Macromolecule Insights - Protein Bioinformatics Analysis

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The Calcium Ion Channel

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Sequence Alignment of the Calcium Ion Channel (with Clustalw)a

alpha subunit of the calcium ion channel

alpha1.1  ------------------------------------------------------------
alpha1.2  -MVNENTRMYIPEENHQGSNYGSPRPAHANMNANAAAGLAPEHIPTPGAALSWQAAIDAA 59
alpha1.3  MMMMMMMKKMQHQRQQQADHANEANYARGTRLPLSGEGPTSQPNSSKQTVLSWQAAIDAA 60
alpha2.1  ---------------------------MARFGDEMPARYGGGGSGAAAGVVVGSGGGRGA 33
alpha2.2  ---------------------------MVRFGDELGGRYGGPGGGERA----RGGGAGGA 29
alpha2.3  ---------------------------MARFGEAVVARPGSGDGDSDQ-------SRNRQ 26
alpha3.2  ------------------------MTEGARAADEVRVPLGAPPPGPAALVGASPESPGAP 36
                                                                      

alpha1.1  -----------MEPSSPQDEGLRKKQ----PKKPVPEILPRPPRALFCLTLENPLRKACI 45
alpha1.2  RQAKLMGSAGNATISTVSST-QRKRQQYGKPKKQGSTTATRPPRALLCLTLKNPIRRACI 118
alpha1.3  RQAKAAQTMSTSAPPPVGSLSQRKRQQYAKSKKQGNSSNSRPARALFCLSLNNPIRRACI 120
alpha2.1  GGSRQGG-QPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAK 92
alpha2.2  GGPGPGGLQPGQRVLYKQSIAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAK 89
alpha2.3  GTPVPAS---GQAAAYKQTKAQRARTMALYNPIPVRQNCFTVNRSLFIFGEDNIVRKYAK 83
alpha3.2  GREAERGSELGVSPS--ESPAAERGAELGADEEQRVPYPALAATVFFCLGQTTRPRSWCL 94
                                .                      :: :   .  *  . 

alpha1.1  SIVEWKPFETIILLTIFANCVALAVYLPMPEDDN-NSLNLGLEKLEYFFLIVFSIEAAMK 104
alpha1.2  SIVEWKPFEIIILLTIFANCVALAIYIPFPEDDS-NATNSNLERVEYLFLIIFTVEAFLK 177
alpha1.3  SIVEWKPFDIFILLAIFANCVALAIYIPFPEDDS-NSTNHNLEKVEYAFLIIFTVETFLK 179
alpha2.1  KITEWPPFEYMILATIIANCIVLALEQHLPDDDK-TPMSERLDDTEPYFIGIFCFEAGIK 151
alpha2.2  RITEWPPFEYMILATIIANCIVLALEQHLPDGDK-TPMSERLDDTEPYFIGIFCFEAGIK 148
alpha2.3  KLIDWPPFEYMILATIIANCIVLALEQHLPEDDK-TPMSRRLEKTEPYFIGIFCFEAGIK 142
alpha3.2  RLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDVECGSERCNILEAFDAFIFAFFAVEMVIK 154
           :     *: . : .*: **:.*.:     : :  .     *:  :  :: .* .*  :*

alpha1.1  IIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGAGLDVKAL 164
alpha1.2  VIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKAD-GANALGGKGAGFDVKAL 236
alpha1.3  IIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKETEGGNHSSGKSGGFDVKAL 239
alpha2.1  IIALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEF-----------------DLRTL 194
alpha2.2  IIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTDF-----------------DLRTL 191
alpha2.3  IVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHV-------------DLRTL 189
alpha3.2  MVALG-LFGQKCYLGDTWNRLDFFIVVAGMMEYSLDGHN---------------VSLSAI 198
          ::* *  :   .*: . ** :** :*. *::                        .: ::

alpha1.1  RAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMHK 224
alpha1.2  RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHK 296
alpha1.3  RAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFIGKMHK 299
alpha2.1  RAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHT 254
alpha2.2  RAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHK 251
alpha2.3  RAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHR 249
alpha3.2  RTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRN 258
          *:.******: :. :**:::::. ::.::  * :: ** :* .:::.*:*:::: * :: 

alpha1.1  TCYFIGT------------DIVATVENEEPSPCART-GSGRR------------------ 253
alpha1.2  TCYNQEG------------IADVPAE-DDPSPCALETGHGRQ------------------ 325
alpha1.3  TCFFAD--------------SDIVAE-EDPAPCAFS-GNGRQ------------------ 325
alpha2.1  TCFEEG--------------TDDIQGESP-APCGTEEPART------------------- 280
alpha2.2  ACFPN---------------STDAEPVGD-FPCGKEAPARL------------------- 276
alpha2.3  ACFMNN--------------SGILEGFDPPHPCGVQG----------------------- 272
alpha3.2  RCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPGRRELRMPCTLG 318
           *:                             *.                          

alpha1.1  ---------------------CTINGSECRGGWPGPNHGITHFDNFGFSMLTVYQCITME 292
alpha1.2  ---------------------CQN-GTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITME 363
alpha1.3  ---------------------CTANGTECRSGWVGPNGGITNFDNFAFAMLTVFQCITME 364
alpha2.1  ----------------------CPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITME 318
alpha2.2  ----------------------CEGDTECREYWPGPNFGITNFDNILFAILTVFQCITME 314
alpha2.3  ----------------------CPAGYECKD-WIGPNDGITQFDNILFAVLTVFQCITME 309
alpha3.2  WEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLE 378
                                      *:    .*: *  :***: :: ::::* **:*

alpha1.1  GWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAKSRGTFQK 352
alpha1.2  GWTDVLYWVNDAVGRDWPWIYFVTLIIIGSFFVLNLVLGVLSGEFSKEREKAKARGDFQK 423
alpha1.3  GWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQK 424
alpha2.1  GWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLK 378
alpha2.2  GWTDILYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLK 374
alpha2.3  GWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMK 369
alpha3.2  GWVDIMYYVMDAHS-FYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQR 437
          **. ::*   ** .    ::**: *::.****::** * *:: :*:: ::: .      :

alpha1.1  LREKQQ----------------------------LDEDLRGYMSWITQGEVMDVEDFREG 384
alpha1.2  LREKQQ----------------------------LEEDLKGYLDWITQAEDIDPENEDEG 455
alpha1.3  LREKQQ----------------------------LEEDLKGYLDWITQAEDIDPENEEEG 456
alpha2.1  LRRQQQ----------------------------IERELNGYMEWISKAEEVILAEDETD 410
alpha2.2  LRRQQQ----------------------------IERELNGYLEWIFKAEEVMLAEEDRN 406
alpha2.3  LRRQQQ----------------------------IERELNGYRAWIDKAEEVMLAEENKN 401
alpha3.2  ARHLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSAVQG 497
           *. .:                              ..*. *  *  : .     .   .

alpha1.1  ----------------------------------------------------------KL 386
alpha1.2  MD---------------------------------------------------EEKPRNM 464
alpha1.3  GE---------------------------------------------------EGK-RNT 464
alpha2.1  GEQ----------------------------------------------RHPFDGALRRT 424
alpha2.2  AEE----------------------------------------------KSPLD-VLKRA 419
alpha2.3  AG------------------------------------------------TSALEVLRRA 413
alpha3.2  QGPGHRQRRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACDTRLVRAGAPP 557
                                                                      

alpha1.1  SLDEGGSDTESLYEIAG--------------LNKII---QFIRHWRQWNRI--------- 420
alpha1.2  SMPTSETESVNTENVAGGDIEGENCGARLAHRISKS---KFSRYWRRWNRF--------- 512
alpha1.3  SMPTSETESVNTENVSG-EGENRGCCGSLCQAISKS---KLSRRWRRWNRF--------- 511
alpha2.1  TIKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERR--------- 475
alpha2.2  ATKKSRNDLIHAEEGEDRFADLCAVGSPFARASLKSGKTESSSYFRRKEKM--------- 470
alpha2.3  TIKRSRTEAMTRDSSDEHCVDISSVGTPLARASIKSAKVDGVSYFRHKERL--------- 464
alpha3.2  SPPSPGRGPPDAESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPTIL 617
          :            .                               :              

alpha1.1  ------------------------------------------------------------
alpha1.2  ------------------------------------------------------------
alpha1.3  ------------------------------------------------------------
alpha2.1  ------------------------------------------------------------
alpha2.2  ------------------------------------------------------------
alpha2.3  ------------------------------------------------------------
alpha3.2  PSGVGSGKGSTSPGPKGKWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLS 677
                                                                      

alpha1.1  ------------------------------------------------------------
alpha1.2  ------------------------------------------------------------
alpha1.3  ------------------------------------------------------------
alpha2.1  ------------------------------------------------------------
alpha2.2  ------------------------------------------------------------
alpha2.3  ------------------------------------------------------------
alpha3.2  GLSVPCPLPSPPAGTLTCELKSCPYCTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHG 737
                                                                      

alpha1.1  --------------------------------------------FRWKCHDIVKSKVFYW 436
alpha1.2  --------------------------------------------CRRKCRAAVKSNVFYW 528
alpha1.3  --------------------------------------------NRRRCRAAVKSVTFYW 527
alpha2.1  --------------------------------------------MRFYIRRMVKTQAFYW 491
alpha2.2  --------------------------------------------FRFFIRRMVKAQSFYW 486
alpha2.3  --------------------------------------------LRISIRHMVKSQVFYW 480
alpha3.2  DRWDPTRPPRATDTPGPGPGSPQRRAQQRAAPGEPGWMGRLWVTFSGKLRRIVDSKYFSR 797
                                                           :  *.:  *  

alpha1.1  LVILIVALNTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIF 496
alpha1.2  LVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLF 588
alpha1.3  LVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVSLF 587
alpha2.1  TVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSF 551
alpha2.2  VVLCVVALNTLCVAMVHYNQPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSF 546
alpha2.3  IVLSLVALNTACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSF 540
alpha3.2  GIMMAILVNTLSMGVEYHEQPEELTNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPY 857
           ::  : :**  :.  :::**  *:     ::  : .:*  ** :*: . *   *: . :

