Sequence Alignment of the Integrin Protein (with Clustalw)a
Isoform Sequence Alignment (Homo sapiens)
of Integrins
alpha subunits:
alpha1 MAP-RPRARPGVAVACCWLLTVVLRCCVSFNVDVKNSMTFSGPVED-MFGYTVQQYENEE 58
alpha2 MGPERTGAAPLPLLLVLALSQGILNCCLAYNVGLPEAKIFSGPSSE-QFGYAVQQFINPK 59
alpha10 -------MELPFVTHLFLPLVFLTGLCSPFNLDEHHPRLFPGPPEA-EFGYSVLQHVGGG 52
alpha11 -------MDLPRGLVVAWALSLWPGFTDTFNMDTRKPRVIPGSRTA-FFGYTVQQHDISG 52
alphaD ------------MTFGTVLLLSVLASYHGFNLDVEEPTIFQEDAGG--FGQSVVQF---G 43
alphaX ----------MTRTRAALLLFTALATSLGFNLDTEELTAFRVDSAG--FGDSVVQY---A 45
alphaM -------------MALRVLLLTALTLCHGFNLDTENAMTFQENARG--FGQSVVQL---Q 42
alphaL ----MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQV---G 53
alpha8 ------------------------------------------------------------
alphaV ------------------------------------------------------------
alpha5 ------------------------------------------------------------
alpha2b ------------------------------------------------------------
alpha3a ------------------------------------------------------------
alpha3b ------------------------------------------------------------
alpha6a ------------------------------------------------------------
alpha6b ------------------------------------------------------------
alpha7 ------------------------------------------------------------
alpha4 ------------------------------------------------------------
alpha9 ------------------------------------------------------------
alphaE -----------MWLFHTLLCIASLALLAAFNVDVARPWLTPKGGAPFVLSSLLHQDPSTN 49
alpha1 GKWVLIGSPLVGQPKNRTG----------------------------------DVYKCPV 84
alpha2 GNWLLVGSPWSGFPENRMG----------------------------------DVYKCPV 85
alpha10 QRWMLVGAPWDGPSGDRRG----------------------------------DVYRCPV 78
alpha11 NKWLVVGAPLETNGYQKTG----------------------------------DVYKCPV 78
alphaD GSRLVVGAPLEVVAANQTG----------------------------------RLYDCAA 69
alphaX NSWVVVGAPQKITAANQTG----------------------------------GLYQCGY 71
alphaM GSRVVVGAPQEIVAANQRG----------------------------------SLYQCDY 68
alphaL NG-VIVGAPGE---GNSTG----------------------------------SLYQCQS 75
alpha8 ------------------------------------------------------------
alphaV ------------------------------------------------------------
alpha5 ------------------------------------------------------------
alpha2b ------------------------------------------------------------
alpha3a ------------------------------------------------------------
alpha3b ------------------------------------------------------------
alpha6a ------------------------------------------------------------
alpha6b ------------------------------------------------------------
alpha7 ------------------------------------------------------------
alpha4 ------------------------------------------------------------
alpha9 ------------------------------------------------------------
alphaE QTWLLVTSPRTKRTPGPLHRCSLVQDEILCHPVEHVPIPKGRHRGVTVVRSHHGVLICIQ 109
alpha1 GRGESLPCVKLDLPVNTSIPNVTEVKENMTFGSTLVTNP-NGGFLACGPLYA-YRCGHLH 142
alpha2 DLS-TATCEKLNLQTSTSIPNVTEMKTNMSLGLILTRNMGTGGFLTCGPLWA-QQCGNQY 143
alpha10 GGAHNAPCAKGHLG-DYQLGNSSHPAVNMHLGMSLLETDGDGGFMACAPLWS-RACGSSV 136
alpha11 IHGN---CTKLNLG-RVTLSNVSERKDNMRLGLSLATNPKDNSFLACSPLWS-HECGSSY 133
alphaD ATG---MCQPIPLHIRPEAVN-------MSLGLTLAASTNGSRLLACGPTLH-RVCGENS 118
alphaX STG---ACEPIGLQVPPEAVN-------MSLGLSLASTTSPSQLLACGPTVH-HECGRNM 120
alphaM STG---SCEPIRLQVPVEAVN-------MSLGLSLAATTSPPQLLACGPTVH-QTCSENT 117
alphaL GTG---HCLPVTLRG-SNYTS-------KYLGMTLATDPTDGSILACDPGLS-RTCDQNT 123
alpha8 ------------------------------------------------------------
alphaV ------------------------------------------------------------
alpha5 ------------------------------------------------------------
alpha2b ------------------------------------------------------------
alpha3a ------------------------------------------------------------
alpha3b ------------------------------------------------------------
alpha6a ------------------------------------------------------------
alpha6b ------------------------------------------------------------
alpha7 ------------------------------------------------------------
alpha4 ------------------------------------------------------------
alpha9 ------------------------------------------------------------
alphaE VLVRRPHSLSSELTGTCSLLGPDLRPQAQANFFDLENLLDPDARVDTGDCYSNKEGGGED 169
alpha1 YTTGICSDVSPT-FQVVNSIAP-VQECS-TQLDIVIVLDGSNSIYP--WDSVTAFLNDLL 197
alpha2 YTTGVCSDISPD-FQLSASFSPATQPCP-SLIDVVVVCDESNSIYP--WDAVKNFLEKFV 199
alpha10 FSSGICARVDAS-FQPQGSLAPTAQRCP-TYMDVVIVLDGSNSIYP--WSEVQTFLRRLV 192
alpha11 YTTGMCSRVNSN-FRFSKTVAPALQRCQ-TYMDIVIVLDGSNSIYP--WVEVQHFLINIL 189
alphaD YSKGSCLLLGSR-WEIIQTVPDATPECPHQEMDIVFLIDGSGSIDQNDFNQMKGFVQAVM 177
alphaX YLTGLCFLLGP--TQLTQRLPVSRQECPRQEQDIVFLIDGSGSISSRNFATMMNFVRAVI 178
alphaM YVKGLCFLFGSNLRQQPQKFPEALRGCPQEDSDIAFLIDGSGSIIPHDFRRMKEFVSTVM 177
alphaL YLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVM 183
alpha8 ------------------------MSPGASRGPRGSQAPLIAPLCCAAAALGMLLWSPAC 36
alphaV ------------------------MAFPPRRRLR--LGPRGLPLLLSGLLL------PLC 28
alpha5 --------------------MGSRTPESPLHAVQLRWGPRRRPPLLPLLLLLLPP-PPRV 39
alpha2b -------------------------------MARALCPLQALWLLEWVLLLLGPCAAPPA 29
alpha3a ------------------------------MGPGPSRAPRAPRLMLCALALMVAAGGCVV 30
alpha3b ------------------------------MGPGPSRAPRAPRLMLCALALMVAAGGCVV 30
alpha6a -----------------------------MAAAG--------QLCLLY--LSAGLLSRLG 21
alpha6b -----------------------------MAAAG--------QLCLLY--LSAGLLSRLG 21
alpha7 -----------------------------MAGARSRDPWGASGICYLFGSLLVELLFSRA 31
alpha4 -----------------------------MAWEARREPGPRRAAVRETVMLLLCLGVPTG 31
alpha9 -----------------------------MGGPAAPRGAGR---LRALLLALVVAGIPAG 28
alphaE DVNTARQRRALEKEEEEDKEEEEDEEEEEAGTEIAIILDGSGSIDPPDFQRAKDFISNMM 229
alpha1 ERMDIGPKQTQVGIVQYGENVTHEFNLNKYSSTEEVLVAAKKIVQRGGRQTMTALGIDTA 257
alpha2 QGLDIGPTKTQVGLIQYANNPRVVFNLNTYKTKEEMIVATSQTSQYGGDLTNTFGAIQYA 259
alpha10 GKLFIDPEQIQVGLVQYGESPVHEWSLGDFRTKEEVVRAAKNLSRREGRETKTAQAIMVA 252
alpha11 KKFYIGPGQIQVGVVQYGEDVVHEFHLNDYRSVKDVVEAASHIEQRGGTETRTAFGIEFA 249
alphaD GQFEG--TDTLFALMQYSNLLKIHFTFTQFRTSPSQQSLVDPIVQLKG-LTFTATGILTV 234
alphaX SQFQR--PSTQFSLMQFSNKFQTHFTFEEFRRSSNPLSLLASVHQLQG-FTYTATAIQNV 235
alphaM EQLKK--SKTLFSLMQYSEEFRIHFTFKEFQNNPNPRSLVKPITQLLG-RTHTATGIRKV 234
alphaL KKLSN--TSYQFAAVQFSTSYKTEFDFSDYVKWKDPDALLKHVKHMLL-LTNTFGAINYV 240
alpha8 QAFNLDVEK--LTVYSGPKGSYFGYAVDFHIPDART--ASVLVGAPKANTSQPDIV-EGG 91
alphaV RAFNLDVDS--PAEYSGPEGSYFGFAVDFFVPSASSR-MFLLVGAPKANTTQPGIV-EGG 84
alpha5 GGFNLDAEA--PAVLSGPPGSFFGFSVEFYRPGTDG--VSVLVGAPKANTSQPGVL-QGG 94
alpha2b WALNLDPVQ--LTFYAGPNGSQFGFSLDFHKDSHGR--VAIVVGAPR--TLGPSQE-ETG 82
alpha3a SAFNLDTRF-LVVKEAGNPGSLFGYSVALHRQTERQQRYLLLAGAPRELAVPDGYT-NRT 88
alpha3b SAFNLDTRF-LVVKEAGNPGSLFGYSVALHRQTERQQRYLLLAGAPRELAVPDGYT-NRT 88
alpha6a AAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRA-NRT 80
alpha6b AAFNLDTREDNVIRKYGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRA-NRT 80
alpha7 VAFNLDVMG--ALRKEGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQA-NRT 88
alpha4 RPYNVDTES--ALLYQGPHNTLFGYSVVLHSHGANR---WLLVGAPTANWLANASVINPG 86
alpha9 -AYNLDPQR--PVHFQGPADSFFGYAVLEHFHDNTR---WVLVGAPKADSKYSPSVKSPG 82
alphaE RNFYEKCFECNFALVQYGGVIQTEFDLRDSQDVMASLARVQNITQVGS-VTKTASAMQHV 288
: .
