Sequence Alignment of the Fibronectin Protein (with Clustalw)a
Isoform and Species Sequence Alignment
of Fibronectin
X.tropicalis MRWGALTG---LLLALCLCAVVRSAP--SSKKRRQAQQQQ---VVQPHGSPDSQQKGCYD 52
X.laevis MRRGALTG---LLLVLCLSVVLRAAPSATSKKRRQAQQQQQQQVVQPQGTQDNHQKGCYD 57
Mouse MLRGPGPGRLLLLAVLCLGTSVRCTE--AGKSKRQAQQIVQ---PQSPVAVSQSKPGCFD 55
Rat MLRGPGPGRLLLLAVLCLGTSVRCTE--TGKSKRQAQQIVQ---PPSPVAVSQSKPGCFD 55
Fibronectin1.2 MLRGPGPG-LLLLAVQCLGTAVPSTG--ASKSKRQAQQMVQ---PQSPVAVSQSKPGCYD 54
Fibronectin1.4 MLRGPGPG-LLLLAVQCLGTAVPSTG--ASKSKRQAQQMVQ---PQSPVAVSQSKPGCYD 54
Fibronectin1.1 MLRGPGPG-LLLLAVQCLGTAVPSTG--ASKSKRQAQQMVQ---PQSPVAVSQSKPGCYD 54
Fibronectin1.5 MLRGPGPG-LLLLAVQCLGTAVPSTG--ASKSKRQAQQMVQ---PQSPVAVSQSKPGCYD 54
Fibronectin1.6 MLRGPGPG-LLLLAVQCLGTAVPSTG--ASKSKRQAQQMVQ---PQSPVAVSQSKPGCYD 54
Fibronectin1.3 MLRGPGPG-LLLLAVQCLGTAVPSTG--ASKSKRQAQQMVQ---PQSPVAVSQSKPGCYD 54
Zebrafish MFGGPLGT---ALAVALLACAVQCMPKGTGKHKRQAQEHSVS---------SVSQDGCVM 48
* *. * . * : . :.* :****: . : **
X.tropicalis NGKYYQINQQWERTYLGNTLVCTCYGGGRGFNCESKPESEETCFDKYTGVTYRVGETYER 112
X.laevis NGKYYQINQQWERTYLGNTLVCTCYGGGRGFNCESKPESEETCFDKYTGVSYRVGETYER 117
Mouse NGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEPEETCFDKYTGNTYKVGDTYER 115
Rat NGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEPEETCFDKYTGNTYKVGDTYER 115
Fibronectin1.2 NGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYER 114
Fibronectin1.4 NGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYER 114
Fibronectin1.1 NGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYER 114
Fibronectin1.5 NGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYER 114
Fibronectin1.6 NGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYER 114
Fibronectin1.3 NGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYER 114
Zebrafish DGQFYGAGEQWERIYLGSTLLCTCHGVSK-IECKSKPDAEETCYDKVNSRSYRVGETYER 107
:*:.* .:**** ***.:*:***:* .: ::*:***:.****:** .. :*:**:****
X.tropicalis PKDNMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGK 172
X.laevis PKDNMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGK 177
Mouse PKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDKWRRPHETGGYMLECLCLGNGK 175
Rat PKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDKWRRPHETGGYMLECLCLGNGK 175
Fibronectin1.2 PKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGK 174
Fibronectin1.4 PKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGK 174
Fibronectin1.1 PKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGK 174
Fibronectin1.5 PKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGK 174
Fibronectin1.6 PKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGK 174
Fibronectin1.3 PKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGK 174
Zebrafish PKDGMIWDCTCIGSARGKISCTIANRCHEGGHSYKIGDTWQRPHDTGDYMLECVCLGNGK 167
***.*********:.**:*************:******.*:***:**.*****:******
X.tropicalis GEWTCKPVAERCYDNTAGISYVVGQTWEKPYQGWMMVDCTCLGEGSGRITCSSKNRCNDQ 232
X.laevis GEWTCKPVAERCYDNTAGTSYVVGQTWEKPYQGWMMVDCTCLGEGNGRITCSSKNRCNDQ 237
Mouse GEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITCTSRNRCNDQ 235
Rat GEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITCTSRNRCNDQ 235
Fibronectin1.2 GEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQ 234
Fibronectin1.4 GEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQ 234
Fibronectin1.1 GEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQ 234
Fibronectin1.5 GEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQ 234
Fibronectin1.6 GEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQ 234
Fibronectin1.3 GEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQ 234
Zebrafish GEWTCKPVADACYDNTAGTSYMVGETWEKPYQGWMIVDCTCLGEGSGRITCTSRNRCNDQ 227
*******:*: *:*::** **:**:**********:*********.*****:*:******
X.tropicalis DTRTSYRIGNSWSKTDTRGNLLQCICTGNGRGEWKCDRHSSAQATGTGSNP--ITNIQTT 290
X.laevis DTKTSYRIGDTWSKTDTRGNLLQCICTGNGRGEWKCERHSSAQATGTGSNP--ITNIQTA 295
Mouse DTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKCERH-ALQSASAGSGS--FTDVRTA 292
Rat DTRTSYRIGDTWSKKDNRGNLLQCVCTGNGRGEWKCERH-VLQSASAGSGS--FTDVRTA 292
Fibronectin1.2 DTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGP--FTDVRAA 292
Fibronectin1.4 DTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGP--FTDVRAA 292
Fibronectin1.1 DTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGP--FTDVRAA 292
Fibronectin1.5 DTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGP--FTDVRAA 292
Fibronectin1.6 DTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGP--FTDVRAA 292
Fibronectin1.3 DTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGP--FTDVRAA 292
Zebrafish DTRTSYRIGDTWSKTDSRGHVLQCLCTGNGRGEWKCERHASLHTTSLGTGSRVVTNVQPA 287
**:******::***.*.**::***:***********:** :::. *:.. .*:::.:
X.tropicalis LFQPDSELEP--YGHCVTDNGVLYSLGMRWLKAQGSKQMLCTCLGNGVSCEET-VETITF 347
X.laevis LYQPDSQLEP--YGHCVTDNGVLYSLGMRWLRTQGSKQMLCTCLGNGVSCEET-VATITF 352
Mouse IYQPQTHPQPAPYGHCVTDSGVVYSVGMQWLKSQGNKQMLCTCLGNGVSCQET-AVTQTY 351
Rat IYQPQTHPQPAPYGHCVTDSGVVYSVGMQWLKSQGDKQMLCTCLGNGVSCQET-AVTQTY 351
Fibronectin1.2 VYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQET-AVTQTY 351
Fibronectin1.4 VYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQET-AVTQTY 351
Fibronectin1.1 VYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQET-AVTQTY 351
Fibronectin1.5 VYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQET-AVTQTY 351
Fibronectin1.6 VYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQET-AVTQTY 351
Fibronectin1.3 VYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQET-AVTQTY 351
Zebrafish VYHPQGVPEHPVEGSCLTEAGVSYAPGMRWSKAQGSKQMLCTCLGNGVSCEESESQSQVY 347
