Macromolecule Insights - Protein Bioinformatics Analysis

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The Coagulation Factor V Protein

Sequence Alignment of the Coagulation Factor V Protein (with Clustalw)^a

Species Sequence Alignment of Coagulation Factor V

Cow             MFLACPGFWVLVVLGSSWAGWGNLGAEAAKLRQFYVAAQSIRWNYRPESTHLSSKPFETS 60
Pig             MFPALPCPWVLVVLGTSWAAWGNLGTEAARVRQFYVAAQSISWNYHPEPTHPSSSPFATS 60
Human           MFPGCPRLWVLVVLGTSWVGWGSQGTEAAQLRQFYVAAQGISWSYRPEPTNSSLNLSVTS 60
Mouse           MLLVCPCFFLLVVLGTRWAGWGSHQAEAAQLRQFYVAAQGILWNYHPEPTDPSLN-SIPS 59
Zebrafish       ---MKLRSWPGALHGLALLAFLCHCATAVER-HYYIAAVNINWDYTSGQQR-----TGQS 51
                        :  .: *    .:    : *..  ::*:** .* *.* .            *

Cow             FKKIVYREYEAYFQKEKPQSRTSGLLGPTLYAEVGDIMKVHFKNKAHKPLSIHAQGIKYS 120
Pig             FKKIVYREYEAYFQKEKPPSRMSGLLGPTLYADVGDIMKVHFRNKADKPLSIHPQGIKYS 120
Human           FKKIVYREYEPYFKKEKPQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYS 120
Mouse           FKKIVYREYEQYFKKEKPRSSNSGLLGPTLYAEVGDVIKVHFRNKADKPLSIHPQGIKYS 119
Zebrafish       YKKVVYREYNEGFKQPKAHPLSSGLLGPTLRGQEGDTIIVTFRNMADHPCSLHPHGIAYG 111
                :**:*****:  *:: *. .  ******** .: ** : * *:* *.:* *:*.:** *.

Cow             KFSEGASYSDHTLPMEKMDDAVAPGQEYTYEWIISEHSGPTHDDPPCLTHIYYSYVNLVE 180
Pig             KFAEGASYPDHTFLVEKMDDAVAPGQEYTYEWNISEDSGPTHNDPPCLTHIYYSYENLIQ 180
Human           KLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIE 180
Mouse           KFSEGASYADHTFPAERKDDAVAPGEEYTYEWIVSEDSGPTPDDPPCLTHIYYSYENLTQ 179
Zebrafish       KQSEGSLYFDNTSLLEKNDDVIQPGEEHTYQWDVTSDVTPTAADPPCITYTYLSHFDIVR 171
                * :**: * *:*   *: **.: **.*:**:* ::..  **  ****:*: * *: :: .

Cow             DFNSGLIGPLLICKKGTLTEDGTQKMFEKQHVLMFAVFDESKSWN------QTSSLMYTV 234
Pig             DFNSGLIGPLLICKKGTLTEDGIQKMFDKQYVLMFAVFDESKSWN------QSSSLMYTV 234
Human           DFNSGLIGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSWS------QSSSLMYTV 234
Mouse           DFNSGLIGPLLICKKGTLTEDGTQKMFDKQHVLLFAVFDESKSRS------QSPSLMYTI 233
Zebrafish       DYNTGLIGPMLICKKGTLDDSGNQIHFHQESVLLFGVFDENKSWYSTGDSPQPLNVKYTI 231
                *:*:*****:******** :.* *  *.:: **:*.****.**        *. .: **:

Cow             NGYVNGTMPDITVCAHDHISWHLIGMSSGPELFSIHFNGQVLEQNHHKISAITLVSATST 294
Pig             NGYVNGTMPDITVCAYDHISWHLIGMSSGPELFSIHFSGQVLEQNHHKVSAITLVSATST 294
Human           NGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHHKVSAITLVSATST 294
Mouse           NGFVNKTMPDITVCAHDHVSWHLIGMSSGPELFSIHFNGQVLEQNQHKVSTVTLVSATST 293
Zebrafish       NGYTNGSVPDLDICAHSKVSWHLLGMSSEPELFSVHFNGQVLLHDGHKTSAVGIISGTAT 291
                **:.* ::**: :**:.::****:**** *****:**.**** :: ** *:: ::*.*:*