alpha1 RKEAFTEARGARRGVKKVMVIVTDGESHDNH-RLKKVIQDCEDENIQRFSIAILGSYNRG 316
alpha2 RKYAYSAASGGRRSATKVMVVVTDGESHDGS-MLKAVIDQCNHDNILRFGIAVLGYLNRN 318
alpha10 CTEGFSQSHGGRPEAARLLVVVTDGESHDGE-ELPAALKACEAGRVTRYGIAVLGHYLRR 311
alpha11 RSEAFQK--GGRKGAKKVMIVITDGESHDSP-DLEKVIQQSERDNVTRYAVAVLGYYNRR 306
alphaD VTQLFHHKNGARKSAKKILIVITDGQKYKDPLEYSDVIPQAEKAGIIRYAIGVG-----H 289
alphaX VHRLFHASYGARRDAAKILIVITDGKKEGDSLDYKDVIPMADAAGIIRYAIGVG-----L 290
alphaM VRELFNITNGARKNAFKILVVITDGEKFGDPLGYEDVIPEADREGVIRYVIGVG-----D 289
alphaL ATEVFREELGARPDATKVLIIITDG-------EATDSGNIDAAKDIIRYIIGIG-----K 288
alpha8 AVYYCPWPAEGSAQCRQIPFDTTNNRKIRVNGT----KEPIEFKSNQWFGATVK-AHK-- 144
alphaV QVLKCDWSST--RRCQPIEFDATGNRDYAKD-------DPLEFKSHQWFGASVR-SKQ-- 132
alpha5 AVYLCPWGAS-PTQCTPIEFDSKGSRLLESSLSSSEGEEPVEYKSLQWFGATVR-AHG-- 150
alpha2b GVFLCPWRAE-GGQCPSLLFDLRDETRNVGS------QTLQTFKARQGLGASVV-SWS-- 132
alpha3a GAVYLCPLTAHKDDCERMNITVKNDP-------------GHHIIEDMWLGVTVA-SQGPA 134
alpha3b GAVYLCPLTAHKDDCERMNITVKNDP-------------GHHIIEDMWLGVTVA-SQGPA 134
alpha6a GGLYSCDITARG-PCTRIEFDNDADP-------------TSESKEDQWMGVTVQ-SQGPG 125
alpha6b GGLYSCDITARG-PCTRIEFDNDADP-------------TSESKEDQWMGVTVQ-SQGPG 125
alpha7 GGLFACPLSLEETDCYRVDIDQGADM-------------QKESKENQWLGVSVR-SQGPG 134
alpha4 AIYRCRIGKNPGQTCEQLQLGSPN--GEPCG------KTCLEERDNQWLGVTLSRQPGEN 138
alpha9 AVFKCRVHTNPDRRCTELDMARGKNRGTSCG------KTCREDRDDEWMGVSLARQPKAD 136
alphaE LDSIFTSSHGSRRKASKVMVVLTDGGIFEDPLNLTTVINSPKMQGVERFAIGVG-----E 343
: . :
alpha1 NLSTEKFVEEIKSIASEPTEKHFFNVSDELALVTIVKTLGERIFALEA----TADQSAAS 372
alpha2 ALDTKNLIKEIKAIASIPTERYFFNVSDEAALLEKAGTLGEQIFSIEG----TVQG-GDN 373
alpha10 QRDPSSFLREIRTIASDPDERFFFNVTDEAALTDIVDALGDRIFGLEG----SHAENESS 367
alpha11 GINPETFLNEIKYIASDPDDKHFFNVTDEAALKDIVDALGDRIFSLEG----TNK-NETS 361
alphaD AFQGPTARQELNTISSAPPQDHVFKVDNFAALGSIQKQLQEKIYAVEG----TQSRASSS 345
alphaX AFQNRNSWKELNDIASKPSQEHIFKVEDFDALKDIQNQLKEKIFAIEG----TETTSSSS 346
alphaM AFRSEKSRQELNTIASKPPRDHVFQVNNFEALKTIQNQLREKIFAIEG----TQTGSSSS 345
alphaL HFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEG----TSKQDLTS 344
alpha8 GKVVACAPLYHWRTLKPTP--EKDPVGTCYVAIQNFSAYAEFSPCRN--------SNADP 194
alphaV DKILACAPLYHWRTEMKQ---EREPVGTCFLQDG--TKTVEYAPCRS--------QDIDA 179
alpha5 SSILACAPLYSWRTEKEP---LSDPVGTCYLSTDNFTRILEYAPCRS--------DFSWA 199
alpha2b DVIVACAPWQHWNVLEKTEEAEKTPVGSCFLAQPESGRRAEYSPCRGNTLSRIYVENDFS 192
alpha3a GRVLVCAHRYTQVLWSGS-EDQRRMVGKCYVRGNDLELDSSDDWQTYHN-EMCNSN-TDY 191
alpha3b GRVLVCAHRYTQVLWSGS-EDQRRMVGKCYVRGNDLELDSSDDWQTYHN-EMCNSN-TDY 191
alpha6a GKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWS---FCDGRLRGH 182
alpha6b GKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWS---FCDGRLRGH 182
alpha7 GKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGEWK---FCEGRPQGH 191
alpha4 GSIVTCGHRWKNIFYIKNE--NKLPTGGCYGVPPDLRTELSKRIAPCYQ----DYVKKFG 192
alpha9 GRVLACAHRWKNIYYEAD---HILPHGFCYIIPSNLQAKG-RTLIPCYE----EYKKKYG 188
alphaE EFKSARTARELNLIASDPDETHAFKVTNYMALDGLLSKLRYNIISMEG-------TVGDA 396
alpha1 FEMEMSQTGFSAHYS--QDWVMLGAVGAYDWNGTVVMQKASQIIIPRNTTFNVE------ 424
alpha2 FQMEMSQVGFSADYSSQNDILMLGAVGAFGWSGTIVQKTSHGHLIFPKQAFDQI------ 427
alpha10 FGLEMSQIGFSTHRL--KDGILFGMVGAYDWGGSVLWLEGGHRLFPPRMALEDE------ 419
alpha11 FGLEMSQTGFSSHVV--EDGVLLGAVGAYDWNGAVLKETSAGKVIPLRESYLKE------ 413
alphaD FQHEMSQEGFSTALT--MDGLFLGAVGSFSWSGGAFLYPPN----MSP-TFINM------ 392
alphaX FELEMAQEGFSAVFT--PDGPVLGAVGSFTWSGGAFLYPPN----MSP-TFINM------ 393
alphaM FEHEMSQEGFSAAIT--SNGPLLSTVGSYDWAGGVFLYTSK----EKS-TFINM------ 392
alphaL FNMELSSSGISADLS--RGHAVVGAVGAKDWAGGFLDLKAD----LQDDTFIGN------ 392
alpha8 EGQGYCQAGFSLDFYKN-GDLIVGGPGSFYWQG-QVITASVADIIANYSFKDILRKLAGE 252
alphaV DGQGFCQGGFSIDFTKA-DRVLLGGPGSFYWQG-QLISDQVAEIVSKYDPNVYSIKYNNQ 237
alpha5 AGQGYCQGGFSAEFTKT-GRVVLGGPGSYFWQG-QILSATQEQIAESYYPEYLINLVQGQ 257
alpha2b WDKRYCEAGFSSVVTQA-GELVLGAPGGYYFLG-LLAQAPVADIFSSYRPGILLWHVSSQ 250
alpha3a LETGMCQLGTSGGFTQN--TVYFGAPGAYNWKGNSYMIQRKEWDLSEYSYKD------PE 243
alpha3b LETGMCQLGTSGGFTQN--TVYFGAPGAYNWKGNSYMIQRKEWDLSEYSYKD------PE 243
alpha6a EKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGE 242
alpha6b EKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGE 242
alpha7 EQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKGLLFVTNIDSSDPDQLVYKT----LDPA 247
alpha4 ENFASCQAGISSFYTKD--LIVMGAPGSSYWTGSLFVYNITTNKYKAFLDKQ-------- 242
alpha9 EEHGSCQAGIAGFFTEE--LVVMGAPGSFYWAGTIKVLNLTDNTYLKLNDEV-------- 238
alphaE LHYQLAQIGFSAQILDE-RQVLLGAVGAFDWSGGALLYDTRSRRGRFLNQTAAA------ 449
.. * : .. * : *
alpha1 ----STKKNEPLASYLGYTVNSATASSGD--VLYIAGQPRYNHTGQVIIYRMED--GNIK 476
alpha2 ----LQDRN--HSSYLGYSV-AAISTGES--THFVAGAPRANYTGQIVLYSVNEN-GNIT 477
alpha10 ----FPPALQNHAAYLGYSVSSMLLRGGR--RLFLSGAPRFRHRGKVIAFQLKKD-GAVR 472
alpha11 ----FPEELKNHGAYLGYTVTSVVSSRQG--RVYVAGAPRFNHTGKVILFTMHNN-RSLT 466
alphaD ----SQENVDMRDSYLGYSTELALWKGVQ--NLVLG-APRYQHTGKAVIFTQVSR--QWR 443
alphaX ----SQENVDMRDSYLGYSTELALWKGVQ--SLVLG-APRYQHTGKAVIFTQVSR--QWR 444
alphaM ----TRVDSDMNDAYLGYAAAIILRNRVQ--SLVLG-APRYQHIGLVAMFRQNTG--MWE 443
alphaL ----EPLTPEVRAGYLGYTVTWLPSRQKT--SLLASGAPRYQHMGRVLLFQEPQGGGHWS 446
alpha8 -KQTEVAPASYDDSYLGYSVAAGEFTGDS-QQELVAGIPRGAQNFGYVSIINSTDMTFIQ 310
alphaV -LATRTAQAIFDDSYLGYSVAVGDFNGDG-IDDFVSGVPRAARTLGMVYIYDGKNMSSLY 295
alpha5 -LQTRQASSIYDDSYLGYSVAVGEFSGDD-TEDFVAGVPKGNLTYGYVTILNGSDIRSLY 315
alpha2b SLSFDSSNPEYFDGYWGYSVAVGEFDGDLNTTEYVVGAPTWSWTLGAVEILDS-YYQRLH 309
alpha3a DQG---------NLYIGYTMQVGSFILHPKNITIVTGAPRHRHMGAVFLLSQEA-GGDLR 293
alpha3b DQG---------NLYIGYTMQVGSFILHPKNITIVTGAPRHRHMGAVFLLSQEA-GGDLR 293
alpha6a TEHDESLVPVPANSYLGFSLDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLL 302
alpha6b TEHDESLVPVPANSYLGFSLDSGKGIVSKDEITFVSGAPRANHSGAVVLLKRDMKSAHLL 302
alpha7 DRLPGPAGDLALNSYLGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDS-ASRLV 306
alpha4 -------NQVKFGSYLGYSVGAGHFRSQH-TTEVVGGAPQHEQIGKAYIFSIDEKE--LN 292
alpha9 -------IMNRRYTYLGYAVTAGHFSHPS-TIDVVGGAPQDKGIGKVYIFRADRRSGTLI 290
alphaE ----AADAEAAQYSYLGYAVAVLHKTCSL---SYIAGAPRYKHHGAVFELQKEGR--EAS 500
* *:: *
alpha1 ILQTLSGEQIGSYFGSILTTTDIDKDSNTDILLVGAPMYMGTEKEEQ----GKVYVYALN 532
alpha2 VIQAHRGDQIGSYFGSVLCSVDVDKDTITDVLLVGAPMYMSDLKKEE----GRVYLFTIK 533
alpha10 VAQSLQGEQIGSYFGSELCPLDTDRDGTTDVLLVAAPMFLGPQNKET----GRVYVYLVG 528
alpha11 IHQAMRGQQIGSYFGSEITSVDIDGDGVTDVLLVGAPMYFN-EGRER----GKVYVYELR 521
alphaD KKAEVTGTQIGSYFGASLCSVDVDSDGSTDLILIGAPHYYE--QTRG----GQVSVCPLP 497
alphaX MKAEVTGTQIGSYFGASLCSVDVDSDGSTDLVLIGAPHYYE--QTRG----GQVSVCPLP 498
alphaM SNANVKGTQIGAYFGASLCSVDVDSNGSTDLVLIGAPHYYE--QTRG----GQVSVCPLP 497
alphaL QVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYG--EQRG----GRVFIY--Q 498
alpha8 N---FTGEQMASYFGYTVVVSDVNSDG-LDDVLVGAPLFMEREFESNPREVGQIYLYLQ- 365
alphaV N---FTGEQMAAYFGFSVAATDINGDD-YADVFIGAPLFMDRGSDGKLQEVGQVSVSLQ- 350
alpha5 N---FSGEQMASYFGYAVAATDVNGDG-LDDLLVGAPLLMDRTPDGRPQEVGRVYVYLQ- 370
alpha2b R---LRGEQMASYFGHSVAVTDVNGDG-RHDLLVGAPLYMESRADRKLAEVGRVYLFLQP 365
alpha3a RRQVLEGSQVGAYFGSAIALADLNNDG-WQDLLVGAPYYFERKEEVG----GAIYVFMNQ 348
alpha3b RRQVLEGSQVGAYFGSAIALADLNNDG-WQDLLVGAPYYFERKEEVG----GAIYVFMNQ 348
alpha6a PEHIFDGEGLASSFGYDVAVVDLNKDG-WQDIVIGAPQYFDRDGEVG----GAVYVYMNQ 357
alpha6b PEHIFDGEGLASSFGYDVAVVDLNKDG-WQDIVIGAPQYFDRDGEVG----GAVYVYMNQ 357
alpha7 PEVMLSGERLTSGFGYSLAVADLNSDG-WPDLIVGAPYFFERQEELG----GAVYVYLNQ 361
alpha4 ILHEMKGKKLGSYFGASVCAVDLNADG-FSDLLVGAPMQSTIREEGR------VFVYINS 345
alpha9 KIFQASGKKMGSYFGSSLCAVDLNGDG-LSDLLVGAPMFSEIRDEGQ------VTVYINR 343
