     DPDACDPHTGQCLRCLHHTEGPHCAHCKPGFHGQAARQSCHRCTCNLLGTNPQQCP-SPD 1054
beta4     DPESCSRVTGECLRCLHNTQGANCQLCKPGHYGSALNQTCRRCSCHASGVSPMECPPGGG 1039
beta3     ------------------------------------------------------------
                                                                            

beta1     -CQCDKATGQCLCLPNVIGQNCDRCAPNTWQLASGTGCDPCNCNAAHSFGPSCNEFTGQC 1103
beta2     QCHCDPSSGQCPCLPNVQGPSCDRCAPNFWNLTSGHGCQPCACHPSRARGPTCNEFTGQC 1114
beta4     ACLCDPVTGACPCLPNVTGLACDRCADGYWNLVPGRGCQSCDCDPRTSQSSHCDQLTGQC 1099
beta3     DMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQC 500
             **  :* * ***** *  **:**   *:*..* **:.* *..  : .. *:::****

beta1     QCMPGFGGRTCS-----ECQELFWGDPDVECRACDCDPRGIETPQCDQSTGQCVCVEGVE 1158
beta2     HCRAGFGGRTCS-----ECQELHWGDPGLQCHACDCDSRGIDTPQCHRFTGHCSCRPGVS 1169
beta4     PCKLGYGGKRCS-----ECQENYYGDPPGRCIPCDCNRAGTQKPICDPDTGMCRCREGVS 1154
beta3     PCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLT 560
           *  *:**  **     :* :  :**    * .***:  * : * *.  :* * *  *: 

beta1     GPRCDKCTRGYSGVFPDCTPCHQCFALWDVIIAELTNRTHRFLEKAKALK-ISG-VIGPY 1216
beta2     GVRCDQCARGFSGIFPACHPCHACFGDWDRVVQDLAARTQRLEQRAQELQ-QTG-VLGAF 1227
beta4     GQRCDRCARGHSQEFPTCLQCHLCFDQWDHTISSLSKAVQGLMRLAANME-DKRETLPVC 1213
beta3     GPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFGRLRNATASLWSGPGLEDRGL 620
          * ***:* **..  :* *  ** **  :*  : . :     : . :  :           

beta1     RETVDSVERKVSEIKDIL-AQSPAAEPLKNIGNLFEEAEKLIKDVTEMMAQVEVKLSDTT 1275
beta2     ESSFWHMQEKLGIVQGIVGARNTSAASTAQLVEATEELRREIGEATEHLTQLEADLTDVQ 1287
beta4     EADFKDLRGNVSEIERILKHPVFPSGKFLKVKDYHDSVRRQIMQLNEQLKAVY-EFQDLK 1272
beta3     ASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRRTLQGLQLDLPLEEETLSLPR 680
             .   . ::  :. ::     .     :: .   . .: :      :      :    

beta1     SQSNSTAKELDSLQTEAESLDNTVKELAEQLEFIKNSDIRGALDSITKYFQMSLEAEERV 1335
beta2     DENFNANHALSGLERDRLALNLTLRQLDQHLDLLKHSNFLGAYDSIRHAHSQSAEAERRA 1347
beta4     DTIERAKNEADLLLED-------LQEEIDLQSSVLNASIADSSENIKKYYHISSSAEKKI 1325
beta3     --------DLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLSTAYEQSAQAAQQV 732
                    . *  .        :.  :  . :  :.  .:   :   .  * .* .: 

beta1     NASTTEPNSTVEQSALMRDRVEDVMMERESQFKEKQEEQARLLDELAGKLQSLDLSAAAE 1395
beta2     NTSALAVPSPVSNSASARHRTEALMDAQKEDFNSKHMANQRALGKLSAHTHTLSLTDINE 1407
beta4     N----ETSSTINTSANTRNDLLTILDTLTS--------KGNLSLERLKQIKIPDIQILNE 1373
beta3     S----DSSRLLDQLRDSRREAERLVRQAGG---GGGTGSPKLVALRLEMSSLPDLTPTFN 785
          .         :.     *     ::             . .            .:    :