:::*: : * *:*: ** *: **:* ::**.**************:*: : .:
X.tropicalis GGNANGEPCAIPFTHDGKTYYSCTGEGRQDGKLWCATTSNYDTDKKYSFCNEQRALVQTR 407
X.laevis GGNANGEPCAIPFTHDGKTYYSCTSEGRQDGKLWCATTSNYDSDKKYSFCTEQLALVQTR 412
Mouse GGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHAVLVQTR 411
Rat GGNSNGEPCVLPFHYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHAVLVQTR 411
Fibronectin1.2 GGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTR 411
Fibronectin1.4 GGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTR 411
Fibronectin1.1 GGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTR 411
Fibronectin1.5 GGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTR 411
Fibronectin1.6 GGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTR 411
Fibronectin1.3 GGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTR 411
Zebrafish GGTSGGEPCAFPFVFMGETFYSCTSEGRNDGQLWCSTSSDFEKDYKYSFCTSNNVVVTTR 407
**.:.****.:** . *.*:**** ***:**:***:*:*::: * *****..: .:* **
X.tropicalis GGNSNGALCNFPFLYNNRNYTDCTSEGRRDSMKWCGTTANYDADQKFGFCPMAAHEEICT 467
X.laevis GGNSNGALCNFPFLYNNLNYTDCTSEGRQDSMKWCGTTANYDADQKFGFCPMAAHEEICT 472
Mouse GGNSNGALCHFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICT 471
Rat GGNSNGALCHFPFLYSNRNYSDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICT 471
Fibronectin1.2 GGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICT 471
Fibronectin1.4 GGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICT 471
Fibronectin1.1 GGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICT 471
Fibronectin1.5 GGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICT 471
Fibronectin1.6 GGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICT 471
Fibronectin1.3 GGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICT 471
Zebrafish GGNSNGALCQFPFLYNGRNYTDCTADGRRDGMKWCGTTYNFDKEQRFGFCPMAAHEEVCT 467
*********:*****.. **:***::**:*.******* *:* :*:***********:**
X.tropicalis TNEGVMYRVGDQWDKQHD-QGHMMRCTCVGNGRGEWTCVAYSQLKDQCIVDGITYDVNSS 526
X.laevis TNEGVMYRVGDQWDKQHD-QGHMMRCTCVGNGRGEWSCVAYSQLKDQCIVDGLTYNVNSS 531
Mouse TNEGVMYRIGDQWDKQHD-LGHMMRCTCVGNGRGEWACIPYSQLRDQCIVDDITYNVNDT 530
Rat TNEGVMYRIGDQWDKQHD-LGHMMRCTCVGNGRGQWACIPYSQLRDQCIVDDITYNVNDT 530
Fibronectin1.2 TNEGVMYRIGDQWDKQHD-MGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDT 530
Fibronectin1.4 TNEGVMYRIGDQWDKQHD-MGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDT 530
Fibronectin1.1 TNEGVMYRIGDQWDKQHD-MGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDT 530
Fibronectin1.5 TNEGVMYRIGDQWDKQHD-MGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDT 530
Fibronectin1.6 TNEGVMYRIGDQWDKQHD-MGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDT 530
Fibronectin1.3 TNEGVMYRIGDQWDKQHD-MGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDT 530
Zebrafish TNEGVMYRVGDQWDRRHDVLGHMMRCTCVGNGRGEWSCIAYSQLKDQCIVDNLTYEVNQT 527
********:*****::** **************:*:*:.****:******.:**:**.:
X.tropicalis FTKRHEEGHMMNCTCYGQGRGRWKCDAIDQCQDTETRQFYQIGDSWEKHLQGVRYQCYCY 586
X.laevis FTKLHEEGHMMNCTCFGQGRGRWKCDAIDQCQDTETRQFYQIGDSWEKHLQGVQYQCYCY 591
Mouse FHKRHEEGHMLNCTCFGQGRGRWKCDPIDQCQDSETRTFYQIGDSWEKFVHGVRYQCYCY 590
Rat FHKRHEEGHMLNCTCFGQGRGRWKCDPIDRCQDSETRTFYQIGDSWEKFVHGVRYQCYCY 590
Fibronectin1.2 FHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCY 590
Fibronectin1.4 FHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCY 590
Fibronectin1.1 FHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCY 590
Fibronectin1.5 FHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCY 590
Fibronectin1.6 FHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCY 590
Fibronectin1.3 FHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCY 590
Zebrafish FTKRHDEGYTMNCTCFGQGRGRWKCDAIDQCQEPETRVFYQIGESWDKLIQGIHYRCYCY 587
* * *:**: :****:**********.:*:**:.** *****:**:* ::*::*:****
X.tropicalis GKGIGEWHCQPLSTSPAGTGPVQVIITESSNFPNSHPIQWNAPQPSHIKNYILRWKPKLK 646
X.laevis GKGIGEWHCQPLSTSQAGTGPVQVIITESANFPTSHPIQWNAPQASHIKNYILRWKPKLK 651
Mouse GRGIGEWHCQPLQTYPGTTGPVQVIITETPSQPNSHPIQWNAPEPSHITKYILRWRPKTS 650
Rat GRGIGEWHCQPLQTYPGTTGPVQVIITETPSQPNSHPIQWNAPEPSHITKYILRWRPKTS 650
Fibronectin1.2 GRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNS 650
Fibronectin1.4 GRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNS 650
Fibronectin1.1 GRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNS 650
Fibronectin1.5 GRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNS 650
Fibronectin1.6 GRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNS 650
Fibronectin1.3 GRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNS 650
Zebrafish GNGIGELSCEPQHSISGGHRPVQVIISEAGNQPNSHPIQWNAPASAHITQYILKWRPKNT 647
*.**** *:* : . **:*:*:*: . *.********* .:**.:***:*:** .
X.tropicalis TGPWKQATIPGHLNSYTISGLKPGILYEGQLISILQYGNREVTTFDFTTT-STIHRSSQT 705
X.laevis AGPWKQATIPGHLNSYTISGLKPGILYEGQLISILQYGNREVTTFDFTTT-TTIHRHSQT 710
Mouse TGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYGHREVTRFDFTTS-ASTPVTSNT 709
Rat TGRWKEATIPGHLNSYTIKGLTPGVIYEGQLISIQQYGHQEVTRFDFTTS-ASTPVTSNT 709
Fibronectin1.2 VGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNT 710
Fibronectin1.4 VGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNT 710
Fibronectin1.1 VGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNT 710
Fibronectin1.5 VGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNT 710
Fibronectin1.6 VGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNT 710
Fibronectin1.3 VGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNT 710
Zebrafish HIQWMEVTIPGHVNSYTIAGLKPGVTYEGQLISILRFGRRETTRFDFSTVHGSLETSE-- 705
* :.*****:***** **.**: ******** ::*.:*.* ***:* : .
