Sequence Alignment of the Laminin Protein (Homo sapiens) (with Clustalw)a
Isoform Sequence Alignment
of Laminin
laminin alpha subunit
alpha3-1 MAAAARPRGRALGPVLPPTPLLLLVLRVLPACGATARDPGAAAGLSLHPTYFNLAEAARI 60
alpha3-2 ------------------------------------------------------------
alpha5 --MAKRLCAGSALCVRGPRGPAPLLLVGLALLGAARAREEAGGGFSLHPPYFNLAEGARI 58
alpha2a --------MPGAAGVLLLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALI 52
alpha2b --------MPGAAGVLLLLLLSGGLGGVQAQRPQQQRQSQAHQQRGLFPAVLNLASNALI 52
alpha1 ----------MRGGVLLVLLLC-----VAAQCRQ----------RGLFPAILNLASNAHI 35
alpha4 ------------------------------------------------------------
alpha3-1 WATATCGERGPGEG--RPQPELYCKLVGGPTAPGSGH-TIQGQFCDYCN--SEDPRKAHP 115
alpha3-2 ------------------------------------------------------------
alpha5 AASATCGEEAPARGSPRPTEDLYCKLVGGPVAGGDPNQTIRGQYCDICT--AANSNKAHP 116
alpha2a TTNATCGEKG---------PEMYCKLVEH-----VPGQPVRNPQCRICNQNSSNPNQRHP 98
alpha2b TTNATCGEKG---------PEMYCKLVEH-----VPGQPVRNPQCRICNQNSSNPNQRHP 98
alpha1 STNATCGEKG---------PEMFCKLVEH-----VPGRPVRNPQCRICDGNSANPRERHP 81
alpha4 ------------------------------------------------------------
alpha3-1 VTNAIDGSERWWQSPPLSSGTQYNRVNLTLDLGQLFHVAYILIKFANSPRPDLWVLERSV 175
alpha3-2 ------------------------------------------------------------
alpha5 ASNAIDGTERWWQSPPLSRGLEYNEVNVTLDLGQVFHVAYVLIKFANSPRPDLWVLERSM 176
alpha2a ITNAIDGKNTWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSL 158
alpha2b ITNAIDGKNTWWQSPSIKNGIEYHYVTITLDLQQVFQIAYVIVKAANSPRPGNWILERSL 158
alpha1 ISHAIDGTNNWWQSPSIQNGREYHWVTITLDLRQVFQVAYVIIKAANAPRPGNWILERSL 141
alpha4 ------------------------------------------------------------
alpha3-1 DFGSTYSPWQYFAHSKVDCLKEFGREANMA---VTRDDDVLCVTEYSRIVPLENGEVVVS 232
alpha3-2 ------------------------------------------------------------
alpha5 DFGRTYQPWQFFASSKRDCLERFGPQTLER---ITRDDAAICTTEYSRIVPLENGEIVVS 233
alpha2a DD-VEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHIS 217
alpha2b DD-VEYKPWQYHAVTDTECLTLYNIYPRTGPPSYAKDDEVICTSFYSKIHPLENGEIHIS 217
alpha1 DG-TTFSPWQYYAVSDSECLSRYNITPRRGPPTYRADDEVICTSYYSRLVPLEHGEIHTS 200
alpha4 ------------------------------------------------------------
alpha3-1 LINGRPGAKNFTFSHTLREFTKATNIRLRFLRTNTLLGHLISKAQR-----DPTVTRRYY 287
alpha3-2 ------------------------------------------------------------
alpha5 LVNGRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLLGHLMGKALR-----DPTVTRRYY 288
alpha2a LINGRPSAD--DPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYY 275
alpha2b LINGRPSAD--DPSPELLEFTSARYIRLRFQRIRTLNADLMMFAHKDPREIDPIVTRRYY 275
alpha1 LINGRPSAD--DLSPKLLEFTSARYIRLRLQRIRTLNADLMTLSHREPKELDPIVTRRYY 258
alpha4 ------------------------------------------------------------
alpha3-1 YSIKDISIGGQCVCNGHAEVCNINNPEKLF--RCECQHHTCGETCDRCCTGYNQRRWRPA 345
alpha3-2 ------------------------------------------------------------
alpha5 YSIKDISIGGRCVCHGHADACDAKDPTDPFRLQCTCQHNTCGGTCDRCCPGFNQQPWKPA 348
alpha2a YSVKDISVGGMCICYGHARACPLDPATNKS--RCECEHNTCGDSCDQCCPGFHQKPWRAG 333
alpha2b YSVKDISVGGMCICYGHARACPLDPATNKS--RCECEHNTCGDSCDQCCPGFHQKPWRAG 333
alpha1 YSIKDISVGGMCICYGHASSCPWDETTKKL--QCQCEHNTCGESCNRCCPGYHQQPWRPG 316
alpha4 ------------------------------------------------------------
alpha3-1 AWEQSHECEACNCHGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQC 405
alpha3-2 ------------------------------------------------------------
alpha5 TANSANECQSCNCYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERC 408
alpha2a TFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETC 393
alpha2b TFLTKTECEACNCHGKAEECYYDENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETC 393
alpha1 TVSSGNTCEACNCHNKAKDCYYDESVAKQKKSLNTAGQFRGGGVCINCLQNTMGINCETC 376
alpha4 ------------------------------------------------------------
alpha3-1 AKGYYRPYGVPVDAPDGCIPCSCDPEHADG-CEQGSGRCHCKPNFHGDNCEKCAIGYYNF 464
alpha3-2 ------------------------------------------------------------
alpha5 LPGFYRSPNHPLDSPHVCRRCNCESDFTDGTCEDLTGRCYCRPNFSGERCDVCAEGFTGF 468
alpha2a TDGFFRPKGVSPNYPRPCQPCHCD------------------------------------ 417
alpha2b TDGFFRPKGVSPNYPRPCQPCHCD------------------------------------ 417
alpha1 IDGYYRPHKVSPYEDEPCRPCNCD------------------------------------ 400
alpha4 ------------------------------------------------------------
alpha3-1 PFCLRIP---------IFPVSTPSSEDPVAGDIKG------------------------- 490
alpha3-2 ------------------------------------------------------------
alpha5 PSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNACRKDPRVGRCLCKPNFQGTHCEL 528
alpha2a ------------------------------------------------------------
alpha2b ------------------------------------------------------------
alpha1 ------------------------------------------------------------
alpha4 ------------------------------------------------------------
alpha3-1 ----------------------------------------------------------CD 492
alpha3-2 ------------------------------------------------------------
alpha5 CAPGFYGPGCQPCQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPLCQLCG 588
alpha2a ------------------------------------------------------------
alpha2b ------------------------------------------------------------
alpha1 ------------------------------------------------------------
alpha4 ------------------------------------------------------------
alpha3-1 CNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRS--------------------------- 525
alpha3-2 ------------------------------------------------------------
alpha5 CSPAGTLPEGCDEAGRCLCQPEFAGPHCDRCRPGYHGFPNCQACTCDPRGALDQLCGAGG 648
alpha2a --PIGSLNEVCVKD---------------------------------------------- 429
alpha2b --PIGSLNEVCVKD---------------------------------------------- 429
alpha1 --PVGSLSSVCIKD---------------------------------------------- 412
alpha4 ------------------------------------------------------------
alpha3-1 ------------------GFYSFPICQACWCSALGSYQMPCSSVTGQCECRPGVTGQRCD 567
alpha3-2 ------------------------------------------------------------
alpha5 LCRCRPGYTGTACQECSPGFHGFPSCVPCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCD 708
alpha2a ---------------------------------EKH--ARRGLAPGSCHCKTGFGGVSCD 454
alpha2b ---------------------------------EKH--ARRGLAPGSCHCKTGFGGVSCD 454
alpha1 ---------------------------------DLHSDLHNGKQPGQCPCKEGYTGEKCD 439
alpha4 ------------------------------------------------------------
alpha3-1 RCLSGAYDFPHCQGSSSACDPAGTIN----SNLGYCQCKLHVEGPTCSRCKLLYWNLDKE 623
alpha3-2 ------------------------------------------------------------
alpha5 TCVPGAYNFPYCEAGSCHPAGLAPVDPALPEAQVPCMCRAHVEGPSCDRCKPGFWGLSPS 768
alpha2a RCARGYTGYPDCKACNCSGLGSKNEDP----CFGPCICKENVEGGDCSRCKSGFFNLQED 510
alpha2b RCARGYTGYPDCKACNCSGLGSKNEDP----CFGPCICKENVEGGDCSRCKSGFFNLQED 510
alpha1 RCQLGYKDYPTCVSCGCNPVGSASDEP----CTGPCVCKENVEGKACDRCKPGFYNLKEK 495
alpha4 ------------------------------------------------------------
alpha3-1 NPSGCSECKCHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGYFALEKSNYFGCQG 683
alpha3-2 ------------------------------------------------------------
alpha5 NPEGCTRCSCDLRGTLGGVAECQPGTGQCFCKPHVCGQACASCKDGFFGLDQADYFGCRS 828
alpha2a NWKGCDECFCSGVSNR--------------CQSSYWTYGKIQDMSGWYLTDLPGRIRVAP 556
alpha2b NWKGCDECFCSGVSNR--------------CQSSYWTYGKIQDMSGWYLTDLPGRIRVAP 556
alpha1 NPRGCSECFCFGVSDV--------------CSSLSWPVGQVNSMSGWLVTDLISPRKIPS 541
alpha4 ------------------------------------------------------------
alpha3-1 CQCDIGGALSSMCSGPSGVCQCREHVVGKVCQRPENNYYFPDLHHMKYEIEDGSTPNGRD 743
alpha3-2 ------------------------------------------------------------
alpha5 CRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHYLPDLHHLRLELEEAATPEGHA 888
alpha2a QQDDLDSPQ-----------QISISNAEARQALPHSYYWSAPAPYLGNKLPAVGGQLTFT 605
alpha2b QQDDLDSPQ-----------QISISNAEARQALPHSYYWSAPAPYLGNKLPAVGGQLTFT 605
alpha1 QQDALGGRH-----------QVSINNTAVMQRLAPKYYWAAPEAYLGNKLTAFGGFLKYT 590
alpha4 ------------------------------------------------------------
alpha3-1 LRFGFDPLAFPEFSWRGYAQMTSVQNDVRITLNVGKSSGSLFRVILRYVNPGTEAVSGHI 803
alpha3-2 ------------------------------------------------------------
alpha5 VRFGFNPLEFENFSWRGYAQMAPVQP--RIVARLNLTSPDLFWLVFRYVNRGAMSVSGRV 946
alpha2a ISYDLE---------------------------EEEEDTERVLQLMIILEGNDLSIS--- 635
alpha2b ISYDLE---------------------------EEEEDTERVLQLMIILEGNDLSIS--- 635
alpha1 VSYDIP---------------------------VETVDSNLMSHADVIIKGNGLTLS--- 620
alpha4 ------------------------------------------------------------
alpha3-1 TIYPSWG-------AAQSKEIIFLPSKEPAFVTVPGNGFADPFSITPGIWVACIKAEGVL 856
alpha3-2 ------------------------------------------------------------
alpha5 SVREEGRSATCANCTAQSQPVAFPPSTEPAFITVPQRGFGEPFVLNPGTWALRVEAEGVL 1006
alpha2a --------------TAQDEVYLHPSEEHTNVLLLKEESFTIHGTHFPVRRKEFMTVLANL 681
