Sequence Alignment of the Calcium Ion Channel (with Clustalw)a
alpha subunit of the calcium ion channel
alpha1.1 ------------------------------------------------------------
alpha1.2 -MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAA 59
alpha1.3 MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA 60
alpha2.1 ---------------------------MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGA 33
alpha2.2 ---------------------------MVRFGDELGGRYGGPGGGERA----RGGGAGGA 29
alpha2.3 ---------------------------MARFGEAVVARPGSGDGDSDQ-------SRNRQ 26
alpha3.2 ------------------------MTEGARAADEVRVPLGAPPPGPAALVGASPESPGAP 36
alpha1.1 -----------MEPSSPQDEGLRKKQ----PKKPVPEILPRPPRALFCLTLENPLRKACI 45
alpha1.2 RQAKLMGSAGNATISTVSST-QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACI 118
alpha1.3 RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI 120
alpha2.1 GGSRQGG-QPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
alpha2.2 GGPGPGGLQPGQRVLYKQSIAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAK 89
alpha2.3 GTPVPAS---GQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNRSLFIFGEDNIVRKYAK 83
alpha3.2 GREAERGSELGVSPS--ESPAAERGAELGADEEQRVPYPALAATVFFCLGQTTRPRSWCL 94
. :: : . * .
alpha1.1 SIVEWKPFETIILLTIFANCVALAVYLPMPEDDN-NSLNLGLEKLEYFFLIVFSIEAAMK 104
alpha1.2 SIVEWKPFEIIILLTIFANCVALAIYIPFPEDDS-NATNSNLERVEYLFLIIFTVEAFLK 177
alpha1.3 SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDS-NSTNHNLEKVEYAFLIIFTVETFLK 179
alpha2.1 KITEWPPFEYMILATIIANCIVLALEQHLPDDDK-TPMSERLDDTEPYFIGIFCFEAGIK 151
alpha2.2 RITEWPPFEYMILATIIANCIVLALEQHLPDGDK-TPMSERLDDTEPYFIGIFCFEAGIK 148
alpha2.3 KLIDWPPFEYMILATIIANCIVLALEQHLPEDDK-TPMSRRLEKTEPYFIGIFCFEAGIK 142
alpha3.2 RLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIK 154
: *: . : .*: **:.*.: : : . *: : :: .* .* :*
alpha1.1 IIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKAL 164
alpha1.2 VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD-GANALGGKGAGFDVKAL 236
alpha1.3 IIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKAL 239
alpha2.1 IIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEF-----------------DLRTL 194
alpha2.2 IIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDF-----------------DLRTL 191
alpha2.3 IVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHV-------------DLRTL 189
alpha3.2 MVALG-LFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHN---------------VSLSAI 198
::* * : .*: . ** :** :*. *:: .: ::
alpha1.1 RAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHK 224
alpha1.2 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
alpha1.3 RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHK 299
alpha2.1 RAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHT 254
alpha2.2 RAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHK 251
alpha2.3 RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
alpha3.2 RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 258
*:.******: :. :**:::::. ::.:: * :: ** :* .:::.*:*:::: * ::
alpha1.1 TCYFIGT------------DIVATVENEEPSPCART-GSGRR------------------ 253
alpha1.2 TCYNQEG------------IADVPAE-DDPSPCALETGHGRQ------------------ 325
alpha1.3 TCFFAD--------------SDIVAE-EDPAPCAFS-GNGRQ------------------ 325
alpha2.1 TCFEEG--------------TDDIQGESP-APCGTEEPART------------------- 280
alpha2.2 ACFPN---------------STDAEPVGD-FPCGKEAPARL------------------- 276
alpha2.3 ACFMNN--------------SGILEGFDPPHPCGVQG----------------------- 272
alpha3.2 RCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLG 318
*: *.
alpha1.1 ---------------------CTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITME 292
alpha1.2 ---------------------CQN-GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
alpha1.3 ---------------------CTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITME 364
alpha2.1 ----------------------CPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITME 318
alpha2.2 ----------------------CEGDTECREYWPGPNFGITNFDNILFAILTVFQCITME 314
alpha2.3 ----------------------CPAGYECKD-WIGPNDGITQFDNILFAVLTVFQCITME 309
alpha3.2 WEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLE 378
*: .*: * :***: :: ::::* **:*
alpha1.1 GWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQK 352
alpha1.2 GWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQK 423
alpha1.3 GWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQK 424
alpha2.1 GWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLK 378
alpha2.2 GWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLK 374
alpha2.3 GWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMK 369
alpha3.2 GWVDIMYYVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR 437
**. ::* ** . ::**: *::.****::** * *:: :*:: ::: . :
alpha1.1 LREKQQ----------------------------LDEDLRGYMSWITQGEVMDVEDFREG 384
alpha1.2 LREKQQ----------------------------LEEDLKGYLDWITQAEDIDPENEDEG 455
alpha1.3 LREKQQ----------------------------LEEDLKGYLDWITQAEDIDPENEEEG 456
alpha2.1 LRRQQQ----------------------------IERELNGYMEWISKAEEVILAEDETD 410
alpha2.2 LRRQQQ----------------------------IERELNGYLEWIFKAEEVMLAEEDRN 406
alpha2.3 LRRQQQ----------------------------IERELNGYRAWIDKAEEVMLAEENKN 401
alpha3.2 ARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQG 497
*. .: ..*. * * : . . .
alpha1.1 ----------------------------------------------------------KL 386
alpha1.2 MD---------------------------------------------------EEKPRNM 464
alpha1.3 GE---------------------------------------------------EGK-RNT 464
alpha2.1 GEQ----------------------------------------------RHPFDGALRRT 424
alpha2.2 AEE----------------------------------------------KSPLD-VLKRA 419
alpha2.3 AG------------------------------------------------TSALEVLRRA 413
alpha3.2 QGPGHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACDTRLVRAGAPP 557
alpha1.1 SLDEGGSDTESLYEIAG--------------LNKII---QFIRHWRQWNRI--------- 420
alpha1.2 SMPTSETESVNTENVAGGDIEGENCGARLAHRISKS---KFSRYWRRWNRF--------- 512
alpha1.3 SMPTSETESVNTENVSG-EGENRGCCGSLCQAISKS---KLSRRWRRWNRF--------- 511
alpha2.1 TIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERR--------- 475
alpha2.2 ATKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKM--------- 470
alpha2.3 TIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERL--------- 464
alpha3.2 SPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPTIL 617
: . :
alpha1.1 ------------------------------------------------------------
alpha1.2 ------------------------------------------------------------
alpha1.3 ------------------------------------------------------------
alpha2.1 ------------------------------------------------------------
alpha2.2 ------------------------------------------------------------
alpha2.3 ------------------------------------------------------------
alpha3.2 PSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLS 677
alpha1.1 ------------------------------------------------------------
alpha1.2 ------------------------------------------------------------
alpha1.3 ------------------------------------------------------------
alpha2.1 ------------------------------------------------------------
alpha2.2 ------------------------------------------------------------
alpha2.3 ------------------------------------------------------------
alpha3.2 GLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHG 737
alpha1.1 --------------------------------------------FRWKCHDIVKSKVFYW 436
alpha1.2 --------------------------------------------CRRKCRAAVKSNVFYW 528
alpha1.3 --------------------------------------------NRRRCRAAVKSVTFYW 527
alpha2.1 --------------------------------------------MRFYIRRMVKTQAFYW 491
alpha2.2 --------------------------------------------FRFFIRRMVKAQSFYW 486
alpha2.3 --------------------------------------------LRISIRHMVKSQVFYW 480
alpha3.2 DRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIVDSKYFSR 797
: *.: *
alpha1.1 LVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIF 496
alpha1.2 LVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
alpha1.3 LVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLF 587
alpha2.1 TVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSF 551
alpha2.2 VVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSF 546
alpha2.3 IVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSF 540
alpha3.2 GIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPY 857
:: : :** :. :::** *: :: : .:* ** :*: . * *: . :
alpha1.1 NRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSI 556
alpha1.2 NRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSV 648
alpha1.3 NRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSM 647
alpha2.1 NCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSM 611
alpha2.2 NCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSM 606
alpha2.3 NCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSM 600
alpha3.2 NIFDGIIVVISVWEIVGQADG-----GLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTM 912
* ** : .: * : *:**:* .****::*:.:. :* . :. *:.::
alpha1.1 RSIASLLLLLFLFIVIFALLGMQLFGGRYDFE----DTEVRRSNFDNFPQALISVFQVLT 612
alpha1.2 RSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD----EMQTRRSTFDNFPQSLLTVFQILT 704
alpha1.3 KSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD----ETQTKRSTFDNFPQALLTVFQILT 703
alpha2.1 KSIISLLFLLFLFIVVFALLGMQLFGGQFNFD----EGTP-PTNFDTFPAAIMTVFQILT 666
alpha2.2 KSIISLLFLLFLFIVVFALLGMQLFGGQFNFQ----DETP-TTNFDTFPAAILTVFQILT 661
alpha2.3 KSIISLLFLLFLFIVVFALLGMQLFGGRFNFN----DGTP-SANFDTFPAAIMTVFQILT 655
alpha3.2 DNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQILT 972
.: :: **:***.:*::***:*** ::.:. : .**.: ::::***:**
alpha1.1 GEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTS 672
alpha1.2 GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
alpha1.3 GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
alpha2.1 GEDWNEVMYDGIKSQGGVQ-GGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK 725
alpha2.2 GEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK 720
alpha2.3 GEDWNEVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK 714
alpha3.2 QEDWNVVLYNGMAS------TSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANR 1026