alpha1.1  NRFDCFVVCSGILEILLVESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSI 556
alpha1.2  NRFDCFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSV 648
alpha1.3  NRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWTSLSNLVASLLNSM 647
alpha2.1  NCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSM 611
alpha2.2  NCFDFGVIVGSVFEVVWAAIKPGSSFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSM 606
alpha2.3  NCFDFGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSM 600
alpha3.2  NIFDGIIVVISVWEIVGQADG-----GLSVLRTFRLLRVLKLVRFLPALRRQLVVLVKTM 912
          * **  :   .: * :          *:**:* .****::*:.:.  :* . :. *:.::

alpha1.1  RSIASLLLLLFLFIVIFALLGMQLFGGRYDFE----DTEVRRSNFDNFPQALISVFQVLT 612
alpha1.2  RSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD----EMQTRRSTFDNFPQSLLTVFQILT 704
alpha1.3  KSIASLLLLLFLFIIIFSLLGMQLFGGKFNFD----ETQTKRSTFDNFPQALLTVFQILT 703
alpha2.1  KSIISLLFLLFLFIVVFALLGMQLFGGQFNFD----EGTP-PTNFDTFPAAIMTVFQILT 666
alpha2.2  KSIISLLFLLFLFIVVFALLGMQLFGGQFNFQ----DETP-TTNFDTFPAAILTVFQILT 661
alpha2.3  KSIISLLFLLFLFIVVFALLGMQLFGGRFNFN----DGTP-SANFDTFPAAIMTVFQILT 655
alpha3.2  DNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRKNFDSLLWAIVTVFQILT 972
           .: ::  **:***.:*::***:*** ::.:.    :      .**.:  ::::***:**

alpha1.1  GEDWTSMMYNGIMAYGGPSYPGMLVCIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTS 672
alpha1.2  GEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTS 764
alpha1.3  GEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNT 763
alpha2.1  GEDWNEVMYDGIKSQGGVQ-GGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK 725
alpha2.2  GEDWNAVMYHGIESQGGVS-KGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK 720
alpha2.3  GEDWNEVMYNGIRSQGGVS-SGMWSAIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTK 714
alpha3.2  QEDWNVVLYNGMAS------TSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANR 1026
           ***. ::*.*: :       .   .:**: *   *** *:*:::** *:.:    . . 

alpha1.1  AQKAKAEEKKRRKMSKGLPDKSEEEK------------------------------STMA 702
alpha1.2  AQKEEEEEKERKKLAR---TASPEKKQELVEKP------------------AVGESKEEK 803
alpha1.3  AQKEEAEEKERKKIAR---KESLENK------------------------------KNNK 790
alpha2.1  DEQEEEEAANQKLALQKAKEVAEVSPLSAANMS--------------IAVKEQQKNQKPA 771
alpha2.2  DEEEMEEAANQKLALQKAKEVAEVSPMSAANIS--------------IAARQQ--NSAKA 764
alpha2.3  DEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWEPRSSHLRERRRRHH 774
alpha3.2  SDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPN------------GHLEGRGSLSP 1074
           :    :   :                                                 

alpha1.1  KKLEQKPKGEGIPTTAKLKIDEFESNVNEV------------------------------ 732
alpha1.2  IELKSITADGESPPATKINMDDLQPNENED------------------------------ 833
alpha1.3  PEVNQIANSD-----NKVTIDDYR-EEDED------------------------------ 814
alpha2.1  KSVWEQRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQEN 831
alpha2.2  RSVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRD 824
alpha2.3  MSVWEQRTSQLRKHMQMSSQEALNREEAP-------TMNPLNPLNPLSSLNPLNAHPSLY 827
alpha3.2  PLIMCTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGP 1134
            :                 :                                       

alpha1.1  ------------------------------------------------------------
alpha1.2  ------------------------------------------------------------
alpha1.3  ------------------------------------------------------------
alpha2.1  RNNNTNKSRAAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAE 891
alpha2.2  GARGPVGGKARPEAAEAPEG----VDPPRRHHRHRDKDKTPAAGDQDRAEAPKAESGEPG 880
alpha2.3  RRPRAIEGLALGLALEKFEE----ERISRGGSLKGDGGDRSSALDNQRTPLSLGQREPPW 883
alpha3.2  SGAWSSRRSSWSSLGRAPSLK--------------------------------------- 1155
                                                                      

alpha1.1  ------------------------------------------------------------
alpha1.2  ------------------------------------------------------------
alpha1.3  ------------------------------------------------------------
alpha2.1  LSREGPYGRESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTG 951
alpha2.2  AREERPR------PHRSHSKEAAGPPEARSERGRGPGPE-------GGRRHHRRGSPEEA 927
alpha2.3  LARPCHG------NCDPTQQEAGGGEAVVTFEDRARHRQ------SQRRSRHRRVRTEGK 931
alpha3.2  ------------------------------------------------------------
                                                                      

alpha1.1  ------KDPYP-----SADFPGDDEEDEPEIPLSPR------------------------ 757
alpha1.2  ------KSPYP-----NPETTGEEDEEEPEMPVGPR------------------------ 858
alpha1.3  ------KDPYPPCDVPVGEEEEEEEEDEPEVPAGPR------------------------ 844
alpha2.1  ADGEHRRHRAHRR--PGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHG 1009
alpha2.2  AEREPRRHRAHRHQDPSKECAGAKGERRARHRGGPR-----AGPREAESGEEPARRHRAR 982
alpha2.3  ESSSASRSRSASQERSLDEAMPTEGEKDHELRGNHG----AKEPTIQEERAQDLRRTNSL 987
alpha3.2  --RRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAALPPTK 1213
                            .    .     .   .                          

alpha1.1  ------------------------------------------------------------
alpha1.2  ------------------------------------------------------------
alpha1.3  ------------------------------------------------------------
alpha2.1  APATYEGDARREDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNM 1069
alpha2.2  HKAQPAHEAVEKETTEKEATEKE------------------------------AEIVEAD 1012
alpha2.3  MVSRGSGLAGGLDEADTPLVLPH-------------------------------PELEVG 1016
alpha3.2  CRDRDGQVVALPSDFFLRIDSHR------------------------------------- 1236
                                                                      

alpha1.1  ------------------------------------------------------------
alpha1.2  ------------------------------------------------------------
alpha1.3  ------------------------------------------------------------
alpha2.1  KNNKLATAESAAPHGSLGHAGLPQSPAKMGNSTDPGPMLAIPAMATNPQNAASRRTPNNP 1129
alpha2.2  KEKELRNHQPREPHCDLETSG----------TVTVGPMHTLPSTCLQKVEEQ-------- 1054
alpha2.3  KHVVLTEQEPEGSSEQALLGN---------VQLDMGRVISQSEPDLSCITAN-------- 1059
alpha3.2  ------------------------------------------------------------
                                                                      

alpha1.1  ------------------------------------------------------------
alpha1.2  ------------------------------------------------------------
alpha1.3  ------------------------------------------------------------
alpha2.1  GNPSNPGPPKTPENSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKN 1189
alpha2.2  --------PEDADNQRNVTR-MGSQP-------PDPNTIVHIPVMLTGPLGEATVVPSGN 1098
alpha2.3  ------TDKATTESTSVTVAIPDVDP-------LVDSTVVHISNKTDG---EASPLKEAE 1103
alpha3.2  ---------------------------------------------------------EDA 1239
                                                                      

alpha1.1  -------------PRPLAELQLKEKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNF 804
alpha1.2  -------------PRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNL 905
alpha1.3  -------------PRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNL 891
alpha2.1  ANPDPLPKKEEEKKEEEEDDRGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMC 1249
alpha2.2  VD---LESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEVV 1155
alpha2.3  IR----EDEEEVEKKKQKKEKRETG-KAMVPHSSMFIFSTTNPIRRACHYIVNLRYFEMC 1158
alpha3.2  AELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWALYLFSPQNRFRVSCQKVITHKMFDHV 1299
                                .          ::: :*  * :*  *: ::.   *   

alpha1.1  ILLFILLSSAALAAEDPIRADSMRNQILKHF--------------------DIGFTSVFT 844
alpha1.2  ILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKILGNADYVFTSIFT 965
alpha1.3  ILVFIMLSSAALAAEDPIRSHSFRNTILGYF--------------------DYAFTAIFT 931
alpha2.1  ILMVIAMSSIALAAEDPVQPNAPRNNVLRYF--------------------DYVFTGVFT 1289
alpha2.2  ILVVIALSSIALAAEDPVRTDSPRNNALKYL--------------------DYIFTGVFT 1195
alpha2.3  ILLVIAASSIALAAEDPVLTNSERNKVLRYF--------------------DYVFTGVFT 1198
alpha3.2  VLVFIFLNCVTIALERPDIDPGSTERVFLSVS-------------------NYIFTAIFV 1340
          :*..*  .. ::* * *    .  :  :  .                    :  **.:*.