alpha2b --------------TAQDEVYLHPSEEHTNVLLLKEESFTIHGTHFPVRRKEFMTVLANL 681
alpha1 --------------TQAEGLSLQPYEEYLNVVRLVPENFQDFHSKRQIDRDQLMTVLANV 666
alpha4 ------------------------------------------------------------
alpha3-1 LDYLVLLPRDYYEASVLQLPVTEPCAY---AGPPQENCLLYQHLPVTRFPCTLACEARHF 913
alpha3-2 ------------------------------------------------------------
alpha5 LDYVVLLPSAYYEAALLQLRVTEACTYRPSAQQSGDNCLLYTHLPLDGFPSAAGLEALCR 1066
alpha2a KRVLLQITYSFGMDAIFRLSS--------------------------------------- 702
alpha2b KRVLLQITYSFGMDAIFRLSS--------------------------------------- 702
alpha1 THLLIRANYNSAKMALYRLES--------------------------------------- 687
alpha4 ------------------------------------------------------------
alpha3-1 LLDGEPRPVAVRQPTPAHPVMVDLSGREVELHLRLRIPQVGHYVVVVEYSTEAAQLFVVD 973
alpha3-2 ------------------------------------------------------------
alpha5 QDNSLPRPCPTEQLSPSHPPLITCTGSDVDVQLQVAVPQPGRYALVVEYANEDARQEVGV 1126
alpha2a ----------------------------VNLESAVSYPTDGSIAAAVEVCQCPPGYTGSS 734
alpha2b ----------------------------VNLESAVSYPTDGSIAAAVEVCQCPPGYTGSS 734
alpha1 ----------------------------VSLDIASSNAIDLVVAADVEHCECPQGYTGTS 719
alpha4 ------------------------------------------------------------
alpha3-1 VNVKSSGSVLAGQVNIYSCNYSVLCRSAVIDHMSRIAMYELLADADIQLKGHMARFLLHQ 1033
alpha3-2 ------------------------------------------------------------
alpha5 AVHTPQRAPQQGLLSLHPCLYSTLCRGTARDTQDHLAVFHLDSEASVRLTAEQARFFLHG 1186
alpha2a CESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTG------------- 781
alpha2b CESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTG------------- 781
alpha1 CESCLSGYYRVDGILFGGICQPCECHGHAAECN-VHGVCIACAHNTT------------- 765
alpha4 ------------------------------------------------------------
alpha3-1 VCIIPIEEFSAEYVRPQVHCIASYGRFVNQSATCVSLAHETPPTALILDVLSGRPFPH-- 1091
alpha3-2 ------------------------------------------------------------
alpha5 VTLVPIEEFSPEFVEPRVSCISSHGAFGPNSAACLPSRFPKPPQPIILRDCQVIPLPPGL 1246
alpha2a ---------------------------GPYCDKCLPGFYGEPTK---------------- 798
alpha2b ---------------------------GPYCDKCLPGFYGEPTK---------------- 798
alpha1 ---------------------------GVHCEQCLPGFYGEPSR---------------- 782
alpha4 ------------------------------------------------------------
alpha3-1 -----------------LPQQSSPSVDVLPGVTLKAPQNQVTLRGRVPHLGRYVFVIHFY 1134
alpha3-2 ------------------------------------------------------------
alpha5 PLTHAQDLTPAMSPAGPRPRPPTAVDPDAEPTLLREPQATVVFTTHVPTLGRYAFLLHGY 1306
alpha2a -----------------------GTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGC 835
alpha2b -----------------------GTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGC 835
alpha1 -----------------------GTPGDCQPCACPLTIASNNFSPTCHLNDGDEVVCDWC 819
alpha4 ------------------------------------------------------------
alpha3-1 QAAHPTFPAQVSVDGGWPRAGSFHASFCPHVLGCRDQVIAEGQIEFDISEPEVAATVKVP 1194
alpha3-2 ------------------------------------------------------------
alpha5 QPAHPTFPVEVLINAGRVWQGHANASFCPHGYGCRTLVVCEGQALLDVTHSELTVTVRVP 1366
alpha2a PVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTG 895
alpha2b PVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTG 895
alpha1 APGYSGAWCERCADGYYGNPTVPGESCVPCDCSGNVDPSEAGHCDSVTGECLKCLGNTDG 879
alpha4 ------------------------------------------------------------
alpha3-1 EGKSLVLVRVLVVPAENYDYQILHKKSMDKSLEFITNCGKNSFYLDPQTASRFCKNSARS 1254
alpha3-2 ------------------------------------------------------------
alpha5 KGRWLWLDYVLVVPENVYSFGYLREEPLDKSYDFISHCAAQGYHISPSSSSLFCRNAAAS 1426
alpha2a RYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGT 955
alpha2b RYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKAGT 955
alpha1 AHCERCADGFYGDAVTAKNCRACECHVKGSHSAVCHLETGLCDCKPNVTGQQCDQCLHGY 939
alpha4 ------------------------------------------------------------
alpha3-1 LVAFYHKGALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFPR--CKPC 1312
alpha3-2 ------------------------------------------------------------
alpha5 LSLFYNNGARPCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFPN--CRPC 1484
alpha2a FGLQSARGCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTAC 1014
alpha2b FGLQSARGCVPCNCNSFGSKSFDCEE-SGQCWCQPGVTGKKCDRCAHGYFNFQEGGCTAC 1014
alpha1 YGLDSGHGCRPCNCSVAGSVSDGCTD-EGQCHCVPGVAGKRCDRCAHGFYAYQDGSCTPC 998
alpha4 ------------------------------------------------------------
alpha3-1 SCGRR--LCEEMTGQCRCPPRTVRPQCEVCETHSFSFHPMAGCEGCNCSRRGTIEAAMPE 1370
alpha3-2 ---------------------------------------------------------MPP 3
alpha5 DCGAR--LCDELTGQCICPPRTIPPDCLLCQPQTFGCHPLVGCEECNCSGPGIQELTDPT 1542
alpha2a ECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVG---SLDFQ 1071
alpha2b ECSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWGHSITTGCKACNCSTVG---SLDFQ 1071
alpha1 DCPHTQNTCDPETGECVCPPHTQGVKCEECEDGHWGYDAEVGCQACNCSLVG---STHHR 1055
alpha4 ----------------------------------------------------------MA 2
alpha3-1 CDRDSGQCRCKPRITGRQCDRCASGFYRFPECVPCNCNRDGTEPGVCD---------PGT 1421
alpha3-2 AVRRSACSMGWLWIFGAALGQCLG------------------------------------ 27
alpha5 CDTDSGQCKCRPNVTGRRCDTCSPGFHGYPRCRPCDCHEAGTAPGVCD---------PLT 1593
alpha2a CNVNTGQCNCHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQT 1131
alpha2b CNVNTGQCNCHPKFSGAKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQT 1131
alpha1 CDVVTGHCQCKSKFGGRACDQCSLGYRDFPDCVPCDCDLRGTSGDACNLEQGLCGCVEET 1115
alpha4 LSSAWRSVLPLWLLWSAACSRAASG----------------------------------- 27
. . .
alpha3-1 GACLCKENVEGTECNVCREGSFHLDPANLKGCTSCFCFGVNNQC-HSSHKRRTKFVDMLG 1480
alpha3-2 ---------------------------------------------YSSQQQR-------- 34
alpha5 GQCYCKENVQGPKCDQCSLGTFSLDAANPKGCTRCFCFGATERC-RSSSYTRQEFVDMEG 1652
alpha2a GQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAE 1191
alpha2b GQCTCKVNVEGIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAE 1191
alpha1 GACPCKENVFGPQCNECREGTFALRADNPLGCSPCFCSGLSHLCSELEDYVRTPVTLGSD 1175
alpha4 --------------------------------------------------------DDNA 31
alpha3-1 WHLETADRVDIPVSFNPGSNSMVADLQELPATIHSAS------WVAPTSYLGDKVSSYGG 1534
alpha3-2 ----------VPFLQPPGQSQLQASYVEFRP----------------------------- 55
alpha5 WVLLSTDRQVVPHERQPGTEMLRADLRHVPEAVPEAFPEL--YWQAPPSYLGDRVSSYGG 1710
alpha2a QTILPLVDEALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGG 1251
alpha2b QTILPLVDEALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGG 1251
alpha1 QPLLRVVSQSNLRGTTEGVYYQAPDFLLDAATVRQHIRAEPFYWRLPQQFQGDQLMAYGG 1235
alpha4 FPFDIEGSSAVGRQDPPETSEPRVALGRLPP----------------------------- 62
alpha3-1 YLTYQAKSFGLPGDMVL-LEKKPDV-QLTGQHMSIIYEETNTPRPDRLHHGRVHVVEGNF 1592
alpha3-2 ------------------------------------------------------------
alpha5 TLRYELHSETQRGDVFVPMESRPDV-VLQGNQMSITFLEPAYPTPGHVHRGQLQLVEGNF 1769
alpha2a KLKYAIYFEAREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEW 1311
alpha2b KLKYAIYFEAREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEW 1311
alpha1 KLKYSVAFYSLDGVGTSNFEPQVLIKGGR-IRKQVIYMDAPAPENGVRQEQEVAMRENFW 1294
alpha4 ------------------------------------------------------------
alpha3-1 RHAS----SRAPVSREELMTVLSRLADVRIQGLYFTETQRLTLSEVGLEEASDTGSGRIA 1648
alpha3-2 ------------------------------------------------------------
alpha5 RHTE----TRNTVSREELMMVLASLEQLQIRALFSQISSAVFLRRVALEVASPAGQGALA 1825
alpha2a KYYGDDPRVHRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMT 1371
alpha2b KYYGDDPRVHRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMT 1371
alpha1 KYFN--SVSEKPVTREDFMSVLSDIEYILIKASYGQGLQQSRISDISMEVGRKAEKLHPE 1352
alpha4 ------------------------------------------------------------
alpha3-1 L----AVEICACPPAYAGDSCQGCSPGYYR--------DHKGLYTGRCVPCNCNGHSNQC 1696
alpha3-2 --------------------SQGCSPGYYR--------DHKGLYTGRCVPCNCNGHSNQC 87
alpha5 S----NVELCLCPASYRGDSCQECAPGFYR--------DVKGLFLGRCVPCQCHGHSDRC 1873
alpha2a P-PADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGG-RTPGPTLGTCVPCQCNGHSSLC 1429
alpha2b P-PADLIEKCDCPLGYSGLSCEACLPGFYRLRSQPGG-RTPGPTLGTCVPCQCNGHSSLC 1429
alpha1 EEVASLLENCVCPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSDTC 1412
alpha4 -------------------AAEKCNAGFFH------------TLSGECVPCDCNGNSNEC 91
.: * .*:.: . ****.*:.:*. *
alpha3-1 QDGSGICVNCQHNTAGEHCERCQEGYYG---NAVHGSCRACPCPH---TNSFATGCVVNG 1750
alpha3-2 QDGSGICVNCQHNTAGEHCERCQEGYYG---NAVHGSCRACPCPH---TNSFATGCVVNG 141
alpha5 LPGSGVCVDCQHNTEGAHCERCQAGFVSS-RDDPSAPCVSCPCPLSVPSNNFAEGCVLRG 1932
alpha2a DPETSICQNCQHHTAGDFCERCALGYYGI-VKGLPNDCQQCACPLISSSNNFSPSCVAEG 1488
alpha2b DPETSICQNCQHHTAGDFCERCALGYYGI-VKGLPNDCQQCACPLISSSNNFSPSCVAEG 1488
alpha1 DPNTGKCLNCGDNTAGDHCDVCTSGYYGK-VTGSASDCALCACPHSPPAS-FSPTCVLEG 1470
alpha4 LDGSGYCVHCQRNTTGEHCEKCLDGYIGDSIRGAPQFCQPCPCPLPHLAN-FAESCYRKN 150
:. * .* :* * .*: * *: . * *.** :. *: * ..