alphaE FLPVLEGEQMGSYFGSELCPVDIDMDGSTDFLLVAAPFYHVHGEEGR------VYVYRLS 554
* : : ** : * : : :.:.** : :
alpha1 QT-RFEYQMSLEPIKQTCCSSRQHNSCTTENKNEPCGARFGTAIAAVKDLNLDGFNDIVI 591
alpha2 EG-ILGQHQFLE------------GPEGIEN------TRFGSAIAALSDINMDGFNDVIV 574
alpha10 QQSLLTLQGTLQP-------------EPPQD------ARFGFAMGALPDLNQDGFADVAV 569
alpha11 QN-LFVYNGTLKDS------------HSYQN------ARFGSSIASVRDLNQDSYNDVVV 562
alphaD RGRVQWQCDAVLRG------------EQGHP-----WGRFGAALTVLGDVNEDKLIDVAI 540
alphaX RGWRRWWCDAVLYG------------EQGHP-----WGRFGAALTVLGDVNGDKLTDVVI 541
alphaM RGRARWQCDAVLYG------------EQGQP-----WGRFGAALTVLGDVNGDKLTDVAI 540
alphaL RRQLGFEEVSELQG------------DPGYP-----LGRFGEAITALTDINGDGLVDVAV 541
alpha8 VSSLLFRDP-QILTGT------------------ETFGRFGSAMAHLGDLNQDGYNDIAI 406
alphaV RASGDFQT--TKLNGF------------------EVFARFGSAIAPLGDLDQDGFNDIAI 390
alpha5 HPAGIEPTPTLTLTGH------------------DEFGRFGSSLTPLGDLDQDGYNDVAI 412
alpha2b RGPHALGAPSLLLTGT------------------QLYGRFGSAIAPLGDLDRDGYNDIAV 407
alpha3a AGTSFPAHPSLLLHGP------------------SGS-AFGLSVASIGDINQDGFQDIAV 389
alpha3b AGTSFPAHPSLLLHGP------------------SGS-AFGLSVASIGDINQDGFQDIAV 389
alpha6a QGRWNNVKP-IRLNGT------------------KDS-MFGIAVKNIGDINQDGYPDIAV 397
alpha6b QGRWNNVKP-IRLNGT------------------KDS-MFGIAVKNIGDINQDGYPDIAV 397
alpha7 GGHWAGISP-LRLCGS------------------PDS-MFGISLAVLGDLNQDGFPDIAV 401
alpha4 GSGAVMNAMETNLVGSD-----------------KYAARFGESIVNLGDIDNDGFEDVAI 388
alpha9 GNGALEEQLA--LTGDG-----------------AYNAHFGESIASLDDLDNDGFPDVAI 384
alphaE EQDGSFSLARILSGHPG-----------------FTNARFGFAMAAMGDLSQDKLTDVAI 597
** :: : *:. * *: :
alpha1 GAPLEDD-----H-GGAVYIYHGSGK-TIRKEYAQRIP--SGGDGKTLKFFGQSIHGEMD 642
alpha2 GSPLENQ-----N-SGAVYIYNGHQG-TIRTKYSQKILGSDGAFRSHLQYFGRSLDGYGD 627
alpha10 GAPLEDG-----H-QGALYLYHGTQS-GVRPHPAQRIA--AASMPHALSYFGRSVDGRLD 620
alpha11 GAPLEDN-----H-AGAIYIFHGFRG-SILKTPKQRIT--ASELATGLQYFGCSIHGQLD 613
alphaD GAPGEQE-----N-RGAVYLFHGASESGISPSHSQRIAS--SQLSPRLQYFGQALSGGQD 592
alphaX GAPGEEE-----N-RGAVYLFHGVLGPSISPSHSQRIAG--SQLSSRLQYFGQALSGGQD 593
alphaM GAPGEED-----N-RGAVYLFHGTSGSGISPSHSQRIAG--SKLSPRLQYFGQSLSGGQD 592
alphaL GAPLEEQ--------GAVYIFNGRHG-GLSPQPSQRIEG--TQVLSGIQWFGRSIHGVKD 590
alpha8 GVPFAGK-----DQRGKVLIYNGNKD-GLNTKPSQVLQG-VWASHAVPSGFGFTLRGDSD 459
alphaV AAPYGGE-----DKKGIVYIFNGRST-GLNAVPSQILEG-QWAARSMPPSFGYSMKGATD 443
alpha5 GAPFGGE-----TQQGVVFVFPGGPG-GLGSKPSQVLQP-LWAASHTPDFFGSALRGGRD 465
alpha2b AAPYGGP-----SGRGQVLVFLGQSE-GLRSRPSQVLDS-PFPTG---SAFGFSLRGAVD 457
alpha3a GAPFEG--------LGKVYIYHSSSK-GLLRQPQQVIHG-EKLGLPGLATFGYSLSGQMD 439
alpha3b GAPFEG--------LGKVYIYHSSSK-GLLRQPQQVIHG-EKLGLPGLATFGYSLSGQMD 439
alpha6a GAPYDD--------LGKVFIYHGSAN-GINTKPTQVLKG-ISP------YFGYSIAGNMD 441
alpha6b GAPYDD--------LGKVFIYHGSAN-GINTKPTQVLKG-ISP------YFGYSIAGNMD 441
alpha7 GAPFDG--------DGKVFIYHGSSL-GVVAKPSQVLEG-EAVGIK---SFGYSLSGSLD 448
alpha4 GAPQED------DLQGAIYIYNGRAD-GISSTFSQRIEG-LQIS-KSLSMFGQSISGQID 439
alpha9 GAPKED------DFAGAVYIYHGDAG-GIVPQYSMKLSG-QKIN-PVLRMFGQSISGGID 435
alphaE GAPLEGFGADDGASFGSVYIYNGHWD-GLSASPSQRIRA--STVAPGLQYFGMSMAGGFD 654
. * * : :: . : : ** :: * *
alpha1 LNGDGLTDVTIGGL--GGAALFWSRDVAVVKVTMNFEPNKVNIQKKNCHMEGKETVCINA 700
alpha2 LNGDSITDVSIGAF--GQVVQLWSQSIADVAIEASFTPEKITLVNKNAQIILK------- 678
alpha10 LDGDDLVDVAVGAQ--GAAILLSSRPIVHLTPSLEVTPQAISVVQRDCRRRGQEAVCLTA 678
alpha11 LNEDGLIDLAVGAL--GNAVILWSRPVVQINASLHFEPSKINIFHRDCKRSGRDATCLAA 671
alphaD LTQDGLMDLAVGAR--GQVLLLRSLPVLKVGVAMRFSPVEVAKAVYRCWEEKPSALEAGD 650
alphaX LTQDGLVDLAVGAR--GQVLLLRTRPVLWVGVSMQFIPAEIPRSAFECREQVVSEQTLVQ 651
alphaM LTMDGLVDLTVGAQ--GHVLLLRSQPVLRVKAIMEFNPREVARNVFECNDQVVKGKEAGE 650
alphaL LEGDGLADVAVGAE--SQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYS-TSNKMKEG 647
alpha8 IDKNDYPDLIVGAFGTGKVAVYRARPVVTVDAQLLLHPMIINLENKTCQVPDSMTSAACF 519
alphaV IDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCF 503
alpha5 LDGNGYPDLIVGSFGVDKAVVYRGRPIVSASASLTIFPAMFNPEERSCSLEG--NPVACI 523
alpha2b IDDNGYPDLIVGAYGANQVAVYRAQPVVKASVQLLVQDS-LNPAVKSCVLPQTKTPVSCF 516
alpha3a VDENFYPDLLVGSL-SDHIVLLRARPVINIVHKTLVP--RPAVLDPALCTATS--CVQVE 494
alpha3b VDENFYPDLLVGSL-SDHIVLLRARPVINIVHKTLVP--RPAVLDPALCTATS--CVQVE 494
alpha6a LDRNSYPDVAVGSL-SDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVK 500
alpha6b LDRNSYPDVAVGSL-SDSVTIFRSRPVINIQKTITVTPNRIDLRQKTACGAPSGICLQVK 500
alpha7 MDGNQYPDLLVGSL-ADTAVLFRARPILHVSHEVSIAPRSIDLEQPNCAGGHS-VCVDLR 506
alpha4 ADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVNRTKFDCVENGWPSVCIDLT 499
alpha9 MDGNGYPDVTVGAFMSDSVVLLRARPVITVDVSIFLPGSINITAPQCHDGQQPVNCLNVT 495
alphaE ISGDGLADITVGTL--GQAVVFRSRPVVRLKVSMAFTPSALPIGFN-----------GVV 701
: *: :* . :
alpha1 TVCFDVKLKSKEDTIYEADLQYRVTLDS----LRQISRSFFSGTQERKVQRNITVR---- 752
alpha2 -LCFSAKFRPTK-QNNQVAIVYNITLDADGFSSRVTSRGLFKENNERCLQKNMVVN---- 732
alpha10 ALCFQVTSRTPGRWDHQFYMRFTASLDE----WTAGARAAFDGSGQRLSPRRLRLSV--- 731
alpha11 FLCFTPIFLAPHFQTTTVGIRYNATMDE----RRYTPRAHLDEGGDRFTNRAVLLSS--- 724
alphaD ATVCLTIQKSSLDQLG--DIQSSVRFDLALDPGRLTSRAIFNETKNPTLTRRKTLGL--- 705
alphaX SNICLYIDKRSKNLLGSRDLQSSVTLDLALDPGRLSPRATFQETKNRSLSRVRVLGL--- 708
alphaM VRVCLHVQKSTRDRLREGQIQSVVTYDLALDSGRPHSRAVFNETKNSTRRQTQVLGL--- 707
alphaL VNITICFQIKSLYPQFQGRLVANLTYTLQLDGHRTRRRGLFPGGR-HELRRNIAVTT--- 703
alpha8 SLRVCASVTGQSIAN-TIVLMAEVQLDSLKQKGAIKRTLFLDNHQAHRVFPLVIKR---- 574
alphaV NVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISR---- 559
alpha5 NLSFCLNASGKHVAD-SIGFTVELQLDWQKQKGGVRRALFLASRQATLTQTLLIQN---- 578
alpha2b NIQMCVGATGHNIPQ-KLSLNAELQLDRQKPRQG-RRVLLLGSQQAGTTLNLDLGG---- 570
alpha3a LCFAYNQSAGNPNYRRNITLAYTLEADRDRR----PPRLRFAG--SESAVFHGFFS---- 544
alpha3b LCFAYNQSAGNPNYRRNITLAYTLEADRDRR----PPRLRFAG--SESAVFHGFFS---- 544
alpha6a SCFEYTANPAG--YNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSE-PKYTQELT--LK 555
alpha6b SCFEYTANPAG--YNPSISIVGTLEAEKERRKSGLSSRVQFRNQGSE-PKYTQELT--LK 555
alpha7 VCFSYIAVPSS--YSPTVALDYVLDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLK 564
alpha4 LCFSYKGKEVPG----YIVLFYNMSLDVNRKAE-SPPRFYFSSNG-TSDVITGSIQVS-- 551
alpha9 TCFSFHGKHVPG----EIGLNYVLMADVAKKEKGQMPRVYFVLLGETMGQVTEKLQLT-- 549
alphaE NVRLCFEISSVTTASESGLREALLNFTLDVDVGKQRRRLQCSDVRSCLGCLREWSSG--- 758
alpha1 ---KSE-CTKHSFYMLD---KHDFQDSVRITLDFNLTDPE------------NGPVLDDS 793
alpha2 ---QAQSCPEHIIYIQE---PSDVVNSLDLRVDISLENPG------------TSPALEAY 774
alpha10 ---GNVTCEQLHFHVLD---TSDYLRPVALTVTFALDNTTK-----------PGPVLNEG 774
alpha11 ---GQELCERINFHVLD---TADYVKPVTFSVEYSLEDPD------------HGPMLDDG 766
alphaD ---GIHCETLKLLLPDC---VEDVVSPIILHLNFSLVR------EPIPSPQNLRPVLAVG 753
alphaX ---KAHCENFNLLLPSC---VEDSVTPITLRLNFTLVG------KPLLAFRNLRPMLAAD 756
alphaM ---TQTCETLKLQLPNC---IEDPVSPIVLRLNFSLVG------TPLSAFGNLRPVLAED 755
alphaL ---SMSCTDFSFHFPVC---VQDLISPINVSLNFSLWEEEGTP-RDQRAQGKDIPPILRP 756
alpha8 -QKSHQCQDFIVYLRDETE-FRDKLSPINISLNYSLDESTFK------EGLEVKPILNYY 626
alphaV -GGLMQCEELIAYLRDESE-FRDKLTPITIFMEYRLDYRTAA------DTTGLQPILNQF 611
alpha5 -GAREDCREMKIYLRNESE-FRDKLSPIHIALNFSLDPQAPV------DSHGLRPALHYQ 630
alpha2b -KHSPICHTTMAFLRDEAD-FRDKLSPIVLSLNVSLPP----------TEAGMAPAVVLH 618
alpha3a -MPEMRCQKLELLLMDN---LRDKLRPIIISMNYSLPLRMPDRPRLGLRSLDAYPILNQA 600
alpha3b -MPEMRCQKLELLLMDN---LRDKLRPIIISMNYSLPLRMPDRPRLGLRSLDAYPILNQA 600
alpha6a RQKQKVCMEETLWLQDN---IRDKLRPIPITASVEIQEPSSRRRVN--SLPEVLPILNSD 610
alpha6b RQKQKVCMEETLWLQDN---IRDKLRPIPITASVEIQEPSSRRRVN--SLPEVLPILNSD 610
alpha7 HQHDRVCGDAMFQLQEN---VKDKLRAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAH 621
alpha4 -SREANCRTHQAFMRKD---VRDILTPIQIEAAYHLGPHVISKR-STEEFPPLQPILQQK 606