alpha1.1  VEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESS-------AISVVKILR 897
alpha1.2  LEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS-------AINVVKILR 1018
alpha1.3  VEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVSFGIQSS-------AISVVKILR 984
alpha2.1  FEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGN---SKGKDINTIKSLR 1346
alpha2.2  FEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSG----SKGKDINTIKSLR 1251
alpha2.3  FEMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLR 1258
alpha3.2  AEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMAS-AGGAKILGVLRVLR 1399
           *:::*:   * .    :: :. :*:** ::*  :*: : .           : .:: **

alpha1.1  VLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFRC 957
alpha1.2  VLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFACIGVQLFKGKLYTC 1078
alpha1.3  VLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRC 1044
alpha2.1  VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHC 1406
alpha2.2  VLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFYC 1311
alpha2.3  VLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYC 1318
alpha3.2  LLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYC 1459
          :**.****:.*.*   ** *.: :. ::  : **:::   : ::*. :.*******:: *

alpha1.1  TDLSKMTEEECRGYYYVYKDGDPMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWP 1017
alpha1.2  SDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWP 1138
alpha1.3  TDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWP 1104
alpha2.1  TDESKEFEKDCRGKYLLYEKNE---VKARDREWKKYEFHYDNVLWALLTLFTVSTGEGWP 1463
alpha2.2  TDESKELERDCRGQYLDYEKEE---VEAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWP 1368
alpha2.3  TDSSKDTEKECIGNYVDHEKNK---MEVKGREWKRHEFHYDNIIWALLTLFTVSTGEGWP 1375
alpha3.2  EGPDTRNISTKAQCR------------AAHYRWVRRKYNFDNLGQALMSLFVLSSKDGWV 1507
           .  .                           * . .:.:**:  *:::**.:*: :** 

alpha1.1  QLLYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQ------ 1071
alpha1.2  ELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQ------ 1192
alpha1.3  ALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIFVGFVIVTFQEQ------ 1158
alpha2.1  QVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ------ 1517
alpha2.2  MVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQ------ 1422
alpha2.3  QVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQ------ 1429
alpha3.2  NIMYDGLDAVGVDQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEA 1567
           ::  .:*    :  *  . .  : :::: ::::..**.:*:**..:: .*::       

alpha1.1  -GETEYKNCELDKNQRQCVQYALKARPLRCYIPKN--PYQYQVWYIVTSSYFEYLMFALI 1128
alpha1.2  -GEQEYKNCELDKNQRQCVEYALKARPLRRYIPKN--QHQYKVWYVVNSTYFEYLMFVLI 1249
alpha1.3  -GEKEYKNCELDKNQRQCVEYALKARPLRRYIPKN--PYQYKFWYVVNSSPFEYMMFVLI 1215
alpha2.1  -GDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMI 1576
alpha2.2  -GDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPFEYFIMAMI 1481
alpha2.3  -GDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMI 1488
alpha3.2  EEARRREEKRLRRLERRRRSTFPSPEAQRRPYYADYSPTRRSIHSLCTSHYLDLFITFII 1627
                .:  * : :*   .   ....       :    :     .  *  ::  :  :*

alpha1.1  MLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFL 1188
alpha1.2  LLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFL 1309
alpha1.3  MLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSL 1275
alpha2.1  ALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFV 1636
alpha2.2  ALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVFDFV 1541
alpha2.3  ALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFI 1548
alpha3.2  CVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLA 1687
           :*.: : *:.*  .   .      *  ** :* .*  **::**    :* * ** :*  

alpha1.1  IVIGSIIDVILSEIDT--------------------FLASSGGLYCLGGGCGNVDPDESA 1228
alpha1.2  IVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENS 1369
alpha1.3  IVIGSIIDVALSEADP-----------------------TESENVPVPTATP-GNSEESN 1311
alpha2.1  TVLGSITDILVTEFG-------------------------------------------NN 1653
alpha2.2  TVLGSITDILVTEIAE----------------------------------------T-NN 1560
alpha2.3  TVIGSITEIILTDSKL----------------------------------------VNTS 1568
alpha3.2  IVLLSLMGITLEEIEMS-------------------------------------AALPIN 1710
           *: *:  : : :                                               

alpha1.1  RISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQM 1288
alpha1.2  RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQV 1429
alpha1.3  RISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQM 1371
alpha2.1  FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1713
alpha2.2  FINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1620
alpha2.3  GFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1628
alpha3.2  PTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVEL 1770
               :::::*  *::***  .  :* ** *.::::  :  : **: :****** :*:::

alpha1.1  FGKIALVDGTQ--------INRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCDP 1340
alpha1.2  FGKIALNDTTE--------INRNNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAP 1481
alpha1.3  FGKVAMRDNNQ--------INRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDP 1423
alpha2.1  FGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDK 1773
alpha2.2  FGNIALDDDTS--------INRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSNQACDE 1672
alpha2.3  FGNIKLDEESH--------INRHNNFRSFFGSLMLLFRSATGEAWQEIMLSCLGEKGCEP 1680
alpha3.2  FGRLECSEDNPCEG-----LSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLR--ECSR 1823
          **.:               :..: .* .*  :.: *** :**: *: *:        *  

alpha1.1  ESD-YAPGE-EYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHH 1398
alpha1.2  ESEPSNSTEGETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1541
alpha1.3  ESD-YNPGE-EYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHH 1481
alpha2.1  NSGIL-----TRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1828
alpha2.2  QAN-------ATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1725
alpha2.3  DTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHH 1740
alpha3.2  EDK------HCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKE-------- 1869
          :                ::  **::* :.. *:::*:.***:*.:::  .::        

alpha1.1  LDEFKAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNS- 1457
alpha1.2  LDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNS- 1600
alpha1.3  LDEFKRIWSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNS- 1540
alpha2.1  LDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVAD- 1887
alpha2.2  LDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNE 1785
alpha2.3  LDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAE- 1799
alpha3.2  AREDAELDAEIELEMAQGPGSARRVDADRPPLPQESPGARDAPNLVARKVSVSRMLSLP- 1928
            *   : :* :                    *  . *   . .:. :::    :     

alpha1.1  DGTVTFNATLFALVRTALKIKTEG---NFEQANEELRAIIKKIWKRTSMKLLDQVIPPIG 1514
alpha1.2  DGTVMFNATLFALVRTALRIKTEG---NLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG 1657
alpha1.3  DGTVMFNATLFALVRTALKIKTEG---NLEQANEELRAVIKKIWKKTSMKLLDQVVPPAG 1597
alpha2.1  DNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHK 1947
alpha2.2  DMTVHFTSTLMALIRTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPHK 1845
alpha2.3  DMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPK 1859
alpha3.2  NDSYMFRPVVPASAPHPRPLQEVE---METYGAGTPLGSVASVHSPPAESCASLQIPLAV 1985
          : :  * ..: *    .  ::                     :    . .  .  :.   

alpha1.1  DDEVTVGKFYATFLIQEHFRKFMKRQEEYYGYR------PKKDIVQIQAGLRTIEEEAAP 1568
alpha1.2  DDEVTVGKFYATFLIQEYFRKFKKRKEQGLVGK-----PSQRNALSLQAGLRTLHDIG-P 1711
alpha1.3  DDEVTVGKFYATFLIQDYFRKFKKRKEQGLVGKY----PAKNTTIALQAGLRTLHDIG-P 1652
alpha2.1  STDLTVGKIYAAMMIMEYYRQSKAKKLQAMRE-----EQDRTPLMFQRMEPPSPTQEGGP 2002
alpha2.2  PDEMTVGKVYAALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVL 1905
alpha2.3  ASDLTVGKIYAAMMIMDYYKQSKVKKQRQQLE------EQKNAPMFQRMEPSSLPQEIIA 1913
alpha3.2  SSPARSGEPLHALSPRGTARSPSLSRLLCRQEA-----VHTDSLEGKIDSPRDTLDPAEP 2040
                *:   ::      :.    :                             :    

alpha1.1  EICRTVSGDLAAEEELER---AMVEAAMEEGIFRRTGGLFGQVDNFLER--TNSLPPVMA 1623
alpha1.2  EIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFT 1771
alpha1.3  EIRRAISCDLQDDEP------EETKREEEDDVFKRNGALLGNHVNHVNSDRRDSLQQTNT 1706
alpha2.1  G-----QNALPSTQLDPG----GALMAHESGLKESPSWVTQRAQEMFQKTGTWSPEQGPP 2053
alpha2.2  RGARVFLRQKSSTSLSNG----GAIQNQESGIKESVSWGTQRTQDAPHEARPP-LERGHS 1960
alpha2.3  N-----AKALPYLQQDP--------VSGLSGRSGYPSMSPLSPQDIFQLACMDPADDGQF 1960
alpha3.2  GEKTPVRPVTQGGSLQSP------PRSPRPASVRTRKHTFGQRCVSSRPAAPGGEEAEAS 2094
                       .                                 .            

alpha1.1  NQRPLQFAEIEME---EMESPVFLEDFPQDPRTNPLAR-----------ANTNNAN---- 1665
alpha1.2  TQRPLHINKAGSS-QGDTESPSHEKLVDSTFTPSSYS-------STGSNANINNANNTAL 1823
alpha1.3  THRPLHVQRPSIPPASDTEKPLFPPAGNSVCHNHHNHNSIGKQVPTSTNANLNNANMSKA 1766
alpha2.1  TDMPN--SQPNSQ---SVEMREMGRDGYSDSEHYLPME------GQGRAASMPRLPAENQ 2102
alpha2.2  TEIPVGRSGALAV---DVQMQSITRRGP-DGEPQPGLE------SQGRAASMPRLAAETQ 2010
alpha2.3  QERQS--LEPEVS---ELKSVQPSNHGIYLPSDTQEHA------GSGRASSMPRLTVDPQ 2009
alpha3.2  DPADEEVSHITSS-----ACPWQPTAEPHGPEASPVAG---------------------- 2127
                                                                      

alpha1.1  ------------------------------------------------------------
alpha1.2  GRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSSNRERHVPMCEDLELRRDSGSAG 1883
alpha1.3  AHGKRPS--IGNLEHVSENG-HHSSHKHDREPQRRSSVKRTRYY----ETYIRSDSGDEQ 1819
alpha2.1  RRRGRPRG----------------------------------------NNLSTISDTSPM 2122
alpha2.2  P----------------------------------------------------VTDASPM 2018
alpha2.3  V----------------------------------------------------VTDPSSM 2017
alpha3.2  ------------------------------------------------------------
                                                                      

alpha1.1  ---------------------ANVAYGNSNHSNSHVFSSVHYEREFPEETETP------- 1697
alpha1.2  TQAHCLLLRKAN-PSRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEML 1942
alpha1.3  LPTICREDPEIHGYFRDPHCLGEQEYFSSEECYEDDSSPTWSRQNYGYYSRYPGRNIDSE 1879
alpha2.1  KRSASVLG--PKARRLDDYSLERVPPEENQRHHQ-----RRRDRSHRASERSLGRYTDVD 2175
alpha2.2  KRSISTLAQRPRGTHLCSTTPDRPPPSQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMD 2078
alpha2.3  RRSFSTIR----DKRSNSSWLEEFSMERSSENTY-----KSRRRSYHSSLRLSAHRLNSD 2068
alpha3.2  -------------------GERDLRRLYSVDAQGFLDKPGRADEQWRPSAELGS------ 2162
                                                     ..     .         