alpha3-1 GDVR--CSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQ----LGSCHPLTGD 1804
alpha3-2 GDVR--CSCKAGYTGTQCERCAPGYFGNPQKFGGSCQPCSCNSNGQ----LGSCHPLTGD 195
alpha5 GRTQ--CLCKPGYAGASCERCAPGFFGNPLVLGSSCQPCDCSGNGDPNLLFSDCDPLTGA 1990
alpha2a LDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGS---LPVPCDPVTGF 1545
alpha2b LDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGS---LPVPCDPVTGF 1545
alpha1 DHDFRCDACLLGYEGKHCERCSSSYYGNPQTPGGSCQKCDCNPHGS---VHGDCDRTSGQ 1527
alpha4 GAVR--CICNENYAGPNCERCAPGYYGNPLLIGSTCKKCDCSGNSDPNLIFEDCDEVTGQ 208
* .* * ****:..: *.* *.:*: *.*. .. *. :*
alpha3-1 CINQEPKDSSP------------------------------------------------- 1815
alpha3-2 CINQEPKDSSP------------------------------------------------- 206
alpha5 CRGCLRHTTGPRCEICAPGFYGNALLPGNCTRCDCTPCGTEACDPHSGHCLCKAGVTGRR 2050
alpha2a CTCRPGATGRKCDG---------------------------------------------- 1559
alpha2b CTCRPGATGRKCDG---------------------------------------------- 1559
alpha1 CVCRLGASGLRCDE---------------------------------------------- 1541
alpha4 CRNCLRNTTGFKCERCAPGYYGDARIAKNCAVCN-------------------------- 242
*
alpha3-1 ------------------------------------------------------------
alpha3-2 ------------------------------------------------------------
alpha5 CDRCQEGHFGFDGCGGCRPCACGPAAEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLP 2110
alpha2a ------------------------------------------------------------
alpha2b ------------------------------------------------------------
alpha1 ------------------------------------------------------------
alpha4 ------------------------------------------------------------
alpha3-1 --------------------------------------------------AEECDDC-DS 1824
alpha3-2 --------------------------------------------------AEECDDC-DS 215
alpha5 EQGCRRCQCPGGRCDPHTGRCNCPPGLSGERCDTCSQQHQVPVPGGPVGHSIHCEVC-DH 2169
alpha2a ------------------------------------------CKHWHAREGWECVFCGDE 1577
alpha2b ------------------------------------------CKHWHAREGWECVFCGDE 1577
alpha1 ------------------------------------------CEPRHILMETDCVSCDDE 1559
alpha4 ----------------------------------CGGGPCDSVTGECLEEGFEPPTGCDK 268
. *
alpha3-1 CVMTLLNDLATMGEQLRLVKSQLQGLSASAGLLEQMRHMETQAKDLRNQLLNYRSAISNH 1884
alpha3-2 CVMTLLNDLATMGEQLRLVKSQLQGLSASAGLLEQMRHMETQAKDLRNQLLNYRSAISNH 275
alpha5 CVVLLLDDLERAGALLPAIHEQLRGINASSMAWARLHRLNASIADLQSQLRSPLGPRHET 2229
alpha2a CTGLLLGDLARLEQMVMSIN-LTGPLPAPYKMLYGLENMTQELKHLLSPQRAPERLIQLA 1636
alpha2b CTGLLLGDLARLEQMVMSIN-LTGPLPAPYKMLYGLENMTQELKHLLSPQRAPERLIQLA 1636
alpha1 CVGVLLNDLDEIGDAVLSLN-LTGIIPVPYGILSNLENTTKYLQESLLKENMQK---DLG 1615
alpha4 CVWDLTDDLRLAALSIEEGKSGVLSVSSGAAAHRHVNEINATIYLLKTKLSERENQYALR 328
*. * .** : : : :..
alpha3-1 GSKIEGLERELTDLNQEFETLQEKAQVNSRKAQTLNNNVNRATQSAKELDVKIKNVIRNV 1944
alpha3-2 GSKIEGLERELTDLNQEFETLQEKAQVNSRKAQTLNNNVNRATQSAKELDVKIKNVIRNV 335
alpha5 AQQLEVLEQQSTSLGQDARRLGGQAVGTRDQASQLLAGTEATLGHAKTLLAAIRAVDRTL 2289
alpha2a EGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVNEKA 1696
alpha2b EGNLNTLVTEMNELLTRATKVTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVNEKA 1696
alpha1 KIKLEGVAEETDNLQKKLTRMLASTQKVNRATERIFKESQDLAIAIERLQMSITEIMEKT 1675
alpha4 KIQINNAENTMKSLLSDVEELVEKENQASRKGQLVQKESMDTINHASQLVEQAHDMRDKI 388
::: .* : . . . * : .
alpha3-1 HILLKQISGTDGEGNNVPSGD-FSREWAEAQRMMRELRNRNFGKHLREAEADKRESQLLL 2003
alpha3-2 HILLKQISGTDGEGNNVPSGD-FSREWAEAQRMMRELRNRNFGKHLREAEADKRESQLLL 394
alpha5 SELMSQTGHLGLANASAPSGEQLLRTLAEVERLLWEMRARDLGAPQAAAEAELAAAQRLL 2349
alpha2a IKLNETLGTRDEAFERN-----LEGLQKEIDQMIKELRRKNLETQKEIAEDELVAAEALL 1751
alpha2b IKLNETLGTRDEAFERN-----LEGLQKEIDQMIKELRRKNLETQKEIAEDELVAAEALL 1751
alpha1 T-LNQTLDEDFLLPNST-----LQNMQQNGTSLLEIMQIRDFTQLHQNATLELKAAEDLL 1729
alpha4 QEINNKMLYYGEEHELSPKE--ISEKLVLAQKMLEEIRSRQPFFTQRELVDEEADEAYEL 446
: . : :: :: :: : *
alpha3-1 NRIRTWQKTHQGENNGLANSIRDSLNEYEAKLSDLRARLQEAAAQAKQANGLNQENERAL 2063
alpha3-2 NRIRTWQKTHQGENNGLANSIRDSLNEYEAKLSDLRARLQEAAAQAKQANGLNQENERAL 454
alpha5 ARVQEQLSSLWEENQALATQTRDRLAQHEAGLMDLREALNRAVDATREAQELNSRNQERL 2409
alpha2a KKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREANRLFAVNQKNM 1811
alpha2b KKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREANRLFAVNQKNM 1811
alpha1 SQIQENYQKPLEELEVLKEAASHVLSKHNNELKAAEALVREAEAKMQESNHLLLMVNANL 1789
alpha4 LSQAESWQRLHNETRTLFPVVLEQLDDYNAKLSDLQEALDQALNHVRDAEDMNRATAARQ 506
* . : . * .:: : : .* :::: :
alpha3-1 GAIQRQVKEINSLQSDFTKYLTTADSSLLQTNIALQLMEKSQKEYEKLAASLNEARQELS 2123
alpha3-2 GAIQRQVKEINSLQSDFTKYLTTADSSLLQTNIALQLMEKSQKEYEKLAASLNEARQELS 514
alpha5 EEALQRKQELSRDNATLQATLHAARDTLASVFRLLHSLDQAKEELERLAASLDGARTPLL 2469
alpha2a TALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPMSEELN 1871
alpha2b TALEKKKEAVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPMSEELN 1871
alpha1 REFSDKKLHVQEEQNLTSELIVQGRGLIDAAAAQTDAVQDALEHLEDHQDKLLLWSAKIR 1849
alpha4 RDHEKQQERVREQMEVVNMSLSTSADSLTTPRLTLSELDDIIKNASGIYAEIDGAKSELQ 566
: : : . . : ::. . . .: :
alpha3-1 DKVRELSRSAG---KTSLVEEAEKHARSLQELAKQLEEIKRNASGDELVRCAVDAATAYE 2180
alpha3-2 DKVRELSRSAG---KTSLVEEAEKHARSLQELAKQLEEIKRNASGDELVRCAVDAATAYE 571
alpha5 QRMQTFSPAGS---KLRLVEAAEAHAQQLGQLALNLSSIILDVNQDRLTQRAIEASNAYS 2526
alpha2a DKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKN--ISFNATAAFKAYS 1929
alpha2b DKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKN--ISFNATAAFKAYS 1929
alpha1 HHIDDLVMHMSQRNAVDLVYRAEDHAAEFQRLADVLYSGLENIRN--VSLNATSAAYVHY 1907
alpha4 VKLSNLSNLSH-----DLVQEAIDHAQDLQQEANELSRKLHSSDMNGLVQKALDASNVYE 621
:: : * * ** .: : * . : * * .:
alpha3-1 NILNAIKAAEDAANRAASASESA--LQTVIKEDLPRKAKTLSSNSDKLLNEAKMTQKKLK 2238
alpha3-2 NILNAIKAAEDAANRAASASESA--LQTVIKEDLPRKAKTLSSNSDKLLNEAKMTQKKLK 629
alpha5 RILQAVQAAEDAAGQALQQADHT--WATVVRQGLVDRAQQLLANS-TALEEAMLQEQQRL 2583
alpha2a NIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVK 1989
alpha2b NIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVK 1989
alpha1 NIQSLIEESEELARDAHRTVTETSLLSES----LVSNGKAAVQRSSRFLKEGNNLSRKLP 1963
alpha4 NIVNYVSEANETAEFALNTTDRIYDAVSGIDTQIIYHK----DESENLLNQARELQAKAE 677
.* . :. ::. * * : .* *::. .
alpha3-1 QEVSPALNNLQQTLNIVTVQKEVIDTNLTTLRDGLHGIQRGDIDAMISSAKSMVRKANDI 2298
alpha3-2 QEVSPALNNLQQTLNIVTVQKEVIDTNLTTLRDGLHGIQRGDIDAMISSAKSMVRKANDI 689
alpha5 GLVWAALQGARTQLRDVRAKKDQLEAHIQAAQA-MLAMDTDETSKKIAHAKAVAAEAQDT 2642
alpha2a ENE-DHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPN-DTAAKLQAVKDKARQANDT 2047
alpha2b ENE-DHLNGLKTRIENADARNGDLLRTLNDTLGKLSAIPN-DTAAKLQAVKDKARQANDT 2047
alpha1 GIA-LELSELRNKTNRFQENAVEITRQTNESLLILRAIPK-GIRDKGAKTKELATSASQS 2021
alpha4 SSSDEAVADTSRRVGGALARKSALKTRLSDAVKQLQAAERGDAQQRLGQSRLITEEANRT 737
: . : : . : . .*.