beta1     MTCGTPPGASCSETECGGPNCRTDEGERKCGGPGCGGLVTVAHNAWQKAMDLDQDVLSAL 1455
beta2     LVCGAPGDAPCATSPCGGAGCRDEDGQPRCGGLSCNGAAATADLALGRARHTQAELQRAL 1467
beta4     KVCGDPGNVPCVPLPCGGALCTGRKGHRKCRGPGCHGSLTLSTNALQKAQEAKSIIRNLD 1433
beta3     KLCGNSRQMACTPISCPGELCPQDNG--TACGSRCRGVLPRAGGAFLMAGQVAEQLRGFN 843
            ** .   .*    * *  *   .*   . *  * *  . :  *   * .    :    

beta1     AEVEQLSKMVSEAKLRADEAKQSAEDILLKTNATKEKMDKSNEELRNLIKQIRNFLTQDS 1515
beta2     AEGGSILSRVAETRRQASEAQQRAQAALDKANASRGQVEQANQELQELIQSVKDFLNQEG 1527
beta4     KQVRGLKNQIESISEQAEVSKNNALQLREKLGNIRNQSDSEEENINLFIKKVKNFLLEEN 1493
beta3     AQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLTDPD 903
           :     . :      *.  :. *     : .  : : :.  .. . :*:.:::** : .

beta1     ADLDSIEAVANEVLKMEMPSTPQQLQNLTEDIRERVESLSQVEVILQHSAADIARAEMLL 1575
beta2     ADPDSIEMVATRVLELSIPASAEQIQHLAGAIAERVRSLADVDAILARTVGDVRRAEQLL 1587
beta4     VPPEDIEKVANGVLDIHLPIPSQNLTDELVKIQKHMQLCEDYRTDENRLNEEADGAQKLL 1553
beta3     TDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARARRLQ 963
          .    *: *:  ** : :*  .  : .    *        :      :   :   *. * 

beta1     EEAKRASKSATDVKVTADMVKEALEEAEKAQVAAEKAIKQADEDIQGTQNLLTSIESETA 1635
beta2     QDARRARSWAEDEKQKAETVQAALEEAQRAQGIAQGAIRGAVADTRDTEQTLYQVQERMA 1647
beta4     VKAKAAEKAAN-ILLNLDKTLNQLQQAQITQGRANSTITQLTANITKIKKNVLQAENQTR 1612
beta3     AEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQVLR 1023
           .*. * . *       : .   *.:.  :   *: ::     .    :. : . :.   

beta1     ASEETLFNASQRISELERNVEELKRKAAQNSGEAEYIEKVVYTVKQSAEDVKKTLDGELD 1695
beta2     GAERALSSAGERARQLDALLEALKLKRAGNSLAASTAEETAGSAQGRAQEAEQLLRGPLG 1707
beta4     EMKSELELAKQRS-GLEDGLSLLQTKLQRHQDHAVNAKVQAESAQHQAGSLEKEFV-ELK 1670
beta3     PAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFERIKQ 1083
            :  :    ::   :   :. *: :   :   *   :  .  ..  * . :: :     

beta1     EKYKKVENLIAKKTEESADARRKAEMLQNEAKTLLAQANSKLQLLKDLERKYEDNQRYLE 1755
beta2     DQYQTVKALAERKAQGVLAAQARAEQLRDEARDLLQAAQDKLQRLQELEGTYEENERALE 1767
beta4     KQYAILQRKTS-TTGLTKETLGKVKQLKDAAEKLAGDTEAKIRRITDLERKIQDLNLSRQ 1729
beta3     KYAELKDRLGQ--SSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAIM 1141
          .     .      :        : : ::  *. *   :   :  : ::*      .    