alpha9 -YMEETCRHYVAHVKRR---VQDVISPIVFEAAYSLSEHVTGE--EERELPPLTPVLRWK 603
alphaE ---SQLCEDLLLMPTEGELCEEDCFSNASVKVSYQLQTPEGQ-------TDHPQPILDRY 808
* . : * :
alpha1 LPNSVHEYIPFAKD-CGNKEKCISDLSLHVATT---EKD--------------------- 828
alpha2 SETAKVFSIPFHKD-CGEDGLCISDLVLDVRQIPAAQEQ--------------------- 812
alpha10 SPTSIQKLVPFSKD-CGPDNECVTDLVLQVNMDIRGSRK--------------------- 812
alpha11 WPTTLRVSVPFWNG-CNEDEHCVPDLVLDARSDLPTAMEYCQRVLRKPAQDCSAYTLSFD 825
alphaD SQDLFTASLPFEKN-CGQDGLCEGDLGVTLSFSG-------------------------- 786
alphaX AQRYFTASLPFEKN-CGADHICQDNLGISFSFPG-------------------------- 789
alphaM AQRLFTALFPFEKN-CGNDNICQDDLSITFSFMS-------------------------- 788
alphaL SLHSETWEIPFEKN-CGEDKKCEANLRVSFSPAR-------------------------- 789
alpha8 RENIVSEQAHILVD-CGEDNLCVPDLKLSARPDKHQ------------------------ 661
alphaV TPANISRQAHILLD-CGEDNVCKPKLEVSVDSDQKK------------------------ 646
alpha5 SKSRIEDKAQILLD-CGEDNICVPDLQLEVFGEQNH------------------------ 665
alpha2b GDTHVQEQTRIVLD-CGEDDVCVPQLQLTASVTGSP------------------------ 653
alpha3a QALENHTEVQFQKE-CGPDNKCESNLQMRAAFVSEQQQKLSRLQYS-------------- 645
alpha3b QALENHTEVQFQKE-CGPDNKCESNLQMRAAFVSEQQQKLSRLQYS-------------- 645
alpha6a EPKTAHIDVHFLKEGCGDDNVCNSNLKLEYK-FCTREGNQDKFSYLPIQKG--------- 660
alpha6b EPKTAHIDVHFLKEGCGDDNVCNSNLKLEYK-FCTREGNQDKFSYLPIQKG--------- 660
alpha7 QPSTQRAEIHFLKQGCGEDKICQSNLQLVHARFCTRVSDT-EFQPLPMDVDG-------- 672
alpha4 KEKDIMKKT-INFARFCAHENCSADLQVSAKIGFLKPHEN-------------------- 645
alpha9 KGQKIAQKNQTVFERNCRSEDCAADLQLQGKLLLSSMDEK-------------------- 643
alphaE TEPFAIFQLPYEKA-CKNKLFCVAELQLATTVSQQE------------------------ 843
* .* :
alpha1 --LLIVRSQNDKFNVSLTVKN----------TKDS-AYNTRTIVHYSPNLVFSGIEAIQK 875
alpha2 --PFIVSNQNKRLTFSVTLKN----------KRES-AYNTGIVVDFSENLFFASFSLPVD 859
alpha10 -APFVVRGGRRKVLVSTTLEN----------RKEN-AYNTSLSLIFSRNLHLASLTPQRE 860
alpha11 TTVFIIESTRQRVAVEATLEN----------RGEN-AYSTVLNISQSANLQFASLIQKED 874
alphaD -LQTLTVGSSLELNVIVTVWN----------AGED-SYGTVVSLYYPAGLSHRRVSGAQK 834
alphaX -LKSLLVGSNLELNAEVMVWN----------DGED-SYGTTITFSHPAGLSYRYVAEGQK 837
alphaM -LDCLVVGGPREFNVTVTVRN----------DGED-SYRTQVTFFFPLDLSYRKVSTLQN 836
alphaL -SRALRLTAFASLSVELSLSN----------LEED-AYWVQLDLHFPPGLSFRKVEMLKP 837
alpha8 ----VIIGDENHLMLIINARN----------EGEG-AYEAELFVMIPEEADYVGIERNNK 706
alphaV ----IYIGDDNPLTLIVKAQN----------QGEG-AYEAELIVSIPLQADFIGVVRNNE 691
alpha5 ----VYLGDKNALNLTFHAQN----------VGEGGAYEAELRVTAPPEAEYSGLVRHPG 711
alpha2b ----LLVGADNVLELQMDAAN----------EGEG-AYEAELAVHLPQGAHYMRALSNVE 698
alpha3a -------RDVRKLLLSINVTN----TRTSERSGED-AHEALLTLVVPPALLLS-SVRPPG 692
alpha3b -------RDVRKLLLSINVTN----TRTSERSGED-AHEALLTLVVPPALLLS-SVRPPG 692
alpha6a -VPELVLKDQKDIALEITVTNSPSNPRNPTKDGDD-AHEAKLIATFPDTLTYS-AYRELR 717
alpha6b -VPELVLKDQKDIALEITVTNSPSNPRNPTKDGDD-AHEAKLIATFPDTLTYS-AYRELR 717
alpha7 TTALFALSGQPVIGLELMVTNLPSDPAQPQADGDD-AHEAQLLVMLPDSLHYS-GVRALD 730
alpha4 -KTYLAVGSMKTLMLNVSLFN----------AGDD-AYETTLHVKLPVGLYFIKILELEE 693
alpha9 -TLYLALGAVKNISLNISISN----------LGDD-AYDANVSFNVSRELFFINMWQKEE 691
alphaE ----LVVGLTKELTLNINLTN----------SGED-SYMTSMALNYPRNLQLKRMQKPPS 888
. * :. :: . .
alpha1 ---------------DSCES--NHNITCKVGYPFLRRGEMVTFKILFQFNTSYLMENVTI 918
alpha2 G---------TEVTCQVAAS--QKSVACDVGYPALKREQQVTFTINFDFNLQNLQNQASL 908
alpha10 S---------PIKVECAAPS--AHARLCSVGHPVFQTGAKVTFLLEFEFSCSSLLSQVFV 909
alpha11 S---------DGSIECVNEERRLQKQVCNVSYPFFRAKAKVAFRLDFEFSKSIFLHHLEI 925
alphaD QPHQSALRLACETVPTEDEG--LRSSRCSVNHPIFHEGSNGTFIVTFDVSYKATLGDRML 892
alphaX QGQLRSLHLTCDSAPVGSQG--TWSTSCRINHLIFRGGAQITFLATFDVSPKAVLGDRLL 895
alphaM QRSQRSWRLACESASSTEVSGALKSTSCSINHPIFPENSEVTFNITFDVDSKASLGNKLL 896
alphaL HSQIP---VSCEELPE-ESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVE 893
alpha8 G--------FRPLSCEYKMENVTRMVVCDLGNPMVSG-TNYSLGLRFAVPRLEKTNMSIN 757
alphaV A--------LARLSCAFKTENQTRQVVCDLGNPMKAG-TQLLAGLRFSVHQQSEMDTSVK 742
alpha5 N--------FSSLSCDYFAVNQSRLLVCDLGNPMKAG-ASLWGGLRFTVPHLRDTKKTIQ 762
alpha2b G--------FERLICNQKKENETRVVLCELGNPMKKN-AQIGIAMLVSVGNLEEAGESVS 749
alpha3a ---------------ACQANET---IFCELGNPFKRN-QRMELLIAFEVIGVTLHTRDLQ 733
alpha3b ---------------ACQANET---IFCELGNPFKRN-QRMELLIAFEVIGVTLHTRDLQ 733
alpha6a A--------FPEKQLSCVANQNGSQADCELGNPFKRN-SNVTFYLVLSTTEVTFDTPDLD 768
alpha6b A--------FPEKQLSCVANQNGSQADCELGNPFKRN-SNVTFYLVLSTTEVTFDTPDLD 768
alpha7 ----------PAEKPLCLSNENASHVECELGNPMKRG-AQVTFYLILSTSGISIETTELE 779
alpha4 ----------KQINCEVTDNSGVVQLDCSIGYIYVDHLSRIDISFLLDVSSLSRAEEDLS 743
alpha9 ----------MGISCELLESD---FLKCSVGFPFMRSKSKYEFSVIFDTSHLSGEEEVLS 738
alphaE P---------NIQCDDPQPVASVLIMNCRIGHPVLKR-SSAHVSVVWQLEENAFPNRTAD 938
* :.
alpha1 YLSATSDSEE---PPETLSDNVVNISIPVKYEVGLQFYSSASEYHISIAANETVPEVINS 975
alpha2 SFQALSESQE-----ENKADNLVNLKIPLLYDAEIHLTRSTNINFYEISSDGNVPSIVHS 963
alpha10 KLTASSDSLE---RNGTLQDNTAQTSAYIQYEPHLLFSSESTLHRYEVHPYGTLP----- 961
alpha11 ELAAGSDSNE---RDSTKEDNVAPLRFHLKYEADVLFTRSSSLSHYEVKPNSSLER---- 978
alphaD MRASASSEN----NKASSSKATFQLELPVKYAVYTMISRQEESTKYFNFATSDEKK---- 944
alphaX LTANVSSEN----NTPRTSKTTFQLELPVKYAVYTVVSSHEQFTKYLNFSESEEKE---- 947
alphaM LKANVTSEN----NMPRTNKTEFQLELPVKYAVYMVVTSHGVSTKYLNFTAS-ENT---- 947
alphaL LHANVTCNNE---DSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPK-------- 942
alpha8 FDLQIRSSNK---DNPDSNFVSLQINITAVAQVEIRGVSHPPQIVLPIH-NWEPEEEPHK 813
alphaV FDLQIQSSNL---FDKVSPVVSHKVDLAVLAAVEIRGVSSPDHIFLPIP-NWEHKENPET 798
alpha5 FDFQILSKNL---NNSQSDVVSFRLSVEAQAQVTLNGVSKPEAVLFPVS-DWHPRDQPQK 818
alpha2b FQLQIRSKNS---QNPNSKIVLLDVPVRAEAQVELRGNSFPASLVVAAE-EGEREQN--S 803
alpha3a VQLQLSTSS----HQDNLWPMILTLLVDYTLQTSLSMVNHRLQSFFGG--TVMGESGMKT 787
alpha3b VQLQLSTSS----HQDNLWPMILTLLVDYTLQTSLSMVNHRLQSFFGG--TVMGESGMKT 787
alpha6a INLKLETTS----NQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGG--TVVGEQAMKS 822
alpha6b INLKLETTS----NQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGG--TVVGEQAMKS 822
alpha7 VELLLATIS----EQE-LHPVSARARVFIELPLSIAGMAIPQQLFFSG--VVRGERAMQS 832
alpha4 ITVHATCENEEEMDNLKHSRVTVAIPLKYEVKLTVHGFVNPTSFVYGSNDENE------P 797
alpha9 FIVTAQSGNTERSESLHDNTLVLMVPLMHEVDTSITGIMSPTSFVYGESVDAANFIQLDD 798
alphaE ITVTVTNSNE--------RRSLANETHTLQFRHGFVAVLSKPSIMYVNTGQG-------- 982
alpha1 TEDIGNEINIFYLIRKSGS--FPMPELKLSISFPNMTSNGYPVLYPTGLSSSENA----- 1028
alpha2 FEDVG-PKFIFSLKVTTGS--VPVSMATVIIHIPQYTKEKNPLMYLTGVQTDKAG----- 1015
alpha10 -VGPGPEFKTTLRVQNLGC--YVVSGLIISALLPAVAHGGNYFLSLSQVITNNA------ 1012
alpha11 YDGIGPPFSCIFRIQNLGL--FPIHGMMMKITIPIATRSGNRLLKLRDFLTDEAN----- 1031
alphaD -------MKEAEHRYRVNN--LSQRDLAISINFWVPVLLNGVAVWDVVMEAPSQ------ 989
alphaX -------SHVAMHRYQVNN--LGQRDLPVSINFWVPVELNQEAVWMDVEVSHPQN----- 993
alphaM -------SRVMQHQYQVSN--LGQRSLPISLVFLVPVRLNQTVIWDRPQVTFSEN----- 993
alphaL ----------GPKIHQVKH--MYQVRIQPSIHDHNIPTLEAVVGVPQP---PSEG----- 982
alpha8 EEEVGPLVEHIYELHNIGP--STISDTILEVGWPFSA-RDEFLLYIFHIQTLG------P 864
alphaV EEDVGPVVQHIYELRNNGP--SSFSKAMLHLQWPYKY-NNNTLLYILHYDIDG------P 849
alpha5 EEDLGPAVHHVYELINQGP--SSISQGVLELSCPQAL-EGQQLLYVTRVTG--------- 866
alpha2b LDSWGPKVEHTYELHNNGP--GTVNGLHLSIHLPGQS-QPSDLLYILDIQPQG------G 854
alpha3a VEDVGSPLKYEFQVGPMGEGLVGLGTLVLGLEWPYEVSNGKWLLYPTEITVHG----NGS 843
alpha3b VEDVGSPLKYEFQVGPMGEGLVGLGTLVLGLEWPYEVSNGKWLLYPTEITVHG----NGS 843
alpha6a EDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKG----LEK 878
alpha6b EDEVGSLIEYEFRVINLGKPLTNLGTATLNIQWPKEISNGKWLLYLVKVESKG----LEK 878
alpha7 ERDVGSKVKYEVTVSNQGQSLRTLGSAFLNIMWPHEIANGKWLLYPMQVELEGGQGPGQK 892
alpha4 ETCMVEKMNLTFHVINTGN--SMAPNVSVEIMVPNSFSPQTDKLFNILDVQT-------- 847