***. ::*.*: : . .:**: * *** *:*:::** *:.: . .
alpha1.1 AQKAKAEEKKRRKMSKGLPDKSEEEK------------------------------STMA 702
alpha1.2 AQKEEEEEKERKKLAR---TASPEKKQELVEKP------------------AVGESKEEK 803
alpha1.3 AQKEEAEEKERKKIAR---KESLENK------------------------------KNNK 790
alpha2.1 DEQEEEEAANQKLALQKAKEVAEVSPLSAANMS--------------IAVKEQQKNQKPA 771
alpha2.2 DEEEMEEAANQKLALQKAKEVAEVSPMSAANIS--------------IAARQQ--NSAKA 764
alpha2.3 DEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRRRHH 774
alpha3.2 SDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPN------------GHLEGRGSLSP 1074
: : :
alpha1.1 KKLEQKPKGEGIPTTAKLKIDEFESNVNEV------------------------------ 732
alpha1.2 IELKSITADGESPPATKINMDDLQPNENED------------------------------ 833
alpha1.3 PEVNQIANSD-----NKVTIDDYR-EEDED------------------------------ 814
alpha2.1 KSVWEQRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQEN 831
alpha2.2 RSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRD 824
alpha2.3 MSVWEQRTSQLRKHMQMSSQEALNREEAP-------TMNPLNPLNPLSSLNPLNAHPSLY 827
alpha3.2 PLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGP 1134
: :
alpha1.1 ------------------------------------------------------------
alpha1.2 ------------------------------------------------------------
alpha1.3 ------------------------------------------------------------
alpha2.1 RNNNTNKSRAAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAE 891
alpha2.2 GARGPVGGKARPEAAEAPEG----VDPPRRHHRHRDKDKTPAAGDQDRAEAPKAESGEPG 880
alpha2.3 RRPRAIEGLALGLALEKFEE----ERISRGGSLKGDGGDRSSALDNQRTPLSLGQREPPW 883
alpha3.2 SGAWSSRRSSWSSLGRAPSLK--------------------------------------- 1155
alpha1.1 ------------------------------------------------------------
alpha1.2 ------------------------------------------------------------
alpha1.3 ------------------------------------------------------------
alpha2.1 LSREGPYGRESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTG 951
alpha2.2 AREERPR------PHRSHSKEAAGPPEARSERGRGPGPE-------GGRRHHRRGSPEEA 927
alpha2.3 LARPCHG------NCDPTQQEAGGGEAVVTFEDRARHRQ------SQRRSRHRRVRTEGK 931
alpha3.2 ------------------------------------------------------------
alpha1.1 ------KDPYP-----SADFPGDDEEDEPEIPLSPR------------------------ 757
alpha1.2 ------KSPYP-----NPETTGEEDEEEPEMPVGPR------------------------ 858
alpha1.3 ------KDPYPPCDVPVGEEEEEEEEDEPEVPAGPR------------------------ 844
alpha2.1 ADGEHRRHRAHRR--PGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHG 1009
alpha2.2 AEREPRRHRAHRHQDPSKECAGAKGERRARHRGGPR-----AGPREAESGEEPARRHRAR 982
alpha2.3 ESSSASRSRSASQERSLDEAMPTEGEKDHELRGNHG----AKEPTIQEERAQDLRRTNSL 987
alpha3.2 --RRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTK 1213
. . . .
alpha1.1 ------------------------------------------------------------
alpha1.2 ------------------------------------------------------------
alpha1.3 ------------------------------------------------------------
alpha2.1 APATYEGDARREDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNM 1069
alpha2.2 HKAQPAHEAVEKETTEKEATEKE------------------------------AEIVEAD 1012
alpha2.3 MVSRGSGLAGGLDEADTPLVLPH-------------------------------PELEVG 1016
alpha3.2 CRDRDGQVVALPSDFFLRIDSHR------------------------------------- 1236
alpha1.1 ------------------------------------------------------------
alpha1.2 ------------------------------------------------------------
alpha1.3 ------------------------------------------------------------
alpha2.1 KNNKLATAESAAPHGSLGHAGLPQSPAKMGNSTDPGPMLAIPAMATNPQNAASRRTPNNP 1129
alpha2.2 KEKELRNHQPREPHCDLETSG----------TVTVGPMHTLPSTCLQKVEEQ-------- 1054
alpha2.3 KHVVLTEQEPEGSSEQALLGN---------VQLDMGRVISQSEPDLSCITAN-------- 1059
alpha3.2 ------------------------------------------------------------
alpha1.1 ------------------------------------------------------------
alpha1.2 ------------------------------------------------------------
alpha1.3 ------------------------------------------------------------
alpha2.1 GNPSNPGPPKTPENSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKN 1189
alpha2.2 --------PEDADNQRNVTR-MGSQP-------PDPNTIVHIPVMLTGPLGEATVVPSGN 1098
alpha2.3 ------TDKATTESTSVTVAIPDVDP-------LVDSTVVHISNKTDG---EASPLKEAE 1103
alpha3.2 ---------------------------------------------------------EDA 1239
alpha1.1 -------------PRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNF 804
alpha1.2 -------------PRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNL 905
alpha1.3 -------------PRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNL 891
alpha2.1 ANPDPLPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMC 1249
alpha2.2 VD---LESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVV 1155
alpha2.3 IR----EDEEEVEKKKQKKEKRETG-KAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMC 1158
alpha3.2 AELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHV 1299
. ::: :* * :* *: ::. *
alpha1.1 ILLFILLSSAALAAEDPIRADSMRNQILKHF--------------------DIGFTSVFT 844
alpha1.2 ILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFT 965
alpha1.3 ILVFIMLSSAALAAEDPIRSHSFRNTILGYF--------------------DYAFTAIFT 931
alpha2.1 ILMVIAMSSIALAAEDPVQPNAPRNNVLRYF--------------------DYVFTGVFT 1289
alpha2.2 ILVVIALSSIALAAEDPVRTDSPRNNALKYL--------------------DYIFTGVFT 1195
alpha2.3 ILLVIAASSIALAAEDPVLTNSERNKVLRYF--------------------DYVFTGVFT 1198
alpha3.2 VLVFIFLNCVTIALERPDIDPGSTERVFLSVS-------------------NYIFTAIFV 1340
:*..* .. ::* * * . : : . : **.:*.