X.tropicalis ETGETTPLPPLVATSESVTEITASSFLVSWVSASDTVSGFRVEYELSEDGD---EKRYLE 762
X.laevis ESGETTPLPPLVSISESVTEITASSFLVSWVSASDTVSGFRVEYELSEDGD---EKRYLE 767
Mouse VTGETAPYSPVVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGD---EPQYLD 766
Rat VTGETAPFSPVVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGD---EPQYLD 766
Fibronectin1.2 VTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGD---EPQYLD 767
Fibronectin1.4 VTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGD---EPQYLD 767
Fibronectin1.1 VTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGD---EPQYLD 767
Fibronectin1.5 VTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGD---EPQYLD 767
Fibronectin1.6 VTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGD---EPQYLD 767
Fibronectin1.3 VTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGD---EPQYLD 767
Zebrafish --GETTQPPRMVDTSESVTEITSSSFVISWVSASDTVSGFRVEYELSEEGGQTGQPMILD 763
***: . :* ********:***::********************:*. : *:
X.tropicalis LPNTATSVSIPDLLPGRRYNVNVYQITEEGEKSLILSTTQTTAPDAPPDHNVENVDDTSI 822
X.laevis LPNTATSVNIPDLLPGRRYNVNVYQITEEGEKSLILSTTQTTAPDAPPEHNVENVDDTSI 827
Mouse LPSTATSVNIPDLLPGRKYIVNVYQISEEGKQSLILSTSQTTAPDAPPDPTVDQVDDTSI 826
Rat LPSTATSVNIPDLLPGRKYIVNVYQISEEGKQSLILSTSQTTAPDAPPDPTVDQVDDTSI 826
Fibronectin1.2 LPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDPTVDQVDDTSI 827
Fibronectin1.4 LPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDPTVDQVDDTSI 827
Fibronectin1.1 LPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDPTVDQVDDTSI 827
Fibronectin1.5 LPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDPTVDQVDDTSI 827
Fibronectin1.6 LPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDPTVDQVDDTSI 827
Fibronectin1.3 LPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDPTVDQVDDTSI 827
Zebrafish LPHSATSVNISELLPGRKYTVNVYEVTGEGEPNLILTTSQTTAPDAPSDHEVEDVADTSI 823
** :****.*.:*****:* ****::: :*: .***:*:********.: *::* ****
X.tropicalis LIKWTKPQAPVTGYRVVYSPSVEGSS--TELNLPSTATSVSLTELLPGIEYNITIYAVED 880
X.laevis MIKWNKPQAPITGYRVVYSPSVEGSS--TELNLPSTANSVTLTELLPGIEYNITIYAVED 885
Mouse VVRWSRPQAPITGYRIVYSPSVEGSS--TELNLPETANSVTLSDLQPGVQYNITIYAVEE 884
Rat VVRWSRPQAPITGYRIVYSPSVEGSS--TELNLPETANSVTLSDLQPGVQYNITIYAVEE 884
Fibronectin1.2 VVRWSRPQAPITGYRIVYSPSVEGSS--TELNLPETANSVTLSDLQPGVQYNITIYAVEE 885
Fibronectin1.4 VVRWSRPQAPITGYRIVYSPSVEGSS--TELNLPETANSVTLSDLQPGVQYNITIYAVEE 885
Fibronectin1.1 VVRWSRPQAPITGYRIVYSPSVEGSS--TELNLPETANSVTLSDLQPGVQYNITIYAVEE 885
Fibronectin1.5 VVRWSRPQAPITGYRIVYSPSVEGSS--TELNLPETANSVTLSDLQPGVQYNITIYAVEE 885
Fibronectin1.6 VVRWSRPQAPITGYRIVYSPSVEGSS--TELNLPETANSVTLSDLQPGVQYNITIYAVEE 885
Fibronectin1.3 VVRWSRPQAPITGYRIVYSPSVEGSS--TELNLPETANSVTLSDLQPGVQYNITIYAVEE 885
Zebrafish RISWSKPLAPITGYRVVYTPSEEGSSGSVELNLPEHSTSLTLGDLRPGVLYNISIFSVEE 883
: *.:* **:****:**:** **** .*****. :.*::* :* **: ***:*::**:
X.tropicalis SLESVPIFIQQGTTGTPQTVIVPSPTDLQLVEVTDIKITIMWNPPQSEVSGYRVVVKPVS 940
X.laevis SLESVPVFIQQGTTGTPQTVIVPSPTDLQLVEVTDVKIIIMWTSPQSEVSGYRVVVKPVS 945
Mouse NQESTPVFIQQETTGTPRSDNVPPPTDLQFVELTDVKVTIMWTPPDSVVSGYRVEVLPVS 944
Rat NQESTPVFIQQETTGVPRSDDVPAPKDLQFVEVTDVKVTIMWTPPNSAVTGYRVDVLPVN 944
Fibronectin1.2 NQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVN 945
Fibronectin1.4 NQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVN 945
Fibronectin1.1 NQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVN 945
Fibronectin1.5 NQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVN 945
Fibronectin1.6 NQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVN 945
Fibronectin1.3 NQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVN 945
Zebrafish NQESEPVFVQVTTAGEPLAEEVPSPTDLQFYEVSDSKITITWTSPSSEVSGYRVSVGEVG 943
. ** *:.:* *:* * : **.* ***: *::* *: * *..*.* *:**** * *.
X.tropicalis PSDRDVQNLPVSRNTFAEVVNLHPGRTYTFEVYAVNRGQESEPLAGDFTTKLDAPSDLQF 1000
X.laevis PAGRDVQNLPVNRNTFAEVVNLQPGRTYSFEVYAVNRGQESEPLVGEFATKLDAPTDLQF 1005
Mouse LPGEHGQRLPVNRNTFAEITGLSPGVTYLFKVFAVHQGRESNPLTAQQTTKLDAPTNLQF 1004
Rat LPGEHGQRLPVNRNTFAEVTGLSPGVTYLFKVFAVHQGRESKPLTAQQTTKLDAPTNLQF 1004
Fibronectin1.2 LPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQF 1005
Fibronectin1.4 LPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQF 1005
Fibronectin1.1 LPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQF 1005
Fibronectin1.5 LPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQF 1005
Fibronectin1.6 LPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQF 1005
Fibronectin1.3 LPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQF 1005
Zebrafish PDGFDEEVLSVTQNAYAEITHLQPGTLYRFFIFSLKSGEESEPLVGEQATKPDPQTDIYF 1003