beta1     DKAQELARLEGEVRSLLKDISQKVAVYSTCL- 1786
beta2     SKAAQLDGLEARMRSVLQAINLQVQIYNTCQ- 1798
beta4     AKADQLRILEDQVVAIKNEIVEQEKKYARCYS 1761
beta3     LRSADLTGLEKRVEQIRDHINGRVLYYATCK- 1172
           :: :*  ** .:  : . *  :   *  *  

Accession numbers of the laminin beta subunits used in the protein sequence alignment: NP_002282 laminin, beta 1; NP_002283 laminin, beta 2; NP_001017402 laminin subunit beta 3; NP_031382 laminin, beta 4

laminin gamma subunit

gamma2a   ------------------------------------------------------------
gamma2b   ------------------------------------------------------------
gamma1    MRGSHRAAPALRPRGRLWPVLAVLAAAAAAGCAQAAMDECTDEGGRPQRCMPEFVNAAFN 60
gamma3    -----------MAAAALLLGLALLAPRAAG----AGMGACYDGAGRPQRCLPVFENAAFG 45
                                                                            

gamma2a   ------------------------------------------------------------
gamma2b   ------------------------------------------------------------
gamma1    VTVVATNTCGTPPEEYCVQTGVTGVTKSCHLCDAGQPHLQHGAAFLTDYNNQADTTWWQS 120
gamma3    RLAQASHTCGSPPEDFCPHVGAAGAGAHCQRCDAADPQRHHNASYLTDFHSQDESTWWQS 105
                                                                            

gamma2a   ------------------------------------------------------------
gamma2b   ------------------------------------------------------------
gamma1    QTMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSG 180
gamma3    PSMAFGVQYPTSVNITLRLGKAYEITYVRLKFHTSRPESFAIYKRSRADGPWEPYQFYSA 165
                                                                            

gamma2a   ------------------------------------------------------------
gamma2b   ------------------------------------------------------------
gamma1    SCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVL 240
gamma3    SCQKTYGRPEGQYLRPGEDERVAFCTSEFSDISPLSGGNVAFSTLEGRPSAYNFEESPGL 225
                                                                            

gamma2a   ------------------------------------MPALWLG----------------- 7
gamma2b   ------------------------------------MPALWLG----------------- 7
gamma1    QEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNGHASECMKNEF 300
gamma3    QEWVTSTELLISLDRLNTFGDDIFKDPKVLQSYYYAVSDFSVGGRCKCNGHASECGPDVA 285
                                              :. : :*                 

gamma2a   -----------------CCLCFSLLLPAARATSRRE----VCDCNGKSRQCIFDRELHRQ 46
gamma2b   -----------------CCLCFSLLLPAARATSRRE----VCDCNGKSRQCIFDRELHRQ 46
gamma1    DKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRS 360
gamma3    GQLACRCQHNTTGTDCERCLPFFQDRPWARGTAEAAHECLPCNCSGRSEECTFDRELFRS 345
                            ** *    *  *.*:.       *:*.*:*.:* ** **.*.

gamma2a   TGNGFRCLNCNDNTDGIHCEKCKNGFYRHRERDRCLPCNCNSKGSLSARCDNSGRCSCKP 106
gamma2b   TGNGFRCLNCNDNTDGIHCEKCKNGFYRHRERDRCLPCNCNSKGSLSARCDNSGRCSCKP 106
gamma1    TGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSYGRCSCKP 420
gamma3    TGHGGRCHHCRDHTAGPHCERCQENFYHWDPRMPCQPCDCQSAGSLHLQCDDTGTCACKP 405
          **:* :* :*.*:* * ***:*::.*::   .  * .*.*.. ***  :**. * *:***

gamma2a   GVTGARCDRCLPGFHMLTDAGCTQDQRLLDSKCDCDPAGIAGPC--DAGRCVCKPAVTGE 164
gamma2b   GVTGARCDRCLPGFHMLTDAGCTQDQRLLDSKCDCDPAGIAGPC--DAGRCVCKPAVTGE 164
gamma1    GVMGDKCDRCQPGFHSLTEAGCRP--------CSCDPSGSIDECNIETGRCVCKDNVEGF 472
gamma3    TVTGWKCDRCLPGFHSLSEGGCRP--------CTCNPAGSLDTCDPRSGRCPCKENVEGN 457
           * * :**** **** *::.**          * *:*:*  . *   :*** **  * * 