alpha1.1 VEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESS-------AISVVKILR 897
alpha1.2 LEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS-------AINVVKILR 1018
alpha1.3 VEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSS-------AISVVKILR 984
alpha2.1 FEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGN---SKGKDINTIKSLR 1346
alpha2.2 FEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSG----SKGKDINTIKSLR 1251
alpha2.3 FEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLR 1258
alpha3.2 AEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMAS-AGGAKILGVLRVLR 1399
*:::*: * . :: :. :*:** ::* :*: : . : .:: **
alpha1.1 VLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRC 957
alpha1.2 VLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTC 1078
alpha1.3 VLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRC 1044
alpha2.1 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHC 1406
alpha2.2 VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYC 1311
alpha2.3 VLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYC 1318
alpha3.2 LLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYC 1459
:**.****:.*.* ** *.: :. :: : **::: : ::*. :.*******:: *
alpha1.1 TDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWP 1017
alpha1.2 SDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWP 1138
alpha1.3 TDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWP 1104
alpha2.1 TDESKEFEKDCRGKYLLYEKNE---VKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWP 1463
alpha2.2 TDESKELERDCRGQYLDYEKEE---VEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWP 1368
alpha2.3 TDSSKDTEKECIGNYVDHEKNK---MEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWP 1375
alpha3.2 EGPDTRNISTKAQCR------------AAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWV 1507
. . * . .:.:**: *:::**.:*: :**
alpha1.1 QLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQ------ 1071
alpha1.2 ELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQ------ 1192
alpha1.3 ALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQ------ 1158
alpha2.1 QVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ------ 1517
alpha2.2 MVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQ------ 1422
alpha2.3 QVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ------ 1429
alpha3.2 NIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEA 1567
:: .:* : * . . : :::: ::::..**.:*:**..:: .*::
alpha1.1 -GETEYKNCELDKNQRQCVQYALKARPLRCYIPKN--PYQYQVWYIVTSSYFEYLMFALI 1128
alpha1.2 -GEQEYKNCELDKNQRQCVEYALKARPLRRYIPKN--QHQYKVWYVVNSTYFEYLMFVLI 1249
alpha1.3 -GEKEYKNCELDKNQRQCVEYALKARPLRRYIPKN--PYQYKFWYVVNSSPFEYMMFVLI 1215
alpha2.1 -GDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMI 1576
alpha2.2 -GDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMI 1481
alpha2.3 -GDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMI 1488
alpha3.2 EEARRREEKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFII 1627
.: * : :* . .... : : . * :: : :*
alpha1.1 MLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFL 1188
alpha1.2 LLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFL 1309
alpha1.3 MLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSL 1275
alpha2.1 ALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFV 1636
alpha2.2 ALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFV 1541
alpha2.3 ALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFI 1548
alpha3.2 CVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLA 1687
:*.: : *:.* . . * ** :* .* **::** :* * ** :*
alpha1.1 IVIGSIIDVILSEIDT--------------------FLASSGGLYCLGGGCGNVDPDESA 1228
alpha1.2 IVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENS 1369
alpha1.3 IVIGSIIDVALSEADP-----------------------TESENVPVPTATP-GNSEESN 1311
alpha2.1 TVLGSITDILVTEFG-------------------------------------------NN 1653
alpha2.2 TVLGSITDILVTEIAE----------------------------------------T-NN 1560
alpha2.3 TVIGSITEIILTDSKL----------------------------------------VNTS 1568
alpha3.2 IVLLSLMGITLEEIEMS-------------------------------------AALPIN 1710
*: *: : : :
alpha1.1 RISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQM 1288
alpha1.2 RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV 1429
alpha1.3 RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQM 1371
alpha2.1 FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1713
alpha2.2 FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1620
alpha2.3 GFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1628
alpha3.2 PTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVEL 1770
:::::* *::*** . :* ** *.:::: : : **: :****** :*:::
alpha1.1 FGKIALVDGTQ--------INRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDP 1340
alpha1.2 FGKIALNDTTE--------INRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAP 1481
alpha1.3 FGKVAMRDNNQ--------INRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDP 1423
alpha2.1 FGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDK 1773
alpha2.2 FGNIALDDDTS--------INRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDE 1672
alpha2.3 FGNIKLDEESH--------INRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEP 1680
alpha3.2 FGRLECSEDNPCEG-----LSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLR--ECSR 1823
**.: :..: .* .* :.: *** :**: *: *: *
alpha1.1 ESD-YAPGE-EYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHH 1398
alpha1.2 ESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1541
alpha1.3 ESD-YNPGE-EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1481
alpha2.1 NSGIL-----TRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1828
alpha2.2 QAN-------ATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1725
alpha2.3 DTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1740
alpha3.2 EDK------HCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKE-------- 1869
: :: **::* :.. *:::*:.***:*.::: .::
alpha1.1 LDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNS- 1457
alpha1.2 LDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNS- 1600
alpha1.3 LDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS- 1540
alpha2.1 LDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVAD- 1887
alpha2.2 LDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNE 1785
alpha2.3 LDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAE- 1799
alpha3.2 AREDAELDAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLP- 1928
* : :* : * . * . .:. ::: :
alpha1.1 DGTVTFNATLFALVRTALKIKTEG---NFEQANEELRAIIKKIWKRTSMKLLDQVIPPIG 1514
alpha1.2 DGTVMFNATLFALVRTALRIKTEG---NLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG 1657
alpha1.3 DGTVMFNATLFALVRTALKIKTEG---NLEQANEELRAVIKKIWKKTSMKLLDQVVPPAG 1597
alpha2.1 DNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHK 1947
alpha2.2 DMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHK 1845
alpha2.3 DMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPK 1859
alpha3.2 NDSYMFRPVVPASAPHPRPLQEVE---METYGAGTPLGSVASVHSPPAESCASLQIPLAV 1985
: : * ..: * . :: : . . . :.
alpha1.1 DDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYR------PKKDIVQIQAGLRTIEEEAAP 1568
alpha1.2 DDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-----PSQRNALSLQAGLRTLHDIG-P 1711
alpha1.3 DDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKY----PAKNTTIALQAGLRTLHDIG-P 1652
alpha2.1 STDLTVGKIYAAMMIMEYYRQSKAKKLQAMRE-----EQDRTPLMFQRMEPPSPTQEGGP 2002
alpha2.2 PDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVL 1905
alpha2.3 ASDLTVGKIYAAMMIMDYYKQSKVKKQRQQLE------EQKNAPMFQRMEPSSLPQEIIA 1913
alpha3.2 SSPARSGEPLHALSPRGTARSPSLSRLLCRQEA-----VHTDSLEGKIDSPRDTLDPAEP 2040
*: :: :. : :
alpha1.1 EICRTVSGDLAAEEELER---AMVEAAMEEGIFRRTGGLFGQVDNFLER--TNSLPPVMA 1623
alpha1.2 EIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFT 1771
alpha1.3 EIRRAISCDLQDDEP------EETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNT 1706
alpha2.1 G-----QNALPSTQLDPG----GALMAHESGLKESPSWVTQRAQEMFQKTGTWSPEQGPP 2053
alpha2.2 RGARVFLRQKSSTSLSNG----GAIQNQESGIKESVSWGTQRTQDAPHEARPP-LERGHS 1960
alpha2.3 N-----AKALPYLQQDP--------VSGLSGRSGYPSMSPLSPQDIFQLACMDPADDGQF 1960
alpha3.2 GEKTPVRPVTQGGSLQSP------PRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEAS 2094
. .
alpha1.1 NQRPLQFAEIEME---EMESPVFLEDFPQDPRTNPLAR-----------ANTNNAN---- 1665
alpha1.2 TQRPLHINKAGSS-QGDTESPSHEKLVDSTFTPSSYS-------STGSNANINNANNTAL 1823
alpha1.3 THRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKA 1766
alpha2.1 TDMPN--SQPNSQ---SVEMREMGRDGYSDSEHYLPME------GQGRAASMPRLPAENQ 2102
alpha2.2 TEIPVGRSGALAV---DVQMQSITRRGP-DGEPQPGLE------SQGRAASMPRLAAETQ 2010
alpha2.3 QERQS--LEPEVS---ELKSVQPSNHGIYLPSDTQEHA------GSGRASSMPRLTVDPQ 2009
alpha3.2 DPADEEVSHITSS-----ACPWQPTAEPHGPEASPVAG---------------------- 2127
alpha1.1 ------------------------------------------------------------
alpha1.2 GRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRERHVPMCEDLELRRDSGSAG 1883
alpha1.3 AHGKRPS--IGNLEHVSENG-HHSSHKHDREPQRRSSVKRTRYY----ETYIRSDSGDEQ 1819
alpha2.1 RRRGRPRG----------------------------------------NNLSTISDTSPM 2122
alpha2.2 P----------------------------------------------------VTDASPM 2018
alpha2.3 V----------------------------------------------------VTDPSSM 2017
alpha3.2 ------------------------------------------------------------
alpha1.1 ---------------------ANVAYGNSNHSNSHVFSSVHYEREFPEETETP------- 1697
alpha1.2 TQAHCLLLRKAN-PSRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEML 1942
alpha1.3 LPTICREDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSE 1879
alpha2.1 KRSASVLG--PKARRLDDYSLERVPPEENQRHHQ-----RRRDRSHRASERSLGRYTDVD 2175
alpha2.2 KRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMD 2078
alpha2.3 RRSFSTIR----DKRSNSSWLEEFSMERSSENTY-----KSRRRSYHSSLRLSAHRLNSD 2068
alpha3.2 -------------------GERDLRRLYSVDAQGFLDKPGRADEQWRPSAELGS------ 2162
.. .