alpha9 LECHFQPINITLQVYNTGP--STLPGSSVSISFPNRLSSGGAEMFHVQEMVVG------- 849
alphaE ------LSHHKEFLFHVHGENLFGAEYQLQICVPTKLRGLQVVAVKKLTRTQAS------ 1030
alpha1 ---------------------------NCRPHIFEDPFSIN-SGKKMTTSTDHLKRGTIL 1060
alpha2 ---------------------------DISCNADINPLKIGQTSSSVSFKSENFRHTKEL 1048
alpha10 -----------------------------SCIVQNLTEPPG-----PPVHPEELQHTNRL 1038
alpha11 ----------------------------TSCNIWGNSTEYR-----PTPVEEDLRRAPQL 1058
alphaD ----------------------------SLPCVSERKPPQH------SDFLTQISRSPML 1015
alphaX ---------------------------PSLRCSSEKIAPPA------SDFLAHIQKNPVL 1020
alphaM ---------------------------LSSTCHTKERLPSH------SDFLAELRKAPVV 1020
alphaL ---------------------------PITHQWSVQMEPPV------PCHYEDLERLPDA 1009
alpha8 LQCQPNPNINP--QDIKPAASPEDTPELSAFLRNSTIPHLVRKRDVHVVEFHRQSPAKIL 922
alphaV MNCTSDMEINP--LRIK-ISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHT----L 902
alpha5 LNCTTNHPINPKGLELDPEGSLHHQQKREAPSRSSASSGPQ-----------------IL 909
alpha2b LQCFPQPPVNP--LKVDWGLPIPSPSPIHPAHHKRDRRQIFLPEPEQPSRLQDPV---LV 909
alpha3a WPCRPPGDLINP-LNLTLSDPGDRPSSPQRRRRQLDPGGGQGPPPVTLAAAKKAKSETVL 902
alpha3b WPCRPPGDLINP-LNLTLSDPGDRPSSPQRRRRQLDPGGGQGPPPVTLAAAKKAKSETVL 902
alpha6a VTCEPQKEIN----SLNLTESHNSRKKREITEKQIDDNRK--------FSLFAERKYQTL 926
alpha6b VTCEPQKEIN----SLNLTESHNSRKKREITEKQIDDNRK--------FSLFAERKYQTL 926
alpha7 GLCSPRPNIL----HLDVDSRDRRRRELEPPEQQEPGERQEPSMSWWPVSSAEKKKNITL 948
alpha4 -------------------TTGECHFENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLL 888
alpha9 ------------------QEKGNCSFQKNPTPCIIPQEQ--ENIFHTIFAFFTKSGRKVL 889
alphaE -------------------------------------------------TVCTWSQERAC 1041
alpha1 DCNTCKFATITCNLTSSDIS---QVNVSLILWKPTFIKSYFSSLNLTIRGELRSENAS-- 1115
alpha2 NCRTASCSNVTCWLKDVHMKGEYFVNVTTRIWNGTFASSTFQTVQLTAAAEINTYNPE-- 1106
alpha10 NGSNTQCQVVRCHLGQLAKGTEVSVGLLRLVHNEFFRRAKFKSLTVVSTFELGTEEGS-- 1096
alpha11 NHSNSDVVSINCNI-RLVPNQEINFHLLGNLWLRSLKALKYKSMKIMVNAALQRQFHS-- 1115
alphaD DCSIADCLQFRCDVPSFSVQEELDFTLKGNLSFGWVRETLQKKVLVVSVAEITFDTSV-- 1073
alphaX DCSIAGCLRFRCDVPSFSVQEELDFTLKGNLSFGWVRQILQKKVSVVSVAEITFDTSV-- 1078
alphaM NCSIAVCQRIQCDIPFFGIQEEFNATLKGNLSFDWYIKTSHNHLLIVSTAEILFNDSV-- 1078
alphaL AEPCLPGALFRCPVVFR---QEILVQVIGTLELVGEIEASS-MFSLCSSLSISFNSSK-- 1063
alpha8 NCTNIECLQISCAVGRLEGGESAVLKVRSRLWAHTFLQR--KNDPYALASLVSFEVKKMP 980
alphaV GCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFP 962
alpha5 KCPEAECFRLRCELGPLHQQESQSLQLHFRVWAKTFLQR--EHQPFSLQCEAVYKALKMP 967
alpha2b SCDSAPCTVVQCDLQEMARGQRAMVTVLAFLWLPSLYQR--PLDQFVLQSHAWFNVSSLP 967
alpha3a TCATGRAHCVWLECPIPDAPVVTNVTVKARVWNSTFIEDYRDFDRVRVNGWATLFLRTSI 962
alpha3b TCATGRAHCVWLECPIPDAPVVTNVTVKARVWNSTFIEDYRDFDRVRVNGWATLFLRTSI 962
alpha6a NCSVN-VNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAA 985
alpha6b NCSVN-VNCVNIRCPLRGLDSKASLILRSRLWNSTFLEEYSKLNYLDILMRAFIDVTAAA 985
alpha7 DCARGTANCVVFSCPLYSFDRAAVLHVWGRLWNSTFLEEYSAVKSLEVIVRANITVKSSI 1008
alpha4 YCIKADPHCLNFLCNFGKMESGKEASVHIQLEGRPSILEMDETSALKFEIRATGFPEPNP 948
alpha9 DCEKPGISCLTAHCNFSALAKEESRTIDIYMLLNTEILKKDSSSVIQFMSRAKVKVDPAL 949
alphaE AYSSVQHVEEWHSVSCVIASDKENVTVAAEISWDHSEELLKDVTELQILGEISFNKSL-- 1099
: :
alpha1 ----LVLSSSNQKRELAIQISKDGL-PGRVPLWVILLSAFAGLLLLMLLILALWKIGFFK 1170
alpha2 ----IYVIEDN-TVTIPLMIMKPDE-KAEVPTGVIIGSIIAGILLLLALVAILWKLGFFK 1160
alpha10 ----VLQLTEASRWSESLLEVVQTR-PILISLWILIGSVLGGLLLLALLVFCLWKLGFFA 1151
alpha11 ----PFIFREEDPSRQIVFEISKQE-DWQVPIWIIVGSTLGGLLLLALLVLALWKLGFFR 1170
alphaD ----YSQLPGQEAFMRAQMEMVLEEDEVYNAIPIIMGSSVGALLLLALITATLYKLGFFK 1129
alphaX ----YSQLPGQEAFMRAQTTTVLEKYKVHNPTPLIVGSSIGGLLLLALITAVLYKVGFFK 1134
alphaM ----FTLLPGQGAFVRSQTETKVEPFEVPNPLPLIVGSSVGGLLLLALITAALYKLGFFK 1134
alphaL ----HFHLYGSNASL-AQVVMKVDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFK 1118
alpha8 YTDQPAKLPEGSIAIKTSVIWATPNVSFSIPLWVIILAILLGLLVLAILTLALWKCGFFD 1040
alphaV YKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFK 1022
alpha5 YRILPRQLPQKERQVATAVQWTKAEGSYGVPLWIIILAILFGLLLLGLLIYILYKLGFFK 1027
alpha2b YAVPPLSLPRGEAQVWTQLLRALEER--AIPIWWVLVGVLGGLLLLTILVLAMWKVGFFK 1025
alpha3a PTINMENKT--TWFSVDIDSELVEELPAEIELWLVLVAVGAGLLLLGLIILLLWKCGFFK 1020
alpha3b PTINMENKT--TWFSVDIDSELVEELPAEIELWLVLVAVGAGLLLLGLIILLLWKCDFFK 1020
alpha6a ENIRLPNAG--TQVRVTVFPSKTVAQYSGVPWWIILVAILAGILMLALLVFILWKCGFFK 1043
alpha6b ENIRLPNAG--TQVRVTVFPSKTVAQYSGVPWWIILVAILAGILMLALLVFILWKCGFFK 1043
alpha7 KNLMLRDAS--TVIPVMVYLDPMAVVAEGVPWWVILLAVLAGLLVLALLVLLLWKMGFFK 1066
alpha4 RVIELNK-DENVAHVLLEGLHHQRPKR-YFTIVIISSSLLLGLIVLLLISYVMWKAGFFK 1006
alpha9 RVVEIAHGNPEEVTVVFEALHNLEPRG-YVVGWIIAISLLVGILIFLLLAVLLWKMGFFR 1008
alphaE ------YEGLNAENHRTKITVVFLKDEKYHSLPIIIKGSVGGLLVLIVILVILFKCGFFK 1153
. .:::: : ::: .**
alpha1 RPLKKKMEK--------------------------------------------------- 1179
alpha2 RKYEKMTKNPDEIDETTELSS--------------------------------------- 1181
alpha10 HKKIPEEEKREEKLEQ-------------------------------------------- 1167
alpha11 SARRRREPGLDPTPKVLE------------------------------------------ 1188
alphaD RHYKEMLEDKPEDTATFSGDDFSCVAPNVPLS---------------------------- 1161
alphaX RQYKEMMEEANGQIAPENGTQTPSPPSEK------------------------------- 1163
alphaM RQYKDMMSEGGPPGAEPQ------------------------------------------ 1152
alphaL RNLKEKMEAGRGVPNGIPAEDSEQLASGQEAGDPGCLKPLHEKDSESGGGKD-------- 1170
alpha8 RARPPQEDMTDREQLTNDKTPEA------------------------------------- 1063
alphaV RVRPPQEEQ-EREQLQPHENGEGNSET--------------------------------- 1048
alpha5 RSLPYGTAM-EKAQLKPPATSDA------------------------------------- 1049
alpha2b RNRPPLEEDDEEGE---------------------------------------------- 1039
alpha3a RAR----TRALYEAKRQKAEMKSQ--PSETERLTDDY----------------------- 1051
alpha3b RTRY-YQIMPKYHAVRIREEERYP--PPGSTLPTKKHWVTSWQTRDQYY----------- 1066
alpha6a RSRY-DDSVPRYHAVRIRKEEREIKDEKYIDNLEKKQWITKWNENESYS----------- 1091
alpha6b RNKK-DHYDATYHKAEIHAQPSDK--ERLTSDA--------------------------- 1073
alpha7 RAKHPEATVPQYHAVKIPREDRQQFKEEKTGTILRNNWGSPRREGPDAHPILAADGHPEL 1126
alpha4 RQYKSILQEENRR----DSWSYINSKSNDD------------------------------ 1032
alpha9 RRYKEIIEAEKNRKENEDSWDWVQKNQ--------------------------------- 1035
alphaE RKYQQLNLESIRKAQLKSENLLEEEN---------------------------------- 1179
alpha1 -----------
alpha2 -----------
alpha10 -----------
alpha11 -----------
alphaD -----------
alphaX -----------
alphaM -----------
alphaL -----------
alpha8 -----------
alphaV -----------
alpha5 -----------
alpha2b -----------
alpha3a -----------
alpha3b -----------
alpha6a -----------
alpha6b -----------
alpha7 GPDGHPGPGTA 1137
alpha4 -----------
alpha9 -----------
alphaE -----------
Accession Numbers: NP_852478 - integrin alpha 1 ; NP_002194 integrin alpha 2 ; NP_000410 integrin alpha 2b; NP_002195 integrin alpha 3 isoform a ; NP_005492 integrin alpha 3 isoform b, ;
NP_000876 integrin alpha 4 ; NP_002196 integrin alpha 5 ; NP_001073286 integrin alpha 6 isoform a ; NP_000201 integrin alpha 6 isoform b ; NP_002197 integrin alpha 7 ; NP_003629 integrin alpha 8; NP_002198 integrin alpha 9 ; NP_003628 integrin alpha 10 ; NP_001004439 integrin alpha 11 ; NP_005344 integrin alpha D ; NP_002199 integrin alpha E ; NP_002200 integrin alpha L ; NP_000623 integrin alpha M ; NP_002201 integrin alpha-V ; NP_000878 integrin alpha X ;
beta subunits:
beta1A ------------------MNLQPIFWIGLISSVCC------VFAQTDENRCLKAN----- 31
beta1D ------------------MNLQPIFWIGLISSVCC------VFAQTDENRCLKAN----- 31
beta1C-1 ------------------MNLQPIFWIGLISSVCC------VFAQTDENRCLKAN----- 31