. . : *.:.:*::**:. * ** * * :::: *.**:**..: :** *. ::: *
X.tropicalis TDVTDSTVVIIWRPPQAKIGRYLLSVGQTRGGQPSQFHINPS-ATNHKLESLSPGTEYTI 1059
X.laevis TDVTESTVVIIWIPPQAKIGRYLLSVGQTRGGQPSQFPINPS-VTNHKLENLLPGTEYTV 1064
Mouse VNETDRTVLVTWTPPRARIAGYRLTAGLTRGGQPKQYNVGPL-ASKYPLRNLQPGSEYTV 1063
Rat VNETDRTVLVTWTPPRARIAGYRLTVGLTRGGQPKQYNVGPM-ASKYPLRNLQPGSEYTV 1063
Fibronectin1.2 VNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPS-VSKYPLRNLQPASEYTV 1064
Fibronectin1.4 VNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPS-VSKYPLRNLQPASEYTV 1064
Fibronectin1.1 VNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPS-VSKYPLRNLQPASEYTV 1064
Fibronectin1.5 VNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPS-VSKYPLRNLQPASEYTV 1064
Fibronectin1.6 VNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPS-VSKYPLRNLQPASEYTV 1064
Fibronectin1.3 VNETDSTVLVRWTPPRAQITGYRLTVGLTRRGQPRQYNVGPS-VSKYPLRNLQPASEYTV 1064
Zebrafish SNITEDSAVIVWLPPTAQITGYRLFLTVE-GSNPNSCVFQPSGRSYHPSLNLQPDTEYSA 1062
: *: :.:: * ** *:* * * .:* . . * : : .* * :**:
X.tropicalis SLVALKGNQQSASTTGVFSTLEPVGSIPPYNTEVTETTIVVTWTPVPRIGFKLDVRPSQG 1119
X.laevis SLVALKGNQQSASASGVFSTLEPVGSIPHYNTEVTETTIVVTWTPVPRIGFKLDVRPSQG 1124
Mouse TLVAVKGNQQSPKATGVFTTLQPLRSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQG 1123
Rat TLMAVKGNQQSPKATGVFTTLQPLRSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQG 1123
Fibronectin1.2 SLVAIKGNQESPKATGVFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQG 1124
Fibronectin1.4 SLVAIKGNQESPKATGVFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQG 1124
Fibronectin1.1 SLVAIKGNQESPKATGVFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQG 1124
Fibronectin1.5 SLVAIKGNQESPKATGVFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQG 1124
Fibronectin1.6 SLVAIKGNQESPKATGVFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQG 1124
Fibronectin1.3 SLVAIKGNQESPKATGVFTTLQPGSSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQG 1124
Zebrafish TLHAERGNVLSEGSIATFATTPPMGNAPYFSTDVTDTSIIVSWSPLPKIGYKLTVRPSQG 1122
:* * :** * : ..*:* * . * :.*:**:*:*:::*:* *:**:** ******
X.tropicalis GEAPREVISESGSIVISGLTPGVEYMYSISVLKDGVERDIPITKTVVTPVAPPTNLRLQP 1179
X.laevis GEAPREVISESGSIVISGLTPGVEYTYSISVLTDGVEKDIPITKTVVTPLSPPTNLRLQP 1184
Mouse GEAPREVTSDSGSIVVSGLTPGVEYTYTIQVLRDGQERDAPIVNRVVTPLSPPTNLHLEA 1183
Rat GEAPREVTSDSGSIVVSGLTPGVEYTYTIQVLRDGQERDAPIVNRVVTPLSPPTNLHLEA 1183
Fibronectin1.2 GEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEA 1184
Fibronectin1.4 GEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEA 1184
Fibronectin1.1 GEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEA 1184
Fibronectin1.5 GEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEA 1184
Fibronectin1.6 GEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEA 1184
Fibronectin1.3 GEAPREVTSDSGSIVVSGLTPGVEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEA 1184
Zebrafish GEAPRDVTSELGSVLISGLTPGVEYTYSVQPVISGQEHGNPITRRVVTPLSPPTDLNLES 1182
*****:* *: **:::********* *::. : .* *:. **.. ****::***:*.*:.
X.tropicalis SRDSATLTVYWDSSISPGITGYRITTAPTPMQVGNSLEEEVGPTQTYCLFENLSPGVEYN 1239
X.laevis SRDSATLTVYWDRSISPGITGYRISTTPTPMQVGNSLEEEVGPSQTYCVFENLSPGVEYN 1244
Mouse NPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGTSLEEVVHADQSSCTFENLNPGLEYN 1243
Rat NPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGTALEEVVHADQSSCTFENRNPGLEYN 1243
Fibronectin1.2 NPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYN 1244
Fibronectin1.4 NPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYN 1244
Fibronectin1.1 NPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYN 1244
Fibronectin1.5 NPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYN 1244
Fibronectin1.6 NPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYN 1244
Fibronectin1.3 NPDTGVLTVSWERSTTPDITGYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYN 1244
Zebrafish NPNTGKLTVQWNDANIPDITGYRVTCTPTKGQQGNSLEEFVKAGQNSCTLENLSPGVEYN 1242
. ::. *** *: : *.*****:: :** * *.:*** * . *. * ::* .**:***
X.tropicalis VSVYAVKGEEESSPLSQIFLQEIPQLTDLKYDDVTDTSIDLRWTPLNSSTIIGYRITVVA 1299
X.laevis VSVYAVKEEEESAPLSQMFLQEIPQLTDIKYDDVTDTSIDLRWTPLNSSNIIGYRITVVA 1304
Mouse VSVYTVKDDKESAPISDTVVPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVA 1303
Rat VSVYTVKDDKESAPISDTVIPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVA 1303
Fibronectin1.2 VSVYTVKDDKESVPISDTIIPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVA 1304
Fibronectin1.4 VSVYTVKDDKESVPISDTIIP--------------------------------------- 1265
Fibronectin1.1 VSVYTVKDDKESVPISDTIIPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVA 1304