alpha3-1 TDEVLDGLNPIQTDVERIKDTYGRTQNEDFKKALTDADNSVNKLTNKLPDLWRKIESINQ 2358
alpha3-2 TDEVLDGLNPIQTDVERIKDTYGRTQNEDFKKALTDADNSVNKLTNKLPDLWRKIESINQ 749
alpha5 ATRVQSQLQAMQENVERWQGQYEGLRGQDLGQAVLDAGHSVSTLEKTLPQLLAKLSILEN 2702
alpha2a AKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVKNLEQEAD 2107
alpha2b AKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVKNLEQEAD 2107
alpha1 AVSTLRDVAGLSQELLNTSASLSRVNTTLRETHQLLQDSTMATLLAGR--KVKDVEIQAN 2079
alpha4 TMEVQQATAPMANNLTNWSQNLQHFDSSAYNTAVNSARDAVRNLTEVVPQLLDQLRTVEQ 797
: . : :: . : .: .: :
alpha3-1 QLLPLG--------NISDNMDRIRELIQQARDAASKVAVPMRFNGKSGVEVRLPNDLEDL 2410
alpha3-2 QLLPLG--------NISDNMDRIRELIQQARDAASKVAVPMRFNGKSGVEVRLPNDLEDL 801
alpha5 RGVHNAS------LALSASIGRVRELIAQARGAASKVKVPMKFNGRSGVQLRTPRDLADL 2756
alpha2a RLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGD---CIRTYKPEIKK 2164
alpha2b RLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGD---CIRTYKPEIKK 2164
alpha1 LLFDRLKPLKMLEENLSRNLSEIKLLISQARKQAASIKVAVSADRD---CIRAYQPQISS 2136
alpha4 KRPASN---------VSASIQRIRELIAQTRSVASKIQVSMMFDGQSAVEVHSRTSMDDL 848
:. .: .:: ** *:* * .: *.: . :: .
alpha3-1 KGYTSLSLFLQRPNSRE-NGGTENMFVMYLGNKDASRDYIGMAVVDGQLTCVYNLGDREA 2469
alpha3-2 KGYTSLSLFLQRPNSRE-NGGTENMFVMYLGNKDASRDYIGMAVVDGQLTCVYNLGDREA 860
alpha5 AAYTALKFYLQGPEPEP-GQGTEDRFVMYMGSRQATGDYMGVSLRDKKVHWVYQLGEAG- 2814
alpha2a GSYNNIVVNVKTAVA--------DNLLFYLGS-AKFIDFLAIEMRKGKVSFLWDVGSGVG 2215
alpha2b GSYNNIVVNVKTAVA--------DNLLFYLGS-AKFIDFLAIEMRKGKVSFLWDVGSGVG 2215
alpha1 TNYNTLTLNVKTQEP--------DNLLFYLGS-STASDFLAVEMRRGRVAFLWDLGSGST 2187
alpha4 KAFTSLSLYMKPPVKRPELTETADQFILYLGSKNAKKEYMGLAIKNDNLVYVYNLGTKDV 908
:. : . :: : :::*:*. :::.: : .: ::::*
alpha3-1 ELQVDQILTKSETKEAVMDRVKFQRIYQFARLNYTKGATSSKPETPGVYDMDGRNSNTLL 2529
alpha3-2 ELQVDQILTKSETKEAVMDRVKFQRIYQFARLNYTKGATSSKPETPGVYDMDGRNSNTLL 920
alpha5 ----PAVLSIDEDIGEQFAAVSLDRTLQFGHMSVTVERQMIQETKG---DTVAPGAEGLL 2867
alpha2a RVEYPDLTID----DSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTIL 2271
alpha2b RVEYPDLTID----DSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTIL 2271
alpha1 RLEFPDFPID----DNRWHSIHVARFGNIGSLSVKEMSSNQK---SPTKTSKSPGTANVL 2240
alpha4 EIPLDSKPVSS--WPAYFSIVKIERVGKHGKVFLTVPSLSSTAEEKFIKKGEFSGDDSLL 966
: * . . : :*
alpha3-1 NLDPENVVFYVGGYPPDFKLPSRLSFPPYKGCIELDDLNENVLSLYNFKKTFNLNTTEVE 2589
alpha3-2 NLDPENVVFYVGGYPPDFKLPSRLSFPPYKGCIELDDLNENVLSLYNFKKTFNLNTTEVE 980
alpha5 NLRPDDFVFYVGGYPSTFTPPPLLRFPGYRGCIEMDTLNEEVVSLYNFERTFQLDTAVDR 2927
alpha2a DVDAN-AMLFVGGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTV 2330
alpha2b DVDAN-AMLFVGGLTGKLKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTV 2330
alpha1 DVNNS-TLMFVGGLGGQIKKSPAVKVTHFKGCLGEAFLNGKSIGLWNYIEREGKCRGCFG 2299
alpha4 DLDPEDTVFYVGGVPSNFKLPTSLNLPGFVGCLELATLNNDVISLYNFKHIYNMDPSTSV 1026
:: . :::*** :. . : . : **: :: . :.*:*: .
alpha3-1 PCRRRKEE-----SDKNYFEGTGYARVP-TQPHAPIPT-FGQTIQTTVDRGLLFFAENGD 2642
alpha3-2 PCRRRKEE-----SDKNYFEGTGYARVP-TQPHAPIPT-FGQTIQTTVDRGLLFFAENGD 1033
alpha5 PCARSKSTGDPWLTDGSYLDGTGFARIS-FDSQISTTKRFEQELRLVSYSGVLFFLKQQS 2986
alpha2a SPQVEDSE------GTIQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRD 2384
alpha2b SPQVEDSE------GTIQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATRD 2384
alpha1 SSQNEDP--------SFHFDGSGYSVVEKSLP--ATVTQIIMLFNTFSPNGLLLYLGSYG 2349
alpha4 PCARDKLAFTQSRAASYFFDGSGYAVVRDITRRGKFGQVTRFDIEVRTPADNGLILLMVN 1086
. . ::* *:: : :. : .
alpha3-1 R--FISLNIEDGKLMVRYKLNSELPKERGVG--DAINNGRDHSIQIKIGKLQKRMWINVD 2698
alpha3-2 R--FISLNIEDGKLMVRYKLNSELPKERGVG--DAINNGRDHSIQIKIGKLQKRMWINVD 1089
alpha5 Q--FLCLAVQEGSLVLLYDFGAGLKKAVPLQPPPPLTSASKAIQVFLLGGSRKRVLVRVE 3044
alpha2a LRDFMSVELTDGHIKVSYDLGSGMASVVSNQ-----NHNDGKWKSFTLSRIQKQANISIV 2439
alpha2b LRDFMSVELTDGHIKVSYDLGSGMASVVSNQ-----NHNDGKWKSFTLSRIQKQANISIV 2439
alpha1 TKDFLSIELFRGRVKVMTDLGSGPITLLTDR-----RYNNGTWYKIAFQRNRKQGVLAVI 2404
alpha4 GSMFFRLEMRNGYLHVFYDFGFSSGRVHLEDTLKKAQINDAKYHEISIIYHNDKKMILVV 1146
*: : : * : : .:. : : ..: : :
alpha3-1 --------------VQNTIIDGEVFDFSTYYLGGIP----IAIRERFNISTPA-FRGCMK 2739
alpha3-2 --------------VQNTIIDGEVFDFSTYYLGGIP----IAIRERFNISTPA-FRGCMK 1130
alpha5 RAT-----------VYSVEQDNDLELADAYYLGGVPPDQLPPSLRRLFPTGGS-VRGCVK 3092
alpha2a DID-TNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKARPEVNLKK-YSGCLK 2497
alpha2b DID-TNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNL----RPEVNLKK-YSGCLK 2493
alpha1 DAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGLPRSRVV----RRGVTTKS-FVGCIK 2459
alpha4 DRR----------HVKSMDNEKMKIPFTDIYIGGAPPEILQSRALRAHLPLDINFRGCMK 1196
. *.** * * **:*
alpha3-1 NLKKTSG-VVRLN--DTVGVTKKCSEDWKLVRSASFSRGGQLSFTDLGLPP-TDHLQASF 2795
alpha3-2 NLKKTSG-VVRLN--DTVGVTKKCSEDWKLVRSASFSRGGQLSFTDLGLPP-TDHLQASF 1186
alpha5 GIKALGK-YVDLKRLNTTGVSAGCTADLLVGRAMTFHGHGFLRLALSNVAPLTGNVYSGF 3151
alpha2a DIEISRTPYNILSSPDYVGVTKGCSLEN--VYTVSFPKPGFVELSPVPIDV---GTEINL 2552
alpha2b DIEISRTPYNILSSPDYVGVTKGCSLEN--VYTVSFPKPGFVELSPVPIDV---GTEINL 2548
alpha1 NLEISRSTFDLLRNS--YGVRKGCLLEP--IRSVSFLKGGYIELPPKSLSP---ESEWLV 2512
alpha4 GFQFQKKDFNLLEQTETLGVGYGCPEDSLISRRAYFNGQSFIAS--IQKISFFDGFEGGF 1254
.:: * ** * : * . : .
alpha3-1 GFQTFQPSGILLD-------------HQTWTRNLQVTLEDGYIELSTSDSGSP------I 2836
alpha3-2 GFQTFQPSGILLD-------------HQTWTRNLQVTLEDGYIELSTSDSGSP------I 1227
alpha5 GFHSAQDSALLYY-------------RASPDGLCQVSLQQGRVSLQLLRT---------E 3189
alpha2a SFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLEVHLSTGART-MRKIVI 2611
alpha2b SFSTKNESGIILLGSGGTPAPPRRKRRQTGQAYYVILLNRGRLEVHLSTGART-MRKIVI 2607
alpha1 TFATTNSSGIILAALGGDVEK-RGDREEAHVPFFSVMLIGGNIEVHVNPGDGTGLRKALL 2571
alpha4 NFRTLQPNGLLFY-------------YASGSDVFSISLDNGTVIMDVKGIKVQ------- 1294
* : : ..:: : : * * : :
alpha3-1 FKSPQTYMDGLLHYVSVISDNSGLRLLIDDQLLRNSKR------LKHISSSRQSLRLGGS 2890
alpha3-2 FKSPQTYMDGLLHYVSVISDNSGLRLLIDDQLLRNSKR------LKHISSSRQSLRLGGS 1281
alpha5 VKTQAGFADGAPHYVAFYSNATGVWLYVDDQLQQMKPHRGPPPELQPQPEGPPRLLLGGL 3249
alpha2a RPEPNLFHDGREHSVHVERTRGIFTVQVDENR---RYMQN---LTVEQPIEVKKLFVGGA 2665
alpha2b RPEPNLFHDGREHSVHVERTRGIFTVQVDENR---RYMQN---LTVEQPIEVKKLFVGGA 2661
alpha1 HAPTGTCSDGQAHSISLVRNRRIITVQLDENNPVEMKLGT---LVESRTINVSNLYVGGI 2628
alpha4 -SVDKQYNDGLSHFVISSVSPTRYELIVDKSRVGSKNPTKG--KIEQTQASEKKFYFGGS 1351
** * : : :*.. : .**
alpha3-1 -------------NFEGCISNVFVQRLSLSPEVLDLTSNSLKRDVSLGGCSLNKPPFLML 2937
alpha3-2 -------------NFEGCISNVFVQRLSLSPEVLDLTSNSLKRDVSLGGCSLNKPPFLML 1328
alpha5 PES------GTIYNFSGCISNVFVQRLLGPQRVFDLQQNLGSVNVSTG----CAPALQAQ 3299
alpha2a PPEFQPSPLRNIPPFEGCIWNLVIN-----SVPMDFARPVSFKNADIG------RCAHQK 2714
alpha2b PPEFQPSPLRNIPPFEGCIWNLVIN-----SVPMDFARPVSFKNADIG------RCAHQK 2710
alpha1 PEGEGTSLLTMRRSFHGCIKNLIFN-----LELLDFNSAVGHEQVDLD------TCWLSE 2677
alpha4 PIS------AQYANFTGCISNAYFTRVDRDVEVEDFQRYTEKVHTSLYECPIESSPLFLL 1405
* *** * . *: ...