gamma2a   RCDRCRSGYYNLDGGNPEGCTQCFCYGHSASCRSSAEYSVHKITSTFHQDVDGWKAVQRN 224
gamma2b   RCDRCRSGYYNLDGGNPEGCTQCFCYGHSASCRSSAEYSVHKITSTFHQDVDGWKAVQRN 224
gamma1    NCERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISSTFQIDEDGWRAEQRD 532
gamma3    LCDRCRPGTFNLQPHNPAGCSSCFCYGHSKVCASTAQFQVHHILSDFHQGAEGWWARSVG 517
           *:**:.* :**:  ** **: ***:***  * .:. :.*: * * *: . :** * . .

gamma2a   GSPAKLQWSQRHQDVFSSAQRLDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSA 284
gamma2b   GSPAKLQWSQRHQDVFSSAQRLDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSA 284
gamma1    GSEASLEWSSERQDIAVISDSYFPRYFIAPAKFLGKQVLSYGQNLSFSFRVDRRDTRLSA 592
gamma3    GSEHPPQWSP--NGVLLSPE--DEEELTAPEKFLGDQRFSYGQPLILTFRVPPGD-SPLP 572
          **    :**   :.:   .:      : ** ****.* .**** * : :**   .    .

gamma2a   HDVILEGAGLRITAPLMPLGKTLPCGLTKTYTFRLN-EHPSNNWSPQLSYFEYRRLLRNL 343
gamma2b   HDVILEGAGLRITAPLMPLGKTLPCGLTKTYTFRLN-EHPSNNWSPQLSYFEYRRLLRNL 343
gamma1    EDLVLEGAGLRVSVPLIAQGNSYPSETTVKYVFRLH-EATDYPWRPALTPFEFQKLLNNL 651
gamma3    VQLRLEGTGLALSLRHSSLSGPQDAGHPREVELRFHLQETSEDVAPPLPPFHFQRLLANL 632
           :: ***:** ::    . . .  .  .    :*:: : ..    * *. *.:::** **

gamma2a   TALRIRATYGEYSTG--YIDNVTLISARPVSGAPAPWVEQCICPVGYKGQFCQDCASGYK 401
gamma2b   TALRIRATYGEYSTG--YIDNVTLISARPVSGAPAPWVEQCICPVGYKGQFCQDCASGYK 401
gamma1    TSIKIRGTYSERSAG--YLDDVTLASARPGPGVPATWVESCTCPVGYGGQFCEMCLSGYR 709
gamma3    TSLRLRVSPGPSPAGPVFLTEVRLTSARPGLSPPASWVEICSCPTGYTGQFCESCAPGYK 692
          *::::* : .  .:*  :: :* * ****  . **.*** * **.** ****: * .**:

gamma2a   RDSARLGPFGTCIPCNCQGG-GACDPDTGDCYSGDENPDIECADCPIGFYNDPHDPRS-- 458
gamma2b   RDSARLGPFGTCIPCNCQGG-GACDPDTGDCYSGDENPDIECADCPIGFYNDPHDPRS-- 458
gamma1    RETPNLGPYSPCVLCACNGHSETCDPETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSD 769
gamma3    REMPQGGPYASCVPCTCNQH-GTCDPNTGICVCSHHTEGPSCERCLPGFYGNPFAGQADD 751
          *: .. **:..*: * *:    :***:** * . ... .  *  *  *:*.:.    :  

gamma2a   CKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQ 518
gamma2b   CKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQ 518
gamma1    CQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQ 829
gamma3    CQPCPCPGQSACTTIPESREVVCTHCPPGQRGRRCEVCDDGFFGDPLGLFGHPQPCHQCQ 811
          *:**** .  :*:.:*::.****.:**.*  * ***:* **:****:*  *  : *: **