alpha1.1 ---------------------------ATRGRALGQPCRVLGPHSKPCVEMLKG------ 1724
alpha1.2 SYQDDENRQLTLPEEDK------RDIRQSPKRGFLR-SASLGRRASFHLECLKRQKDRGG 1995
alpha1.3 RPRGYHHPQGFLEDDDSPVC---YDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEE 1936
alpha2.1 TGLGTDLSMTTQSGDLPS-----KERDQERGRPKDRKHRQHHHHHHHHHHPPPPDKDRYA 2230
alpha2.2 GAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYS----CDRFG 2134
alpha2.3 SGHKSDT---------------HRSGGRERGRSKERKHLLSPDVSR-----------CNS 2102
alpha3.2 ---------------------------GEPGEAKAWGPEAEP------------------ 2177
.
alpha1.1 ----------------LLTQRAMPRG-----------------------------QAPPA 1739
alpha1.2 DIS-----QKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQ 2050
alpha1.3 VPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPC 1996
alpha2.1 QERPDHGRARARDQRWSRSPSEGREHMAHRQGSSSVSGSPAPSTSGTSTPRRG-RRQLPQ 2289
alpha2.2 GREP--PKPKPSLSSHPTSPTAGQEPGPHPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQ 2192
alpha2.3 EERGTQADWESPERRQSRSPSEGRSQTPNRQGTGSLSESSIPSVSDTSTPRRS-RRQLPP 2161
alpha3.2 ---------------ALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPS 2222
*
alpha1.1 P--CQCPRVESSMPEDRKSSTPGSLH-----EETP----------------HSRSTRENT 1776
alpha1.2 P--VPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAP 2108
alpha1.3 Y--TPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFRNK 2050
alpha2.1 TPSTPRPHVSYSPVIRKAGGSGPPQQQQQQQQQQQAVARPGRAATSGPRRYPGPTAEPLA 2349
alpha2.2 TPLTPRPSITY-----KTANSSPIHFAG--AQTSLPAFSPGRLSRGLSEHNALLQRDPLS 2245
alpha2.3 VPPKPRPLLSYSSLIRHAGSISPPADGS---EEGSPLTSQALESNNACLTESSNSPHPQQ 2218
alpha3.2 CEATPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFL 2282
.
alpha1.1 SRCSAPATALLIQKALVRGGLGT------------------------------------- 1799
alpha1.2 GRQFHGSASSLVEAVLISEGLGQ------------------------------------- 2131
alpha1.3 NSDKQRSADSLVEAVLISEGLGR------------------------------------- 2073
alpha2.1 GDRPPTGGHSSGRSPRMERRVPGPARSESPRACRHGGARWPASGPHVSEGPPGPRHHGYY 2409
alpha2.2 --QPLAPGSRIGSDPYLGQRLDS------------------------------------- 2266
alpha2.3 --SQHASPQRYISEPYLALHEDS------------------------------------- 2239
alpha3.2 DGSHSVTPESRASSSGAIVPLEP------------------------------------- 2305
alpha1.1 ---------------LAADANFIMATGQALADACQMEPEEVEIMATELLKG--REAPEGM 1842
alpha1.2 ---------------FAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGA 2176
alpha1.3 ---------------YARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGD 2118
alpha2.1 RGSDYDEADGPGSGGGEEAMAGAYDAPPPVRHASSGATGRSPRTPRASGPACASPSRHGR 2469
alpha2.2 ----------------EASVHALPEDTLTFEEAVATNSGRSSRTSYVS--SLTSQSHPLR 2308
alpha2.3 -----------------HASDCGEEETLTFEAAVATSLGRSNTIGSAP------PLRHSW 2276
alpha3.2 ---------------------PESEPPMPVGDPPEKRRGLYLTVPQCPLEKPGSPSATPA 2344
. .
alpha1.1 ASSLG-CLNLG-SSLGSLDQHQG--------SQETLIPPRL----- 1873
alpha1.2 LLPFVNCRDAGQDRAG-GEEDAGCVRARGAPSEEELQDSRVYVSSL 2221
alpha1.3 VGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2161
alpha2.1 RLPNGYYPAHGLARPRGPGSRKGLHEPYSES-DDDWC--------- 2505
alpha2.2 RVPNGYHCTLGLSS--GGRARHSYHHPD----QDHWC--------- 2339
alpha2.3 QMPNGHYRRRRRGGPGPGMMCGAVNNLLSDTEEDDKC--------- 2313
alpha3.2 PGGGADDPV------------------------------------- 2353
beta subunit of the calcium ion channel
beta1-1 --------------MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTS 46
beta1-2 --------------MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTS 46
beta1-3 --------------MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTS 46
beta2-1 --------------------------------------MQCCGLVHRRRVRVSY------ 16
beta2-2 MVQRDMSKSPPTAAAAVAQEIQMELLENVAPAGALGAAAQSYGKGARRKNRFKGSDGSTS 60
beta2-3 -------------------------------------MLDRRLIAPQTKYIIPG------ 17
beta2-4 MVQRDMSKSPPTAAAAVAQEIQMELLENVAPAGALGAAAQSYGKGARRKNRFKGSDGSTS 60
beta2-5 MVQRDMSKSPPTAAAAVAQEIQMELLENVAPAGALGAAAQSYGKGARRKNRFKGSDGSTS 60
beta2-6 ----------------------------MNQGSGLDLLKISYGKGARRKNRFKGSDGSTS 32
beta2-7 -------------------------------MKATWIRLLKRAKGGRLKNSDIC------ 23
beta2-8 ----------------MNQGSGLDLLK------------ISYGKGARRKNRFKGSDGSTS 32
beta3 ---------------------------------------------MYDDSYVPGFEDS-- 13
beta4a ---------------------------------------------MYDNLYLHGIEDS-- 13
beta4b -------------------MSSSSYAKNGTADGPHSPTSQVARGTTTRRSRLKRSDGST- 40
beta4c -------------------------------------MDVVARGTTTRRSRLKRSDGST- 22
beta1-1 SDTTSNSFVRQGSAESYTSRPS-DSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAV 105
beta1-2 SDTTSNSFVRQGSAESYTSRPS-DSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAV 105
beta1-3 SDTTSNSFVRQGSAESYTSRPS-DSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAV 105
beta2-1 -----------GSADSYTSRPS-DSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAV 64
beta2-2 SDTTSNSFVRQGSADSYTSRPS-DSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAV 119
beta2-3 -----------GSADSYTSRPS-DSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAV 65
beta2-4 SDTTSNSFVRQGSADSYTSRPS-DSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAV 119
beta2-5 SDTTSNSFVRQGSADSYTSRPS-DSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAV 119
beta2-6 SDTTSNSFVRQGSADSYTSRPS-DSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAV 91
beta2-7 -----------GSADSYTSRPS-DSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAV 71
beta2-8 SDTTSNSFVRQGSADSYTSRPS-DSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAV 91
beta3 ---------EAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPVAFAV 64
beta4a ---------EAGSADSYTSRPS-DSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAV 63
beta4b --TSTSFILRQGSADSYTSRPS-DSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAV 97
beta4c --TSTSFILRQGSADSYTSRPS-DSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAV 79
***:******* ***********: *:* * ** ***:** *******
beta1-1 RTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKL 165
beta1-2 RTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKL 165
beta1-3 RTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKL 165
beta2-1 RTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKL 124
beta2-2 RTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKL 179
beta2-3 RTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKL 125
beta2-4 RTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKL 179
beta2-5 RTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKL 179
beta2-6 RTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKL 151
beta2-7 RTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKL 131
beta2-8 RTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKL 151
beta3 RTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPSPQRL 124
beta4a KTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRL 123
beta4b KTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRL 157
beta4c KTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRL 139
:***.* :: ** . .:.*:.*****:***:.************ ::.***** :*
beta1-1 DSLRLLQEQKLRQNRLGSSKSGDNSSSSLGDVVTGTRRPTPPASAKQKQ----------- 214
beta1-2 DSLRLLQEQKLRQNRLGSSKSGDNSSSSLGDVVTGTRRPTPPASGNEMTNLAFELDPLEL 225
beta1-3 DSLRLLQEQKLRQNRLGSSKSGDNSSSSLGDVVTGTRRPTPPASAKQKQ----------- 214