alpha1.1  ---------------------------ATRGRALGQPCRVLGPHSKPCVEMLKG------ 1724
alpha1.2  SYQDDENRQLTLPEEDK------RDIRQSPKRGFLR-SASLGRRASFHLECLKRQKDRGG 1995
alpha1.3  RPRGYHHPQGFLEDDDSPVC---YDSRRSPRRRLLPPTPASHRRSSFNFECLRRQSSQEE 1936
alpha2.1  TGLGTDLSMTTQSGDLPS-----KERDQERGRPKDRKHRQHHHHHHHHHHPPPPDKDRYA 2230
alpha2.2  GAPSSAVGPGLPPGEGPTGCRRERERRQERGRSQERRQPSSSSSEKQRFYS----CDRFG 2134
alpha2.3  SGHKSDT---------------HRSGGRERGRSKERKHLLSPDVSR-----------CNS 2102
alpha3.2  ---------------------------GEPGEAKAWGPEAEP------------------ 2177
                                         .                            

alpha1.1  ----------------LLTQRAMPRG-----------------------------QAPPA 1739
alpha1.2  DIS-----QKTVLPLHLVHHQALAVAGLSPLLQRSHSPASFPRPFATPPATPGSRGWPPQ 2050
alpha1.3  VPSSPIFPHRTALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYRDWTPC 1996
alpha2.1  QERPDHGRARARDQRWSRSPSEGREHMAHRQGSSSVSGSPAPSTSGTSTPRRG-RRQLPQ 2289
alpha2.2  GREP--PKPKPSLSSHPTSPTAGQEPGPHPQGSGSVNGSPLLSTSGASTPGRGGRRQLPQ 2192
alpha2.3  EERGTQADWESPERRQSRSPSEGRSQTPNRQGTGSLSESSIPSVSDTSTPRRS-RRQLPP 2161
alpha3.2  ---------------ALGARRKKKMSPPCISVEPPAEDEGSARPSAAEGGSTTLRRRTPS 2222
                                                                    * 

alpha1.1  P--CQCPRVESSMPEDRKSSTPGSLH-----EETP----------------HSRSTRENT 1776
alpha1.2  P--VPTLRLEGVESSEKLNSSFPSIHCGSWAETTPGGGGSSAARRVRPVSLMVPSQAGAP 2108
alpha1.3  Y--TPLIQVEQSEALDQVNGSLPSLHRSSWYTDEP----DISYRTFTPASLTVPSSFRNK 2050
alpha2.1  TPSTPRPHVSYSPVIRKAGGSGPPQQQQQQQQQQQAVARPGRAATSGPRRYPGPTAEPLA 2349
alpha2.2  TPLTPRPSITY-----KTANSSPIHFAG--AQTSLPAFSPGRLSRGLSEHNALLQRDPLS 2245
alpha2.3  VPPKPRPLLSYSSLIRHAGSISPPADGS---EEGSPLTSQALESNNACLTESSNSPHPQQ 2218
alpha3.2  CEATPHRDSLEPTEGSGAGGDPAAKGERWGQASCRAEHLTVPSFAFEPLDLGVPSGDPFL 2282
                             .                                        

alpha1.1  SRCSAPATALLIQKALVRGGLGT------------------------------------- 1799
alpha1.2  GRQFHGSASSLVEAVLISEGLGQ------------------------------------- 2131
alpha1.3  NSDKQRSADSLVEAVLISEGLGR------------------------------------- 2073
alpha2.1  GDRPPTGGHSSGRSPRMERRVPGPARSESPRACRHGGARWPASGPHVSEGPPGPRHHGYY 2409
alpha2.2  --QPLAPGSRIGSDPYLGQRLDS------------------------------------- 2266
alpha2.3  --SQHASPQRYISEPYLALHEDS------------------------------------- 2239
alpha3.2  DGSHSVTPESRASSSGAIVPLEP------------------------------------- 2305
                                                                      

alpha1.1  ---------------LAADANFIMATGQALADACQMEPEEVEIMATELLKG--REAPEGM 1842
alpha1.2  ---------------FAQDPKFIEVTTQELADACDMTIEEMESAADNILSGGAPQSPNGA 2176
alpha1.3  ---------------YARDPKFVSATKHEIADACDLTIDEMESAASTLLNGNVRPRANGD 2118
alpha2.1  RGSDYDEADGPGSGGGEEAMAGAYDAPPPVRHASSGATGRSPRTPRASGPACASPSRHGR 2469
alpha2.2  ----------------EASVHALPEDTLTFEEAVATNSGRSSRTSYVS--SLTSQSHPLR 2308
alpha2.3  -----------------HASDCGEEETLTFEAAVATSLGRSNTIGSAP------PLRHSW 2276
alpha3.2  ---------------------PESEPPMPVGDPPEKRRGLYLTVPQCPLEKPGSPSATPA 2344
                                       .  .                           

alpha1.1  ASSLG-CLNLG-SSLGSLDQHQG--------SQETLIPPRL----- 1873
alpha1.2  LLPFVNCRDAGQDRAG-GEEDAGCVRARGAPSEEELQDSRVYVSSL 2221
alpha1.3  VGPLSHRQDYELQDFGPGYSDEEPDPGR---DEEDLADEMICITTL 2161
alpha2.1  RLPNGYYPAHGLARPRGPGSRKGLHEPYSES-DDDWC--------- 2505
alpha2.2  RVPNGYHCTLGLSS--GGRARHSYHHPD----QDHWC--------- 2339
alpha2.3  QMPNGHYRRRRRGGPGPGMMCGAVNNLLSDTEEDDKC--------- 2313
alpha3.2  PGGGADDPV------------------------------------- 2353
                                                        

beta subunit of the calcium ion channel

beta1-1   --------------MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTS 46
beta1-2   --------------MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTS 46
beta1-3   --------------MVQKTSMSRGPYPPSQEIPMEVFDPSPQGKYSKRKGRFKRSDGSTS 46
beta2-1   --------------------------------------MQCCGLVHRRRVRVSY------ 16
beta2-2   MVQRDMSKSPPTAAAAVAQEIQMELLENVAPAGALGAAAQSYGKGARRKNRFKGSDGSTS 60
beta2-3   -------------------------------------MLDRRLIAPQTKYIIPG------ 17
beta2-4   MVQRDMSKSPPTAAAAVAQEIQMELLENVAPAGALGAAAQSYGKGARRKNRFKGSDGSTS 60
beta2-5   MVQRDMSKSPPTAAAAVAQEIQMELLENVAPAGALGAAAQSYGKGARRKNRFKGSDGSTS 60
beta2-6   ----------------------------MNQGSGLDLLKISYGKGARRKNRFKGSDGSTS 32
beta2-7   -------------------------------MKATWIRLLKRAKGGRLKNSDIC------ 23
beta2-8   ----------------MNQGSGLDLLK------------ISYGKGARRKNRFKGSDGSTS 32
beta3     ---------------------------------------------MYDDSYVPGFEDS-- 13
beta4a    ---------------------------------------------MYDNLYLHGIEDS-- 13
beta4b    -------------------MSSSSYAKNGTADGPHSPTSQVARGTTTRRSRLKRSDGST- 40
beta4c    -------------------------------------MDVVARGTTTRRSRLKRSDGST- 22
                                                                      

beta1-1   SDTTSNSFVRQGSAESYTSRPS-DSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAV 105
beta1-2   SDTTSNSFVRQGSAESYTSRPS-DSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAV 105
beta1-3   SDTTSNSFVRQGSAESYTSRPS-DSDVSLEEDREALRKEAERQALAQLEKAKTKPVAFAV 105
beta2-1   -----------GSADSYTSRPS-DSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAV 64
beta2-2   SDTTSNSFVRQGSADSYTSRPS-DSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAV 119
beta2-3   -----------GSADSYTSRPS-DSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAV 65
beta2-4   SDTTSNSFVRQGSADSYTSRPS-DSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAV 119
beta2-5   SDTTSNSFVRQGSADSYTSRPS-DSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAV 119
beta2-6   SDTTSNSFVRQGSADSYTSRPS-DSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAV 91
beta2-7   -----------GSADSYTSRPS-DSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAV 71
beta2-8   SDTTSNSFVRQGSADSYTSRPS-DSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAV 91
beta3     ---------EAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPVAFAV 64
beta4a    ---------EAGSADSYTSRPS-DSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAV 63
beta4b    --TSTSFILRQGSADSYTSRPS-DSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAV 97
beta4c    --TSTSFILRQGSADSYTSRPS-DSDVSLEEDREAIRQEREQQAAIQLERAKSKPVAFAV 79
                     ***:******* ***********: *:* * **  ***:** *******

beta1-1   RTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKL 165
beta1-2   RTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKL 165
beta1-3   RTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKL 165
beta2-1   RTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKL 124
beta2-2   RTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKL 179
beta2-3   RTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKL 125
beta2-4   RTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKL 179
beta2-5   RTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKL 179
beta2-6   RTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKL 151
beta2-7   RTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKL 131
beta2-8   RTNVSYSAAHEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKL 151
beta3     RTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPSPQRL 124
beta4a    KTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRL 123
beta4b    KTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRL 157
beta4c    KTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPLRL 139
          :***.*     :: ** . .:.*:.*****:***:.************ ::.***** :*