Fibronectin1.5 VSVYTVKDDKESVPISDTIIP--------------------------------------- 1265
Fibronectin1.6 VSVYTVKDDKESVPISDTIIP--------------------------------------- 1265
Fibronectin1.3 VSVYTVKDDKESVPISDTIIP--------------------------------------- 1265
Zebrafish VSVFTVKDDMESVPVFTTVTPDVPKITDLSFINVTDSTIGLSWSPLNSTAVTGYRITVLA 1302
***::** : ** *: .
X.tropicalis AGESVPIYEEFVGPTDGYYKVSGLEPGIDYEISVITLISGGESAPTTIVQHTAVPPPTNL 1359
X.laevis AGESVPIYEEFVGPTDGYYKVSGLEPGIDYEISLITLINGGESAPTTIIQHTAVPPPTNL 1364
Mouse AGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGGESAPTTLTQQTAVPPPTDL 1363
Rat AGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGGESAPTTLTQQTAVPPPTDL 1363
Fibronectin1.2 AGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGGESAPTTLTQQTAVPPPTDL 1364
Fibronectin1.4 ----------------------------------------------------AVPPPTDL 1273
Fibronectin1.1 AGEGIPIFEDFVDSSVGYYTVTGLEPGIDYDISVITLINGGESAPTTLTQQTAVPPPTDL 1364
Fibronectin1.5 ----------------------------------------------------AVPPPTDL 1273
Fibronectin1.6 ----------------------------------------------------AVPPPTDL 1273
Fibronectin1.3 ----------------------------------------------------AVPPPTDL 1273
Zebrafish AGDSVPIFVEFVEPTTGFYTVHGLEPGIDYDITVTTVTENGESEPITITQQTAVPAPYGL 1362
***.* .*
X.tropicalis RFTNVGPDTMRVTWSP---PTSIELSSFLVRYSPVKKPDDVTELSLSPSTNMVVLSNLLP 1416
X.laevis RFTNIGPDNIRVTWSP---PTSIELSSYLVRYSPVKKPDDVTELSLSPSTNMVVLSNLLP 1421
Mouse RFTNIGPDTMRVTWAP---PPSIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLP 1420
Rat RFTNIGPDTMRVTWAP---PPSIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLP 1420
Fibronectin1.2 RFTNIGPDTMRVTWAP---PPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLP 1421
Fibronectin1.4 RFTNIGPDTMRVTWAP---PPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLP 1330
Fibronectin1.1 RFTNIGPDTMRVTWAP---PPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLP 1421
Fibronectin1.5 RFTNIGPDTMRVTWAP---PPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLP 1330
Fibronectin1.6 RFTNIGPDTMRVTWAP---PPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLP 1330
Fibronectin1.3 RFTNIGPDTMRVTWAP---PPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLP 1330
Zebrafish SFGEVTADTMLVTWKAPQVPKSSDINQYIIRYHPVDEDDETTERTVEGSENFVVLRHLVP 1422
* :: .*.: *** . * * ::.. ::** **.: ::.:* ::. * * *** :*:*
X.tropicalis FTEYLVSVHSVYEERESSALNGVAKTYLDSPTGIDFSEITPNSFTVHWIAPRAPITGYRI 1476
X.laevis FTEYLVSVHSVYEERESSSLNGVAKTHLDSPTGIAFSEITPNSFTVHWIAPRGPITGYRI 1481
Mouse GTEYLVSVSSVYEQHESIPLRGRQKTGLDSPTGFDSSDITANSFTVHWVAPRAPITGYII 1480
Rat GTEYLVSVSSVYEQHESIPLRGRQKTGLDSPTGFDSSDVTANSFTVHWVAPRAPITGYII 1480
Fibronectin1.2 GTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRI 1481
Fibronectin1.4 GTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRI 1390
Fibronectin1.1 GTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRI 1481
Fibronectin1.5 GTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRI 1390
Fibronectin1.6 GTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRI 1390
Fibronectin1.3 GTEYVVSVSSVYEQHESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRI 1390
Zebrafish NTEYLVSVICVYEGREGSPAIG-PRELFLMPCCLQFSDVGTTSFTVRWQAPRAIISGYRI 1481
***:*** .*** :*. . * : : * : *:: ..****:* ***. *:** *
X.tropicalis RYQLESGAGRPKEERVPPSRNSITLTHLIPGSEYIVSIIAFNGQQESLPLSGQQATVSDV 1536
X.laevis RYQLESGAGRPKEERVPPSRNSITLTHLIPGSEYLVSIIAINGQQESLPLAGQQATVSDV 1541
Mouse RHHAEHSVGRPRQDRVPPSRNSITLTNLNPGTEYVVSIIAVNGREESPPLIGQQATVSDI 1540
Rat RHHAEHSAGRPRQDRVPPSRNSITLTNLNPGTEYIVTIIAVNGREESPPLIGQQSTVSDV 1540
Fibronectin1.2 RHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSDV 1541
Fibronectin1.4 RHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSDV 1450
Fibronectin1.1 RHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSDV 1541
Fibronectin1.5 RHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSDV 1450
Fibronectin1.6 RHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSDV 1450
Fibronectin1.3 RHHPEHFSGRPREDRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSDV 1450
Zebrafish RYQMTSG-GRAKEERLPPSRSHFTLTGLTPETEYSISVYAVSGSRDSLPLTGTQSTISDA 1540
*:: **.:::*:* **. :*** * * :** ::: *..* .:* * * *:*:**
X.tropicalis PTDLEVTSSSPNTLTISWEAPSVNVRYYRITHSQTGGHGPEKEFTVPGTSNTATIRGLNP 1596
X.laevis PTDLEVTSSSPNTLTISWEAPAVSVRYYRITYSQTGGHGPEKEFTVPGTSNTATIRGLNP 1601
Mouse PRDLEVIASTPTSLLISWEPPAVSVRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKP 1600
Rat PRDLEVIASTPTSLLISWEPPAVSVRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKP 1600