beta2-1 ENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATG-------L 177
beta2-2 ENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATG-------L 232
beta2-3 ENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATG-------L 178
beta2-4 ENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSG--------------- 224
beta2-5 ENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSS---------------- 223
beta2-6 ENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATG-------L 204
beta2-7 ENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATG-------L 184
beta2-8 ENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSG--------------- 196
beta3 ESIRLKQEQK--------ARRSGNPSS-LSDIGN--RRSPPPSLAKQKQ----------- 162
beta4a ENIRIQQEQKR--GRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQ----------- 170
beta4b ENIRIQQEQKR--GRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQ----------- 204
beta4c ENIRIQQEQKR--GRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQ----------- 186
:.:*: :**: .: ..*.** *.:: :..*.:
beta1-1 ----------------------------------KSTEHVPPYDVVPSMRPIILVGPSLK 240
beta1-2 EEEEAELGEQSGSAKTSVSSVTTPPPHGKRIPFFKKTEHVPPYDVVPSMRPIILVGPSLK 285
beta1-3 ----------------------------------KSTEHVPPYDVVPSMRPIILVGPSLK 240
beta2-1 DAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLK 237
beta2-2 DAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLK 292
beta2-3 DAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLK 238
beta2-4 ----------------AKSADEQDQWKTAGLFWRFTTEHTPPYDVVPSMRPVVLVGPSLK 268
beta2-5 ----------------AKQKQK-------------STEHTPPYDVVPSMRPVVLVGPSLK 254
beta2-6 DAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLK 264
beta2-7 DAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLK 244
beta2-8 ----------------AKSADEQDQWKTAGLFWRFTTEHTPPYDVVPSMRPVVLVGPSLK 240
beta3 ----------------------------------KQAEHVPPYDVVPSMRPVVLVGPSLK 188
beta4a ----------------------------------KVTEHIPPYDVVPSMRPVVLVGPSLK 196
beta4b ----------------------------------KVTEHIPPYDVVPSMRPVVLVGPSLK 230
beta4c ----------------------------------KVTEHIPPYDVVPSMRPVVLVGPSLK 212
:** ***********::*******
beta1-1 GYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIIIERSNTRSSLA 300
beta1-2 GYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIIIERSNTRSSLA 345
beta1-3 GYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIIIERSNTRSSLA 300
beta2-1 GYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLA 297
beta2-2 GYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLA 352
beta2-3 GYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLA 298
beta2-4 GYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLA 328
beta2-5 GYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLA 314
beta2-6 GYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLA 324
beta2-7 GYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLA 304
beta2-8 GYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLA 300
beta3 GYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIERSSARSSIA 248
beta4a GYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLA 256
beta4b GYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLA 290
beta4c GYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLA 272
********************:***********:***********.*: *****.:***:*
beta1-1 EVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRG 360
beta1-2 EVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRG 405
beta1-3 EVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRG 360
beta2-1 EVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRG 357
beta2-2 EVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRG 412
beta2-3 EVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRG 358
beta2-4 EVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRG 388
beta2-5 EVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRG 374
beta2-6 EVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRG 384
beta2-7 EVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRG 364
beta2-8 EVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRG 360
beta3 EVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVLQRLIRSRG 308
beta4a EVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRG 316
beta4b EVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRG 350
beta4c EVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRG 332
*************::****.************ *********.:*::*********:***
beta1-1 KSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSSTPP 420
beta1-2 KSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSSTPP 465
beta1-3 KSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSSTPP 420
beta2-1 KSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLP 417
beta2-2 KSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLP 472
beta2-3 KSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLP 418
beta2-4 KSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLP 448
beta2-5 KSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLP 434
beta2-6 KSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLP 444
beta2-7 KSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLP 424
beta2-8 KSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLP 420
beta3 KSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLEDACEHLAEYLEVYWRATHHPAPGPG 368
beta4a KSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPM 376
beta4b KSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPM 410
beta4c KSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPM 392
*** ***.**: * :**.***** **:**************.:***.**:*** .:.
beta1-1 NPLLNRTMATAALAASPAPVSN---LQGPYLASGDQPLERATGEHASMHEYPGELGQPPG 477
beta1-2 NPLLNRTMATAALAASPAPVSN---LQVQVLTS--------------------------- 495
beta1-3 NPLLNRTMATAALAASPAPVSN---LQVQVLTS--------------------------- 450
beta2-1 NPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRS 477
beta2-2 NPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRS 532
beta2-3 NPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRS 478
beta2-4 NPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRS 508
beta2-5 NPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRS 494
beta2-6 NPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRS 504
beta2-7 NPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRS 484
beta2-8 NPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRS 480
beta3 --LLGP----------PSAIPG---LQNQQLLGE-RGEEHSPLERD-------------- 398
beta4a TPLLGRNLGSTALSPYPTAISG---LQSQRMRHSNHSTENSPIERR-------------- 419
beta4b TPLLGRNLGSTALSPYPTAISG---LQSQRMRHSNHSTENSPIERR-------------- 453
beta4c TPLLGRNLGSTALSPYPTAISG---LQSQRMRHSNHSTENSPIERR-------------- 435
**. *: .. *
beta1-1 LYPSSHPPGRAGTLRALSRQDTFDADTPGSRNSAYTELGDSCVDMETDPSEGP---GLGD 534
beta1-2 ----------------LRRN-----------------LG--------------------- 501
beta1-3 ----------------LRRN-----------------LG--------------------- 456
beta2-1 SSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRD 537
beta2-2 SSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRD 592
beta2-3 SSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRD 538