beta1-1   DSLRLLQEQKLRQNRLGSSKSGDNSSSSLGDVVTGTRRPTPPASAKQKQ----------- 214
beta1-2   DSLRLLQEQKLRQNRLGSSKSGDNSSSSLGDVVTGTRRPTPPASGNEMTNLAFELDPLEL 225
beta1-3   DSLRLLQEQKLRQNRLGSSKSGDNSSSSLGDVVTGTRRPTPPASAKQKQ----------- 214
beta2-1   ENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATG-------L 177
beta2-2   ENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATG-------L 232
beta2-3   ENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATG-------L 178
beta2-4   ENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSG--------------- 224
beta2-5   ENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSS---------------- 223
beta2-6   ENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATG-------L 204
beta2-7   ENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATG-------L 184
beta2-8   ENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSG--------------- 196
beta3     ESIRLKQEQK--------ARRSGNPSS-LSDIGN--RRSPPPSLAKQKQ----------- 162
beta4a    ENIRIQQEQKR--GRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQ----------- 170
beta4b    ENIRIQQEQKR--GRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQ----------- 204
beta4c    ENIRIQQEQKR--GRFHGGKSSGNSSSSLGEMVSGTFRATPTSTAKQKQ----------- 186
          :.:*: :**:        .: ..*.** *.::     :..*.:                 

beta1-1   ----------------------------------KSTEHVPPYDVVPSMRPIILVGPSLK 240
beta1-2   EEEEAELGEQSGSAKTSVSSVTTPPPHGKRIPFFKKTEHVPPYDVVPSMRPIILVGPSLK 285
beta1-3   ----------------------------------KSTEHVPPYDVVPSMRPIILVGPSLK 240
beta2-1   DAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLK 237
beta2-2   DAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLK 292
beta2-3   DAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLK 238
beta2-4   ----------------AKSADEQDQWKTAGLFWRFTTEHTPPYDVVPSMRPVVLVGPSLK 268
beta2-5   ----------------AKQKQK-------------STEHTPPYDVVPSMRPVVLVGPSLK 254
beta2-6   DAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLK 264
beta2-7   DAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLK 244
beta2-8   ----------------AKSADEQDQWKTAGLFWRFTTEHTPPYDVVPSMRPVVLVGPSLK 240
beta3     ----------------------------------KQAEHVPPYDVVPSMRPVVLVGPSLK 188
beta4a    ----------------------------------KVTEHIPPYDVVPSMRPVVLVGPSLK 196
beta4b    ----------------------------------KVTEHIPPYDVVPSMRPVVLVGPSLK 230
beta4c    ----------------------------------KVTEHIPPYDVVPSMRPVVLVGPSLK 212
                                              :** ***********::*******

beta1-1   GYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIIIERSNTRSSLA 300
beta1-2   GYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIIIERSNTRSSLA 345
beta1-3   GYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIIIERSNTRSSLA 300
beta2-1   GYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLA 297
beta2-2   GYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLA 352
beta2-3   GYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLA 298
beta2-4   GYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLA 328
beta2-5   GYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLA 314
beta2-6   GYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLA 324
beta2-7   GYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLA 304
beta2-8   GYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLA 300
beta3     GYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIERSSARSSIA 248
beta4a    GYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLA 256
beta4b    GYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLA 290
beta4c    GYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSSLA 272
          ********************:***********:***********.*: *****.:***:*

beta1-1   EVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRG 360
beta1-2   EVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRG 405
beta1-3   EVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLIKSRG 360
beta2-1   EVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRG 357
beta2-2   EVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRG 412
beta2-3   EVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRG 358
beta2-4   EVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRG 388
beta2-5   EVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRG 374
beta2-6   EVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRG 384
beta2-7   EVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRG 364
beta2-8   EVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRG 360
beta3     EVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVLQRLIRSRG 308
beta4a    EVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRG 316
beta4b    EVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRG 350
beta4c    EVQSEIERIFELARSLQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRG 332
          *************::****.************ *********.:*::*********:***

beta1-1   KSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSSTPP 420
beta1-2   KSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSSTPP 465
beta1-3   KSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSSTPP 420
beta2-1   KSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLP 417
beta2-2   KSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLP 472
beta2-3   KSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLP 418
beta2-4   KSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLP 448
beta2-5   KSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLP 434
beta2-6   KSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLP 444
beta2-7   KSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLP 424
beta2-8   KSQAKHLNVQMVAADKLAQCPPELFDVILDENQLEDACEHLADYLEAYWKATHPPSSSLP 420
beta3     KSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLEDACEHLAEYLEVYWRATHHPAPGPG 368
beta4a    KSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPM 376
beta4b    KSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPM 410
beta4c    KSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLGEYLEAYWRATHTTSSTPM 392
          *** ***.**: * :**.***** **:**************.:***.**:*** .:.   

beta1-1   NPLLNRTMATAALAASPAPVSN---LQGPYLASGDQPLERATGEHASMHEYPGELGQPPG 477
beta1-2   NPLLNRTMATAALAASPAPVSN---LQVQVLTS--------------------------- 495
beta1-3   NPLLNRTMATAALAASPAPVSN---LQVQVLTS--------------------------- 450
beta2-1   NPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRS 477
beta2-2   NPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRS 532
beta2-3   NPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRS 478
beta2-4   NPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRS 508
beta2-5   NPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRS 494
beta2-6   NPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRS 504
beta2-7   NPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRS 484
beta2-8   NPLLSRTLATSSLPLSPTLASNSQGSQGDQRTDRSAPIRSASQAEEEPSVEPVKKSQHRS 480
beta3     --LLGP----------PSAIPG---LQNQQLLGE-RGEEHSPLERD-------------- 398
beta4a    TPLLGRNLGSTALSPYPTAISG---LQSQRMRHSNHSTENSPIERR-------------- 419
beta4b    TPLLGRNLGSTALSPYPTAISG---LQSQRMRHSNHSTENSPIERR-------------- 453
beta4c    TPLLGRNLGSTALSPYPTAISG---LQSQRMRHSNHSTENSPIERR-------------- 435
            **.           *:  ..    *                                 

beta1-1   LYPSSHPPGRAGTLRALSRQDTFDADTPGSRNSAYTELGDSCVDMETDPSEGP---GLGD 534
beta1-2   ----------------LRRN-----------------LG--------------------- 501
beta1-3   ----------------LRRN-----------------LG--------------------- 456
beta2-1   SSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRD 537
beta2-2   SSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRD 592
beta2-3   SSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRD 538
beta2-4   SSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRD 568
beta2-5   SSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRD 554
beta2-6   SSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRD 564
beta2-7   SSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRD 544
beta2-8   SSSAPHHNHRSGTSRGLSRQETFDSETQESRDSAYVEPKEDYSHDHVDHYASHRDHNHRD 540
beta3     -SLMPSDE-----ASESSRQAWTGSSQRSSRH-----LEEDYADAYQDLYQPHRQHTSGL 447
beta4a    -SLMTSDENYHNERARKSRNRLSSSSQHSRDHYPL--VEEDYPDSYQDTYKPHRNRGS-- 474
beta4b    -SLMTSDENYHNERARKSRNRLSSSSQHSRDHYPL--VEEDYPDSYQDTYKPHRNRGS-- 508
beta4c    -SLMTSDENYHNERARKSRNRLSSSSQHSRDHYPL--VEEDYPDSYQDTYKPHRNRGS-- 490
                            *:                                        

beta1-1   PAGGGTPPARQGS-----WEDEEEDYEEELTDNRNRGRNKARYCAEGGGPVLGRNKNELE 589
beta1-2   -FWGGLESSQRGS-----VVPQEQEHAM-------------------------------- 523
beta1-3   -FWGGLESSQRGS-----VVPQEQEHAM-------------------------------- 478
beta2-1   ETHGSSDHRHRESRHRSRDVDREQDHNECN-KQRSRHKSKDRYCEKDG-EVISKKRNEAG 595
beta2-2   ETHGSSDHRHRESRHRSRDVDREQDHNECN-KQRSRHKSKDRYCEKDG-EVISKKRNEAG 650
beta2-3   ETHGSSDHRHRESRHRSRDVDREQDHNECN-KQRSRHKSKDRYCEKDG-EVISKKRNEAG 596
beta2-4   ETHGSSDHRHRESRHRSRDVDREQDHNECN-KQRSRHKSKDRYCEKDG-EVISKKRNEAG 626
beta2-5   ETHGSSDHRHRESRHRSRDVDREQDHNECN-KQRSRHKSKDRYCEKDG-EVISKKRNEAG 612
beta2-6   ETHGSSDHRHRESRHRSRDVDREQDHNECN-KQRSRHKSKDRYCEKDG-EVISKKRNEAG 622
beta2-7   ETHGSSDHRHRESRHRSRDVDREQDHNECN-KQRSRHKSKDRYCEKDG-EVISKKRNEAG 602
beta2-8   ETHGSSDHRHRESRHRSRDVDREQDHNECN-KQRSRHKSKDRYCEKDG-EVISKKRNEAG 598
beta3     PSANGHDPQDRLL-----AQDSEHNHSDRN-WQRNRPWPKDSY----------------- 484
beta4a    PGGYSHDSRHRL------------------------------------------------ 486
beta4b    PGGYSHDSRHRL------------------------------------------------ 520
beta4c    PGGYSHDSRHRL------------------------------------------------ 502
              .     :                                                 

beta1-1   GWGRGVYIR- 598
beta1-2   ----------
beta1-3   ----------
beta2-1   EWNRDVYIRQ 605
beta2-2   EWNRDVYIRQ 660
beta2-3   EWNRDVYIRQ 606
beta2-4   EWNRDVYIRQ 636
beta2-5   EWNRDVYIRQ 622
beta2-6   EWNRDVYIRQ 632
beta2-7   EWNRDVYIRQ 612
beta2-8   EWNRDVYIRQ 608
beta3     ----------
beta4a    ----------
beta4b    ----------
beta4c    ----------
                    