Fibronectin1.2 PRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKP 1601
Fibronectin1.4 PRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKP 1510
Fibronectin1.1 PRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKP 1601
Fibronectin1.5 PRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKP 1510
Fibronectin1.6 PRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKP 1510
Fibronectin1.3 PRDLEVVAATPTSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKP 1510
Zebrafish PTDLEVISSTPTSITVRWDAPSVTVRYYRITHGESGGSDAPLEFMVPGSQSTATIEDLRP 1600
* **** :::*.:: : *:.*:*.*******:.::** .. ** ***:..**** .:.*
X.tropicalis GVSYTITVYAVTGRGDSPASSKPLTIVHMTDVDQPTDMAVTDIQDHSIHVKWSPPPGPVT 1656
X.laevis GVSYTITVYAVTGRGDSPASSKPLTIIHKTDVDQPIDMAVTDIQDHSIHVKWSPPPGPVT 1661
Mouse GADYTITLYAVTGRGDSPASSKPVSINYKTEIDKPSQMQVTDVQDNSISVRWLPSTSPVT 1660
Rat GADYTITLYAVTGRGDSPASSKPVSINYQTEIDKPSQMQVTDVQDNSISVRWLPSTSPVT 1660
Fibronectin1.2 GVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVT 1661
Fibronectin1.4 GVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVT 1570
Fibronectin1.1 GVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVT 1661
Fibronectin1.5 GVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVT 1570
Fibronectin1.6 GVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVT 1570
Fibronectin1.3 GVDYTITVYAVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVT 1570
Zebrafish GTDYTITVYAVTGRGDSPASSTPIHVKHRTDIDSPSQMEVTDVKDNTITVRWTPAAGPIS 1660
*..****:*************.*: : : *::*.* :* ***::*::* *:* *...*::
X.tropicalis GYRVTSVPKSGQGETFSQVVSPDQTEVTIVGLQPAVEYVVSIYSQGENGESEPLVETAVT 1716
X.laevis GYRVTSVPKSGQGETFSQVISPDQTEVTIVGLQPAVEYVVSIYSQGENGESEPLVETAVT 1721
Mouse GYRVTTTPKNGLGPSKTKTASPDQTEMTIEGLQPTVEYVVSVYAQNRNGESQPLVQTAVT 1720
Rat GYRVTTAPKNGLGPTKSQTVSPDQTEMTIEGLQPTVEYVVSVYAQNRNGESQPLVQTAVT 1720
Fibronectin1.2 GYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGESQPLVQTAVT 1721
Fibronectin1.4 GYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGESQPLVQTAVT 1630
Fibronectin1.1 GYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGESQPLVQTAVT 1721
Fibronectin1.5 GYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGESQPLVQTAVT 1630
Fibronectin1.6 GYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGESQPLVQTAVT 1630
Fibronectin1.3 GYRVTTTPKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGESQPLVQTAVT 1630
Zebrafish RYRVNATPLTGEGPVLHAETTSDHTEITFSGLMPAVEYSIKVYALGQDGESLPLVENVVT 1720
***.:.* .* * .*:**:*: ** *:*** :.:*: . .*** ***:..**
X.tropicalis NIDHPKGLTFTDVGVDSIRLAWEVPDGQVTRYRVTYSSPEEGVKELFPAPEGDDDTAELH 1776
X.laevis NIDNPKGLTFTDVGVDSIRLAWEVPDGQVTRYRVTYSSPEDGVKELFPAPEGDDDTAELH 1781
Mouse NIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIRELFPAPDGEDDTAELQ 1780
Rat NIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGDEDTAELH 1780
Fibronectin1.2 NIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEEDTAELQ 1781
Fibronectin1.4 NIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEEDTAELQ 1690
Fibronectin1.1 NIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEEDTAELQ 1781
Fibronectin1.5 ------------------------------------------------------------
Fibronectin1.6 ------------------------------------------------------------
Fibronectin1.3 NIDRPKGLAFTDVDVDSIKIAWESPQGQVSRYRVTYSSPEDGIHELFPAPDGEEDTAELQ 1690
Zebrafish TVDKPKDLSFTDVESSSMRISWDSPDGVVSSYRVLYYSPEEGERELFPAPHGDDESAVLH 1780
X.tropicalis GLRPGTEYTVSIVALHDDMESKPMIGIQSTAIPAPTNLQFSQVTPSGFSLSWHAPTIHLS 1836
X.laevis GLRPGTEYTVSIVALHDDMESKPLIGIQSTAIPAPTNLQFSQVTPSGFSLSWHAPTVHLT 1841
Mouse GLRPGSEYTVSVVALHDDMESQPLIGIQSTAIPAPTNLKFSQVTPTSFTAQWIAPSVQLT 1840
Rat GLRPGSEYTVSVVALHGGMESQPLIGVQSTAIPAPTNLKFTQVSPTTLTAQWTAPSVKLT 1840
Fibronectin1.2 GLRPGSEYTVSVVALHDDMESQPLIGTQSTAIPAPTDLKFTQVTPTSLSAQWTPPNVQLT 1841
Fibronectin1.4 GLRPGSEYTVSVVALHDDMESQPLIGTQSTAIPAPTDLKFTQVTPTSLSAQWTPPNVQLT 1750
Fibronectin1.1 GLRPGSEYTVSVVALHDDMESQPLIGTQSTAIPAPTDLKFTQVTPTSLSAQWTPPNVQLT 1841
Fibronectin1.5 ------------------------------TIPAPTDLKFTQVTPTSLSAQWTPPNVQLT 1660
Fibronectin1.6 ------------------------------TIPAPTDLKFTQVTPTSLSAQWTPPNVQLT 1660
Fibronectin1.3 GLRPGSEYTVSVVALHDDMESQPLIGTQSTAIPAPTDLKFTQVTPTSLSAQWTPPNVQLT 1750
Zebrafish GLRPGTEYTVKVIALHDQSPSTALVGTQTTGIPGPTRLQFSQVGPTSFTVSWSSSDASLT 1840
**.** *:*:** *: :: .* .. *:
X.tropicalis GYLVRVNPKEKTGPMKEVRLSPGVTATTVTGLMVATKYEVNVYALKDTLTSQPLQGLIST 1896
X.laevis GYLVRVNPKEKTGPTKEVRLSPGVAATTVTGLMVATKYEVNVYALKDSLTSQPLQGLIST 1901
Mouse GYRVRVNPKEKTGPMKEINLSPDSSSVIVSGLMVATKYEVSVYALKDTLTSRPAQGVITT 1900