alpha3-1 L--------KGSTRFNKTKTFRINQLLQDTPVASPRSVKVWQDACSPLPKTQANHGALQF 2989
alpha3-2 L--------KGSTRFNKTKTFRINQLLQDTPVASPRSVKVWQDACSPLPKTQANHGALQF 1380
alpha5 T--------PGLGPRGLQATARKASRRSRQPARHP--------ACMLPPHLRTTRDSYQF 3343
alpha2a L--------REDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQF 2766
alpha2b L--------REDEDGAAPAEIVIQPEPVPTPAFPTPTPVLTHGPCAAESEPALLIGSKQF 2762
alpha1 R--------PKLAPDAEDSKLLPEPR-----AFP--------EQCVVDAALEYVPGAHQF 2716
alpha4 HKKGKNLSKPKASQNKKGGKSKDAPSWDPVALKLPERNTPRNSHCHLSNSPRAIEHAYQY 1465
* : *:
alpha3-1 GDIPTSHLLFKLPQELLKPRSQFAVDMQTTSSRGLVFHTG---TKNSFMALYLSKGRLVF 3046
alpha3-2 GDIPTSHLLFKLPQELLKPRSQFAVDMQTTSSRGLVFHTG---TKNSFMALYLSKGRLVF 1437
alpha5 GGSLSSHLEFVGILARHRNWPSLSMHVLPRSSRGLLLFTARLRPGSPSLALFLSNGHFVA 3403
alpha2a GLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMAR-INHADFATVQLRNGLPYF 2825
alpha2b GLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMAR-INHADFATVQLRNGLPYF 2821
alpha1 GLTQNSHFILPFNQSAVRKKLSVELSIRTFASSGLIYYMAH-QNQADYAVLQLHGGRLHF 2775
alpha4 GGTANSRQEFEHLKGDFGAKSQFSIRLRTRSSHGMIFYVSD-QEENDFMTLFLAHGRLVY 1524
* .*: : . : : . :. *:: . . .: * *
alpha3-1 ALGTDGKKLRIKSKEKCNDGKWHTVVFGHDGEKGRLVVDGLRAREGSLPGNSTISIRAP- 3105
alpha3-2 ALGTDGKKLRIKSKEKCNDGKWHTVVFGHDGEKGRLVVDGLRAREGSLPGNSTISIRAP- 1496
alpha5 QMEGLGTRLRAQSRQRSRPGRWHKVSVRWEKNRILLVTDGARAWSQEGPHRQHQGAEHPQ 3463
alpha2a SYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPK-KADILDVVG- 2883
alpha2b SYDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPK-KADILDVVG- 2879
alpha1 MFDLGKGRTKVSHPALLSDGKWHTVKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEG- 2834
alpha4 MFNVGHKKLKIRSQEKYNDGLWHDVIFIRERSSGRLVIDGLRVLEESLPPTEATWKIKG- 1583
: * ** : : **
alpha3-1 ---VYLG-SPPSGKPKSLP--TNS-FVGCLKNFQLDSKPLY--TPSSSFGVSSCLGGPLE 3156
alpha3-2 ---VYLG-SPPSGKPKSLP--TNS-FVGCLKNFQLDSKPLY--TPSSSFGVSSCLGGPLE 1547
alpha5 PHTLFVGGLPASSHSSKLP--VTVGFSGCVKRLRLHGRPLG--APTRMAGVTPCILGPLE 3519
alpha2a --MLYVGGLPINYTTRRIGP-VTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFAN-AQ 2939
alpha2b --MLYVGGLPINYTTRRIGP-VTYSIDGCVRNLHMAEAPADLEQPTSSFHVGTCFAN-AQ 2935
alpha1 --LFYLGGLPSQYQARKIGN-ITHSIPACIGDVTVNSKQLDKDSPVSAFTVNRCYAV-AQ 2890
alpha4 --PIYLGGVAPGKAVKNVQINSIYSFSGCLSNLQLNGASIT--SASQTFSVTPCFEGPME 1639
.::* . : : .*: . : . * * :
alpha3-1 KGIYFSEEGGHVVLAHSVLLGPEFKLVFSIRPRSLTGILIHIGSQ-PGKHLCVYLEAGKV 3215
alpha3-2 KGIYFSEEGGHVVLAHSVLLGPEFKLVFSIRPRSLTGILIHIGSQ-PGKHLCVYLEAGKV 1606
alpha5 AGLFFPGSGGVITLDLPGATLPDVGLELEVRPLAVTGLIFHLGQARTPPYLQLQVTEKQV 3579
alpha2a RGTYFDGTGFAKAVGG-FKVGLDLLVEFEFRTTTTTGVLLGISSQ-KMDGMGIEMIDEKL 2997
alpha2b RGTYFDGTGFAKAVGG-FKVGLDLLVEFEFRTTTTTGVLLGISSQ-KMDGMGIEMIDEKL 2993
alpha1 EGTYFDGSGYAALVKEGYKVQSDVNITLEFRTSSQNGVLLGISTA-KVDAIGLELVDGKV 2949
alpha4 TGTYFSTEGGYVVLDESFNIGLKFEIAFEVRPRSSSGTLVHGHSV-NGEYLNVHMKNGQV 1698
* :* * : .. : :..*. : .* :. : : : ::
alpha3-1 TASMDSGAGGTSTSVTP--KQSLCDGQWHSVAVTIKQHILHLELDTDSSYTAG-QIPFPP 3272
alpha3-2 TASMDSGAGGTSTSVTP--KQSLCDGQWHSVAVTIKQHILHLELDTDSSYTAG-QIPFPP 1663
alpha5 LLRADDGAGEFSTSVTR--PSVLCDGQWHRLAVMKSGNVLRLEVDAQSNHTVG-PLLAAA 3636
alpha2a MFHVDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTS 3057
alpha2b MFHVDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTS 3053
alpha1 LFHVNNGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRITLIVDGNAVGAESPHTQSTS 3009
alpha4 IVKVNNGIRDFSTSVTP--KQSLCDGRWHRITVIRDSNVVQLDVDSEVNHVVG-PLNPKP 1755
:.* :: ****:** : . : : * :* : . . .
alpha3-1 ASTQEPLHLGGAPANLTTLRIPVWKSFFGCLRNIHVNH-----IPVPVTEALEVQGPVSL 3327
alpha3-2 ASTQEPLHLGGAPANLTTLRIPVWKSFFGCLRNIHVNH-----IPVPVTEALEVQGPVSL 1718
alpha5 AGAPAPLYLGGLPEPMAVQPWP--PAYCGCMRRLAVNR-----SPVAMTRSVEVHGAVGA 3689
alpha2a ADTNDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNFAKALELRG-VQP 3116
alpha2b ADTNDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKGTGKPLEVNFAKALELRG-VQP 3112
alpha1 VDTNNPIYVGGYPAGVKQKCLRSQTSFRGCLRKLALIK-SPQVQSFDFSRAFELHG-VFL 3067
alpha4 IDHREPVFVGGVPESLLTPRLAPSKPFTGCIRHFVIDG-----HPVSFSKAALVSGAVSI 1810
. *:.:** * : .: **:* : : . .:.: : * *
alpha3-1 NGCPDQ-- 3333
alpha3-2 NGCPDQ-- 1724
alpha5 SGCPAA-- 3695
alpha2a VSCPAN-- 3122
alpha2b VSCPAN-- 3118
alpha1 HSCPGTES 3075
alpha4 NSCPAA-- 1816
.**
Accession numbers of the laminin alpha subunits used in the protein sequence alignments: NP_005550 laminin, alpha 1; NP_000417 laminin alpha 2 subunit isoform a;
NP_001073291.1| laminin alpha 2 subunit isoform b; NP_937762 laminin alpha
3 subunit isoform 1; NP_000218 laminin alpha 3 subunit isoform 2;
NP_002281 laminin, alpha 4; NP_005551 laminin alpha 5
laminin beta subunit
beta1 -----------MGLLQLLAFSFLALCRARVRAQEPEFSY-GCAEGSCYPATGDLLIGRAQ 48
beta2 MELTSRERGRGQPLPWELRLGLLLSVLAATLAQAPAPDVPGCSRGSCYPATGDLLVGRAD 60
beta4 -------------MQFQLTLFLHLGWLSYSKAQD------DCNRGACHPTTGDLLVGRNT 41
beta3 ---------------MRPFFLLCFALPGLLHAQQ------ACSRGACYPPVGDLLVGRTR 39
: : . ** * .*:*:*..****:**
beta1 KLSVTSTCGLHKPEPYCIVSHLQEDKKCFICNSQDPYHETLNPDSHLIENVVTTFAPNRL 108
beta2 RLTASSTCGLNGPQPYCIVSHLQDEKKCFLCDSRRPFSARDNPHSHRIQNVVTSFAPQRR 120
beta4 QLMASSTCGLSRAQKYCILSYLEGEQKCFICDSRFPYDPYDQPNSHTIENVIVSFEPDRE 101
beta3 FLRASSTCGLTKPETYCTQ-YGEWQMKCCKCDSRQPHNYY----SHRVENVASSSGPMR- 93
* .:***** .: ** : : : ** *:*: *. ** ::** : * *
beta1 KIWWQSENGVENVTIQLDLEAEFHFTHLIMTFKTFRPAAMLIERSSDFGKTWGVYRYFAY 168
beta2 AAWWQSENGIPAVTIQLDLEAEFHFTHLIMTFKTFRPAAMLVERSADFGRTWHVYRYFSY 180
beta4 KKWWQSENGLDHVSIRLDLEALFRFSHLILTFKTFRPAAMLVERSTDYGHNWKVFKYFAK 161
beta3 --WWQSQNDVNPVSLQLDLDRRFQLQEVMMEFQGPMPAGMLIERSSDFGKTWRVYQYLAA 151
****:*.: *:::***: *:: .::: *: **.**:***:*:*:.* *::*::
beta1 DCEASFPGISTGPMKKVDDIICDSRYSDIEPSTEG-EVIFRALDPAFKIEDPYSPRIQNL 227
beta2 DCGADFPGVPLAPPRHWDDVVCESRYSEIEPSTEG-EVIYRVLDPAIPIPDPYSSRIQNL 239
beta4 DCATSFPNITSGQAQGVGDIVCDSKYSDIEPSTGG-EVVLKVLDPSFEIENPYSPYIQDL 220
beta3 DCTSTFPRVRQGRPQSWQDVRCQSLPQRPNARLNGGKVQLNLMDLVSGIPATQSQKIQEV 211
** : ** : . : *: *:* . :. * :* . :* * . * **::
beta1 LKITNLRIKFVKLHTLGDNLLDSRM-EIREKYYYAVYDMVVRGNCFCYGHASECAPVDGF 286
beta2 LKITNLRVNLTRLHTLGDNLLDPRR-EIREKYYYALYELVVRGNCFCYGHASECAPAPGA 298
beta4 VTLTNLRINFTKLHTLGDALLGRRQNDSLDKYYYALYEMIVRGSCFCNGHASECRPMQKM 280
beta3 GEITNLRVNFTRLAPVPQRGYHPPS------AYYAVSQLRLQGSCFCHGHADRCAPKPGA 265
:****:::.:* .: : ***: :: ::*.*** ***..* *
beta1 N---EEVEGMVHGHCMCRHNTKGLNCELCMDFYHDLPWRPAEGRNSNACKKCNCNEHSIS 343
beta2 P---AHAEGMVHGACICKHNTRGLNCEQCQDFYRDLPWRPAEDGHSHACRKCECHGHTHS 355