Cow             TANMTVSPEGRWTIASLIPRHFQAGMQAYIDIKNCAKKTRNPKKLTRDQRRHIKRWEYFI 354
Pig             TANMTVSPEGKWPISSLIPKHFQAGMQAYIDIKNCAKKTRKPKKLTRDQRRHIKRWEYFI 354
Human           TANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITREQRRHMKRWEYFI 354
Mouse           TANMTMSPEGRWIVSSLIPKHYQAGMQAYIDIKNCPKKTRSPKTLTREQRRYMKRWEYFI 353
Zebrafish       SASMTGVHPGRWLVSSHISKHLEAGLHGYLNIRKCDEYTAPKRRLTIEQKKESQEWTYYM 351
                :*.**    *:* ::*  .:* :**::.*::*::* : *   : :* :*::  :.* *::

Cow             AAEEVIWDYAPIIPANMDKKYRSLHLDNFSNRIGKHYKKVVYKQYQDDSFTKRLEDPSSE 414
Pig             AAEEVIWDYAPIIPANMDKKYRSLHLDNFSNQIGKHYKKVVYKQYQDESFTKRLENPNNK 414
Human           AAEEVIWDYAPVIPANMDKKYRSQHLDNFSNQIGKHYKKVMYTQYEDESFTKHTVNPNMK 414
Mouse           AAEEVIWNYAPVIPANMDKIYRSQHLDNFSNQIGKHYKKVIYRQYEEETFTKRTDNPSIK 413
Zebrafish       AAEEVIWDYAPNMPENMDGDFRSKYLKQGPQRIGKKYKKAVFTQYKDGMFKERAEDKQRK 411
                *******:*** :* ***  :** :*.: .::***:***.:: **::  *.::  : . :

Cow             -GDGILGPIIRAQVRDTLKIVFKNMASRSYSIYPHGVTFSPYDNEVNSSSTSG-SNTMIR 472
Pig             -EDGILGPVIRAQVRDTLKIVFKNMASRSYSIYPHGVTFSPYEDDVNSSSTSD-NNTMIR 472
Human           -EDGILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDEVNSSFTSGRNNTMIR 473
Mouse           -QSGILGPVIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDGINSSSTSG-SHTTIR 471
Zebrafish       RELGILGPVIRAQIRDIIKIVFKNKASRPYSIYPHGLTIDKAAEGASYPQGGN----QTY 467
                   *****:****:** :****** ***.*******:*:.   :  . .  ..       

Cow             AVRPGETYTYKWNILESDEPTENDAQCLTRPYYSNVDITRDLASGLIGLLLICKSRSLDR 532
Pig             AVQPGETYTYKWNILESDEPTENDAQCLTRPYYSNVDITRDIASGLIGLLLICKSRSLDK 532
Human           AVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIGLLLICKSRSLDR 533
Mouse           PVQPGETFTYKWNILEFDEPTENDAQCLTRPYYSDVDVTRDIASGLIGLLLICKSRSLDQ 531
Zebrafish       SVQPGETYTYTWSVTEEDVPTDSDPRCLTRMYHSAVDAPRDIASGLVGPLLICKSQSLNK 527
                .*:****:**.*.: * * **:.*.:**** *:* **  **:****:* ******:**::

Cow             RGIQRAADIEQQAVFAVFDENKSWYIEDNIYKFCENPEKVKRDDPKFYESNIMSNFTLPA 592
Pig             RGIQRTADIEQKAVFAVFDENKSWYIEDNIYKFCENPEKVKRDDPKFYESNIMS-----T 587
Human           RGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFYESNIMS-----T 588
Mouse           RGVQRVADIEQQAVFAVFDENKSWYIEDNINKFCENPDEVKRDDPKFYESNIMS-----T 586
Zebrafish       KNVQLKADKEQHAMFTVFDENKSWYQDENINTYCSDPKKVKKDDPEFYKSNVMH-----T 582
                :.:*  ** **:*:*:********* ::** .:*.:*.:**:***:**:**:*      :