gamma subunit of the calcium ion channel

gamma1    ------------------------------MSQTKMLKVRVTLFCILAGIVLAMTAVVTD 30
gamma2    -----------------------------MGLFDRGVQMLLTTVGAFAAFSLMTIAVGTD 31
gamma3    -----------------------------MRMCDRGIQMLITTVGAFAAFSLMTIAVGTD 31
gamma4    -----------------------------MVRCDRGLQMLLTTAGAFAAFSLMAIAIGTD 31
gamma5a   -----------------------------MSACGRKALTLLSSVFAVCGLGLLGIAVSTD 31
gamma5b   -----------------------------MSACGRKALTLLSSVFAVCGLGLLGIAVSTD 31
gamma6a   MMWSNFFLQEENRRRGAAGRRRAHGQGRSGLTPEREGKVKLALLLAAVGATLAVLSVGTE 60
gamma6b   MMWSNFFLQEENRRRGAAGRRRAHGQGRSGLTPEREGKVKLALLLAAVGATLAVLSVGTE 60
gamma6c   MMWSNFFLQEENRRRGAAGRRRAHGQGRSGLTPEREGKVKLALLLAAVGATLAVLSVGTE 60
gamma7    -----------------------------MSHCSSRALTLLSSVFGACGLLLVGIAVSTD 31
gamma8    ------------------MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTD 42
                                                  ::      .  *   :: *:

gamma1    HWAVLSPHMEHHNTTCE----------------------AAHFGLWRICTKRIPMDDS-- 66
gamma2    YWLYSRG-VCKTKSVSE----NETSK--------KNEEVMTHSGLWRTCCLEGNFKGLCK 78
gamma3    YWLYSRG-VCRTKSTSD----NETSR--------KNEEVMTHSGLWRTCCLEGAFRGVCK 78
gamma4    YWLYSSAHICNGTNLTM--DDGPPPR--------RARGDLTHSGLWRVCCIEGIYKGHCF 81
gamma5a   YWLYLEEGVIVPQNQST------------------EIKMSLHSGLWRVCFLAGEERGRCF 73
gamma5b   YWLYLEEGVIVPQNQST------------------EIKMSLHSGLWRVCFLAGEERGRCF 73
gamma6a   FWVELNTYKANGSAVCE----------------------AAHLGLWKACTKRLWQADVPV 98
gamma6b   FWVELNTYKANGSAVCE----------------------AAHLGLWKACTKRLWQADVPV 98
gamma6c   FWVELNTYKANGSAVCE----------------------AAHLGLWKACTKRLWQADVPV 98
gamma7    YWLYMEEGTVLPQNQTT------------------EVKMALHAGLWRVCFFAGREKGRCV 73
gamma8    YWLYTRALICNTTNLTAGGDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCV 102
          .*                                       * ***: *       .   

gamma1    --KTCGP--ITLPGEKNCSYFRHFNPGESSEIFEFTTQKEYSISAAAIAIFSLGFIILGS 122
gamma2    QIDHFPE-DADYEADTAEYFLRAVRASSIFPILSVILLFMGGLCIAASEFY--------- 128
gamma3    KIDHFPE-DADYEQDTAEYLLRAVRASSVFPILSVTLLFFGGLCVAASEFH--------- 128
gamma4    RINHFPE-DNDYDHDSSEYLLRIVRASSVFPILSTILLLLGGLCIGAGRIY--------- 131
gamma5a   TIEYVMPMNTQLTSESTVNVLKMIRSATPFPLVSLFFMFIGFILNNIGHIR--------- 124
gamma5b   TIEYVMPMNTQLTSESTVNVLKMIRSATPFPLVSLFFMFIGFILNNIGHIR--------- 124
gamma6a   DRDTCGP--AELPGEANCTYFKFFTTGENARIFQRTTKKEVNLAAAVIAVLGLAVMALGC 156
gamma6b   DRDTCGP--AELPGEANCTYFKFFTTGENARIFQRTTK---------------------- 134
gamma6c   DRDTCGP--AELPG---------------------------------------------- 110
gamma7    ASEYFLEPEINLVTENTENILKTVRTATPFPMVSLFLVFTAFVISNIGHIR--------- 124
gamma8    KINHFPE-DTDYDHDSAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVY--------- 152
            .                                                         

gamma1    LCVLLSLGKKRDYLLRPASMFYAFAGLCILVSVEVMRQSVKRMIDSED-----TVWIEYY 177
gamma2    --------KTRHNIILSAGIFFVSAGLSNIIGIIVYISANAGDPS-----KSDSKKNSYS 175
gamma3    --------RSRHNVILSAGIFFVSAGLSNIIGIIVYISANAGDPG-----QRDSKK-SYS 174
gamma4    --------SRKNNIVLSAGILFVAAGLSNIIGIIVYISSNTGDPSDK---RDEDKKNHYN 180
gamma5a   --------PHRTILAFVSGIFFILSGLSLVVGLVLYISSINDEMLNRT--KDAETYFNYK 174
gamma5b   --------PHRTILAFVSGIFFILSGLSLVVGLVLYISSINDEMLNRT--KDAETYFNYK 174
gamma6a   LCIIMVLSKGAEFLLRVGAVCFGLSGLLLLVSLEVFRHSVRALLQRVSPEPPPAPRLTYE 216
gamma6b   ------------------------KGLLLLVSLEVFRHSVRALLQRVSPEPPPAPRLTYE 170
gamma6c   -------------------------GLLLLVSLEVFRHSVRALLQRVSPEPPPAPRLTYE 145
gamma7    --------PQRTILAFVSGIFFILSGLSLVVGLVLYISSINDEVMNRP--SSSEQYFHYR 174
gamma8    --------KSKRNIILGAGILFVAAGLSNIIGVIVYISANAGEPGPK---RDEEKKNHYS 201
                                   **  ::.: :   :                   * 

gamma1    YSWSFACACAAFILLFLGGLALLLFSLPRMP----------------------------- 208
gamma2    YGWSFYFGALSFIIAEMVGVLAVHMFIDRHKQLRATARATDYLQA------------SAI 223
gamma3    YGWSFYFGAFSFIIAEIVGVVAVHIYIEKHQQLRAKS-HSEFLKK------------STF 221
gamma4    YGWSFYFGALSFIVAETVGVLAVNIYIEKNKELRFKT-KREFLKA---------SSSSPY 230
gamma5a   YGWSFAFAAISFLLTESAGVMSVYLFMKRY-------------------------TAEDM 209
gamma5b   YGWSFAFAAISFLLTE---VKPVTLSMDRLG-----------------------LGTAPL 208
gamma6a   YSWSLGCGVGAGLILLLGAGCFLLLTLPSWP----------------------------- 247
gamma6b   YSWSLGCGVGAGLILLLGAGCFLLLTLPSWP----------------------------- 201
gamma6c   YSWSLGCGVGAGLILLLGAGCFLLLTLPSWP----------------------------- 176
gamma7    YGWSFAFAASSFLLKEGAGVMSVYLFTKRY-------------------------AEEEM 209
gamma8    YGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQS-RSDLLKAGGGAGGSGGSGPSAI 260
          *.**:  .  : ::        : :                                   

gamma1    -----------RNPWESCMDAEPEH----------------------------------- 222
gamma2    TRIPSYRYRYQRRSRSSSRSTEPSHSRDASPVGIKGFNTLPSTEISMYTLSRDPLKAATT 283
gamma3    ARLPPYRYRFRRRS--SSRSTEP-RSRDLSPIS-KGFHTIPSTDISMFTLSRDPSKITMG 277
gamma4    ARMPSYRYR-RRRSRSSSRSTEASPSRDVSPMGLKITGAIPMGELSMYTLSREPLKVTTA 289
gamma5a   YRPHPGFYRPRLSN---CSDYSGQFLHPD-----AWVRGRSPSDIS----SEASLQMNSN 257
gamma5b   SRGEWGWGRRDIPQPFWTPDHPLYFPSSSQNVSLSYLSGSPPARMSPGPCSCPHVHFPPH 268
gamma6a   -----------WGSLCPKRGHRAT------------------------------------ 260
gamma6b   -----------WGSLCPKRGHRAT------------------------------------ 214
gamma6c   -----------WGSLCPKRGHRAT------------------------------------ 189
gamma7    YRPHPAFYRPRLSD---CSDYSGQFLQPE-----AWRRGRSPSDIS----SDVSIQMTQN 257
gamma8    LRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGGPGGPGFAST-DISMYTLSRDPSKGSVA 319
                             .                                        

gamma1    ------------------------------------------------------------
gamma2    PTATYN-----------------------------SDRD----NSFLQVHNCIQKENKDS 310
gamma3    --TLLN-----------------------------SDRD----HAFLQFHNSTPKEFKES 302
gamma4    ASYS-------------------------------PDQE----ASFLQVHDFFQQDLKEG 314
gamma5a   YPALLKC------------------------------------PDYDQMSSSPC------ 275
gamma5b   SSCVLCR------------------------------------PQPREMRQAPAASPSSA 292
gamma6a   ------------------------------------------------------------
gamma6b   ------------------------------------------------------------
gamma6c   ------------------------------------------------------------
gamma7    YPPAIKY------------------------------------PDHLHISTSPC------ 275
gamma8    AGLAGAGGGGGGAVGAFGGAAGGAGGGGGGGGGAGAERDRGGASGFLTLHNAFPKEAGGG 379
                                                                      

gamma1    ----------------------------------------------
gamma2    LHSN---------------------------------TANRRTTPV 323
gamma3    LHNN---------------------------------PANRRTTPV 315
gamma4    FHVS---------------------------------MLNRRTTPV 327
gamma5a   ----------------------------------------------
gamma5b   VFSL------------------------------------------ 296
gamma6a   ----------------------------------------------
gamma6b   ----------------------------------------------
gamma6c   ----------------------------------------------
gamma7    ----------------------------------------------
gamma8    VTVTVTGPPAPPAPAPPAPSAPAPGTLAKEAAASNTNTLNRKTTPV 425
                                                        