beta4 RGDVFSPPGMVHGQCVCQHNTDGPNCERCKDFFQDAPWRPAADLQDNACRSCSCNSHSSR 340
beta3 SAG-PSTAVQVHDVCVCQHNTAGPNCERCAPFYNNRPWRPAEGQDAHECQRCDCNGHSET 324
**. *:*:*** * *** * *:.: ***** . . : *: *.*: *:
beta1 CHFDMAVYLATGNVSGGVCDDCQHNTMGRNCEQCKPFYYQHPERDIRDPNFCERCTCDPA 403
beta2 CHFDMAVYLASGNVSGGVCDGCQHNTAGRHCELCRPFFYRDPTKDLRDPAVCRSCDCDPM 415
beta4 CHFDMTTYLASGGLSGGVCEDCQHNTEGQHCDRCRPLFYRDPLKTISDPYACIPCECDPD 400
beta3 CHFDPAVFAASQGAYGGVCDNCRDHTEGKNCERCQLHYFRNRRPGASIQETCISCECDPD 384
**** :.: *: . ****:.*:.:* *::*: *: :::. * * ***
beta1 GSQNEGICDSYTDFSTGLIAGQCRCKLNVEGEHCDVCKEGFYDLSSEDPFGCKSCACNPL 463
beta2 GSQDGGRCDSHDDPALGLVSGQCRCKEHVVGTRCQQCRDGFFGLSISDRLGCRRCQCNAR 475
beta4 GTISGGICVSHSDPALGSVAGQCLCKENVEGAKCDQCKPNHYGLSATDPLGCQPCDCNPL 460
beta3 GAVPGAPCDP--------VTGQCVCKEHVQGERCDLCKPGFTGLTYANPQGCHRCDCNIL 436
*: . * . ::*** ** :* * :*: *: .. .*: : **: * **
beta1 GTIPGGNPCDSETGHCYCKRLVTGQHCDQCLPEHWGLSNDLDGCRPCDCDLGGALNNSCF 523
beta2 GTVPGSTPCDPNSGSCYCKRLVTGRGCDRCLPGHWGLSHDLLGCRPCDCDVGGALDPQCD 535
beta4 GSLP-FLTCDVDTGQCLCLSYVTGAHCEECTVGYWGLGNHLHGCSPCDCDIGGAYSNVCS 519
beta3 GSRR-------------------------------------------------------- 440
*:
beta1 AESGQCSCRPHMIGRQCNEVEPGYYFATLDHYLYEAEEAN--------------LGPGVS 569
beta2 EGTGQCHCRQHMVGRRCEQVQPGYFRPFLDHLIWEAEDT---------------RGQVLD 580
beta4 PKNGQCECRPHVTGRSCSEPAPGYFFAPLNFYLYEAEEATTLQGLAPLGSETFGQSPAVH 579
beta3 ------------------------------------------------------------
beta1 IVERQYIQDRIPSWTGAGFVRVPEGAYLEFFIDNIPYSMEYDILIRYEPQLPDHWEKAVI 629
beta2 VVERLVTPGETPSWTGSGFVRLQEGQTLEFLVASVPKAMDYDLLLRLEPQVPEQWAELEL 640
beta4 VVLGEPVPGNPVTWTGPGFARVLPGAGLRFAVNNIPFPVDFTIAIHYETQSAADWT-VQI 638
beta3 ------------------------------------------------------------
beta1 TVQRPGRIPTSSRCGNTIPDDDNQVVSLSPGSRYVVLPRPVCFEKGTNYTVRLELPQYTS 689
beta2 IVQRPGPVPAHSLCGHLVPKDDRIQGTLQPHARYLIFPNPVCLEPGISYKLHLKLVR-TG 699
beta4 VVNPPG---GSEHCIPKTLQSKPQSFALPAATRIMLLPTPICLEPDVQYSIDVYFSQPLQ 695
beta3 ------------------------------------------------------------
beta1 SDSDVESPYT----LIDSLVLMPYCKSLDIFTVGGSGDGVVTNSAWETFQRYRCLENSRS 745
beta2 GSAQPETPYSGPGLLIDSLVLLPRVLVLEMFSGGD----AAALERQATFERYQCHEEGLV 755
beta4 GESHAHSHVL-----VDSLGLIPQINSLENF---------CSKQDLDEYQLHNCVEIASA 741
beta3 ------------------------------------------------------------
beta1 VVKTPMTDVCRNIIFSISALLHQTGLACECDPQGSLSSVCDPNGGQCQCRPNVVGRTCNR 805
beta2 PSKTSPSEACAPLLISLSTLIYNGALPCQCNPQGSLSSECNPHGGQCLCKPGVVGRRCDL 815
beta4 MGPQVLPGACERLIISMSAKLHDGAVACKCHPQGSVGSSCSRLGGQCQCKPLVVGRCCDR 801
beta3 ------------------------------------------------------------
beta1 CAPGTFGFGPSGCKPCECHLQGSVNAFCNPVTGQCHCFQGVYARQCDRCLPGHWGFPSCQ 865
beta2 CAPGYYGFGPTGCQACQCSHEGALSSLCEKTSGQCLCRTGAFGLRCDRCQRGQWGFPSCR 875
beta4 CSTGSYDLGHHGCHPCHCHPQGSKDTVCDQVTGQCPCHGEVSGRRCDRCLAGYFGFPSCH 861
beta3 ------------------------------------------------------------
beta1 PCQCNGHADDCDPVTGECLNCQDYTMGHNCERCLAGYYGDPIIGSGDHCRPCPCPDGPDS 925
beta2 PCVCNGHADECNTHTGACLGCRDHTGGEHCERCIAGFHGDPRLPYGGQCRPCPCPEGPGS 935
beta4 PCPCNRFAELCDPETGSCFNCGGFTTGRNCERCIDGYYGNP--SSGQPCRPCLCPDDPSS 919
beta3 ------------------------------------------------------------
beta1 GRQFARSCYQDPVTLQLACVCDPGYIGSRCDDCASGYFGNPSEVGGSCQPCQCHNNIDTT 985
beta2 QRHFATSCHQDEYSQQIVCHCRAGYTGLRCEACAPGHFGDPSRPGGRCQLCECSGNIDPM 995
beta4 NQYFAHSCYQNLWSSDVICNCLQGYTGTQCGECSTGFYGNPRISGAPCQPCACNNNIDVT 979
beta3 ------------------------------------------------------------
beta1 DPEACDKETGRCLKCLYHTEGEHCQFCRFGYYGDALRQDCRKCVCNYLGTVQEHCN-GSD 1044
beta2 DPDACDPHTGQCLRCLHHTEGPHCAHCKPGFHGQAARQSCHRCTCNLLGTNPQQCP-SPD 1054
beta4 DPESCSRVTGECLRCLHNTQGANCQLCKPGHYGSALNQTCRRCSCHASGVSPMECPPGGG 1039
beta3 ------------------------------------------------------------
beta1 -CQCDKATGQCLCLPNVIGQNCDRCAPNTWQLASGTGCDPCNCNAAHSFGPSCNEFTGQC 1103
beta2 QCHCDPSSGQCPCLPNVQGPSCDRCAPNFWNLTSGHGCQPCACHPSRARGPTCNEFTGQC 1114
beta4 ACLCDPVTGACPCLPNVTGLACDRCADGYWNLVPGRGCQSCDCDPRTSQSSHCDQLTGQC 1099
beta3 DMPCDEESGRCLCLPNVVGPKCDQCAPYHWKLASGQGCEPCACDPHNSLSPQCNQFTGQC 500
** :* * ***** * **:** *:*..* **:.* *.. : .. *:::****
beta1 QCMPGFGGRTCS-----ECQELFWGDPDVECRACDCDPRGIETPQCDQSTGQCVCVEGVE 1158
beta2 HCRAGFGGRTCS-----ECQELHWGDPGLQCHACDCDSRGIDTPQCHRFTGHCSCRPGVS 1169
beta4 PCKLGYGGKRCS-----ECQENYYGDPPGRCIPCDCNRAGTQKPICDPDTGMCRCREGVS 1154
beta3 PCREGFGGLMCSAAAIRQCPDRTYGDVATGCRACDCDFRGTEGPGCDKASGRCLCRPGLT 560
* *:** ** :* : :** * .***: * : * *. :* * * *:
beta1 GPRCDKCTRGYSGVFPDCTPCHQCFALWDVIIAELTNRTHRFLEKAKALK-ISG-VIGPY 1216
beta2 GVRCDQCARGFSGIFPACHPCHACFGDWDRVVQDLAARTQRLEQRAQELQ-QTG-VLGAF 1227
beta4 GQRCDRCARGHSQEFPTCLQCHLCFDQWDHTISSLSKAVQGLMRLAANME-DKRETLPVC 1213
beta3 GPRCDQCQRGYCNRYPVCVACHPCFQTYDADLREQALRFGRLRNATASLWSGPGLEDRGL 620
* ***:* **.. :* * ** ** :* : . : : . : :
beta1 RETVDSVERKVSEIKDIL-AQSPAAEPLKNIGNLFEEAEKLIKDVTEMMAQVEVKLSDTT 1275
beta2 ESSFWHMQEKLGIVQGIVGARNTSAASTAQLVEATEELRREIGEATEHLTQLEADLTDVQ 1287
beta4 EADFKDLRGNVSEIERILKHPVFPSGKFLKVKDYHDSVRRQIMQLNEQLKAVY-EFQDLK 1272
beta3 ASRILDAKSKIEQIRAVLSSPAVTEQEVAQVASAILSLRRTLQGLQLDLPLEEETLSLPR 680
. . :: :. :: . :: . . .: : : :
beta1 SQSNSTAKELDSLQTEAESLDNTVKELAEQLEFIKNSDIRGALDSITKYFQMSLEAEERV 1335
beta2 DENFNANHALSGLERDRLALNLTLRQLDQHLDLLKHSNFLGAYDSIRHAHSQSAEAERRA 1347
beta4 DTIERAKNEADLLLED-------LQEEIDLQSSVLNASIADSSENIKKYYHISSSAEKKI 1325
beta3 --------DLESLDRSFNGLLTMYQRKREQFEKISSADPSGAFRMLSTAYEQSAQAAQQV 732
. * . :. : . : :. .: : . * .* .:
beta1 NASTTEPNSTVEQSALMRDRVEDVMMERESQFKEKQEEQARLLDELAGKLQSLDLSAAAE 1395
beta2 NTSALAVPSPVSNSASARHRTEALMDAQKEDFNSKHMANQRALGKLSAHTHTLSLTDINE 1407
beta4 N----ETSSTINTSANTRNDLLTILDTLTS--------KGNLSLERLKQIKIPDIQILNE 1373
beta3 S----DSSRLLDQLRDSRREAERLVRQAGG---GGGTGSPKLVALRLEMSSLPDLTPTFN 785
. :. * :: . . .: :
beta1 MTCGTPPGASCSETECGGPNCRTDEGERKCGGPGCGGLVTVAHNAWQKAMDLDQDVLSAL 1455
beta2 LVCGAPGDAPCATSPCGGAGCRDEDGQPRCGGLSCNGAAATADLALGRARHTQAELQRAL 1467
beta4 KVCGDPGNVPCVPLPCGGALCTGRKGHRKCRGPGCHGSLTLSTNALQKAQEAKSIIRNLD 1433
beta3 KLCGNSRQMACTPISCPGELCPQDNG--TACGSRCRGVLPRAGGAFLMAGQVAEQLRGFN 843
** . .* * * * .* . * * * . : * * . :
beta1 AEVEQLSKMVSEAKLRADEAKQSAEDILLKTNATKEKMDKSNEELRNLIKQIRNFLTQDS 1515
beta2 AEGGSILSRVAETRRQASEAQQRAQAALDKANASRGQVEQANQELQELIQSVKDFLNQEG 1527
beta4 KQVRGLKNQIESISEQAEVSKNNALQLREKLGNIRNQSDSEEENINLFIKKVKNFLLEEN 1493
beta3 AQLQRTRQMIRAAEESASQIQSSAQRLETQVSASRSQMEEDVRRTRLLIQQVRDFLTDPD 903
: . : *. :. * : . : : :. .. . :*:.:::** : .