Cow             INGYVPESIPILGFCFDDTVQWHFCSVGTQNDILTIHFTGHSFIYGKRHEDTLTLFPMQG 652
Pig             INGYVPESIPTLGFCFDDTVQWHFCSVRTHDNILTIHFTGHSFIYGKRHEDTLTLFPMRG 647
Human           INGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKRHEDTLTLFPMRG 648
Mouse           INGYVPESISTLGFCFDDTVQWHFCSVGTHDDILTIHFTGHSFIYGRRHEDTLTLFPMRG 646
Zebrafish       INGYVYESGQELGFCHGEIVTWHVSSVGEQDYIQTATFYGHTFELKNREEDILSLFPMTG 642
                ***** **   ****..: * **..**  :: * *  * **:*   .*.** *:**** *

Cow             ESVTVTMDNVGTWMLTTMNSNPRSKKLRLRFRDAKCIRNDDDDSYEIIYEPSGSTAMTTK 712
Pig             ESVTVTMDNVGTWMLTTMNSNPRNKKLQLKFRDVKCIRDDDEDSYEIIYEPSSSTTLTTR 707
Human           ESVTVTMDNVGTWMLTSMNSSPRSKKLRLKFRDVKCIPDDDEDSYEIFE-PPESTVMATR 707
Mouse           ESVTVTMDNVGTWMLTTMNSNPKRRNLRLRFRDVKCNRDYDNEDSYEIYEPPAPTSMTTR 706
Zebrafish       ETITMNMVNIGIWLLASLNSHDSTKGMRVKFKDLECFRDYVIEYDYEDGKFTAWKPPTIN 702
                *::*:.* *:* *:*:::**    : ::::*:* :*  :   :        .  .  : .

Cow             KIHDSSE-IEDENDADSDYQDELALILGLRSFRNSSLNQEKDELNLTALALEKDSEFIPP 771
Pig             KMHDSSENKEEENDDEYDYQDLLASVLGIRSFRNSSLYQEDDEFNLTALALENNSEFIPP 767
Human           KMHDRLEPEDEESDADYDYQNRLAAALGIRSFRNSSLNQEEEEFNLTALALENGTEFVSS 767
Mouse           RIHDSLENEFGIDNEDDDYQYLLASSLGIRSFKNSSLNPEENEFNLTALALENSSEFISP 766
Zebrafish       EIK-KEEPVRARPDVVDEYSDLFAETLNLRTFNN--VKDEVEIIDLTFLDQDDG--LLPI 757
                .::   *      :   :*.  :*  *.:*:*.*  :  * : ::** *  :..  ::. 

Cow             SANRSLDSNSSSRSHVSRLIAKNFAESLKTLLHLEAPAAGSPLEHAG-LDKNSALNPPMA 830
Pig             STDRAVDSNSSSPGNISRAPANTFTEPRKILPHPEATKAGSPRRHTG-LVKNLVLNRRRT 826
Human           NTDIIVGSNYSSPSNISKFTVNNLAEPQKAPSHQQATTAGSPLRHL--IGKNSVLNSSTA 825
Mouse           STDRVVDSNSSR--ILSKIINNNLKDFQRTLPGSGATVAGTLLRNLIGLDENFVLNSSTE 824
Zebrafish       VEEKSLG---SSNENLHNATLQSFIETHGLLMEEGDLDKGE--------SSNKVLN---- 802
                  :  :.   *    : .   :.: :             *          .* .**    

Cow             EHSSPYSEDPREDHPLSDVTGVSLLPFGTG-FKNRKPAKHQRFQVGRGQAAKHKFSQTRF 889
Pig             QHSDPYSEDPIENPLQSVITGISLLPFGTEGFRNREHPKHKRFKAGRDQAAKHRFSQMEF 886
Human           EHSSPYSEDPIEDPLQPDVTGIRLLSLGAGEFKSQEHAKHKGPKVERDQAAKHRFSWMKL 885
Mouse           HRSSSYHENDMENP-QSNITMVYLLPLGPKGSGNREQDKPKTIKTGRPHMMKHRFSWMKA 883
Zebrafish       -----------------DSTDKALLETTTTFDSNRVVALNN----ETDSIILDFPIVERK 841
                                   *   **   .    .:     :           .     . 