beta1C-2 ------------------MNLQPIFWIGLISSVCC------VFAQTDENRCLKAN----- 31
beta1B ------------------MNLQPIFWIGLISSVCC------VFAQTDENRCLKAN----- 31
beta2 -----------------MLGLRPPLLALVGLLSLG-------CVLSQECTKFK------- 29
beta7 -----------------MVAL-PMVLVLLLVLSRGESELDAKIPSTGDATEWRNPHLSML 42
beta3 ----------------MRARPRPRPLWATVLALGA----LAGVGVGGPNICTTRG----- 35
beta5 ------------------MPRAPAPLYACLLGLCA----LLPR-LAGLNICTSGS----- 32
beta6 ------------------MGIELLCLFFLFLGRND----HVQG------GCALGG----- 27
beta8 MCGSALAFFTAAFVCLQNDRRGPASFLWAAWVFSL----VLGLGQGEDNRCASSN----- 51
beta4-2 -----------------MAGPRPSPWARLLLAALIS----VSLSGTLANRCKKAP----- 34
beta4-3 -----------------MAGPRPSPWARLLLAALIS----VSLSGTLANRCKKAP----- 34
beta4-1 -----------------MAGPRPSPWARLLLAALIS----VSLSGTLANRCKKAP----- 34
beta1A -----AKSCGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDIENPRGS 86
beta1D -----AKSCGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDIENPRGS 86
beta1C-1 -----AKSCGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDIENPRGS 86
beta1C-2 -----AKSCGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDIENPRGS 86
beta1B -----AKSCGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDIENPRGS 86
beta2 -----VSSCRECIESGPGCTWCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSL 84
beta7 GSCQPAPSCQKCILSHPSCAWCKQLNFTASGEAEARRCARREELLARGCPLEELEEPRGQ 102
beta3 -----VSSCQQCLAVSPMCAWCSDEALPLG----SPRCDLKENLLKDNCAPESIEFPVSE 86
beta5 -----ATSCEECLLIHPKCAWCSKEDFGSPR-SITSRCDLRANLVKNGCG-GEIESPASS 85
beta6 -----AETCEDCLLIGPQCAWCAQENFTHPS-GVGERCDTPANLLAKGCQLNFIENPVSQ 81
beta8 -----AASCARCLALGPECGWCVQEDFISGG-SRSERCDIVSNLISKGCSVDSIEYPSVH 105
beta4-2 -----VKSCTECVRVDKDCAYCTDEMFRDR------RCNTQAELLAAGCQRESIVVMESS 83
beta4-3 -----VKSCTECVRVDKDCAYCTDEMFRDR------RCNTQAELLAAGCQRESIVVMESS 83
beta4-1 -----VKSCTECVRVDKDCAYCTDEMFRDR------RCNTQAELLAAGCQRESIVVMESS 83
. :* *: * :* . : ** * .* :
beta1A KDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLY 146
beta1D KDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLY 146
beta1C-1 KDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLY 146
beta1C-2 KDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLY 146
beta1B KDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLY 146
beta2 AETQEDH--------------NGGQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLY 130
beta7 QEVLQDQPLSQGAR-------GEGATQLAPQRVRVTLRPGEPQQLQVRFLRAEGYPVDLY 155
beta3 ARVLEDRPLSDKGSGDS-----SQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIY 141
beta5 FHVLRSLPLSSKGSGSAG----WDVIQMTPQEIAVNLRPGDKTTFQLQVRQVEDYPVDLY 141
beta6 VEILKNKPLSVGRQKNS-----SDIVQIAPQSLILKLRPGGAQTLQVHVRQTEDYPVDLY 136
beta8 VIIPTENEIN---------------TQVTPGEVSIQLRPGAEANFMLKVHPLKKYPVDLY 150
beta4-2 FQITEETQIDTTLR----------RSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLY 133
beta4-3 FQITEETQIDTTLR----------RSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLY 133
beta4-1 FQITEETQIDTTLR----------RSQMSPQGLRVRLRPGEERHFELEVFEPLESPVDLY 133
. *: * : : **.. : : . *:*:*
beta1A YLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTP-AKLRN 205
beta1D YLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTP-AKLRN 205
beta1C-1 YLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTP-AKLRN 205
beta1C-2 YLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTP-AKLRN 205
beta1B YLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTP-AKLRN 205
beta2 YLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHP-DKLRN 189
beta7 YLMDLSYSMKDDLERVRQLGHALLVRLQEVTHSVRIGFGSFVDKTVLPFVSTVP-SKLRH 214
beta3 YLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALEN 201
beta5 YLMDLSLSMKDDLDNIRSLGTKLAEEMRKLTSNFRLGFGSFVDKDISPFSYTAP-RYQTN 200
beta6 YLMDLSASMDDDLNTIKELGSRLSKEMSKLTSNFRLGFGSFVEKPVSPFVKTTP-EEIAN 195
beta8 YLVDVSASMHNNIEKLNSVGNDLSRKMAFFSRDFRLGFGSYVDKTVSPYISIHP-ERIHN 209
beta4-2 ILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRP-EKLKE 192
beta4-3 ILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRP-EKLKE 192
beta4-1 ILMDFSNSMSDDLDNLKKMGQNLARVLSQLTSDYTIGFGKFVDKVSVPQTDMRP-EKLKE 192
*:*.* ** ::: :..:* * : .: . :*** :*:* * * .
beta1A PCT--S-EQNCTSPFSYKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCG 262
beta1D PCT--S-EQNCTSPFSYKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCG 262
beta1C-1 PCT--S-EQNCTSPFSYKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCG 262
beta1C-2 PCT--S-EQNCTSPFSYKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCG 262
beta1B PCT--S-EQNCTSPFSYKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCG 262
beta2 PCP--NKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACP 247
beta7 PCP--TRLERCQSPFSFHHVLSLTGDAQAFEREVGRQSVSGNLDSPEGGFDAILQAALCQ 272
beta3 PC--YDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCD 259
beta5 PCIGYKLFPNCVPSFGFRHLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCK 260
beta6 PCS--SIPYFCLPTFGFKHILPLTNDAERFNEIVKNQKISANIDTPEGGFDAIMQAAVCK 253
beta8 QCS--DYNLDCMPPHGYIHVLSLTENITEFEKAVHRQKISGNIDTPEGGFDAMLQAAVCE 267
beta4-2 PWP------NSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCT 246
beta4-3 PWP------NSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCT 246
beta4-1 PWP------NSDPPFSFKNVISLTEDVDEFRNKLQGERISGNLDAPEGGFDAILQTAVCT 246
. . ..: ::: ** *. : : :* * *:****:**::*.: *
beta1A SLIGWRN-VTRLLVFSTDAGFHFAGDGK--LGGIVLPNDGQCHLENN-MYTMSHYYDYPS 318
beta1D SLIGWRN-VTRLLVFSTDAGFHFAGDGK--LGGIVLPNDGQCHLENN-MYTMSHYYDYPS 318
beta1C-1 SLIGWRN-VTRLLVFSTDAGFHFAGDGK--LGGIVLPNDGQCHLENN-MYTMSHYYDYPS 318
beta1C-2 SLIGWRN-VTRLLVFSTDAGFHFAGDGK--LGGIVLPNDGQCHLENN-MYTMSHYYDYPS 318
beta1B SLIGWRN-VTRLLVFSTDAGFHFAGDGK--LGGIVLPNDGQCHLENN-MYTMSHYYDYPS 318
beta2 EEIGWRN-VTRLLVFATDDGFHFAGDGK--LGAILTPNDGRCHLEDN-LYKRSNEFDYPS 303
beta7 EQIGWRN-VSRLLVFTSDDTFHTAGDGK--LGGIFMPSDGHCHLDSNGLYSRSTEFDYPS 329
beta3 EKIGWRNDASHLLVFTTDAKTHIALDGR--LAGIVQPNDGQCHVGSDNHYSASTTMDYPS 317
beta5 EKIGWRKDALHLLVFTTDDVPHIALDGK--LGGLVQPHDGQCHLNEANEYTASNQMDYPS 318
beta6 EKIGWRNDSLHLLVFVSDADSHFGMDSK--LAGIVIPNDGLCHLDSKNEYSMSTVLEYPT 311
beta8 SHIGWRKEAKRLLLVMTDQTSHLALDSK--LAGIVVPNDGNCHLKN-NVYVKSTTMEHPS 324
beta4-2 RDIGWRPDSTHLLVFSTESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPS 306
beta4-3 RDIGWRPDSTHLLVFSTESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPS 306
beta4-1 RDIGWRPDSTHLLVFSTESAFHYEADGANVLAGIMSRNDERCHLDTTGTYTQYRTQDYPS 306
**** :**:. :: * *. *..:. * **: * ::*:
beta1A IAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSL 378
beta1D IAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSL 378
beta1C-1 IAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSL 378
beta1C-2 IAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSL 378
beta1B IAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSL 378
beta2 VGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVQLIKNAYNKL 363
beta7 VGQVAQALSAANIQPIFAVTSAALPVYQELSKLIPKSAVGELSEDSSNVVQLIMDAYNSL 389
beta3 LGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKI 377
beta5 LALLGEKLAENNINLIFAVTKNHYMLYKNFTALIPGTTVEILDGDSKNIIQLIINAYNSI 378
beta6 IGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEEL 371
beta8 LGQLSEKLIDNNINVIFAVQGKQFHWYKDLLPLLPGTIAGEIESKAANLNNLVVEAYQKL 384
beta4-2 VPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLEEAFNRI 366
beta4-3 VPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLEEAFNRI 366
beta4-1 VPTLVRLLAKHNIIPIFAVTNYSYSYYEKLHTYFPVSSLGVLQEDSSNIVELLEEAFNRI 366
: : * *: **** *:. :* : :. .: *: :*: .*: :