beta1 ADLDSIEAVANEVLKMEMPSTPQQLQNLTEDIRERVESLSQVEVILQHSAADIARAEMLL 1575
beta2 ADPDSIEMVATRVLELSIPASAEQIQHLAGAIAERVRSLADVDAILARTVGDVRRAEQLL 1587
beta4 VPPEDIEKVANGVLDIHLPIPSQNLTDELVKIQKHMQLCEDYRTDENRLNEEADGAQKLL 1553
beta3 TDAATIQEVSEAVLALWLPTDSATVLQKMNEIQAIAARLPNVDLVLSQTKQDIARARRLQ 963
. *: *: ** : :* . : . * : : : *. *
beta1 EEAKRASKSATDVKVTADMVKEALEEAEKAQVAAEKAIKQADEDIQGTQNLLTSIESETA 1635
beta2 QDARRARSWAEDEKQKAETVQAALEEAQRAQGIAQGAIRGAVADTRDTEQTLYQVQERMA 1647
beta4 VKAKAAEKAAN-ILLNLDKTLNQLQQAQITQGRANSTITQLTANITKIKKNVLQAENQTR 1612
beta3 AEAEEARSRAHAVEGQVEDVVGNLRQGTVALQEAQDTMQGTSRSLRLIQDRVAEVQQVLR 1023
.*. * . * : . *.:. : *: :: . :. : . :.
beta1 ASEETLFNASQRISELERNVEELKRKAAQNSGEAEYIEKVVYTVKQSAEDVKKTLDGELD 1695
beta2 GAERALSSAGERARQLDALLEALKLKRAGNSLAASTAEETAGSAQGRAQEAEQLLRGPLG 1707
beta4 EMKSELELAKQRS-GLEDGLSLLQTKLQRHQDHAVNAKVQAESAQHQAGSLEKEFV-ELK 1670
beta3 PAEKLVTSMTKQLGDFWTRMEELRHQARQQGAEAVQAQQLAEGASEQALSAQEGFERIKQ 1083
: : :: : :. *: : : * : . .. * . :: :
beta1 EKYKKVENLIAKKTEESADARRKAEMLQNEAKTLLAQANSKLQLLKDLERKYEDNQRYLE 1755
beta2 DQYQTVKALAERKAQGVLAAQARAEQLRDEARDLLQAAQDKLQRLQELEGTYEENERALE 1767
beta4 KQYAILQRKTS-TTGLTKETLGKVKQLKDAAEKLAGDTEAKIRRITDLERKIQDLNLSRQ 1729
beta3 KYAELKDRLGQ--SSMLGEQGARIQSVKTEAEELFGETMEMMDRMKDMELELLRGSQAIM 1141
. . : : : :: *. * : : : ::* .
beta1 DKAQELARLEGEVRSLLKDISQKVAVYSTCL- 1786
beta2 SKAAQLDGLEARMRSVLQAINLQVQIYNTCQ- 1798
beta4 AKADQLRILEDQVVAIKNEIVEQEKKYARCYS 1761
beta3 LRSADLTGLEKRVEQIRDHINGRVLYYATCK- 1172
:: :* ** .: : . * : * *
Accession numbers of the laminin beta subunits used in the protein sequence alignment: NP_002282 laminin, beta 1; NP_002283 laminin, beta 2; NP_001017402 laminin subunit beta 3; NP_031382 laminin, beta 4
laminin gamma subunit
gamma2a ------------------------------------------------------------
gamma2b ------------------------------------------------------------
gamma1 MRGSHRAAPALRPRGRLWPVLAVLAAAAAAGCAQAAMDECTDEGGRPQRCMPEFVNAAFN 60
gamma3 -----------MAAAALLLGLALLAPRAAG----AGMGACYDGAGRPQRCLPVFENAAFG 45
gamma2a ------------------------------------------------------------
gamma2b ------------------------------------------------------------
gamma1 VTVVATNTCGTPPEEYCVQTGVTGVTKSCHLCDAGQPHLQHGAAFLTDYNNQADTTWWQS 120
gamma3 RLAQASHTCGSPPEDFCPHVGAAGAGAHCQRCDAADPQRHHNASYLTDFHSQDESTWWQS 105
gamma2a ------------------------------------------------------------
gamma2b ------------------------------------------------------------
gamma1 QTMLAGVQYPSSINLTLHLGKAFDITYVRLKFHTSRPESFAIYKRTREDGPWIPYQYYSG 180
gamma3 PSMAFGVQYPTSVNITLRLGKAYEITYVRLKFHTSRPESFAIYKRSRADGPWEPYQFYSA 165
gamma2a ------------------------------------------------------------
gamma2b ------------------------------------------------------------
gamma1 SCENTYSKANRGFIRTGGDEQQALCTDEFSDISPLTGGNVAFSTLEGRPSAYNFDNSPVL 240
gamma3 SCQKTYGRPEGQYLRPGEDERVAFCTSEFSDISPLSGGNVAFSTLEGRPSAYNFEESPGL 225
gamma2a ------------------------------------MPALWLG----------------- 7
gamma2b ------------------------------------MPALWLG----------------- 7
gamma1 QEWVTATDIRVTLNRLNTFGDEVFNDPKVLKSYYYAISDFAVGGRCKCNGHASECMKNEF 300
gamma3 QEWVTSTELLISLDRLNTFGDDIFKDPKVLQSYYYAVSDFSVGGRCKCNGHASECGPDVA 285
:. : :*
gamma2a -----------------CCLCFSLLLPAARATSRRE----VCDCNGKSRQCIFDRELHRQ 46
gamma2b -----------------CCLCFSLLLPAARATSRRE----VCDCNGKSRQCIFDRELHRQ 46
gamma1 DKLVCNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRS 360
gamma3 GQLACRCQHNTTGTDCERCLPFFQDRPWARGTAEAAHECLPCNCSGRSEECTFDRELFRS 345
** * * *.*:. *:*.*:*.:* ** **.*.
gamma2a TGNGFRCLNCNDNTDGIHCEKCKNGFYRHRERDRCLPCNCNSKGSLSARCDNSGRCSCKP 106
gamma2b TGNGFRCLNCNDNTDGIHCEKCKNGFYRHRERDRCLPCNCNSKGSLSARCDNSGRCSCKP 106
gamma1 TGHGGHCTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSPVGSLSTQCDSYGRCSCKP 420
gamma3 TGHGGRCHHCRDHTAGPHCERCQENFYHWDPRMPCQPCDCQSAGSLHLQCDDTGTCACKP 405
**:* :* :*.*:* * ***:*::.*:: . * .*.*.. *** :**. * *:***
gamma2a GVTGARCDRCLPGFHMLTDAGCTQDQRLLDSKCDCDPAGIAGPC--DAGRCVCKPAVTGE 164
gamma2b GVTGARCDRCLPGFHMLTDAGCTQDQRLLDSKCDCDPAGIAGPC--DAGRCVCKPAVTGE 164
gamma1 GVMGDKCDRCQPGFHSLTEAGCRP--------CSCDPSGSIDECNIETGRCVCKDNVEGF 472
gamma3 TVTGWKCDRCLPGFHSLSEGGCRP--------CTCNPAGSLDTCDPRSGRCPCKENVEGN 457
* * :**** **** *::.** * *:*:* . * :*** ** * *
gamma2a RCDRCRSGYYNLDGGNPEGCTQCFCYGHSASCRSSAEYSVHKITSTFHQDVDGWKAVQRN 224
gamma2b RCDRCRSGYYNLDGGNPEGCTQCFCYGHSASCRSSAEYSVHKITSTFHQDVDGWKAVQRN 224
gamma1 NCERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISSTFQIDEDGWRAEQRD 532
gamma3 LCDRCRPGTFNLQPHNPAGCSSCFCYGHSKVCASTAQFQVHHILSDFHQGAEGWWARSVG 517
*:**:.* :**: ** **: ***:*** * .:. :.*: * * *: . :** * . .
gamma2a GSPAKLQWSQRHQDVFSSAQRLDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSA 284
gamma2b GSPAKLQWSQRHQDVFSSAQRLDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSA 284