Cow             PAHKTRTRLSQDNSSSSRMGPWEDIP-----------------SDLLLLQQKDPYKILNG 932
Pig             PAHKTGRHISQDNSSSSSMGPLEDLS-----------------SDLLLLERKDP-STING 928
Human           LAHKVGRHLSQDTGSPSGMRPWEDLPSQDTGSPSRMRPWKDPPSDLLLLKQSNSSKILVG 945
Mouse           PAGKTGRHSNPKN-SYSGMKSEEDIP-----------------SELIPLKQKITSKFLNR 925
Zebrafish       VRSAPSKPMNEPESVTMNFKTTEHIN--------------------------SSLERINA 875
                         .        : . *.:                            . . :  

Cow             EWHLVSEKGSYEIIQDANENKTVNKLPNSPQND--SRTWGENIPFKNSHGKQSGHPTFLV 990
Pig             KWHLVSEKGSYEIVQDADEDMAVNKLPNNPQNA--SRSWGENIPFTNKHGKQRGHP-IFV 985
Human           RWHLASEKGSYEIIQDTDEDTAVNNWLISPQNA--SRAWGESTPLANKPGKQSGHPKFPR 1003
Mouse           RWRVASEKGSYEIIAANGEDTDVDKLTNSPQNQNITVPRGESTSHTNTTRKPSDLPTFSG 985
Zebrafish       IYSPITETN-INTMTETHTDFSITPFDGSTGEMN--FTLEDDTALLNSS----------- 921
                 :   :*..  : :     :  :     .. :     .  :. .  *.            

Cow             TRRKPLQDRQDRRNSRLKEGLPLIRTRRKKKEEKPAYHVPLSPRSFHPLRGEVNASFSDR 1050
Pig             TRHKLLQERQDEGNSILKKGRFFIRTRRKKKERKPVHHVPLSPRSFNPLRGEANTPFSDR 1045
Human           VRHKSLQVRQDGGKSRLKKSQFLIKTRKKKKE-KHTHHAPLSPRTFHPLRSEAYNTFSER 1062
Mouse           VGHKSPHVRQEEENSGFQKRQLFIRTRKKKKNKKLALHSPLSPRGFDPLRGHNHSPFPDR 1045
Zebrafish       -ESEPLQSNQNSENRIAFQEELNAKDGTDVDSNNSVKNQIFK---YNVPSGDTLSNSSKI 977
                   :  : .*:  :    :     :   . .. : . :  :.   :.   ..     .. 

Cow             RH-NHSLLLHASNETSLSIDLNQTFPSMNLSLAASLPDHDQTSPNDTTSQTSSPPDLYPT 1109
Pig             RQ-NHSLLLHESNETFPPTDLNQTFPSMNLSLIASHPDHNQNLPNDTH-QTSSPLDLYQT 1103
Human           RL-KHSLVLHKSNETSLPTDLNQTLPSMDFGWIASLPDHNQNSSNDTG-QASCPPGLYQT 1120
Mouse           RLLNHSLLLHKSNETALSPDLNQTSPSMST--DRSLPDYNQYSKNDTE-QMSSSLDLYQS 1102
Zebrafish       QVEEDFVLLDSSYFSEMSTTMEYDVSQKDTVKGESK-ETAQSQELSSTKKTYSGEIILES 1036
                :  :. ::*. *  :  .  ::   .. .     *  :  *    .:  :  .   :  :

Cow             VSPEEHYQIFPIQDSDPTHSTTAPSNRSPDPTHSTTAPSNRSPPTQPSQIPNYDLRNRAI 1169
Pig             VTPDEPYQTAPIQDLDPTHSTAVPSHQSSLP--------------EPIQMHDYDLRNKAS 1149
Human           VPPEEHYQTFPIQDPDQMHSTSDPSHRSSSP--------------ELSEMLEYDRSHKSF 1166
Mouse           VPAEEHSPTFPAQDPDQTHSTTDPSYRSSPP--------------ELSQGLDYDLSHDFY 1148
Zebrafish       LP--DITSAFNLNSSSVLRNNSLESNESSNE-------------------TLFMSSNATF 1075
                :.  :       :. .  :..:  * .*.                       :   :   