alalph2delta subunit

alpha2delta1  ----------------------------------------------MAAGCLLALTLTLF 14
alpha2delta2  MAVPARTCGASRPGPARTARPWPGCGPHPGPGTRRP---------TSGPPRPLWLLLPLL 51
alpha2delta3  -------------------------MAGPGSPRRAS------------RGASALLAAALL 23
alpha2delta4  -MVCGCSALLPLPNPRPTMPATPNFLANPSSSSRWIPLQPMPVAWAFVQKTSALLWLLLL 59
                                                                    *   *:

alpha2delta1  QSLLIGPSSEEPFPSAVTIKSWVDKMQEDLVTLAKTASGVNQLVDIYEKYQDLYTVEPNN 74
alpha2delta2  PLLAAPGASAYSFPQQHTMQHWARRLEQEVDGVMRIFGGVQQLREIYKDNRNLFEVQENE 111
alpha2delta3  YAALGDVVRSEQQIPLSVVKLWASAFGGEIKSIAAKYSGSQLLQKKYKEYEKDVAIEEID 83
alpha2delta4  GTSLSPAWG-QAKIPLETVKLWADTFGGDLYNTVTKYSGSLLLQKKYKDVESSLKIEEVD 118
                               .:: *.  :  ::       .*   * . *:. ..   ::  :

alpha2delta1  ARQLVEIAARDIEKLLSNRSKALVSLALEAEKVQAAHQWREDFASNEVVYYNAKDDLD-- 132
alpha2delta2  PQKLVEKVAGDIESLLDRKVQALKRLADAAENFQKAHRWQDNIKEEDIVYYDAKADAELD 171
alpha2delta3  GLQLVKKLAKNMEEMFHKKSEAVRRLVEAAEEAHLKHEFDADLQYEYFNAVLINERDK-- 141
alpha2delta4  GLELVRKFSEDMENMLRRKVEAVQNLVEAAEEADLNHEFNESLVFDYYNSVLINERDE-- 176
                :**.  : ::*.:: .: :*:  *.  **: .  *.:  .:  :       :   .  

alpha2delta1  -PEKNDSEPGSQR--IKPVFIEDANFGRQISYQHAAVHIPTDIYEGSTIVLNELNWTSAL 189
alpha2delta2  DPESEDVERGSKASTLRLDFIEDPNFKNKVNYSYAAVQIPTDIYKGSTVILNELNWTEAL 231
alpha2delta3  --DGNFLELGKEFILAPNDHFNN----LPVNISLSDVQVPTNMYNKDPAIVNGVYWSESL 195
alpha2delta4  --KGNFVELGAEFLLESNAHFSN----LPVNTSISSVQLPTNVYNKDPDILNGVYMSEAL 230
                . :  * * :       .:.:      :. . : *::**::*: .. ::* :  :.:*

alpha2delta1  DEVFKKNREEDPSLLWQVFGSATGLARYYPASPWVDNSRTPNKIDLYDVRRRPWYIQGAA 249
alpha2delta2  ENVFMENRRQDPTLLWQVFGSATGVTRYYPATPWR----APKKIDLYDVRRRPWYIQGAS 287
alpha2delta3  NKVFVDNFDRDPSLIWQYFGSAKGFFRQYPGIKWEP---DENGVIAFDCRNRKWYIQAAT 252
alpha2delta4  NAVFVENFQRDPTLTWQYFGSATGFFRIYPGIKWTP---DENGVITFDCRNRGWYIQAAT 287
              : ** .*  .**:* ** ****.*. * **.  *       : :  :* *.* ****.*:

alpha2delta1  SPKDMLILVDVSGSVSGLTLKLIRTSVSEMLETLSDDDFVNVASFNSNAQDVS-CFQ-HL 307
alpha2delta2  SPKDMVIIVDVSGSVSGLTLKLMKTSVCEMLDTLSDDDYVNVASFNEKAQPVS-CFT-HL 345
alpha2delta3  SPKDVVILVDVSGSMKGLRLTIAKQTVSSILDTLGDDDFFNIIAYNEELHYVEPCLNGTL 312
alpha2delta4  SPKDIVILVDVSGSMKGLRMTIAKHTITTILDTLGENDFVNIIAYNDYVHYIEPCFKGIL 347
              ****::*:******:.** :.: : ::  :*:**.::*:.*: ::*.  : :. *:   *

alpha2delta1  VQANVRNKKVLKDAVNNITAKGITDYKKGFSFAFEQLLNYNVSRAN--CNKIIMLFTDGG 365
alpha2delta2  VQANVRNKKVFKEAVQGMVAKGTTGYKAGFEYAFDQLQNSNITRAN--CNKMIMMFTDGG 403
alpha2delta3  VQADRTNKEHFREHLDKLFAKGIGMLDIALNEAFNILSDFNHTGQGSICSQAIMLITDGA 372
alpha2delta4  VQADRDNREHFKLLVEELMVKGVGVVDQALREAFQILKQFQEAKQGSLCNQAIMLISDGA 407
              ***:  *:: ::  :: : .**    . .:  **: * : : :  .  *.: **:::**.

alpha2delta1  EERAQEIFNKYNK-DKKVRVFRFSVGQHNYERGPIQWMACENKGYYYEIPSIGAIRINTQ 424
alpha2delta2  EDRVQDVFEKYNWPNRTVRVFTFSVGQHNYDVTPLQWMACANKGYYFEIPSIGAIRINTQ 463
alpha2delta3  VDTYDTIFAKYNWPDRKVRIFTYLIGREAAFADNLKWMACANKGFFTQISTLADVQENVM 432
alpha2delta4  VEDYEPVFEKYNWPDCKVRVFTYLIGREVSFADRMKWIACNNKGYYTQISTLADTQENVM 467
               :  : :* ***  : .**:* : :*:.      ::*:** ***:: :*.::.  : *. 

alpha2delta1  EYLDVLGRPMVLAGDKAKQVQWTNVYLDALELGLVITG------TLPVFNITGQFENKTN 478
alpha2delta2  EYLDVLGRPMVLAGKEAKQVQWTNVYEDALGLGLVVTG------TLPVFNLTQDGPGEK- 516
alpha2delta3  EYLHVLSRPKVID--QEHDVVWTEAYIDSTLPQAQKLTDDQGPVLMTTVAMPVFSKQNET 490
alpha2delta4  EYLHVLSRPMVIN--HDHDIIWTEAYMDSKLLSSQAQS----LTLLTTVAMPVFSKKNET 521
              ***.**.** *:   . ::: **:.* *:                :... :.     :  

alpha2delta1  LKNQLILGVMGVDVSLEDIKRLTPRFTLCPNGYYFAIDPNGYVLLHPNLQPKNPK----- 533
alpha2delta2  -KNQLILGVMGIDVALNDIKRLTPNYTLGANGYVFAIDLNGYVLLHPNLKPQTTN----- 570
alpha2delta3  RSKGILLGVVGTDVPVKELLKTIPKYKLGIHGYAFAITNNGYILTHPELRLLYEEGKKRR 550
alpha2delta4  RSHGILLGVVGSDVALRELMKLAPRYKLGVHGYAFLNTNNGYILSHPDLRPLYREGKKLK 581
               .: ::***:* **.:.:: :  *.:.*  :** *    ***:* **:*:    :     

alpha2delta1  -SQEPVTLDFLDAELENDIKVEIRNKMIDGESGEKTFRTLVKSQDERYIDKGNRTYTWTP 592
alpha2delta2  -FREPVTLDFLDAELEDENKEEIRRSMIDGNKGHKQIRTLVKSLDERYIDEVTRNYTWVP 629
alpha2delta3  -KPNYSSVDLSEVEWEDR-DDVLRNAMVNRKTGKFSMEVKKTVDKGKRVLVMTNDYYYTD 608
alpha2delta4  PKPNYNSVDLSEVEWEDQ-AESLRTAMINRETGTLSMDVKVPMDKGKRVLFLTNDYFFTD 640
                 :  ::*: :.* *:     :*  *:: :.*   : .     . : :   .. * :. 

alpha2delta1  VNGTDYSLALVLPTYS---FYYIKAKLEETITQARSKKGKMKDSETLKPDNFEESGYTFI 649
alpha2delta2  IRSTNYSLGLVLPPYS---TFYLQANLSDQILQVKLRISKLKDFEFLLPSSFESEGHVFI 686
alpha2delta3  IKGTPFSLGVALSRGHGKYFFRGNVTIEEGLHDLEHPDVSLADEWSYCNTDLHPEHRHLS 668
alpha2delta4  ISDTPFSLGVVLSRGHGEYILLGNTSVEEGLHDLLHPDLALAGDWIYCITDIDPDHRKLS 700
              : .* :**.:.*.          :..:.: : :       : .       .:. .   : 

alpha2delta1  APRDYCNDLKISDNNTEFLLNFNEFIDRKTPNNPSCNADLINRVLLDAGFTNELVQNYWS 709
alpha2delta2  APREYCKDLNASDNNTEFLKNFIELMEKVTPDSKQCNNFLLHNLILDTGITQQLVERVWR 746
alpha2delta3  QLEAIKLYLKGKEPLLQCDKELIQEVLFDAVVSAPIEAYWTSLALNKSENSDKGVEVAFL 728
alpha2delta4  QLEAMIRFLARKDPDLECDEELVREVLFDAVVTAPMEAYWTALALNMSEESEHVVDMAFL 760
                .     *  .:   :   :: . :   :  .   :       :  :  ::. *:  : 

alpha2delta1  KQ-KNIKGVKARFVVTDGGITRVYPKEAGENWQENPETYEDSFYKRSLDNDNYVFTAPYF 768
alpha2delta2  DQDLNTYSLLAVFAATDGGITRVFPNKAAEDWTENPEPFNASFYRRSLDNHGYVFKPPHQ 806
alpha2delta3  GT-RTGLSRINLFVGAEQLTNQDFLKAGDKENIFNADHFPLWYRRAAEQIPGSFVYSIPF 787
alpha2delta4  GT-RAGLLRSSLFVGSEKVSDRKFLTPEDEASVFTLDRFPLWYRQASEHPAGSFVFNLRW 819
                          *. ::    : : .   :    . : :   : : : .  . ..     