gamma2a   CNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACNCN-- 576
gamma2b   CNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACNCN-- 576
gamma1    CSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLY 889
gamma3    CSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHCEHCQEGFYGSALAPRPADKCMPCSCHPQ 871
          *..*:**.* ***: *:*.**:*::**:* :*::*: *::*..***.***** .*.*:  

gamma2a   ------------------------------------------------------------
gamma2b   ------------------------------------------------------------
gamma1    GTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDI 949
gamma3    GSVSEQMPCDPVTGQCSCLPHVTARDCSRCYPGFFDLQPGRGCRSCKCHPLGSQEDQCHP 931
                                                                      

gamma2a   -------------------------------------PMGSEPVGCRSDGTCVCKPGFGG 599
gamma2b   -------------------------------------PMGSEPVGCRSDGTCVCKPGFGG 599
gamma1    RTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKDDGRCECREGFVG 1009
gamma3    KTGQCTCRPGVTGQACDRCQLGFFGFSIKGCRACRCSPLGAASAQCHENGTCVCRPGFEG 991
                                               * *: .  *:.:* * *: ** *

gamma2a   PNCEH------------GAFSCPACYNQVKIQMDQFMQQLQRMEALISKAQGGDGVVPDT 647
gamma2b   PNCEH------------GAFSCPACYNQVKIQMDQFMQQLQRMEALISKAQGGDGVVPDT 647
gamma1    NRCDQCEENYFYNRSWPGCQECPACYRLVKDKVADHRVKLQELESLIANLGTGDEMVTDQ 1069
gamma3    YKCDRCHDNFFLTADGTHCQQCPSCYALVKEEAAKLKARLTLTEGWLQGSDCGSPWGPLD 1051
           .*::             . .**:**  ** :  .   :*   *. :     *.   .  

gamma2a   ELEGRMQQAEQALQDILRDAQISEGASRSLGLQLAKVRSQENSYQSRLDDLKMTVERVRA 707
gamma2b   ELEGRMQQAEQALQDILRDAQISEGASRSLGLQLAKVRSQENSYQSRLDDLKMTVERVRA 707
gamma1    AFEDRLKEAEREVMDLLREAQDVKDVDQNLMDRLQRVNNTLSSQISRLQNIRNTIEETGN 1129
gamma3    ILLG-----EAPRGDVYQGHHLLPGAREAFLEQMMSLEGAVKAAREQLQRLNKGARCAQA 1106
           : .     *    *: :  :   .. . :  ::  :..  .:  .:*: :.   . .  

gamma2a   LGSQYQNRVRDTHRLITQMQLSLAESEASLGNTNIPASDHYVGPNGFKSLAQEATRLAES 767
gamma2b   LGSQYQNRVRDTHRLITQMQLSLAESEASLGNTNIPASDHYVGPNGFKSLAQEATRLAES 767
gamma1    LAEQARAHVENTERLIEIASRELEKAKVAAANVSVTQPESTGDPNNMTLLAEEARKLAER 1189
gamma3    GSQKTCTQLADLEAVLESSEEEILHAAAILASLEIPQ-EGPSQPTKWSHLATEARALARS 1165
           ..:   :: : . ::   . .: .: .  .. .:.  :    *.  . ** **  **. 

gamma2a   HVESASNMEQLTRETEDYSKQALSLVRKALHEGVGSGSGSPDGAVVQGLVEKLEKTKSLA 827
gamma2b   HVESASNMEQLTRETEDYSKQALSLVRKALHEGVGSGSGSPDGAVVQGLVEKLEKTKSLA 827
gamma1    HKQEADDIVRVAKTANDTSTEAYNLLLRTLAG------ENQTAFEIEELNRKYEQAKNIS 1243
gamma3    HRDTATKIAATAWRALLASNTSYALLWNLLEG-------RVALETQRDLEDRYQEVQAAQ 1218
          * : * .:   :  :   *. :  *: . *                . *  : ::.:   