Cow             PTDVSQIFPSLELEVWQTATSLDLSQPSISPDLGQMALSPDPGQESLSPDLGQTSLSPDL 1229
Pig             PTDVSEMFFSLKLKAGHRTTSPDLNQTSLSPELSQTTLSPDPGHVTLSPDLSQTTLSPDL 1209
Human           PTDISQMSPSSEHEVWQTVISPDLSQVTLSPELSQTNLSPDLSHTTLSPELIQRNLSPAL 1226
Mouse           PDDIGLTSFFPDQSQ-KSSFSSDDDQAIPSSDLSLFTISPELDQTIIYPDLDQLLLSPED 1207
Zebrafish       SDSTNATSSDSSTATFADFSNTTFSNATFSDFSNRISQMSDSSNATLS-DSSNATLS-DS 1133
                . . .      .        .   .:   *   .     .: .:  :  :  :  **   

Cow             SQESLSPDLGQTALSPDPSQESLSPDLGQTALSPDPSQESLSPDLGQTALSPDPGQESLS 1289
Pig             SHTTLSPDLGHTTLSPDLSHTTLSPDLSQTTLSPDLSHTTLSPDLGHTTLSPDLSHTTLS 1269
Human           GQMPISPDLSHTTLSPDLSHTTLSLDLSQTNLSPELSQTNLSPALGQMPLSPDLSHTTLS 1286
Mouse           NQKTSSPDLGQVPLSPDDNQKTSSPDLGQVSLSPDDNQKTSSPDLGQVPLSLDDNQKTTS 1267
Zebrafish       SNATLS-DSSNATLS-DSSNATLS-NSSNATFS-DSSNKTFSDSSNATLFGVSYSSNTT- 1188
                .: . * * .:..** * .: : * : .:. :* : .: . *   .   :. . .  :  

Cow             PDLGQTSLSPDLSQESLSPDLGQTALSPDP---------SQESLSPDLGQTALSPDPSQE 1340
Pig             PDLGHATLSPDLSHTTLSPDLGHTTLSPDLGHTTLSPDFSQTTLSPDLGHTTLSSDVSHT 1329
Human           LDFSQTNLSPELSHMTLSPELSQTNLSPALGQMPISPDLSHTTLSLDFSQTNLSPELSQT 1346
Mouse           PDLGQVPLSPDDNQMITSPDLGQVPLSSDN----------QKTSSPDLGQVPLFPEDNQ- 1316
Zebrafish       --LSDFSLESEMTEYILSSANDTIKS-------------HSEVVSNTSQLSSSESTENIS 1233
                  :..  *..: ..   *.  .                      *         .  .  

Cow             SLSPDLGQTSLSPDLGQESLSPDLGQTALSPDPSQESLSPDLGQTSLSPDLGQESLSPDL 1400
Pig             TLSPDLSHTTLSPDLSHTTLSPDLGHTTLSPDLSQTTLSPDLGHMTLSPDLSHTTLSPDL 1389
Human           NLSPALGQMPLSPDPSHTTLSLDLSQTNLSPELSQTNLSPDLSEMPLFADLSQIPLTPDL 1406
Mouse           NYFLDLSQVPLSSDQNQETSSTDL--LTLSPDFGQTVLSPDLDQLPLPSDNSQVTVSPDL 1374
Zebrafish       LLYGSLNASSMKND--SESESEEEVVIYLNKNHSEAILTSHLDQK---EEHWGYESKHEL 1288
                     *.  .:. *    : * :     *. : .:  *:..*..     :      . :*

Cow             GQTALSPDLSQESLSPDLGQTPLSPDL---------------------------SLESLS 1433
Pig             GHTTLSPDLSHTTLSPDLGHMTLSPDLGQTTLSLDFGQTTLSPDLSHMTLSSELSHETLS 1449
Human           DQMTLSPDLGETDLSPNFGQMSLSPDL---------------------------SQVTLS 1439
Mouse           SLLTLSPDFNEIILAPDLGQVTLSPDL-----------------------------IQTN 1405
Zebrafish       VHKELPDHMNKYVKDKSAANSNK------------------------------------- 1311
                    *. .:..     . .:                                        

Cow             PDLSQL-------------------------------DLKQTSPPLDLNQTSHTSESSQS 1462
Pig             PDLSQVTLSPDLSEIPFSPDLWQTTLSSDLNETTLSPDLRQTSPHPDPDKTSYISESSQS 1509
Human           PDISDTTLLP---------------------------DLSQISPPPDLDQIFYPSESSQS 1472
Mouse           PALNHG----------------------------------HKASSADPDQASYPPDSGQA 1431
Zebrafish       PKIEKE--------------------------------KKKVYQRVKPKKGYGMKTKKSK 1339
                * :..                                   :     . .:      . . 