gamma1 GSEASLEWSSERQDIAVISDSYFPRYFIAPAKFLGKQVLSYGQNLSFSFRVDRRDTRLSA 592
gamma3 GSEHPPQWSP--NGVLLSPE--DEEELTAPEKFLGDQRFSYGQPLILTFRVPPGD-SPLP 572
** :** :.: .: : ** ****.* .**** * : :** . .
gamma2a HDVILEGAGLRITAPLMPLGKTLPCGLTKTYTFRLN-EHPSNNWSPQLSYFEYRRLLRNL 343
gamma2b HDVILEGAGLRITAPLMPLGKTLPCGLTKTYTFRLN-EHPSNNWSPQLSYFEYRRLLRNL 343
gamma1 EDLVLEGAGLRVSVPLIAQGNSYPSETTVKYVFRLH-EATDYPWRPALTPFEFQKLLNNL 651
gamma3 VQLRLEGTGLALSLRHSSLSGPQDAGHPREVELRFHLQETSEDVAPPLPPFHFQRLLANL 632
:: ***:** :: . . . . . :*:: : .. * *. *.:::** **
gamma2a TALRIRATYGEYSTG--YIDNVTLISARPVSGAPAPWVEQCICPVGYKGQFCQDCASGYK 401
gamma2b TALRIRATYGEYSTG--YIDNVTLISARPVSGAPAPWVEQCICPVGYKGQFCQDCASGYK 401
gamma1 TSIKIRGTYSERSAG--YLDDVTLASARPGPGVPATWVESCTCPVGYGGQFCEMCLSGYR 709
gamma3 TSLRLRVSPGPSPAGPVFLTEVRLTSARPGLSPPASWVEICSCPTGYTGQFCESCAPGYK 692
*::::* : . .:* :: :* * **** . **.*** * **.** ****: * .**:
gamma2a RDSARLGPFGTCIPCNCQGG-GACDPDTGDCYSGDENPDIECADCPIGFYNDPHDPRS-- 458
gamma2b RDSARLGPFGTCIPCNCQGG-GACDPDTGDCYSGDENPDIECADCPIGFYNDPHDPRS-- 458
gamma1 RETPNLGPYSPCVLCACNGHSETCDPETGVCNCRDNTAGPHCEKCSDGYYGDSTAGTSSD 769
gamma3 REMPQGGPYASCVPCTCNQH-GTCDPNTGICVCSHHTEGPSCERCLPGFYGNPFAGQADD 751
*: .. **:..*: * *: :***:** * . ... . * * *:*.:. :
gamma2a CKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQ 518
gamma2b CKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQ 518
gamma1 CQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQ 829
gamma3 CQPCPCPGQSACTTIPESREVVCTHCPPGQRGRRCEVCDDGFFGDPLGLFGHPQPCHQCQ 811
*:**** . :*:.:*::.****.:**.* * ***:* **:****:* * : *: **
gamma2a CNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACNCN-- 576
gamma2b CNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACNCN-- 576
gamma1 CSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLY 889
gamma3 CSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHCEHCQEGFYGSALAPRPADKCMPCSCHPQ 871
*..*:**.* ***: *:*.**:*::**:* :*::*: *::*..***.***** .*.*:
gamma2a ------------------------------------------------------------
gamma2b ------------------------------------------------------------
gamma1 GTMKQQSSCNPVTGQCECLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDI 949
gamma3 GSVSEQMPCDPVTGQCSCLPHVTARDCSRCYPGFFDLQPGRGCRSCKCHPLGSQEDQCHP 931
gamma2a -------------------------------------PMGSEPVGCRSDGTCVCKPGFGG 599
gamma2b -------------------------------------PMGSEPVGCRSDGTCVCKPGFGG 599
gamma1 RTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKDDGRCECREGFVG 1009
gamma3 KTGQCTCRPGVTGQACDRCQLGFFGFSIKGCRACRCSPLGAASAQCHENGTCVCRPGFEG 991
* *: . *:.:* * *: ** *
gamma2a PNCEH------------GAFSCPACYNQVKIQMDQFMQQLQRMEALISKAQGGDGVVPDT 647
gamma2b PNCEH------------GAFSCPACYNQVKIQMDQFMQQLQRMEALISKAQGGDGVVPDT 647
gamma1 NRCDQCEENYFYNRSWPGCQECPACYRLVKDKVADHRVKLQELESLIANLGTGDEMVTDQ 1069
gamma3 YKCDRCHDNFFLTADGTHCQQCPSCYALVKEEAAKLKARLTLTEGWLQGSDCGSPWGPLD 1051
.*:: . .**:** ** : . :* *. : *. .
gamma2a ELEGRMQQAEQALQDILRDAQISEGASRSLGLQLAKVRSQENSYQSRLDDLKMTVERVRA 707
gamma2b ELEGRMQQAEQALQDILRDAQISEGASRSLGLQLAKVRSQENSYQSRLDDLKMTVERVRA 707
gamma1 AFEDRLKEAEREVMDLLREAQDVKDVDQNLMDRLQRVNNTLSSQISRLQNIRNTIEETGN 1129
gamma3 ILLG-----EAPRGDVYQGHHLLPGAREAFLEQMMSLEGAVKAAREQLQRLNKGARCAQA 1106
: . * *: : : .. . : :: :.. .: .:*: :. . .
gamma2a LGSQYQNRVRDTHRLITQMQLSLAESEASLGNTNIPASDHYVGPNGFKSLAQEATRLAES 767
gamma2b LGSQYQNRVRDTHRLITQMQLSLAESEASLGNTNIPASDHYVGPNGFKSLAQEATRLAES 767
gamma1 LAEQARAHVENTERLIEIASRELEKAKVAAANVSVTQPESTGDPNNMTLLAEEARKLAER 1189
gamma3 GSQKTCTQLADLEAVLESSEEEILHAAAILASLEIPQ-EGPSQPTKWSHLATEARALARS 1165
..: :: : . :: . .: .: . .. .:. : *. . ** ** **.
gamma2a HVESASNMEQLTRETEDYSKQALSLVRKALHEGVGSGSGSPDGAVVQGLVEKLEKTKSLA 827
gamma2b HVESASNMEQLTRETEDYSKQALSLVRKALHEGVGSGSGSPDGAVVQGLVEKLEKTKSLA 827
gamma1 HKQEADDIVRVAKTANDTSTEAYNLLLRTLAG------ENQTAFEIEELNRKYEQAKNIS 1243
gamma3 HRDTATKIAATAWRALLASNTSYALLWNLLEG-------RVALETQRDLEDRYQEVQAAQ 1218
* : * .: : : *. : *: . * . * : ::.:
gamma2a QQLTREATQAEIEADRSYQHSLRLLDSVSRLQGVSDQSFQVEEAKRIKQKADSLSTLVTR 887
gamma2b QQLTREATQAEIEADRSYQHSLRLLDSVSRLQGVSDQSFQVEEAKRIKQKADSLSTLVTR 887
gamma1 QDLEKQAARVHEEAKRAGDKAVEIYASVAQLSPLDSETLENEANN-IKMEAENLEQLIDQ 1302
gamma3 KALRTAVAEVLPEAESVLATVQQVGADTAPYLAL----LASPGALPQKSRAEDLGLKAKA 1274
: * .:.. **. .: ..: : : * .*:.*
gamma2a HMDEFKRTQKNLGNWKEEAQQLLQNGKSGREKSDQLLSRANLAKSRAQEALSMGNATFYE 947
gamma2b HMDEFKRTQKNLGNWKEEAQQLLQNGKSGREKSDQLLSRANLAKSRAQEALSMGNATFYE 947
gamma1 KLKDYEDLREDMRGKELEVKNLLEKGKTEQQTADQLLARADAAKALAEEAAKKGRDTLQE 1362
gamma3 LEKTVASWQHMATEAARTLQTAAQATLRQTEPLTKLHQEARAALTQASSSVQAATVTVMG 1334
. :. : : : :* .* * : *..: . . *.
gamma2a VESILKNLREFDLQVDNRKAEAEEAMKRLSYISQKVSDASDKTQQAERALGSAAADAQRA 1007
gamma2b VESILKNLREFDLQVDNRKAEAEEAMKRLSYISQKVSDASDKTQQAERALGSAAADAQRA 1007
gamma1 ANDILNNLKDFDRRVNDNKTAAEEALRKIPAINQTITEANEKTREAQQALGSAAADATEA 1422
gamma3 ARTLLADLEGMKLQFPRPKDQAALQRKADSVSDRLLADTRKKTKQAERMLGNAAPLSSSA 1394
.. :* :*. :. :. * * : . .: :::: .**::*:: **.**. : *
gamma2a KNGAGEALEISSEIEQEIGSLNLEANVTADGALAMEKGLASLKSEMREVEGELERKELEF 1067
gamma2b KNGAGEALEISSEIEQEIGSLNLEANVTADGALAMEKGLASLKSEMREVEGELERKELEF 1067
gamma1 KNKAHEAERIASAVQKNATSTKAEAERTFAEVTDLDNEVNNMLKQLQEAEKELKRKQDDA 1482
gamma3 KKKGREAEVLAKDSAKLAKALLRERKQAHRRASRLTSQTQATLQQASQQVLASEARR--- 1451
*: . ** ::. : : * : : . : . .: : : :.
gamma2a DTNMDAVQMVITEAQKVDTRAKNAGVTIQDTLNTLDGLLHLMDQPLSVDE--EGLVLLEQ 1125
gamma2b DTNMDAVQMVITEAQKVDTRAKNAGVTIQDTLNTLDGLLHLMGM---------------- 1111
gamma1 DQDMMMAGMASQAAQEAEINARKAKNSVTSLLSIINDLLEQLGQLDTVDL--NKLNEIEG 1540
gamma3 -QELEEAERVGAGLSEMEQQIRESRISLEKDIETLSELLARLGSLDTHQAPAQALNETQW 1510
:: . . .: : . ::: :: . :. :. ** :.
gamma2a KLSRAKTQINS--QLRPMMSELEERARQQRGHLHLLETSIDGILADVKNLENIRDNLPPG 1183
gamma2b ------------------------------------------------------------
gamma1 TLNKAKDEMKVS-DLDRKVSDLENEAKKQEAAIMDYNRDIEEIMKDIRNLEDIRKTLPSG 1599
gamma3 ALERLRLQLGSPGSLQRKLSLLEQESQQQELQIQGFESDLAEIRADKQNLEAILHSLPEN 1570
gamma2a CYNTQALEQQ 1193
gamma2b ----------
gamma1 CFNTPSIEKP 1609
gamma3 CASWQ----- 1575
Accession numbers of the laminin gamma subunits used in the protein sequence alignment: NP_002284 laminin, gamma 1; NP_005553 laminin, gamma 2 isoform a;
NP_061486 laminin, gamma 2 isoform b; NP_006050 laminin, gamma 3
Predicted General Properties of the Laminin Protein (Homo sapiens) - Primary Sequence Analysis (with ProtParam) b
alpha1 subunit
Number of amino acids: 3075
Molecular weight: 337083.8
Theoretical pI: 5.93
Total number of negatively charged residues (Asp + Glu): 357
Total number of positively charged residues (Arg + Lys): 301
Atomic composition: Carbon C 14587 Hydrogen H 23009 Nitrogen N 4187 Oxygen O 4590 Sulfur S 206
Formula: C14587H23009N4187O4590S206
Total number of atoms: 46579
Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 288395 Abs 0.1% (=1 g/l) 0.856, assuming ALL Cys residues appear as half cystines Ext. coefficient 278020 Abs 0.1% (=1 g/l) 0.825, assuming NO Cys residues appear as half cystines
Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).
Instability index: The instability index (II) is computed to be 40.96 This classifies the protein as unstable.
Aliphatic index: 77.65
Grand average of hydropathicity (GRAVY): -0.335
beta1 subunit
Number of amino acids: 1786
Molecular weight: 198066.4
Theoretical pI: 4.84
Total number of negatively charged residues (Asp + Glu): 271
Total number of positively charged residues (Arg + Lys): 174
Atomic composition: Carbon C 8471 Hydrogen H 13260 Nitrogen N 2398 Oxygen O 2767 Sulfur S 159
Formula: C8471H13260N2398O2767S159
Total number of atoms: 27055 Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 162815 Abs 0.1% (=1 g/l) 0.822, assuming ALL Cys residues appear as half cystines Ext. coefficient 154940 Abs 0.1% (=1 g/l) 0.782, assuming NO Cys residues appear as half cystines
Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).
Instability index: The instability index (II) is computed to be 43.48 This classifies the protein as unstable.
Aliphatic index: 67.78
Grand average of hydropathicity (GRAVY): -0.469
gamma1 subunit
Number of amino acids: 1609
Molecular weight: 177602.8
Theoretical pI: 5.01
Total number of negatively charged residues (Asp + Glu): 241
Total number of positively charged residues (Arg + Lys): 177
Atomic composition: Carbon C 7540 Hydrogen H 11871 Nitrogen N 2217 Oxygen O 2507 Sulfur S 122
Formula: C7540H11871N2217O2507S122
Total number of atoms: 24257
Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 133800 Abs 0.1% (=1 g/l) 0.753, assuming ALL Cys residues appear as half cystines Ext. coefficient 127550 Abs 0.1% (=1 g/l) 0.718, assuming NO Cys residues appear as half cystines
Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).
Instability index: The instability index (II) is computed to be 43.53 This classifies the protein as unstable.
Aliphatic index: 63.00
Grand average of hydropathicity (GRAVY): -0.615