gamma2a   QQLTREATQAEIEADRSYQHSLRLLDSVSRLQGVSDQSFQVEEAKRIKQKADSLSTLVTR 887
gamma2b   QQLTREATQAEIEADRSYQHSLRLLDSVSRLQGVSDQSFQVEEAKRIKQKADSLSTLVTR 887
gamma1    QDLEKQAARVHEEAKRAGDKAVEIYASVAQLSPLDSETLENEANN-IKMEAENLEQLIDQ 1302
gamma3    KALRTAVAEVLPEAESVLATVQQVGADTAPYLAL----LASPGALPQKSRAEDLGLKAKA 1274
          : *   .:..  **.       .:  ..:    :    :        * .*:.*      

gamma2a   HMDEFKRTQKNLGNWKEEAQQLLQNGKSGREKSDQLLSRANLAKSRAQEALSMGNATFYE 947
gamma2b   HMDEFKRTQKNLGNWKEEAQQLLQNGKSGREKSDQLLSRANLAKSRAQEALSMGNATFYE 947
gamma1    KLKDYEDLREDMRGKELEVKNLLEKGKTEQQTADQLLARADAAKALAEEAAKKGRDTLQE 1362
gamma3    LEKTVASWQHMATEAARTLQTAAQATLRQTEPLTKLHQEARAALTQASSSVQAATVTVMG 1334
            .     :.         :   :      :   :*  .*  * : *..: . .  *.  

gamma2a   VESILKNLREFDLQVDNRKAEAEEAMKRLSYISQKVSDASDKTQQAERALGSAAADAQRA 1007
gamma2b   VESILKNLREFDLQVDNRKAEAEEAMKRLSYISQKVSDASDKTQQAERALGSAAADAQRA 1007
gamma1    ANDILNNLKDFDRRVNDNKTAAEEALRKIPAINQTITEANEKTREAQQALGSAAADATEA 1422
gamma3    ARTLLADLEGMKLQFPRPKDQAALQRKADSVSDRLLADTRKKTKQAERMLGNAAPLSSSA 1394
          .. :* :*. :. :.   *  *    :  .  .: :::: .**::*:: **.**. :  *

gamma2a   KNGAGEALEISSEIEQEIGSLNLEANVTADGALAMEKGLASLKSEMREVEGELERKELEF 1067
gamma2b   KNGAGEALEISSEIEQEIGSLNLEANVTADGALAMEKGLASLKSEMREVEGELERKELEF 1067
gamma1    KNKAHEAERIASAVQKNATSTKAEAERTFAEVTDLDNEVNNMLKQLQEAEKELKRKQDDA 1482
gamma3    KKKGREAEVLAKDSAKLAKALLRERKQAHRRASRLTSQTQATLQQASQQVLASEARR--- 1451
          *: . **  ::.   :   :   * : :   .  : .      .:  :     : :.   

gamma2a   DTNMDAVQMVITEAQKVDTRAKNAGVTIQDTLNTLDGLLHLMDQPLSVDE--EGLVLLEQ 1125
gamma2b   DTNMDAVQMVITEAQKVDTRAKNAGVTIQDTLNTLDGLLHLMGM---------------- 1111
gamma1    DQDMMMAGMASQAAQEAEINARKAKNSVTSLLSIINDLLEQLGQLDTVDL--NKLNEIEG 1540
gamma3    -QELEEAERVGAGLSEMEQQIRESRISLEKDIETLSELLARLGSLDTHQAPAQALNETQW 1510
            ::  .  .    .: : . :::  :: . :. :. **  :.                 