alpha2delta1  NKSG-PGAYES---GIMVSKAVEIYIQGKLLKPAVVGIKIDVNSWIENFTKTSIR----- 819
alpha2delta2  DALLRPLELENDTVGILVSTAVELSLGRRTLRPAVVGVKLDLEAWAEKFKVLASNRTHQD 866
alpha2delta3  STGP--VNKSN---VVTASTSIQLLDERKSPVVAAVGIQMKLEFFQRKFWTASRQ----- 837
alpha2delta4  AEGPESAGEPM---VVTASTAVAVTVDKRTAIAAAAGVQMKLEFLQRKFWAATRQ----- 871
                             : .*.:: :    :    *..*:::.::   .:*   : .     

alpha2delta1  -----DPCAGPVCDCKRNSDVMDCVILDDGGFLLMANHDDYTNQIGRFFGEIDPSLMRHL 874
alpha2delta2  QPQKCGPNSHCEMDCEVNNEDLLCVLIDDGGFLVLSNQNHQWDQVGRFFSEVDANLMLAL 926
alpha2delta3  -----CASLDGKCSISCDDETVNCYLIDNNGFILVSED---YTQTGDFFGEIEGAVMNKL 889
alpha2delta4  -----CSTVDGPCTQSCEDSDLDCFVIDNNGFILISKR---SRETGRFLGEVDGAVLTQL 923
                    .        . :.. : * ::*:.**:::::      : * *:.*::  ::  *

alpha2delta1  VNISVYAFNKSYDYQSVCEPGAAPKQGAGHRSAYVPSVADILQIGWWATAAAWSILQQFL 934
alpha2delta2  YNNSFYTRKESYDYQAACAPQPPGNLGAAPRGVFVPTVADFLNLAWWTSAAAWSLFQQLL 986
alpha2delta3  LTMGSFKRITLYDYQAMCRANKESSDGAHG--LLDPYNAFLSAVKWIMTELVLFLVEFNL 947
alpha2delta4  LSMGVFSQVTMYDYQAMCKPSSHHHSAAQP--LVSPISAFLTATRWLLQELVLFLLEWSV 981
               . . :     ****: * .      .*       *  * :    *     .  :.:  :

alpha2delta1  LSLTFPRLLEAVEME--DDDFTASLSKQSCITEQTQYFFDNDSKSFSGVLDCGNCSRIFH 992
alpha2delta2  YGLIYHSWFQADPAE--AEGSPETR-ESSCVMKQTQYYFGSVNASYNAIIDCGNCSRLFH 1043
alpha2delta3  C-SWWHSDMTAK-------AQKLKQTLEPCDTEYPAFVSERTIKETTGNIACEDCSKSFV 999
alpha2delta4  WGSWYDRGAEAKSVFHHSHKHKKQDPLQPCDTEYPVFVYQPAIREANGIVECEPCQKVFV 1041
                  :     *                ..*  : . :       . .. : *  *.: * 

alpha2delta1  GEKLMNTNLIFIMVESKGTCPCDTRLLIQAEQTSD-GPNPCDMVKQPRYRKGPDVCFDNN 1051
alpha2delta2  AQRLTNTNLLFVVAEKPLCSQCEAGRLLQKETHSD-GPEQCELVQRPRYRRGPHICFDYN 1102
alpha2delta3  IQQIPSSNLFMVVVDSSCLCESVAPITMAPIEIRYNESLKCERLKAQKIRRRPESCHGFH 1059
alpha2delta4  VQQIPNSNLLLLVTDPTCDCSIFPPVLQEATEVKYNASVKCDRMRSQKLRRRPDSCHAFH 1101
               ::: .:**::::.:    .   .             .  *: ::  : *: *. *.  :

alpha2delta1  VLEDYTDCGGVSGLNPSLWYIIGIQFLLLWLVSGSTHRLL-------- 1091
alpha2delta2  ATEDTSDCGRGASFPPSLGVLVSLQLLLLLGLPPRPQPQVLVHASRRL 1150
alpha2delta3  PEENARECGGAPSLQAQTVLLLLPL----LLMLFSR------------ 1091
alpha2delta4  PEENAQDCGGASDTSASPPLLLLPVCAWGLLPQLLR------------ 1137
                *:  :**  ..  ..   ::              

Accession numbers of the calcium ion channels used in the protein sequence alignments:

alpha1.1 - Q13698; alpha1.2 - Q13936; alpha1.3 - Q01668; alpha2.1 - O00555; alpha2.2 - Q00975; alpha2.3 - Q15878; alpha3.2 - O95180;

beta1-1 - NP_000714; beta1-2 - NP_954855; beta1-3 - NP_954856; beta2-1 - NP_000715; beta2-2 - NP_963890; beta2-3 - NP_963884; beta2-4 - NP_963891; beta2-5 - NP_963887; beta2-6 - NP_963865; beta2-7 - NP_963864; beta2-8 - NP_963866; beta3 - NP_000716; beta4a - NP_001005747; beta4b - NP_000717; beta4c - NP_001005746;

gamma1 - NP_000718; gamma2 - NP_006069; gamma3 - NP_006530; gamma4 - NP_055220; gamma5a - NP_665810; gamma5b - NP_055219; gamma6a - NP_665813; gamma6b - NP_665814; gamma6c - NP_114103; gamma7 - NP_114102; gamma8 - NP_114101;

alpha2delta1 - P54289; alpha2delta2 - Q9NY47; alpha2delta3 - Q8IZS8; alpha2delta4 - Q7Z3S7

Predicted General Properties of Representative Subunits of the Calcium Ion Channel  (Homo sapiens) - Primary Sequence Analysis (with ProtParam)b

alpha1.1 subunit

Number of amino acids: 1873

Molecular weight: 212350.2

Theoretical pI: 6.17

Total number of negatively charged residues (Asp + Glu): 201

Total number of positively charged residues (Arg + Lys): 186 Atomic composition: Carbon C 9659 Hydrogen H 15061 Nitrogen N 2489 Oxygen O 2683 Sulfur S 105

Formula: C9659H15061N2489O2683S105

Total number of atoms: 29997

Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 227910 Abs 0.1% (=1 g/l) 1.073, assuming ALL Cys residues appear as half cystines Ext. coefficient 225410 Abs 0.1% (=1 g/l) 1.062, assuming NO Cys residues appear as half cystines

Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).

Instability index: The instability index (II) is computed to be 41.16 This classifies the protein as unstable.

Aliphatic index: 97.51

Grand average of hydropathicity (GRAVY): 0.092

 

beta1-1 subunit

Number of amino acids: 598

Molecular weight: 65713.6

Theoretical pI: 6.33

Total number of negatively charged residues (Asp + Glu): 79

Total number of positively charged residues (Arg + Lys): 75

Atomic composition: Carbon C 2863 Hydrogen H 4560 Nitrogen N 830 Oxygen O 914 Sulfur S 15 Formula: C2863H4560N830O914S15

Total number of atoms: 9182

Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 53080 Abs 0.1% (=1 g/l) 0.808, assuming ALL Cys residues appear as half cystines Ext. coefficient 52830 Abs 0.1% (=1 g/l) 0.804, assuming NO Cys residues appear as half cystines

Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).

Instability index: The instability index (II) is computed to be 55.66 This classifies the protein as unstable.

Aliphatic index: 70.65

Grand average of hydropathicity (GRAVY): -0.695

 

gamma1 subunit

Number of amino acids: 222

Molecular weight: 25028.4

Theoretical pI: 6.64

Total number of negatively charged residues (Asp + Glu): 20

Total number of positively charged residues (Arg + Lys): 19

Atomic composition: Carbon C 1138 Hydrogen H 1757 Nitrogen N 287 Oxygen O 308 Sulfur S 20 Formula: C1138H1757N287O308S20

Total number of atoms: 3510

Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 38555 Abs 0.1% (=1 g/l) 1.540, assuming ALL Cys residues appear as half cystines Ext. coefficient 37930 Abs 0.1% (=1 g/l) 1.515, assuming NO Cys residues appear as half cystines

Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).

Instability index: The instability index (II) is computed to be 50.69 This classifies the protein as unstable.

Aliphatic index: 94.50

Grand average of hydropathicity (GRAVY): 0.341

 

alpha2delta1

Number of amino acids: 1091

Molecular weight: 123183.4

Theoretical pI: 5.10

Total number of negatively charged residues (Asp + Glu): 142

Total number of positively charged residues (Arg + Lys): 114

Atomic composition: Carbon C 5510 Hydrogen H 8536 Nitrogen N 1454 Oxygen O 1676 Sulfur S 38 Formula: C5510H8536N1454O1676S38

Total number of atoms: 17214

Extinction coefficients: Extinction coefficients are in units of M-1 cm-1, at 280 nm measured in water. Ext. coefficient 166270 Abs 0.1% (=1 g/l) 1.350, assuming ALL Cys residues appear as half cystines Ext. coefficient 165020 Abs 0.1% (=1 g/l) 1.340, assuming NO Cys residues appear as half cystines

Estimated half-life: The N-terminal of the sequence considered is M (Met). The estimated half-life is: 30 hours (mammalian reticulocytes, in vitro). >20 hours (yeast, in vivo). >10 hours (Escherichia coli, in vivo).

Instability index: The instability index (II) is computed to be 34.41 This classifies the protein as stable.

Aliphatic index: 84.97

Grand average of hydropathicity (GRAVY): -0.345

Bioinformatics References

a Higgins D., Thompson J., Gibson T. Thompson J. D., Higgins D. G., Gibson T. J.(1994). CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting,position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22:4673-4680.

b Gasteiger E., Hoogland C., Gattiker A., Duvaud S., Wilkins M.R., Appel R.D., Bairoch A.; Protein Identification and Analysis Tools on the ExPASy Server;
(In) John M. Walker (ed): The Proteomics Protocols Handbook, Humana Press (2005). pp. 571-607  Full text - Copyright Humana Press.

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