beta1A SSEVILENGKLSEGVTISYKSYCKNGVN--GTGENGRKCSNISIGDEVQFEISITSNKCP 436
beta1D SSEVILENGKLSEGVTISYKSYCKNGVN--GTGENGRKCSNISIGDEVQFEISITSNKCP 436
beta1C-1 SSEVILENGKLSEGVTISYKSYCKNGVN--GTGENGRKCSNISIGDEVQFEISITSNKCP 436
beta1C-2 SSEVILENGKLSEGVTISYKSYCKNGVN--GTGENGRKCSNISIGDEVQFEISITSNKCP 436
beta1B SSEVILENGKLSEGVTISYKSYCKNGVN--GTGENGRKCSNISIGDEVQFEISITSNKCP 436
beta2 SSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQP--RGDCDGVQINVPITFQVKVTATECI 421
beta7 SSTVTLEHSSLPPGVHISYESQCEGPEKREGKAEDRGQCNHVRINQTVTFWVSLQATHCL 449
beta3 RSKVELEVRDLPEELSLSFNATCLNNEV----IPGLKSCMGLKIGDTVSFSIEAKVRGCP 433
beta5 RSKVELSVWDQPEDLNLFFTATCQDGVS----YPGQRKCEGLKIGDTASFEVSLEARSCP 434
beta6 RSEVELEVLGDTEGLNLSFTAICNNGTL----FQHQKKCSHMKVGDTASFSVTVNIPHCE 427
beta8 ISEVKVQVENQVQGIYFNITAICPDGSR----KPGMEGCRNVTSNDEVLFNVTVTMKKCD 440
beta4-2 RSNLDIRALDSPRGLRTEVTSKMFQKTR-TGSFHIRRGEVGIYQVQLRALEHVDGTHVCQ 425
beta4-3 RSNLDIRALDSPRGLRTEVTSKMFQKTR-TGSFHIRRGEVGIYQVQLRALEHVDGTHVCQ 425
beta4-1 RSNLDIRALDSPRGLRTEVTSKMFQKTR-TGSFHIRRGEVGIYQVQLRALEHVDGTHVCQ 425
* : : : : : : *
beta1A -KKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGR 495
beta1D -KKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGR 495
beta1C-1 -KKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGR 495
beta1C-2 -KKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGR 495
beta1B -KKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGR 495
beta2 -QE--QSFVIRALGFTDIVTVQVLPQCECRCR-DQSRDRSLCH-GKGFLECGICRCDTGY 476
beta7 -PEP-HLLRLRALGFSEELIVELHTLCDCNCS-DTQPQAPHCSDGQGHLQCGVCSCAPGR 506
beta3 -QEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGW 492
beta5 SRHTEHVFALRPVGFRDSLEVGVTYNCTCGCSVGLEPNSARCN-GSGTYVCGLCECSPGY 493
beta6 --RRSRHIIIKPVGLGDALELLVSPECNCDCQKEVEVNSSKCHHGNGSFQCGVCACHPGH 485
beta8 VTGGKNYAIIKPIGFNETAKIHIHRNCSCQCEDNRGPKGKCVDETFLDSKCFQCDEN--- 497
beta4-2 LPEDQKGNIHLKPSFSDGLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGW 485
beta4-3 LPEDQKGNIHLKPSFSDGLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGW 485
beta4-1 LPEDQKGNIHLKPSFSDGLKMDAGIICDVCTCELQKEVRSARCSFNGDFVCGQCVCSEGW 485
.: : : * * *
beta1A VGRHCECSTDEVNSEDMDAYCRKENSS-EICSNNGECVCGQCVCRKRDNTNEIYSGKFCE 554
beta1D VGRHCECSTDEVNSEDMDAYCRKENSS-EICSNNGECVCGQCVCRKRDNTNEIYSGKFCE 554
beta1C-1 VGRHCECSTDEVNSEDMDAYCRKENSS-EICSNNGECVCGQCVCRKRDNTNEIYSGKFCE 554
beta1C-2 VGRHCECSTDEVNSEDMDAYCRKENSS-EICSNNGECVCGQCVCRKRDNTNEIYSGKFCE 554
beta1B VGRHCECSTDEVNSEDMDAYCRKENSS-EICSNNGECVCGQCVCRKRDNTNEIYSGKFCE 554
beta2 IGKNCECQTQGRSSQELEGSCRKDNNS-IICSGLGDCVCGQCLCHTSDVPGKLIYGQYCE 535
beta7 LGRLCECSVAELSSPDLESGCRAPNGTGPLCSGKGHCQCGRCSCSGQSS------GHLCE 560
beta3 LGSQCECSEEDYRPS-QQDECSPREGQ-PVCSQRGECLCGQCVCHSSDFG--KITGKYCE 548
beta5 LGTRCECQDGENQSV-YQNLCREAEGK-PLCSGRGDCSCNQCSCFESEFG--KIYGPFCE 549
beta6 MGPRCECGEDMLS----TDSCKEAPDH-PSCSGRGDCYCGQCICHLSPYG--NIYGPYCQ 538
beta8 ---KCHFDEDQFS----SESCKSHKDQ-PVCSGRGVCVCGKCSCHKIKLG--KVYGKYCE 547
beta4-2 SGQTCNCSTGSLS--DIQPCLREGEDK--PCSGRGECQCGHCVCYGEGR----YEGQFCE 537
beta4-3 SGQTCNCSTGSLS--DIQPCLREGEDK--PCSGRGECQCGHCVCYGEGR----YEGQFCE 537
beta4-1 SGQTCNCSTGSLS--DIQPCLREGEDK--PCSGRGECQCGHCVCYGEGR----YEGQFCE 537
*. . ** * * *.:* * * *:
beta1A CDNFNCDRSNGLICG--GNGVCKCRVCECNPNYTGSACDCS-LDTSTCEASNGQICNGRG 611
beta1D CDNFNCDRSNGLICG--GNGVCKCRVCECNPNYTGSACDCS-LDTSTCEASNGQICNGRG 611
beta1C-1 CDNFNCDRSNGLICG--GNGVCKCRVCECNPNYTGSACDCS-LDTSTCEASNGQICNGRG 611
beta1C-2 CDNFNCDRSNGLICG--GNGVCKCRVCECNPNYTGSACDCS-LDTSTCEASNGQICNGRG 611
beta1B CDNFNCDRSNGLICG--GNGVCKCRVCECNPNYTGSACDCS-LDTSTCEASNGQICNGRG 611
beta2 CDTINCERYNGQVCGGPGRGLCFCGKCRCHPGFEGSACQCE-RTTEGCLNPRRVECSGRG 594
beta7 CDDASCERHEGILCGGFGR--CQCGVCHCHANRTGRACECS-GDMDSCISPEGGLCSGHG 617
beta3 CDDFSCVRYKGEMCS--GHGQCSCGDCLCDSDWTGYYCNCT-TRTDTCMSSNGLLCSGRG 605
beta5 CDNFSCARNKGVLCS--GHGECHCGECKCHAGYIGDNCNCS-TDISTCRGRDGQICSERG 606
beta6 CDNFSCVRHKGLLCG--GNGDCDCGECVCRSGWTGEYCNCT-TSTDSCVSEDGVLCSGRG 595
beta8 KDDFSCPYHHGNLCA--GHGECEAGRCQCFSGWEGDRCQCPSAAAQHCVNSKGQVCSGRG 605
beta4-2 YDNFQCPRTSGFLCN--DRGRCSMGQCVCEPGWTGPSCDCP-LSNATCIDSNGGICNGRG 594
beta4-3 YDNFQCPRTSGFLCN--DRGRCSMGQCVCEPGWTGPSCDCP-LSNATCIDSNGGICNGRG 594
beta4-1 YDNFQCPRTSGFLCN--DRGRCSMGQCVCEPGWTGPSCDCP-LSNATCIDSNGGICNGRG 594
* .* * :* .. * * * .. * *:* * *. :*
beta1A ICECGVCKCTDPKFQGQTCEMCQT---CLGVCAEHKECVQCRAFNKGEKKDTCTQECSYF 668
beta1D ICECGVCKCTDPKFQGQTCEMCQT---CLGVCAEHKECVQCRAFNKGEKKDTCTQECSYF 668
beta1C-1 ICECGVCKCTDPKFQGQTCEMCQT---CLGVCAEHKECVQCRAFNKGEKKDTCTQECSYF 668
beta1C-2 ICECGVCKCTDPKFQGQTCEMCQT---CLGVCAEHKECVQCRAFNKGEKKDTCTQECSYF 668
beta1B ICECGVCKCTDPKFQGQTCEMCQT---CLGVCAEHKECVQCRAFNKGEKKDTCTQECSYF 668
beta2 RCRCNVCECHS-GYQLPLCQECPG---CPSPCGKYISCAECLKFEKGPFGKNCSAACPG- 649
beta7 RCKCNRCQCLD-GYYGALCDQCPG---CKTPCERHRDCAECGAFRTGPLATNCSTACAHT 673
beta3 KCECGSCVCIQPGSYGDTCEKCPT---CPDACTFKKECVECKKFDRGALHDENTCNRYCR 662
beta5 HCLCGQCQCTEPGAFGEMCEKCPT---CPDACSTKRDCVECLLLHSGKPDNQ-TCHSLCR 662
beta6 DCVCGKCVCTNPGASGPTCERCPT---CGDPCNSKRSCIECHLSAAGQAREECVDKCKLA 652
beta8 TCVCGRCECTDPRSIGRFCEHCPT---CYTACKENWNCMQCLHPHN-------------- 648
beta4-2 HCECGRCHCHQQSLYTDTICEINYSAIHPGLCEDLRSCVQCQAWGTGEKKGRTCEECNFK 654
beta4-3 HCECGRCHCHQQSLYTDTICEINYSAIHPGLCEDLRSCVQCQAWGTGEKKGRTCEECNFK 654
beta4-1 HCECGRCHCHQQSLYTDTICEINYSAIHPGLCEDLRSCVQCQAWGTGEKKGRTCEECNFK 654
* *. * * . * .* :*
beta1A NITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVN-GNNEVMVHVVENPECPTGP 727
beta1D NITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVN-GNNEVMVHVVENPECPTGP 727
beta1C-1 NITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVN-GNNEVMVHVVENPECPTGP 727
beta1C-2 NITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVN-GNNEVMVHVVENPECPTGP 727
beta1B NITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVN-GNNEVMVHVVENPECPTGP 727
beta2 -LQLSNN------PVKGR---TCKERDSEGCWVAYTLEQQDGMDRYLIYVDESRECVAGP 699
beta7 NVTLALA------PILDDG--WCKER-TLDNQLFFFLVEDDARGTVVLRVRPQE--KGAD 722
beta3 DEIES-VKE---LKDTGKDAVNCTYKNEDDCVVRFQYYED-SSGKSILYVVEEPECPKGP 717
beta5 DEVITWVDT---IVKDDQEAVLCFYKTAKDCVMMFTYVEL-PSGKSNLTVLREPECGNTP 718
beta6 GATISEEED---FSKDG--SVSCSLQGENECLITFLITTD-NEGKTIIHSINEKDCPKPP 706
beta8 ------------------LSQAILDQCKTSCALMEQQHYV-DQTSECFSSPSYLRIFFII 689
beta4-2 VKMVDELKR-----AEEVVVRCSFRDEDDDCTYSYTMEGDGAPGPNSTVLVHKKKDCPPG 709
beta4-3 VKMVDELKR-----AEEVVVRCSFRDEDDDCTYSYTMEGDGAPGPNSTVLVHKKKDCPPG 709
beta4-1 VKMVDELKR-----AEEVVVRCSFRDEDDDCTYSYTMEGDGAPGPNSTVLVHKKKDCPPG 709
beta1A DIIPIVAGVVAGIVLIGLALLLIWK---------LLMIIHDRREFAKFEKEKMNAKWDT- 777
beta1D DIIPIVAGVVAGIVLIGLALLLIWK---------LLMIIHDRREFAKFEKEKMNAKWDT- 777
beta1C-1 DIIPIVAGVVAGIVLIGLALLLIWK---------LLMIIHDRREFAKFEKEKMNAKWDTS 778
beta1C-2 DIIPIVAGVVAGIVLIGLALLLIWK---------LLMIIHDRREFAKFEKEKMNAKWDT- 777
beta1B DIIPIVAGVVAGIVLIGLALLLIWK---------LLMIIHDRREFAKFEKEKMNAKWDT- 777
beta2 NIAAIVGGTVAGIVLIGILLLVIWK---------ALIHLSDLREYRRFEKEKLKSQWNND 750
beta7 HTQAIVLGCVGGIVAVGLGLVLAYR---------LSVEIYDRREYSRFEKEQQQLNWKQD 773
beta3 DILVVLLSVMGAILLIGLAALLIWK---------LLITIHDRKEFAKFEEERARAKWDTA 768
beta5 NAMTILLAVVGSILLVGLALLAIWK---------LLVTIHDRREFAKFQSERSRARYEMA 769
beta6 NIPMIMLGVSLAILLIGVVLLCIWK---------LLVSFHDRKEVAKFEAERSKAKWQTG 757
beta8 FIVTFLIGLLKVLIIRQVILQWNSN---------KIKSSSDYRVSASKKDKLILQSVCTR 740
beta4-2 SFWWLIPLLLLLLPLLALLLLLCWKYCACCKACLALLPCCNRGHMVGFKEDHYMLRENLM 769
beta4-3 SFWWLIPLLLLLLPLLALLLLLCWKYCACCKACLALLPCCNRGHMVGFKEDHYMLRENLM 769
beta4-1 SFWWLIPLLLLLLPLLALLLLLCWKYCACCKACLALLPCCNRGHMVGFKEDHYMLRENLM 769
.: : : . : : .