gamma2a   KLSRAKTQINS--QLRPMMSELEERARQQRGHLHLLETSIDGILADVKNLENIRDNLPPG 1183
gamma2b   ------------------------------------------------------------
gamma1    TLNKAKDEMKVS-DLDRKVSDLENEAKKQEAAIMDYNRDIEEIMKDIRNLEDIRKTLPSG 1599
gamma3    ALERLRLQLGSPGSLQRKLSLLEQESQQQELQIQGFESDLAEIRADKQNLEAILHSLPEN 1570
                                                                      

gamma2a   CYNTQALEQQ 1193
gamma2b   ----------
gamma1    CFNTPSIEKP 1609
gamma3    CASWQ----- 1575                   

Accession numbers of the laminin gamma subunits used in the protein sequence alignment: NP_002284 laminin, gamma 1; NP_005553 laminin, gamma 2 isoform a;
NP_061486 laminin, gamma 2 isoform b; NP_006050 laminin, gamma 3

Predicted General Properties of the Laminin Protein  (Homo sapiens) - Primary Sequence Analysis (with ProtParam) b

alpha1 subunit

Number of amino acids: 3075

Molecular weight: 337083.8

Theoretical pI: 5.93

Total number of negatively charged residues (Asp + Glu): 357

Total number of positively charged residues (Arg + Lys): 301

Atomic composition: Carbon C 14587 Hydrogen H 23009 Nitrogen N 4187 Oxygen O 4590 Sulfur S 206

Formula: C14587H23009N4187O4590S206

Total number of atoms: 46579

Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 288395 Abs 0.1% (=1 g/l) 0.856, assuming ALL Cys residues appear as half cystines Ext. coefficient 278020 Abs 0.1% (=1 g/l) 0.825, assuming NO Cys residues appear as half cystines

Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).

Instability index: The instability index (II) is computed to be 40.96 This classifies the protein as unstable.

Aliphatic index: 77.65

Grand average of hydropathicity (GRAVY): -0.335

 

beta1 subunit

Number of amino acids: 1786

Molecular weight: 198066.4

Theoretical pI: 4.84

Total number of negatively charged residues (Asp + Glu): 271

Total number of positively charged residues (Arg + Lys): 174

Atomic composition: Carbon C 8471 Hydrogen H 13260 Nitrogen N 2398 Oxygen O 2767 Sulfur S 159

Formula: C8471H13260N2398O2767S159

Total number of atoms: 27055 Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 162815 Abs 0.1% (=1 g/l) 0.822, assuming ALL Cys residues appear as half cystines Ext. coefficient 154940 Abs 0.1% (=1 g/l) 0.782, assuming NO Cys residues appear as half cystines

Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).

Instability index: The instability index (II) is computed to be 43.48 This classifies the protein as unstable.

Aliphatic index: 67.78

Grand average of hydropathicity (GRAVY): -0.469

 

gamma1 subunit

Number of amino acids: 1609

Molecular weight: 177602.8

Theoretical pI: 5.01

Total number of negatively charged residues (Asp + Glu): 241

Total number of positively charged residues (Arg + Lys): 177

Atomic composition: Carbon C 7540 Hydrogen H 11871 Nitrogen N 2217 Oxygen O 2507 Sulfur S 122

Formula: C7540H11871N2217O2507S122

Total number of atoms: 24257

Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 133800 Abs 0.1% (=1 g/l) 0.753, assuming ALL Cys residues appear as half cystines Ext. coefficient 127550 Abs 0.1% (=1 g/l) 0.718, assuming NO Cys residues appear as half cystines

Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).

Instability index: The instability index (II) is computed to be 43.53 This classifies the protein as unstable.

Aliphatic index: 63.00

Grand average of hydropathicity (GRAVY): -0.615

Bioinformatics References

a Higgins D., Thompson J., Gibson T. Thompson J. D., Higgins D. G., Gibson T. J.(1994). CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting,position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673-4680.

b Gasteiger E., Hoogland C., Gattiker A., Duvaud S., Wilkins M.R., Appel R.D., Bairoch A.; Protein Identification and Analysis Tools on the ExPASy Server;
(In) John M. Walker (ed): The Proteomics Protocols Handbook, Humana Press (2005). pp. 571-607  Full text - Copyright Humana Press.

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