Cow             LPLPEFGQTFPNADIGQMPSPPPDSTLNNTFIPEEFNPLVVVGLSRDDGDYIEIIPRQKE 1522
Pig             VTLPEFGQTSPFPDLGQRPSPPSHSTLNNTFIPREFNPMVVVGLSRDDGDYVEIIPRQQE 1569
Human           LLLQEFNESFPYPDLGQMPSPSS-PTLNDTFLSKEFNPLVIVGLSKDGTDYIEIIPKEEV 1531
Mouse           SSLPELNRTLPHPDLTHIPPPSPSPTLNNTSLSRKFNPLVVVGLSRVDGDDVEIVPSEEP 1491

Zebrafish       DYKPQPRSSFSPRGFGPSVLTPRGSRPVSSEDELTEKPIVIGVPRRDFNDYELYIPKQDQ 1399
                    :   : .  .:     ..  .   .:      :*:*:    :   *    :* :. 

Cow             ESSEE----DYGEFEFVAYNDPYQTDLRTDINSSRNPDNIAAWYLRSNTGNRKYYYIAAE 1578
Pig             ENSEE----DYVKIDYVEYDDPYQTDVRTDINSSRNPDNIAAWYLRSNNGNRRNYYIAAE 1625
Human           QSSED----DYAEIDYVPYDDPYKTDVRTNINSSRDPDNIAAWYLRSNNGNRRNYYIAAE 1587
Mouse           ERIDE----DYAEDDFVTYNDPYRTDTRTDVNSSRNPDTIAAWYLRGHGGHKKFYYIAAE 1547
Zebrafish       EADFDGLLDHPEEYEYVEYKDPYSKTADVQALDATS----QHLLKMAGDKNTRTYFISVE 1455
                :   :    .  : ::* *.*** .   .:  .: .          .   : : *:*:.*

Cow             EISWDYSKFVQSD----DVDYVPEDTVYKKVVFRKYLDSTFTKLDPQGEYEEHLGILGPV 1634
Pig             ELSWDYSKFTQRE----DIDDVPEHTIYKKVVFRKYLDSTFTKLDPRGEYEEHLGILGPI 1681
Human           EISWDYSEFVQRETDIEDSDDIPEDTTYKKVVFRKYLDSTFTKRDPRGEYEEHLGILGPI 1647
Mouse           EITWNYAEFAQSEMDHEDTGHTPKDTTYKKVVFRKYLDSTFTSRDPRAEYEEHLGILGPV 1607
Zebrafish       EEEWDYAGYGQRR--LDKTAQNERPTVFRKVVFRRYLDSTFSIRDIRGEMDEHLGILGPL 1513
                *  *:*: : *      .     . * ::*****:******:  * :.* :********:

Cow             IRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAIQPNKTYT 1694
Pig             IRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYT 1741
Human           IRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYT 1707
Mouse           IRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDESPEWFQEDDAVQPNSSYT 1667
Zebrafish       IKAEVDQTVMVFFRNRASRPYSLHANGVKYLKQMEGLSYDDESPYWYKQDDAVPPNGTFT 1573
                *:****:.: * *:* *********:*:.* *. ** :*:*:** *:::*:*: ** ::*

Cow             YVWHATTRSGPENPGSACRAWAYYSAVNPEKDIHSGLIGPLLICRKGTLDKETNMPVDMR 1754
Pig             YVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLLICRKGTLHKENNMPVDMR 1801
Human           YVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLLICQKGILHKDSNMPMDMR 1767
Mouse           YVWHATKRSGPENPGSACRAWAYYSAVNVERDIHSGLIGPLLICRKGTLHMERNLPMDMR 1727
Zebrafish       YMWTINPKSGPQNNESDCRTWTYYSAVNPERDINSGLIGPLLVCRKGTLDKK---PEDRR 1630
                *:*  . :***:.  * **:*:****** *:**:********:*:** *. .   * * *