beta2-4 SSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRD 568
beta2-5 SSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRD 554
beta2-6 SSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRD 564
beta2-7 SSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRD 544
beta2-8 SSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRD 540
beta3 -SLMPSDE-----ASESSRQAWTGSSQRSSRH-----LEEDYADAYQDLYQPHRQHTSGL 447
beta4a -SLMTSDENYHNERARKSRNRLSSSSQHSRDHYPL--VEEDYPDSYQDTYKPHRNRGS-- 474
beta4b -SLMTSDENYHNERARKSRNRLSSSSQHSRDHYPL--VEEDYPDSYQDTYKPHRNRGS-- 508
beta4c -SLMTSDENYHNERARKSRNRLSSSSQHSRDHYPL--VEEDYPDSYQDTYKPHRNRGS-- 490
*:
beta1-1 PAGGGTPPARQGS-----WEDEEEDYEEELTDNRNRGRNKARYCAEGGGPVLGRNKNELE 589
beta1-2 -FWGGLESSQRGS-----VVPQEQEHAM-------------------------------- 523
beta1-3 -FWGGLESSQRGS-----VVPQEQEHAM-------------------------------- 478
beta2-1 ETHGSSDHRHRESRHRSRDVDREQDHNECN-KQRSRHKSKDRYCEKDG-EVISKKRNEAG 595
beta2-2 ETHGSSDHRHRESRHRSRDVDREQDHNECN-KQRSRHKSKDRYCEKDG-EVISKKRNEAG 650
beta2-3 ETHGSSDHRHRESRHRSRDVDREQDHNECN-KQRSRHKSKDRYCEKDG-EVISKKRNEAG 596
beta2-4 ETHGSSDHRHRESRHRSRDVDREQDHNECN-KQRSRHKSKDRYCEKDG-EVISKKRNEAG 626
beta2-5 ETHGSSDHRHRESRHRSRDVDREQDHNECN-KQRSRHKSKDRYCEKDG-EVISKKRNEAG 612
beta2-6 ETHGSSDHRHRESRHRSRDVDREQDHNECN-KQRSRHKSKDRYCEKDG-EVISKKRNEAG 622
beta2-7 ETHGSSDHRHRESRHRSRDVDREQDHNECN-KQRSRHKSKDRYCEKDG-EVISKKRNEAG 602
beta2-8 ETHGSSDHRHRESRHRSRDVDREQDHNECN-KQRSRHKSKDRYCEKDG-EVISKKRNEAG 598
beta3 PSANGHDPQDRLL-----AQDSEHNHSDRN-WQRNRPWPKDSY----------------- 484
beta4a PGGYSHDSRHRL------------------------------------------------ 486
beta4b PGGYSHDSRHRL------------------------------------------------ 520
beta4c PGGYSHDSRHRL------------------------------------------------ 502
. :
beta1-1 GWGRGVYIR- 598
beta1-2 ----------
beta1-3 ----------
beta2-1 EWNRDVYIRQ 605
beta2-2 EWNRDVYIRQ 660
beta2-3 EWNRDVYIRQ 606
beta2-4 EWNRDVYIRQ 636
beta2-5 EWNRDVYIRQ 622
beta2-6 EWNRDVYIRQ 632
beta2-7 EWNRDVYIRQ 612
beta2-8 EWNRDVYIRQ 608
beta3 ----------
beta4a ----------
beta4b ----------
beta4c ----------
gamma subunit of the calcium ion channel
gamma1 ------------------------------MSQTKMLKVRVTLFCILAGIVLAMTAVVTD 30
gamma2 -----------------------------MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTD 31
gamma3 -----------------------------MRMCDRGIQMLITTVGAFAAFSLMTIAVGTD 31
gamma4 -----------------------------MVRCDRGLQMLLTTAGAFAAFSLMAIAIGTD 31
gamma5a -----------------------------MSACGRKALTLLSSVFAVCGLGLLGIAVSTD 31
gamma5b -----------------------------MSACGRKALTLLSSVFAVCGLGLLGIAVSTD 31
gamma6a MMWSNFFLQEENRRRGAAGRRRAHGQGRSGLTPEREGKVKLALLLAAVGATLAVLSVGTE 60
gamma6b MMWSNFFLQEENRRRGAAGRRRAHGQGRSGLTPEREGKVKLALLLAAVGATLAVLSVGTE 60
gamma6c MMWSNFFLQEENRRRGAAGRRRAHGQGRSGLTPEREGKVKLALLLAAVGATLAVLSVGTE 60
gamma7 -----------------------------MSHCSSRALTLLSSVFGACGLLLVGIAVSTD 31
gamma8 ------------------MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTD 42
:: . * :: *:
gamma1 HWAVLSPHMEHHNTTCE----------------------AAHFGLWRICTKRIPMDDS-- 66
gamma2 YWLYSRG-VCKTKSVSE----NETSK--------KNEEVMTHSGLWRTCCLEGNFKGLCK 78
gamma3 YWLYSRG-VCRTKSTSD----NETSR--------KNEEVMTHSGLWRTCCLEGAFRGVCK 78
gamma4 YWLYSSAHICNGTNLTM--DDGPPPR--------RARGDLTHSGLWRVCCIEGIYKGHCF 81
gamma5a YWLYLEEGVIVPQNQST------------------EIKMSLHSGLWRVCFLAGEERGRCF 73
gamma5b YWLYLEEGVIVPQNQST------------------EIKMSLHSGLWRVCFLAGEERGRCF 73
gamma6a FWVELNTYKANGSAVCE----------------------AAHLGLWKACTKRLWQADVPV 98
gamma6b FWVELNTYKANGSAVCE----------------------AAHLGLWKACTKRLWQADVPV 98
gamma6c FWVELNTYKANGSAVCE----------------------AAHLGLWKACTKRLWQADVPV 98
gamma7 YWLYMEEGTVLPQNQTT------------------EVKMALHAGLWRVCFFAGREKGRCV 73
gamma8 YWLYTRALICNTTNLTAGGDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCV 102
.* * ***: * .
gamma1 --KTCGP--ITLPGEKNCSYFRHFNPGESSEIFEFTTQKEYSISAAAIAIFSLGFIILGS 122
gamma2 QIDHFPE-DADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFY--------- 128
gamma3 KIDHFPE-DADYEQDTAEYLLRAVRASSVFPILSVTLLFFGGLCVAASEFH--------- 128
gamma4 RINHFPE-DNDYDHDSSEYLLRIVRASSVFPILSTILLLLGGLCIGAGRIY--------- 131
gamma5a TIEYVMPMNTQLTSESTVNVLKMIRSATPFPLVSLFFMFIGFILNNIGHIR--------- 124
gamma5b TIEYVMPMNTQLTSESTVNVLKMIRSATPFPLVSLFFMFIGFILNNIGHIR--------- 124
gamma6a DRDTCGP--AELPGEANCTYFKFFTTGENARIFQRTTKKEVNLAAAVIAVLGLAVMALGC 156
gamma6b DRDTCGP--AELPGEANCTYFKFFTTGENARIFQRTTK---------------------- 134
gamma6c DRDTCGP--AELPG---------------------------------------------- 110
gamma7 ASEYFLEPEINLVTENTENILKTVRTATPFPMVSLFLVFTAFVISNIGHIR--------- 124
gamma8 KINHFPE-DTDYDHDSAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVY--------- 152
.
gamma1 LCVLLSLGKKRDYLLRPASMFYAFAGLCILVSVEVMRQSVKRMIDSED-----TVWIEYY 177
gamma2 --------KTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPS-----KSDSKKNSYS 175
gamma3 --------RSRHNVILSAGIFFVSAGLSNIIGIIVYISANAGDPG-----QRDSKK-SYS 174
gamma4 --------SRKNNIVLSAGILFVAAGLSNIIGIIVYISSNTGDPSDK---RDEDKKNHYN 180
gamma5a --------PHRTILAFVSGIFFILSGLSLVVGLVLYISSINDEMLNRT--KDAETYFNYK 174
gamma5b --------PHRTILAFVSGIFFILSGLSLVVGLVLYISSINDEMLNRT--KDAETYFNYK 174
gamma6a LCIIMVLSKGAEFLLRVGAVCFGLSGLLLLVSLEVFRHSVRALLQRVSPEPPPAPRLTYE 216
gamma6b ------------------------KGLLLLVSLEVFRHSVRALLQRVSPEPPPAPRLTYE 170
gamma6c -------------------------GLLLLVSLEVFRHSVRALLQRVSPEPPPAPRLTYE 145
gamma7 --------PQRTILAFVSGIFFILSGLSLVVGLVLYISSINDEVMNRP--SSSEQYFHYR 174
gamma8 --------KSKRNIILGAGILFVAAGLSNIIGVIVYISANAGEPGPK---RDEEKKNHYS 201
** ::.: : : *
gamma1 YSWSFACACAAFILLFLGGLALLLFSLPRMP----------------------------- 208
gamma2 YGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQA------------SAI 223
gamma3 YGWSFYFGAFSFIIAEIVGVVAVHIYIEKHQQLRAKS-HSEFLKK------------STF 221
gamma4 YGWSFYFGALSFIVAETVGVLAVNIYIEKNKELRFKT-KREFLKA---------SSSSPY 230
gamma5a YGWSFAFAAISFLLTESAGVMSVYLFMKRY-------------------------TAEDM 209
gamma5b YGWSFAFAAISFLLTE---VKPVTLSMDRLG-----------------------LGTAPL 208
gamma6a YSWSLGCGVGAGLILLLGAGCFLLLTLPSWP----------------------------- 247
gamma6b YSWSLGCGVGAGLILLLGAGCFLLLTLPSWP----------------------------- 201
gamma6c YSWSLGCGVGAGLILLLGAGCFLLLTLPSWP----------------------------- 176
gamma7 YGWSFAFAASSFLLKEGAGVMSVYLFTKRY-------------------------AEEEM 209
gamma8 YGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQS-RSDLLKAGGGAGGSGGSGPSAI 260
*.**: . : :: : :
gamma1 -----------RNPWESCMDAEPEH----------------------------------- 222
gamma2 TRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATT 283
gamma3 ARLPPYRYRFRRRS--SSRSTEP-RSRDLSPIS-KGFHTIPSTDISMFTLSRDPSKITMG 277
gamma4 ARMPSYRYR-RRRSRSSSRSTEASPSRDVSPMGLKITGAIPMGELSMYTLSREPLKVTTA 289
gamma5a YRPHPGFYRPRLSN---CSDYSGQFLHPD-----AWVRGRSPSDIS----SEASLQMNSN 257
gamma5b SRGEWGWGRRDIPQPFWTPDHPLYFPSSSQNVSLSYLSGSPPARMSPGPCSCPHVHFPPH 268
gamma6a -----------WGSLCPKRGHRAT------------------------------------ 260
gamma6b -----------WGSLCPKRGHRAT------------------------------------ 214
gamma6c -----------WGSLCPKRGHRAT------------------------------------ 189
gamma7 YRPHPAFYRPRLSD---CSDYSGQFLQPE-----AWRRGRSPSDIS----SDVSIQMTQN 257
gamma8 LRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGGPGGPGFAST-DISMYTLSRDPSKGSVA 319
.