beta1A ----------------GENPIYKSAVTTVVNP---KYEGK-------------------- 798
beta1D ----------------QENPIYKSPINNFKNP---NYGRKAGL----------------- 801
beta1C-1 LSVAQPGVQWCDISSLQPLTSRFQQFSCLSLPSTWDYRVKILFIRVP------------- 825
beta1C-2 -----PGVQWCDISSLQPLTSRFQQFSCLSLPSTWDYRVKILFIRVP------------- 819
beta1B ---------------VSYKTSKKQ--SGL------------------------------- 789
beta2 ------------------NPLFKSATTTVMNPKFAES----------------------- 769
beta7 S-----------------NPLYKSAITTTINPRFQEADSPTL------------------ 798
beta3 N-----------------NPLYKEATSTFT--------NITYRGT--------------- 788
beta5 S-----------------NPLYRKPISTHTVDFTFNKFNKSYNGTVD------------- 799
beta6 T-----------------NPLYRGSTSTFKNVTYKHREKQKVDLSTDC------------ 788
beta8 A-----------------VTYRREKPEEIKMDISKLNAHETFRCNF-------------- 769
beta4-2 ASDHLDTPMLRSGNLKGRDVVRWKVTNNMQRPGFATHAASINPTELVPYGLSLRLARLCT 829
beta4-3 ASDHLDTPMLRSGNLKGRDVVRWKVTNNMQRPGFATHAASINPTELVPYGLSLRLARLCT 829
beta4-1 ASDHLDTPMLRSGNLKGRDVVRWKVTNNMQRPGFATHAASINPTELVPYGLSLRLARLCT 829
beta1A ------------------------------------------------------------
beta1D ------------------------------------------------------------
beta1C-1 ------------------------------------------------------------
beta1C-2 ------------------------------------------------------------
beta1B ------------------------------------------------------------
beta2 ------------------------------------------------------------
beta7 ------------------------------------------------------------
beta3 ------------------------------------------------------------
beta5 ------------------------------------------------------------
beta6 ------------------------------------------------------------
beta8 ------------------------------------------------------------
beta4-2 ENLLKPDTRECAQLRQEVEENLNEVYRQISGVHKLQQTKFRQQPNAGKKQDHTIVDTVLM 889
beta4-3 ENLLKPDTRECAQLRQEVEENLNEVYRQISGVHKLQQTKFRQQPNAGKKQDHTIVDTVLM 889
beta4-1 ENLLKPDTRECAQLRQEVEENLNEVYRQISGVHKLQQTKFRQQPNAGKKQDHTIVDTVLM 889
beta1A ------------------------------------------------------------
beta1D ------------------------------------------------------------
beta1C-1 ------------------------------------------------------------
beta1C-2 ------------------------------------------------------------
beta1B ------------------------------------------------------------
beta2 ------------------------------------------------------------
beta7 ------------------------------------------------------------
beta3 ------------------------------------------------------------
beta5 ------------------------------------------------------------
beta6 ------------------------------------------------------------
beta8 ------------------------------------------------------------
beta4-2 APRSAKPALLKLTEKQVEQRAFHDLKVAPGYYTLTADQDARGMVEFQEGVELVDVRVPLF 949
beta4-3 APRSAKPALLKLTEKQVEQRAFHDLKVAPGYYTLTADQDARGMVEFQEGVELVDVRVPLF 949
beta4-1 APRSAKPALLKLTEKQVEQRAFHDLKVAPGYYTLTADQDARGMVEFQEGVELVDVRVPLF 949
beta1A ------------------------------------------------------------
beta1D ------------------------------------------------------------
beta1C-1 ------------------------------------------------------------
beta1C-2 ------------------------------------------------------------
beta1B ------------------------------------------------------------
beta2 ------------------------------------------------------------
beta7 ------------------------------------------------------------
beta3 ------------------------------------------------------------
beta5 ------------------------------------------------------------
beta6 ------------------------------------------------------------
beta8 ------------------------------------------------------------
beta4-2 IRPEDDDEKQLLVEAIDVPAGTATLGRRLVNITIIKEQARDVVSFEQPEFSVSRGDQVAR 1009
beta4-3 IRPEDDDEKQLLVEAIDVPAGTATLGRRLVNITIIKEQARDVVSFEQPEFSVSRGDQVAR 1009
beta4-1 IRPEDDDEKQLLVEAIDVPAGTATLGRRLVNITIIKEQARDVVSFEQPEFSVSRGDQVAR 1009
beta1A ------------------------------------------------------------
beta1D ------------------------------------------------------------
beta1C-1 ------------------------------------------------------------
beta1C-2 ------------------------------------------------------------
beta1B ------------------------------------------------------------
beta2 ------------------------------------------------------------
beta7 ------------------------------------------------------------
beta3 ------------------------------------------------------------
beta5 ------------------------------------------------------------
beta6 ------------------------------------------------------------
beta8 ------------------------------------------------------------
beta4-2 IPVIRRVLDGGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVDS 1069
beta4-3 IPVIRRVLDGGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVDS 1069
beta4-1 IPVIRRVLDGGKSQVSYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVDS 1069
beta1A ------------------------------------------------------------
beta1D ------------------------------------------------------------
beta1C-1 ------------------------------------------------------------
beta1C-2 ------------------------------------------------------------
beta1B ------------------------------------------------------------
beta2 ------------------------------------------------------------
beta7 ------------------------------------------------------------
beta3 ------------------------------------------------------------
beta5 ------------------------------------------------------------
beta6 ------------------------------------------------------------
beta8 ------------------------------------------------------------
beta4-2 LLRGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRDPDELDRSFTSQMLSSQPPPHGDLGA 1129
beta4-3 LLRGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRDPDELDRSFTSQMLSSQPPPHGDLGA 1129
beta4-1 LLRGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRDPDELDRSFTSQMLSSQPPPHGDLGA 1129
beta1A ------------------------------------------------------------
beta1D ------------------------------------------------------------
beta1C-1 ------------------------------------------------------------
beta1C-2 ------------------------------------------------------------
beta1B ------------------------------------------------------------
beta2 ------------------------------------------------------------
beta7 ------------------------------------------------------------
beta3 ------------------------------------------------------------
beta5 ------------------------------------------------------------
beta6 ------------------------------------------------------------
beta8 ------------------------------------------------------------
beta4-2 PQNPNAKAAGSRKIHFNWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPY 1189
beta4-3 PQNPNAKAAGSRKIHFNWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPY 1189
beta4-1 PQNPNAKAAGSRKIHFNWLPPSGKPMGYRVKYWIQGDSESEAHLLDSKVPSVELTNLYPY 1189
beta1A ------------------------------------------------------------
beta1D ------------------------------------------------------------
beta1C-1 ------------------------------------------------------------
beta1C-2 ------------------------------------------------------------
beta1B ------------------------------------------------------------
beta2 ------------------------------------------------------------
beta7 ------------------------------------------------------------
beta3 ------------------------------------------------------------
beta5 ------------------------------------------------------------
beta6 ------------------------------------------------------------
beta8 ------------------------------------------------------------
beta4-2 CDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGE 1249
beta4-3 CDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGE 1249
beta4-1 CDYEMKVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGE 1249
beta1A ------------------------------------------------------------
beta1D ------------------------------------------------------------
beta1C-1 ------------------------------------------------------------
beta1C-2 ------------------------------------------------------------
beta1B ------------------------------------------------------------
beta2 ------------------------------------------------------------
beta7 ------------------------------------------------------------
beta3 ------------------------------------------------------------
beta5 ------------------------------------------------------------
beta6 ------------------------------------------------------------
beta8 ------------------------------------------------------------
beta4-2 ITAYEVCYGLVNDDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPE 1309
beta4-3 ITAYEVCYGLVNDDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPE 1309
beta4-1 ITAYEVCYGLVNDDNRPIGPMKKVLVDNPKNRMLLIENLRESQPYRYTVKARNGAGWGPE 1309
beta1A ------------------------------------------------------------
beta1D ------------------------------------------------------------
beta1C-1 ------------------------------------------------------------
beta1C-2 ------------------------------------------------------------
beta1B ------------------------------------------------------------
beta2 ------------------------------------------------------------
beta7 ------------------------------------------------------------
beta3 ------------------------------------------------------------
beta5 ------------------------------------------------------------
beta6 ------------------------------------------------------------
beta8 ------------------------------------------------------------
beta4-2 REAIINLATQPKRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDT 1369
beta4-3 REAIINLATQPKRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDT 1369
beta4-1 REAIINLATQPKRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDT 1369
beta1A ------------------------------------------------------------
beta1D ------------------------------------------------------------
beta1C-1 ------------------------------------------------------------
beta1C-2 ------------------------------------------------------------
beta1B ------------------------------------------------------------
beta2 ------------------------------------------------------------
beta7 ------------------------------------------------------------
beta3 ------------------------------------------------------------
beta5 ------------------------------------------------------------
beta6 ------------------------------------------------------------
beta8 ------------------------------------------------------------
beta4-2 ------------------------------------------------------------
beta4-3 ------------------------------------------------------------
beta4-1 GCGWKFEPLLGEELDLRRVTWRLPPELIPRLSASSGRSSDAEAPHGPPDDGGAGGKGGSL 1429
beta1A ------------------------------------------------------------
beta1D ------------------------------------------------------------
beta1C-1 ------------------------------------------------------------
beta1C-2 ------------------------------------------------------------
beta1B ------------------------------------------------------------
beta2 ------------------------------------------------------------
beta7 ------------------------------------------------------------
beta3 ------------------------------------------------------------
beta5 ------------------------------------------------------------
beta6 ------------------------------------------------------------
beta8 ------------------------------------------------------------
beta4-2 ----------EHLVNGRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLT 1419
beta4-3 ----------EHLVNGRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLT 1419
beta4-1 PRSATPGPPGEHLVNGRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLT 1489
beta1A ------------------------------------------------------------
beta1D ------------------------------------------------------------
beta1C-1 ------------------------------------------------------------
beta1C-2 ------------------------------------------------------------
beta1B ------------------------------------------------------------
beta2 ------------------------------------------------------------
beta7 ------------------------------------------------------------
beta3 ------------------------------------------------------------
beta5 ------------------------------------------------------------
beta6 ------------------------------------------------------------
beta8 ------------------------------------------------------------
beta4-2 RDYNSLTRSEHSHSTTLPRDYSTLTSVSSHGLPPIWEHGRSRLPLSWALGSRSRAQMKGF 1479
beta4-3 RDYNSLTRSEHSHSTTLPRDYSTLTSVSSH------------------------------ 1449
beta4-1 RDYNSLTRSEHSHSTTLPRDYSTLTSVSSH------------------------------ 1519
beta1A ------------------------------------------------------------
beta1D ------------------------------------------------------------
beta1C-1 ------------------------------------------------------------
beta1C-2 ------------------------------------------------------------
beta1B ------------------------------------------------------------
beta2 ------------------------------------------------------------
beta7 ------------------------------------------------------------
beta3 ------------------------------------------------------------
beta5 ------------------------------------------------------------
beta6 ------------------------------------------------------------
beta8 ------------------------------------------------------------
beta4-2 PPSRGPRDSIILAGRPAAPSWGPDSRLTAGVPDTPTRLVFSALGPTSLRVSWQEPRCERP 1539
beta4-3 -----------------------DSRLTAGVPDTPTRLVFSALGPTSLRVSWQEPRCERP 1486
beta4-1 -----------------------DSRLTAGVPDTPTRLVFSALGPTSLRVSWQEPRCERP 1556
beta1A ------------------------------------------------------------
beta1D ------------------------------------------------------------
beta1C-1 ------------------------------------------------------------
beta1C-2 ------------------------------------------------------------
beta1B ------------------------------------------------------------
beta2 ------------------------------------------------------------
beta7 ------------------------------------------------------------
beta3 ------------------------------------------------------------
beta5 ------------------------------------------------------------
beta6 ------------------------------------------------------------
beta8 ------------------------------------------------------------
beta4-2 LQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVI 1599
beta4-3 LQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVI 1546
beta4-1 LQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVI 1616
beta1A ------------------------------------------------------------
beta1D ------------------------------------------------------------
beta1C-1 ------------------------------------------------------------
beta1C-2 ------------------------------------------------------------
beta1B ------------------------------------------------------------
beta2 ------------------------------------------------------------
beta7 ------------------------------------------------------------
beta3 ------------------------------------------------------------
beta5 ------------------------------------------------------------
beta6 ------------------------------------------------------------
beta8 ------------------------------------------------------------
beta4-2 TIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLV 1659
beta4-3 TIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLV 1606
beta4-1 TIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLV 1676
beta1A ------------------------------------------------------------
beta1D ------------------------------------------------------------
beta1C-1 ------------------------------------------------------------
beta1C-2 ------------------------------------------------------------
beta1B ------------------------------------------------------------
beta2 ------------------------------------------------------------
beta7 ------------------------------------------------------------
beta3 ------------------------------------------------------------
beta5 ------------------------------------------------------------
beta6 ------------------------------------------------------------
beta8 ------------------------------------------------------------
beta4-2 TCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIES 1719
beta4-3 TCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIES 1666
beta4-1 TCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIES 1736
beta1A ------------------------------------------------------------
beta1D ------------------------------------------------------------
beta1C-1 ------------------------------------------------------------
beta1C-2 ------------------------------------------------------------
beta1B ------------------------------------------------------------
beta2 ------------------------------------------------------------
beta7 ------------------------------------------------------------
beta3 ------------------------------------------------------------
beta5 ------------------------------------------------------------
beta6 ------------------------------------------------------------
beta8 ------------------------------------------------------------
beta4-2 QDGGPFPQLGSRAGLFQHPLQSEYSSITTTHTSATEPFLVDGLTLGAQHLEAGGSLTRHV 1779
beta4-3 QDGGPFPQLGSRAGLFQHPLQSEYSSITTTHTSATEPFLVDGLTLGAQHLEAGGSLTRHV 1726
beta4-1 QDGGPFPQLGSRAGLFQHPLQSEYSSITTTHTSATEPFLVDGLTLGAQHLEAGGSLTRHV 1796
beta1A --------------------------
beta1D --------------------------
beta1C-1 --------------------------
beta1C-2 --------------------------
beta1B --------------------------
beta2 --------------------------
beta7 --------------------------
beta3 --------------------------
beta5 --------------------------
beta6 --------------------------
beta8 --------------------------
beta4-2 TQEFVSRTLTTSGTLSTHMDQQFFQT 1805
beta4-3 TQEFVSRTLTTSGTLSTHMDQQFFQT 1752
beta4-1 TQEFVSRTLTTSGTLSTHMDQQFFQT 1822
Accession Numbers of the integrin sequences used in the protein sequence alignment: NP_596867 integrin beta 1 isoform 1A ; NP_389647 integrin beta 1 isoform 1B ; NP_391987 integrin beta 1 isoform 1C-1 ; NP_391989 integrin beta 1 isoform 1C-2 ; NP_391988 integrin beta 1 isoform 1D ; NP_000202 integrin beta 2 ; NP_000203 integrin beta 3 ; NP_000204 integrin beta 4 isoform 1 ; NP_001005619 integrin beta 4 isoform 2 ; NP_001005731 integrin beta 4 isoform 3 ; NP_002204 integrin beta 5; NP_000879 integrin beta 6; NP_000880 integrin beta 7; NP_002205 integrin beta 8
Predicted General Properties of the alpha-v beta-3 Integrin Protein (Homo sapiens) - Primary Sequence Analysis (with ProtParam)b
alpha-v
subunit
Number of amino acids: 1048
Molecular weight: 116051.8
Theoretical pI: 5.45
Total number of negatively charged residues (Asp + Glu): 122
Total number of positively charged residues (Arg + Lys): 103
Atomic composition: Carbon C 5176 Hydrogen H 8076 Nitrogen N 1398 Oxygen O 1555 Sulfur S 40
Formula: C5176H8076N1398O1555S40
Total number of atoms: 16245
Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 111255 Abs 0.1% (=1 g/l) 0.959, assuming ALL Cys residues appear as half cystines Ext. coefficient 110130 Abs 0.1% (=1 g/l) 0.949, assuming NO Cys residues appear as half cystines
Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).
Instability index: The instability index (II) is computed to be 37.69 This classifies the protein as stable.
Aliphatic index: 86.15
Grand average of hydropathicity (GRAVY): -0.220
beta-3 subunit
Number of amino acids: 788
Molecular weight: 87057.8
Theoretical pI: 5.09