Cow             EFVLLFMVFDEKKSWYYDKKPTRSWR-----RASSEVKNSHEFHAINGMIYNLPGLRMYE 1809
Pig             EFVLLFMVFDEKKSWYYEKKFTRSWR-----LTSSEVKNSHKFHAINGMIYNLPGLRMYE 1856
Human           EFVLLFMTFDEKKSWYYEKKSRSSWR-----LTSSEMKKSHEFHAINGMIYSLPGLKMYE 1822
Mouse           EFVLLFMVFDEKKSWYYEK-SKGSRR-----IESPEEKNAHKFYAINGMIYNLPGLRMYE 1781
Zebrafish       EFVLLFMTFDENKSWLYEENRQRIERKNRRVVMDPNFQDNLKFDAINGIIYSLKGLRMYT 1690
                *******.***:*** *::      *       ..: :.  :* ****:**.* **:** 

Cow             QEWVRLHLLNLGGSRDIHVVHFHGQTLLENGTQQHQLGVWPLLPGSFKTLEMKASKPGWW 1869
Pig             QEWVRLHLLNLGGSRDIHVVHFHGQTLLENGTQQHQLGVWPLLPGSFKTLEMKTSKAGWW 1916
Human           QEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQLGVWPLLPGSFKTLEMKASKPGWW 1882
Mouse           QEWVRLHLLNMGGSRDIHVVHFHGQTLLDNRTKQHQLGVWPLLPGSFKTLEMKASKPGWW 1841
Zebrafish       NQLAKWHLINMGSPKDLHSVHFHGQTFINKELKDHRQGVYPLLPGGFATLEMLPSKPGLW 1750
                :: .: **:*:*..:*:* *******::::  ::*: **:*****.* **** .**.* *

Cow             LLDTEVGEIQRAGMQTPFLIVD------------------RECKMPMGLSTGLIADSQIQ 1911
Pig             LLDTEVGENQRAGMQTPFLIID------------------RECKMPMGLSTGLIADSQIK 1958
Human           LLNTEVGENQRAGMQTPFLIMD------------------RDCRMPMGLSTGIISDSQIK 1924
Mouse           LLDTEVGENQVAGMQTPFLIID------------------KECKMPMGLSTGVISDSQIK 1883
Zebrafish       QLESEVGLSQQRGMQTLFLFDESYKKYRVCQVLRSYLIYFAVCDHPLGLISGTVQDEQIT 1810
                 *::***  *  **** **: :                    *  *:** :* : *.** 

Cow             ASEFWGYWEPKLARLNNGGSYNAWIAEKLSTEFNPEPWIQVDMQKEVLLTGIQTQGAKHY 1971
Pig             ASEFWGHWQPKLARLNNGGSYNAWITDKFSGESNSKPWIQVDMQREVVFTGIQTQGAKYY 2018
Human           ASEFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAKHY 1984
Mouse           ASEYLTYWEPRLARLNNAGSYNAWSIEKTALDFPIKPWIQVDMQKEVVVTGIQTQGAKHY 1943
Zebrafish       ASDTRGQWYPHLARLHNTGKYNAWSTSSEPGQ-----YLQVDFQRPVVISKVATQGAKQF 1865
                **:    * *:****:* *.****  .. . :     ::***:*: *:.: : ***** :

Cow             LKPYYTTEFCVAYSLDRKNWRIFKGNS---------TRNVMY-----FGGNSDASTIKEN 2017
Pig             LKSYYTTEFNVAYSSDQRNWRIFKGNS---------TKNVMY-----FNGNSDASTITEN 2064
Human           LKSCYTTEFYVAYSSNQINWQIFKGNS---------TRNVMY-----FNGNSDASTIKEN 2030
Mouse           LKSCFTTEFQVAYSSDQTNWQIFRGKS---------GKSVMY-----FTGNSDGSTIKEN 1989
Zebrafish       LTHNFVLNYTISYSTDKKKWIYYKGDSDAVRKANIHKTNVFFNARQTFEGNAEAYETKEN 1925
                *.  :. :: ::** :: :*  ::*.*           .*::     * **::.   .**

Cow             QIDPPVVARYIRISPTGSYNKPALRLELQGCEVNGCSTPLGMESGKIENKQITASSFKKS 2077
Pig             QFDPPVVARYIRISPTESYNKPALRLELQGCEVNGCSTPLGMESGNIKNEQITASSFKKS 2124
Human           QFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNGCSTPLGMENGKIENKQITASSFKKS 2090
Mouse           RLDPPIVARYIRIHPTKSYNRPTLRLELQGCEVNGCSTPLGLEDGRIQDKQITASSFKKS 2049
Zebrafish       IFFPPLIGRYVRLHPLHSYNFPTVRLEYYGCELDGCSVPLGMEKGLIDDSKITASSVASN 1985
                 : **::.**:*: *  :** *::***  ***::***.***:*.* *.:.:*****. ..