gamma1 ------------------------------------------------------------
gamma2 PTATYN-----------------------------SDRD----NSFLQVHNCIQKENKDS 310
gamma3 --TLLN-----------------------------SDRD----HAFLQFHNSTPKEFKES 302
gamma4 ASYS-------------------------------PDQE----ASFLQVHDFFQQDLKEG 314
gamma5a YPALLKC------------------------------------PDYDQMSSSPC------ 275
gamma5b SSCVLCR------------------------------------PQPREMRQAPAASPSSA 292
gamma6a ------------------------------------------------------------
gamma6b ------------------------------------------------------------
gamma6c ------------------------------------------------------------
gamma7 YPPAIKY------------------------------------PDHLHISTSPC------ 275
gamma8 AGLAGAGGGGGGAVGAFGGAAGGAGGGGGGGGGAGAERDRGGASGFLTLHNAFPKEAGGG 379
gamma1 ----------------------------------------------
gamma2 LHSN---------------------------------TANRRTTPV 323
gamma3 LHNN---------------------------------PANRRTTPV 315
gamma4 FHVS---------------------------------MLNRRTTPV 327
gamma5a ----------------------------------------------
gamma5b VFSL------------------------------------------ 296
gamma6a ----------------------------------------------
gamma6b ----------------------------------------------
gamma6c ----------------------------------------------
gamma7 ----------------------------------------------
gamma8 VTVTVTGPPAPPAPAPPAPSAPAPGTLAKEAAASNTNTLNRKTTPV 425
alalph2delta subunit
alpha2delta1 ----------------------------------------------MAAGCLLALTLTLF 14
alpha2delta2 MAVPARTCGASRPGPARTARPWPGCGPHPGPGTRRP---------TSGPPRPLWLLLPLL 51
alpha2delta3 -------------------------MAGPGSPRRAS------------RGASALLAAALL 23
alpha2delta4 -MVCGCSALLPLPNPRPTMPATPNFLANPSSSSRWIPLQPMPVAWAFVQKTSALLWLLLL 59
* *:
alpha2delta1 QSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNN 74
alpha2delta2 PLLAAPGASAYSFPQQHTMQHWARRLEQEVDGVMRIFGGVQQLREIYKDNRNLFEVQENE 111
alpha2delta3 YAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEID 83
alpha2delta4 GTSLSPAWG-QAKIPLETVKLWADTFGGDLYNTVTKYSGSLLLQKKYKDVESSLKIEEVD 118
.:: *. : :: .* * . *:. .. :: :
alpha2delta1 ARQLVEIAARDIEKLLSNRSKALVSLALEAEKVQAAHQWREDFASNEVVYYNAKDDLD-- 132
alpha2delta2 PQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELD 171
alpha2delta3 GLQLVKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDK-- 141
alpha2delta4 GLELVRKFSEDMENMLRRKVEAVQNLVEAAEEADLNHEFNESLVFDYYNSVLINERDE-- 176
:**. : ::*.:: .: :*: *. **: . *.: .: : : .
alpha2delta1 -PEKNDSEPGSQR--IKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSAL 189
alpha2delta2 DPESEDVERGSKASTLRLDFIEDPNFKNKVNYSYAAVQIPTDIYKGSTVILNELNWTEAL 231
alpha2delta3 --DGNFLELGKEFILAPNDHFNN----LPVNISLSDVQVPTNMYNKDPAIVNGVYWSESL 195
alpha2delta4 --KGNFVELGAEFLLESNAHFSN----LPVNTSISSVQLPTNVYNKDPDILNGVYMSEAL 230
. : * * : .:.: :. . : *::**::*: .. ::* : :.:*
alpha2delta1 DEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAA 249
alpha2delta2 ENVFMENRRQDPTLLWQVFGSATGVTRYYPATPWR----APKKIDLYDVRRRPWYIQGAS 287
alpha2delta3 NKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEP---DENGVIAFDCRNRKWYIQAAT 252
alpha2delta4 NAVFVENFQRDPTLTWQYFGSATGFFRIYPGIKWTP---DENGVITFDCRNRGWYIQAAT 287
: ** .* .**:* ** ****.*. * **. * : : :* *.* ****.*:
alpha2delta1 SPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVS-CFQ-HL 307
alpha2delta2 SPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPVS-CFT-HL 345
alpha2delta3 SPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTL 312
alpha2delta4 SPKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFVNIIAYNDYVHYIEPCFKGIL 347
****::*:******:.** :.: : :: :*:**.::*:.*: ::*. : :. *: *
alpha2delta1 VQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRAN--CNKIIMLFTDGG 365
alpha2delta2 VQANVRNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITRAN--CNKMIMMFTDGG 403
alpha2delta3 VQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGA 372
alpha2delta4 VQADRDNREHFKLLVEELMVKGVGVVDQALREAFQILKQFQEAKQGSLCNQAIMLISDGA 407
***: *:: :: :: : .** . .: **: * : : : . *.: **:::**.
alpha2delta1 EERAQEIFNKYNK-DKKVRVFRFSVGQHNYERGPIQWMACENKGYYYEIPSIGAIRINTQ 424
alpha2delta2 EDRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRINTQ 463
alpha2delta3 VDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVM 432
alpha2delta4 VEDYEPVFEKYNWPDCKVRVFTYLIGREVSFADRMKWIACNNKGYYTQISTLADTQENVM 467
: : :* *** : .**:* : :*:. ::*:** ***:: :*.::. : *.
alpha2delta1 EYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITG------TLPVFNITGQFENKTN 478
alpha2delta2 EYLDVLGRPMVLAGKEAKQVQWTNVYEDALGLGLVVTG------TLPVFNLTQDGPGEK- 516
alpha2delta3 EYLHVLSRPKVID--QEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNET 490
alpha2delta4 EYLHVLSRPMVIN--HDHDIIWTEAYMDSKLLSSQAQS----LTLLTTVAMPVFSKKNET 521
***.**.** *: . ::: **:.* *: :... :. :
alpha2delta1 LKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKNPK----- 533
alpha2delta2 -KNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTN----- 570
alpha2delta3 RSKGILLGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHPELRLLYEEGKKRR 550
alpha2delta4 RSHGILLGVVGSDVALRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGKKLK 581
.: ::***:* **.:.:: : *.:.* :** * ***:* **:*: :
alpha2delta1 -SQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTP 592
alpha2delta2 -FREPVTLDFLDAELEDENKEEIRRSMIDGNKGHKQIRTLVKSLDERYIDEVTRNYTWVP 629
alpha2delta3 -KPNYSSVDLSEVEWEDR-DDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTD 608
alpha2delta4 PKPNYNSVDLSEVEWEDQ-AESLRTAMINRETGTLSMDVKVPMDKGKRVLFLTNDYFFTD 640
: ::*: :.* *: :* *:: :.* : . . : : .. * :.
alpha2delta1 VNGTDYSLALVLPTYS---FYYIKAKLEETITQARSKKGKMKDSETLKPDNFEESGYTFI 649
alpha2delta2 IRSTNYSLGLVLPPYS---TFYLQANLSDQILQVKLRISKLKDFEFLLPSSFESEGHVFI 686
alpha2delta3 IKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLS 668
alpha2delta4 ISDTPFSLGVVLSRGHGEYILLGNTSVEEGLHDLLHPDLALAGDWIYCITDIDPDHRKLS 700
: .* :**.:.*. :..:.: : : : . .:. . :
alpha2delta1 APRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNADLINRVLLDAGFTNELVQNYWS 709
alpha2delta2 APREYCKDLNASDNNTEFLKNFIELMEKVTPDSKQCNNFLLHNLILDTGITQQLVERVWR 746
alpha2delta3 QLEAIKLYLKGKEPLLQCDKELIQEVLFDAVVSAPIEAYWTSLALNKSENSDKGVEVAFL 728
alpha2delta4 QLEAMIRFLARKDPDLECDEELVREVLFDAVVTAPMEAYWTALALNMSEESEHVVDMAFL 760
. * .: : :: . : : . : : : ::. *: :
alpha2delta1 KQ-KNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYF 768
alpha2delta2 DQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEPFNASFYRRSLDNHGYVFKPPHQ 806
alpha2delta3 GT-RTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIPF 787
alpha2delta4 GT-RAGLLRSSLFVGSEKVSDRKFLTPEDEASVFTLDRFPLWYRQASEHPAGSFVFNLRW 819
*. :: : : . : . : : : : : . . ..