Rat GYRVRVTPKEKTGPMKEINLSPDSTSVIVSGLMVATKYEVSVYALKDTLTSRPAQGVVTT 1900
Fibronectin1.2 GYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVVTT 1901
Fibronectin1.4 GYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVVTT 1810
Fibronectin1.1 GYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVVTT 1901
Fibronectin1.5 GYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVVTT 1720
Fibronectin1.6 GYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVVTT 1720
Fibronectin1.3 GYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLMVATKYEVSVYALKDTLTSRPAQGVVTT 1810
Zebrafish GYRVAVSPKSKSGPTKEENITPDSTEFHATGLMPGTDYEVEVYGVKNSLTSPRVKGEITT 1900
** * *.**.*:** ** .::*. : .:*** .*.***.**.:*::*** :* ::*
X.tropicalis LDNVSPPRRPRVQDVTETTVTLSWRTKTETITGFQIDAIPAGG-QNPIRRTVDADLRSFT 1955
X.laevis LDNVSPPRRPRIQDVTETTVTLSWRTKTETITGFQIDAIPADG-QNPIRRTVDADLRTFT 1960
Mouse LENVSPPRRARVTDATETTITISWRTKTETITGFQVDAIPANG-QTPVQRSISPDVRSYT 1959
Rat LENVSPPRRARVTDATETTITISWRTKTETITGFQVDAIPANG-QTPVQRTISPDVRSYT 1959
Fibronectin1.2 LENVSPPRRARVTDATETTITISWRTKTETITGFQVDAVPANG-QTPIQRTIKPDVRSYT 1960
Fibronectin1.4 LENVSPPRRARVTDATETTITISWRTKTETITGFQVDAVPANG-QTPIQRTIKPDVRSYT 1869
Fibronectin1.1 LENVSPPRRARVTDATETTITISWRTKTETITGFQVDAVPANG-QTPIQRTIKPDVRSYT 1960
Fibronectin1.5 LENVSPPRRARVTDATETTITISWRTKTETITGFQVDAVPANG-QTPIQRTIKPDVRSYT 1779
Fibronectin1.6 LENVSPPRRARVTDATETTITISWRTKTETITGFQVDAVPANG-QTPIQRTIKPDVRSYT 1779
Fibronectin1.3 LENVSPPRRARVTDATETTITISWRTKTETITGFQVDAVPANG-QTPIQRTIKPDVRSYT 1869
Zebrafish PDNISPPRRVRISNVKDSSITLTWRSKTEAISGFLVEATPTMGGHNPIQRTIEPDSRTYT 1960
:*:***** *: :..::::*::**:***:*:** ::* *: * :.*::*::..* *::*
X.tropicalis ITGLQPGTDYKIYLYTLNDNARSSPVIVDVTTA---VDSPSNLRFLTTTSNSLLFTWQPP 2012
X.laevis ITGLQPGTDYKIYLYTLNDNARSSPVTVDVTTA---VDSPSNLRFLTTTSNSLLFTWQPP 2017
Mouse ITGLQPGTDYKIHLYTLNDNARSSPVIIDASTA---IDAPSNLRFLTTTPNSLLVSWQAP 2016
Rat ITGLQPGTDYKIHLYTLNDNARSSPVVIDASTA---IDAPSNLRFLTTTPNSLLVSWQAP 2016
Fibronectin1.2 ITGLQPGTDYKIYLYTLNDNARSSPVVIDASTA---IDAPSNLRFLATTPNSLLVSWQPP 2017
Fibronectin1.4 ITGLQPGTDYKIYLYTLNDNARSSPVVIDASTA---IDAPSNLRFLATTPNSLLVSWQPP 1926
Fibronectin1.1 ITGLQPGTDYKIYLYTLNDNARSSPVVIDASTA---IDAPSNLRFLATTPNSLLVSWQPP 2017
Fibronectin1.5 ITGLQPGTDYKIYLYTLNDNARSSPVVIDASTA---IDAPSNLRFLATTPNSLLVSWQPP 1836
Fibronectin1.6 ITGLQPGTDYKIYLYTLNDNARSSPVVIDASTA---IDAPSNLRFLATTPNSLLVSWQPP 1836
Fibronectin1.3 ITGLQPGTDYKIYLYTLNDNARSSPVVIDASTA---IDAPSNLRFLATTPNSLLVSWQPP 1926
Zebrafish IAGLEPGTNYKINIYTLNGNSRSEPFTLTATTAKPVISPPTNLHFTSLASTSISFTWEPP 2020
*:**:***:*** :****.*:**.*. : .:** :..*:**:* : :..*: .:*:.*
X.tropicalis RARITGYIIRYEKAGGLLKEHLPRLQAGTTESTITNLEPGTEYIVYIIAVRNNQKSEPLV 2072
X.laevis RARITGYIIRYEKAGGLIKEHLPRLPAGTTESTLTNLEPGTEYIIYIIAVRNNMKSEPLV 2077
Mouse RARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLI 2076
Rat RARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLI 2076
Fibronectin1.2 RARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLI 2077
Fibronectin1.4 RARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLI 1986
Fibronectin1.1 RARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLI 2077
Fibronectin1.5 RARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLI 1896
Fibronectin1.6 RARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLI 1896
Fibronectin1.3 RARITGYIIKYEKPGSPPREVVPRPRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLI 1986
Zebrafish RSTITGYYVTYEEAGGIPKELTPRPQAARTFASISGLIPGTEYIIKIVALNGAQRSTPLI 2080
*: **** : **:.*. :* ** .. * ::::.* ***** : ::*:.. :* **:
X.tropicalis GRKRTDELPRLVTLPHPG-KGPEILDVPTDEENTPHITQIKLDNGNGIQLPGSNGQQPSS 2131
X.laevis GRKRTDELPRLVTLPHPG-QGPEILDVPTDEENTPHITQTKLDNGNGIQLPGSNGQQPSS 2136
Mouse GRKKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFITNPGYDTENGIQLPGTTHQQPSV 2136
Rat GRKKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFVTNPGYDTENGIQLPGTSHQQPSV 2136
Fibronectin1.2 GRKK-------------------------TVQKTPFVTHPGYDTGNGIQLPGTSGQQPSV 2112
Fibronectin1.4 GRKK-------------------------TVQKTPFVTHPGYDTGNGIQLPGTSGQQPSV 2021
Fibronectin1.1 GRKKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFVTHPGYDTGNGIQLPGTSGQQPSV 2137
Fibronectin1.5 GRKKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFVTHPGYDTGNGIQLPGTSGQQPSV 1956
Fibronectin1.6 GRKK-------------------------------------------------------- 1900
Fibronectin1.3 GRKKTDELPQLVTLPHPNLHGPEILDVPSTVQKTPFVTHPGYDTGNGIQLPGTSGQQPSV 2046
Zebrafish GKARTQLEIEQLPPQLPNPSRPHLEVLDVPEDNDNFNNHVHVLGPNRHNTLGQQGQHIYT 2140
*: :