Cow             WWGNYWEPFLARLNAQGRVNAWQAKANNNNQWLQIDLLKIKKITAIVTQGCKSLSSEMYV 2137
Pig             WWGDYWEPFRARLNAQGRVNAWQAKANNNNQWLQIDLLKIKKITAITTQGCKSLSSEMYV 2184
Human           WWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYV 2150
Mouse           WWGDYWEPSLARLNAQGRVNAWQAKANNNKQWLQVDLLKIKKVTAIVTQGCKSLSSEMYV 2109
Zebrafish       WYSGQWHPWYARLNKQGTANAWQAKNNDIQPWIQVELKEVKKITGIVTQGAKSMGNEMFV 2045
                *:.. *.*  **** ** .****** *: : *::::* ::**:*.* ***.**:..**:*

Cow             KSYTIHYSDQGTDWKPYREKSSMVDKIFEGNNNVRGHVKNFFNPPIISRFIRIIPKTWNQ 2197
Pig             KRYTIQYSDRGVEWKSYREKSSMVDKIFEGNNNIKGHVKNFFNPPIISRFIRIIPKMWNQ 2244
Human           KSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVIPKTWNQ 2210
Mouse           KSYSIQYSDQGVAWKPYRQKSSMVDKIFEGNSNTKGHMKNFFNPPIISRFIRIIPKTWNQ 2169
Zebrafish       RSYILEYSEDGRRWMKYTDDDDYEQKLFQGNTDNNGQIKNYIYPPIFSRFIRIIPKQWQK 2105
                : * :.**: *  *  *  ...  :*:*:**.: .*::**:: ***:*****:*** *::

Cow             SIALRLELFGCDMY 2211
Pig             SIALRLELFGCDIY 2258
Human           SIALRLELFGCDIY 2224
Mouse           SIALRLELFGCDIY 2183
Zebrafish       SVTMRIELLGCDFE 2119
                *:::*:**:***: 

Accession numbers of the coagulation factor V sequences used in the protein sequence alignment:  Human - NP_000121; Mouse - NP_032002; Cow - NP_776304; Pig - NP_999285; Zebrafish - NP_001007209

Predicted General Properties of the Coagulation Factor V Protein  (Homo sapiens) - Primary Sequence Analysis (with ProtParam)^b

Number of amino acids: 2224

Thoeretical molecular weight: 251703.4

Theoretical pI: 5.68

Total number of negatively charged residues (Asp + Glu): 276

Total number of positively charged residues (Arg + Lys): 219

Atomic composition: Carbon C 11175 Hydrogen H 17239 Nitrogen N 3023 Oxygen O 3462 Sulfur S 74

Formula: C₁₁₁₇₅H₁₇₂₃₉N₃₀₂₃O₃₄₆₂S₇₄

Total number of atoms: 34973

Extinction coefficients: Extinction coefficients are in units of M^-1 cm^-1, at 280 nm measured in water. Ext. coefficient 365430 Abs 0.1% (=1 g/l) 1.452, assuming ALL Cys residues appear as half cystines Ext. coefficient 364180 Abs 0.1% (=1 g/l) 1.447, assuming NO Cys residues appear as half cystines

Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).

Instability index: The instability index (II) is computed to be 48.94 This classifies the protein as unstable.

Aliphatic index: 73.09

Grand average of hydropathicity (GRAVY): -0.599

Bioinformatics References

^a Higgins D., Thompson J., Gibson T. Thompson J. D., Higgins D. G., Gibson T. J.(1994). CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting,position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673-4680.

^b Gasteiger E., Hoogland C., Gattiker A., Duvaud S., Wilkins M.R., Appel R.D., Bairoch A.; Protein Identification and Analysis Tools on the ExPASy Server;
(In) John M. Walker (ed): The Proteomics Protocols Handbook, Humana Press (2005). pp. 571-607  Full text - Copyright Humana Press.