alpha2delta1 NKSG-PGAYES---GIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIR----- 819
alpha2delta2 DALLRPLELENDTVGILVSTAVELSLGRRTLRPAVVGVKLDLEAWAEKFKVLASNRTHQD 866
alpha2delta3 STGP--VNKSN---VVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQ----- 837
alpha2delta4 AEGPESAGEPM---VVTASTAVAVTVDKRTAIAAAAGVQMKLEFLQRKFWAATRQ----- 871
: .*.:: : : *..*:::.:: .:* : .
alpha2delta1 -----DPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHL 874
alpha2delta2 QPQKCGPNSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLAL 926
alpha2delta3 -----CASLDGKCSISCDDETVNCYLIDNNGFILVSED---YTQTGDFFGEIEGAVMNKL 889
alpha2delta4 -----CSTVDGPCTQSCEDSDLDCFVIDNNGFILISKR---SRETGRFLGEVDGAVLTQL 923
. . :.. : * ::*:.**::::: : * *:.*:: :: *
alpha2delta1 VNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSVADILQIGWWATAAAWSILQQFL 934
alpha2delta2 YNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVADFLNLAWWTSAAAWSLFQQLL 986
alpha2delta3 LTMGSFKRITLYDYQAMCRANKESSDGAHG--LLDPYNAFLSAVKWIMTELVLFLVEFNL 947
alpha2delta4 LSMGVFSQVTMYDYQAMCKPSSHHHSAAQP--LVSPISAFLTATRWLLQELVLFLLEWSV 981
. . : ****: * . .* * * : * . :.: :
alpha2delta1 LSLTFPRLLEAVEME--DDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFH 992
alpha2delta2 YGLIYHSWFQADPAE--AEGSPETR-ESSCVMKQTQYYFGSVNASYNAIIDCGNCSRLFH 1043
alpha2delta3 C-SWWHSDMTAK-------AQKLKQTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFV 999
alpha2delta4 WGSWYDRGAEAKSVFHHSHKHKKQDPLQPCDTEYPVFVYQPAIREANGIVECEPCQKVFV 1041
: * ..* : . : . .. : * *.: *
alpha2delta1 GEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSD-GPNPCDMVKQPRYRKGPDVCFDNN 1051
alpha2delta2 AQRLTNTNLLFVVAEKPLCSQCEAGRLLQKETHSD-GPEQCELVQRPRYRRGPHICFDYN 1102
alpha2delta3 IQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFH 1059
alpha2delta4 VQQIPNSNLLLLVTDPTCDCSIFPPVLQEATEVKYNASVKCDRMRSQKLRRRPDSCHAFH 1101
::: .:**::::.: . . . *: :: : *: *. *. :
alpha2delta1 VLEDYTDCGGVSGLNPSLWYIIGIQFLLLWLVSGSTHRLL-------- 1091
alpha2delta2 ATEDTSDCGRGASFPPSLGVLVSLQLLLLLGLPPRPQPQVLVHASRRL 1150
alpha2delta3 PEENARECGGAPSLQAQTVLLLLPL----LLMLFSR------------ 1091
alpha2delta4 PEENAQDCGGASDTSASPPLLLLPVCAWGLLPQLLR------------ 1137
*: :** .. .. ::
Accession numbers of the calcium ion channels used in the protein sequence alignments:
alpha1.1 - Q13698; alpha1.2 - Q13936; alpha1.3 - Q01668; alpha2.1 - O00555;
alpha2.2 - Q00975; alpha2.3 - Q15878; alpha3.2 - O95180;
beta1-1 - NP_000714; beta1-2 - NP_954855; beta1-3 - NP_954856; beta2-1 -
NP_000715; beta2-2 - NP_963890; beta2-3 - NP_963884; beta2-4 - NP_963891;
beta2-5 - NP_963887; beta2-6 - NP_963865; beta2-7 - NP_963864; beta2-8 -
NP_963866; beta3 - NP_000716; beta4a - NP_001005747; beta4b - NP_000717;
beta4c - NP_001005746;
gamma1 - NP_000718; gamma2 - NP_006069; gamma3 - NP_006530; gamma4 - NP_055220;
gamma5a - NP_665810; gamma5b - NP_055219; gamma6a - NP_665813;
gamma6b - NP_665814; gamma6c - NP_114103; gamma7 - NP_114102;
gamma8 - NP_114101;
alpha2delta1 - P54289; alpha2delta2 - Q9NY47; alpha2delta3
- Q8IZS8; alpha2delta4 - Q7Z3S7
Predicted General Properties of Representative Subunits of the Calcium Ion Channel (Homo sapiens) - Primary Sequence Analysis (with ProtParam)b
alpha1.1 subunit
Number of amino acids: 1873
Molecular weight: 212350.2
Theoretical pI: 6.17
Total number of negatively charged residues (Asp + Glu): 201
Total number of positively charged residues (Arg + Lys): 186 Atomic composition: Carbon C 9659 Hydrogen H 15061 Nitrogen N 2489 Oxygen O 2683 Sulfur S 105
Formula: C9659H15061N2489O2683S105
Total number of atoms: 29997
Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 227910 Abs 0.1% (=1 g/l) 1.073, assuming ALL Cys residues appear as half cystines Ext. coefficient 225410 Abs 0.1% (=1 g/l) 1.062, assuming NO Cys residues appear as half cystines
Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).
Instability index: The instability index (II) is computed to be 41.16 This classifies the protein as unstable.
Aliphatic index: 97.51
Grand average of hydropathicity (GRAVY): 0.092
beta1-1 subunit
Number of amino acids: 598
Molecular weight: 65713.6
Theoretical pI: 6.33
Total number of negatively charged residues (Asp + Glu): 79
Total number of positively charged residues (Arg + Lys): 75
Atomic composition: Carbon C 2863 Hydrogen H 4560 Nitrogen N 830 Oxygen O 914 Sulfur S 15 Formula: C2863H4560N830O914S15
Total number of atoms: 9182
Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 53080 Abs 0.1% (=1 g/l) 0.808, assuming ALL Cys residues appear as half cystines Ext. coefficient 52830 Abs 0.1% (=1 g/l) 0.804, assuming NO Cys residues appear as half cystines
Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).
Instability index: The instability index (II) is computed to be 55.66 This classifies the protein as unstable.
Aliphatic index: 70.65
Grand average of hydropathicity (GRAVY): -0.695
gamma1 subunit
Number of amino acids: 222
Molecular weight: 25028.4
Theoretical pI: 6.64
Total number of negatively charged residues (Asp + Glu): 20
Total number of positively charged residues (Arg + Lys): 19
Atomic composition: Carbon C 1138 Hydrogen H 1757 Nitrogen N 287 Oxygen O 308 Sulfur S 20 Formula: C1138H1757N287O308S20
Total number of atoms: 3510
Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 38555 Abs 0.1% (=1 g/l) 1.540, assuming ALL Cys residues appear as half cystines Ext. coefficient 37930 Abs 0.1% (=1 g/l) 1.515, assuming NO Cys residues appear as half cystines
Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).
Instability index: The instability index (II) is computed to be 50.69 This classifies the protein as unstable.
Aliphatic index: 94.50
Grand average of hydropathicity (GRAVY): 0.341
alpha2delta1
Number of amino acids: 1091
Molecular weight: 123183.4
Theoretical pI: 5.10
Total number of negatively charged residues (Asp + Glu): 142
Total number of positively charged residues (Arg + Lys): 114
Atomic composition: Carbon C 5510 Hydrogen H 8536 Nitrogen N 1454 Oxygen O 1676 Sulfur S 38 Formula: C5510H8536N1454O1676S38
Total number of atoms: 17214
Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 166270 Abs 0.1% (=1 g/l) 1.350, assuming ALL Cys residues appear as half cystines Ext. coefficient 165020 Abs 0.1% (=1 g/l) 1.340, assuming NO Cys residues appear as half cystines
Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).
Instability index: The instability index (II) is computed to be 34.41 This classifies the protein as stable.
Aliphatic index: 84.97
Grand average of hydropathicity (GRAVY): -0.345