X.tropicalis GNEGQLIEEHGFRSPLAPTTAVPVRPGKFTPGHYPQERVDIELDTEFPVQRGDLDGPYPH 2191
X.laevis DHEGQLIEEHGFRSPLAPTTAVPVRPGKFAPGRYPQERVDIELDT-FPVQHGDFDGPYPH 2195
Mouse GQQ-MIFEEHGFRRTTPPTAATPVR---LRPRPYLPNVDEEVQIGHVPRGDVDYH-LYPH 2191
Rat GQQ-MIFEEHGFRRTTPPTAATPVR---LRPRPYLPNVDEEVQIGHVPRGDVDYH-LYPH 2191
Fibronectin1.2 GQQ-MIFEEHGFRRTTPPTTATPIR---HRPRPYPPN----------------------- 2145
Fibronectin1.4 GQQ-MIFEEHGFRRTTPPTTATPIR---HRPRPYPPN----------------------- 2054
Fibronectin1.1 GQQ-MIFEEHGFRRTTPPTTATPIR---HRPRPYPPNVGEEIQIGHIPREDVDYH-LYPH 2192
Fibronectin1.5 GQQ-MIFEEHGFRRTTPPTTATPIR---HRPRPYPPNVGEEIQIGHIPREDVDYH-LYPH 2011
Fibronectin1.6 ------------------------------------------------------------
Fibronectin1.3 GQQ-MIFEEHGFRRTTPPTTATPIR---HRPRPYPPN----------------------- 2079
Zebrafish EYQSFNLGNNGQQPHHPNHGEPLVY---IPLPGADGQRVPVVKVNEGQEAGFPFG----- 2192
X.tropicalis GLGPQLNDSGVQEVASHTTISWRPELETTEYIISCHPIEHD-EAPLQFRVPGTSSSATLN 2250
X.laevis GLGPQLNDSGVQEVASHTTISWRPELETTEYIISCHPIDHE-EAPLQFRVPGTSSSATLN 2254
Mouse VPGLNPNASTGQEALSQTTISWTPFQESSEYIISCQPVGTD-EEPLQFQVPGTSTSATLT 2250
Rat VPGLNPNASTGQEALSQTTISWTPFQESSEYIISCQPVGTD-EEPLQFQVPGTSTSATLT 2250
Fibronectin1.2 ---------VGQEALSQTTISWAPFQDTSEYIISCHPVGTD-EEPLQFRVPGTSTSATLT 2195
Fibronectin1.4 ---------VGQEALSQTTISWAPFQDTSEYIISCHPVGTD-EEPLQFRVPGTSTSATLT 2104
Fibronectin1.1 GPGLNPNASTGQEALSQTTISWAPFQDTSEYIISCHPVGTD-EEPLQFRVPGTSTSATLT 2251
Fibronectin1.5 GPGLNPNASTGQEALSQTTISWAPFQDTSEYIISCHPVGTD-EEPLQFRVPGTSTSATLT 2070
Fibronectin1.6 ---------TGQEALSQTTISWAPFQDTSEYIISCHPVGTD-EEPLQFRVPGTSTSATLT 1950
Fibronectin1.3 ---------VGQEALSQTTISWAPFQDTSEYIISCHPVGTD-EEPLQFRVPGTSTSATLT 2129
Zebrafish --GLFNETNLPQESQTQTTIVWQPVPHTSEYVVWCDPITEINEKSFQMRLPGTSTSATLI 2250
** ::*** * * .::**:: *.*: * .:*:::****:****
X.tropicalis GLTQGATYNIIVEAQKGSDKHKVFEKRVTVGSPGSPEGVLQPAEDTCYDTFNGAHYSVGQ 2310
X.laevis GLTRGATYNIVVEAQKGTDKHKVLEKRVTVGSPGSPEGVLQPVEDTCYDTFSGAHYSVGQ 2314
Mouse GLTRGVTYNIIVEALQNQRRHKVREEVVTVGNAVS-EGLNQPTDDSCFDPYTVSHYAIGE 2309
Rat GLTRGVTYNIIVEALHNQRRHKVREEVVTVGNTVN-EGLNQPTDDSCFDPYTVSHYAVGE 2309
Fibronectin1.2 GLTRGATYNIIVEALKDQQRHKVREEVVTVGNSVN-EGLNQPTDDSCFDPYTVSHYAVGD 2254
Fibronectin1.4 GLTRGATYNIIVEALKDQQRHKVREEVVTVGNSVN-EGLNQPTDDSCFDPYTVSHYAVGD 2163
Fibronectin1.1 GLTRGATYNIIVEALKDQQRHKVREEVVTVGNSVN-EGLNQPTDDSCFDPYTVSHYAVGD 2310
Fibronectin1.5 GLTRGATYNIIVEALKDQQRHKVREEVVTVGNSVN-EGLNQPTDDSCFDPYTVSHYAVGD 2129
Fibronectin1.6 GLTRGATYNIIVEALKDQQRHKVREEVVTVGNSVN-EGLNQPTDDSCFDPYTVSHYAVGD 2009
Fibronectin1.3 GLTRGATYNIIVEALKDQQRHKVREEVVTVGNSVN-EGLNQPTDDSCFDPYTVSHYAVGD 2188
Zebrafish GLTSGASYNVLVESVNGDQKQKVLQDVVTVGNSVPGAGVIPTGRDVCYDSFTATYHEVNT 2310
*** *.:**::**: :. ::** :. ****.. *: . * *:*.:. ::: :.
X.tropicalis EWERMSESGFRLWCKCLGYGSGHFRCDSSKWCHDNGVNHRVGEKWDRRGENGQMMSCTCL 2370
X.laevis EWERMSESGFRLWCKCLGYGSGHFRCDSSKWCHDNGVNHRIGEKWDRRGENGQMMSCTCL 2374
Mouse EWERLSDAGFKLTCQCLGFGSGHFRCDSSKWCHDNGVNYKIGEKWDRQGENGQRMSCTCL 2369
Rat EWERLSDSGFKLTCQCLGFGSGHFRCDSSKWCHDNGVNYKIGEKWDRQGENGQRMSCTCL 2369
Fibronectin1.2 EWERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQMMSCTCL 2314
Fibronectin1.4 EWERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQMMSCTCL 2223
Fibronectin1.1 EWERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQMMSCTCL 2370
Fibronectin1.5 EWERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQMMSCTCL 2189
Fibronectin1.6 EWERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQMMSCTCL 2069
Fibronectin1.3 EWERMSESGFKLLCQCLGFGSGHFRCDSSRWCHDNGVNYKIGEKWDRQGENGQMMSCTCL 2248
Zebrafish EWERMSETGFKLWCKCLGLGSGHFRCDSSKWCHDSGHNYRIGEKWDRRAENGHMMSCTCL 2370
****:*::**:* *:*** **********:****.* *:::******:.***: ******
X.tropicalis GNGKGEFKCEPHEATCYDEGKMYNVGEQWQKEYLGAICSCTCYGGQQGWRCDNCRRPGA- 2429
X.laevis GNGKGEFKCEPPEATCYDEGKMYNVGEQWQKEYLGAICSCTCYGGQQGWRCDNCRRPGA- 2433
Mouse GNGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGAA 2429
Rat GNGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGAA 2429
Fibronectin1.2 GNGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGG- 2373
Fibronectin1.4 GNGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGG- 2282
Fibronectin1.1 GNGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGG- 2429
Fibronectin1.5 GNGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGG- 2248
Fibronectin1.6 GNGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGG- 2128
Fibronectin1.3 GNGKGEFKCDPHEATCYDDGKTYHVGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGG- 2307
Zebrafish GNGKGEFKCEPHESTCYDEGKLYQVGNQWQKEYLGAICTCTCYGGQQGWRCENCRRPGA- 2429
*********:* *:****:** *:**:***********:***:***:****:******.
X.tropicalis -VLPDGTAGHTVSQFAQRYQQ----NYNLNCPIECYLPL--QADIQHSEQTQK 2475
X.laevis -VSPDGTAGQTVSQFTQRYQQ----NYNLNCPIECYLPLGLQADTQHSQQTQK 2481
Mouse EPSPDGTTGHTYNQYTQRYNQR--TNTNVNCPIECFMPLDVQADRDDSRE--- 2477
Rat EPSPDGTTGHTYNQYTQRYHQR--TNTNVNCPIECFMPLDVQADRDDSRE--- 2477
Fibronectin1.2 EPSPEGTTGQSYNQYSQRYHQR--TNTNVNCPIECFMPLDVQADREDSRE--- 2421
Fibronectin1.4 EPSPEGTTGQSYNQYSQRYHQR--TNTNVNCPIECFMPLDVQADREDSRE--- 2330
Fibronectin1.1 EPSPEGTTGQSYNQYSQRYHQR--TNTNVNCPIECFMPLDVQADREDSRE--- 2477
Fibronectin1.5 EPSPEGTTGQSYNQYSQRYHQR--TNTNVNCPIECFMPLDVQADREDSRE--- 2296
Fibronectin1.6 EPSPEGTTGQSYNQYSQRYHQR--TNTNVNCPIECFMPLDVQADREDSRE--- 2176
Fibronectin1.3 EPSPEGTTGQSYNQYSQRYHQR--TNTNVNCPIECFMPLDVQADREDSRE--- 2355
Zebrafish EVDADLIQPPVRTDAFDRYRENALRKLNIQCPIECLRPD-LLADAHSPHD--- 2478
.: .: :**.: : *::***** * ** . ..:
Accession numbers of the fibronectin sequences used in the protein sequence alignment:
NP_997647 fibronectin 1 isoform 1 preproprotein [Human Fibronectin1.1]; NP_997640 fibronectin 1 isoform 2 preproprotein [Human Fibronectin1.2]; NP_002017 fibronectin 1 isoform 3 preproprotein [Human Fibronectin1.3]; NP_997643 fibronectin 1 isoform 4 preproprotein [Human Fibronectin1.4]; NP_997639 fibronectin 1 isoform 6 preproprotein [Human Fibronectin1.6]; NP_997641 fibronectin 1 isoform 5 preproprotein [Human Fibronectin1.5]; NP_034363 fibronectin 1 [Mouse]; NP_062016 fibronectin 1 [Rat]; NP_001025695 fibronectin 1 [X.tropicalis]; NP_001081270fibronectin [X.laevis]; NP_571595 fibronectin 1 [Zebrafish]
Predicted General Properties of the Fibronectin Protein (Homo sapiens) - Primary Sequence Analysis (with ProtParam)b
Number of amino acids: 2477
Molecular weight: 272330.3
Theoretical pI: 5.32
Total number of negatively charged residues (Asp + Glu): 271
Total number of positively charged residues (Arg + Lys): 205
Atomic composition: Carbon C 11924 Hydrogen H 18505 Nitrogen N 3311 Oxygen O 3825 Sulfur S 90
Formula: C11924H18505N3311O3825S90
Total number of atoms: 37655
Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 378835 Abs 0.1% (=1 g/l) 1.391, assuming ALL Cys residues appear as half cystines Ext. coefficient 374960 Abs 0.1% (=1 g/l) 1.377, assuming NO Cys residues appear as half cystines
Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo). Instability index: The instability index (II) is computed to be 40.36 This classifies the protein as unstable. Aliphatic index: 68.00 Grand average of hydropathicity (GRAVY): -0.514
Bioinformatics References
a Higgins D., Thompson J., Gibson T. Thompson J. D., Higgins D. G., Gibson T. J.(1994). CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting,position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673-4680.
b Gasteiger E., Hoogland C., Gattiker A., Duvaud S., Wilkins M.R., Appel R.D., Bairoch A.; Protein Identification and Analysis Tools on the ExPASy Server;
(In) John M. Walker (ed): The Proteomics Protocols Handbook, Humana Press (2005). pp. 571-607 Full text - Copyright Humana Press.
